Cited by 561Circadian rhythm and melatoninGut microbiota and healthImmune Response and Inflammation

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Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

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Mukherji, Atish, Kobiita, Ahmad, Ye, Tao, Chambon, Pierre·2013·Cell

DOI 10.1016/j.cell.2013.04.020

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Abstract

Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circadian changes is unknown. Our functional and molecular dissections of the IEC circadian clock demonstrate that its integrity is required for microbiota-IEC dialog. In IEC, the antiphasic expression of the RORα activator and RevErbα repressor clock output regulators generates a circadian rhythmic TLR expression that converts the temporally arrhythmic microbiota signaling into circadian rhythmic JNK and IKKβ activities, which prevents RevErbα activation by PPARα that would disrupt the circadian clock. Moreover, through activation of AP1 and NF-κB, these activities, together with RORα and RevErbα, enable timing homeostatic functions of numerous genes with IEC circadian events. Interestingly, microbiota signaling deficiencies induce a prediabetic syndrome due to ileal corticosterone overproduction consequent to clock disruption.

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Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
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Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615
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IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202

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Seillet, C., Luong, K., Tellier, J., Jacquelot, N., Shen, R. D., Hickey, P. F., Wimmer, V. C., Whitehead, L. W., Rogers, K. L., Smyth, G. K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0567-y · Cited by 242
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Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
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Gut Microbiota: The Brain Peacekeeper
Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188
Control of immunity by glucocorticoids in health and disease
Shimba, A., & Ikuta, K. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00827-8 · Cited by 184
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Gut microbiota regulates stress responsivity via the circadian system
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Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178
Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome
Mukherji, A., Kobiita, A., Damara, M., Misra, N., Méziane, H., Champy, M., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519807112 · Cited by 185
Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics
de Kivit, S., Tobin, M. C., Forsyth, C. B., Keshavarzian, A., & LANDAY, A. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00060 · Cited by 185
The Circadian Clock in Skin
Plikus, M. V., Spyk, E. N. V., Pham, K., Geyfman, M., Kumar, V., Takahashi, J. S., & D, B. A. M. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414563537 · Cited by 179
The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis
Heddes, M., Altaha, B., Niu, Y., Reitmeier, S., Kleigrewe, K., Haller, D., & Kießling, S. (2022) · Nature Communications · doi:10.1038/s41467-022-33609-x · Cited by 183
Human Milk Components Modulate Toll-Like Receptor–Mediated Inflammation
He, Y., Lawlor, N. T., & Newburg, D. S. (2016) · Advances in Nutrition · doi:10.3945/an.115.010090 · Cited by 182
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Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism
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The Circadian Clock Mutation Promotes Intestinal Dysbiosis
Voigt, R. M., Summa, K. C., Forsyth, C. B., Green, S. J., Engen, P. A., Naqib, A. D., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12943 · Cited by 172
Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 179
Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study
Collado, M. C., Engen, P. A., Bandín, C., Cabrera‐Rubio, R., Voigt, R. M., Green, S. J., Naqib, A., Keshavarzian, A., Scheer, F. A. J. L., & Garaulet, M. (2018) · The FASEB Journal · doi:10.1096/fj.201700697rr · Cited by 168
Expressions of Tight Junction Proteins Occludin and Claudin-1 Are under the Circadian Control in the Mouse Large Intestine: Implications in Intestinal Permeability and Susceptibility to Colitis
Oh‐oka, K., Kono, H., Ishimaru, K., Miyake, K., Kubota, T., Ogawa, H., Okumura, K., Shibata, S., & Nakao, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098016 · Cited by 163
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Fawad, J. A., Luzader, D., Hanson, G. F., Moutinho, T. J., McKinney, C. A., Mitchell, P., Brown-Steinke, K., Kumar, A., Park, M., Lee, S., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2022.07.051 · Cited by 174
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Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet
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Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation
Ma, N., Zhang, J., Reiter, R. J., & Ma, X. (2019) · Medicinal Research Reviews · doi:10.1002/med.21628 · Cited by 155
Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk
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Authors: Mukherji, A., Kobiita, A., Ye, T., & Chambon, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Chambon, Pierre
ORCID: Mukherji, Atish
Ye, Tao
Chambon, Pierre
Venue: Cell
Publisher: Elsevier BV
Published: 2013-05
Volume: 153
Issue: 4
Pages: 812-827
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2013.04.020
OpenAlex: W2051984731
Cited by: 560
References: 61
Citations by year: 2026: 21 · 2025: 36 · 2024: 45 · 2023: 43 · 2022: 58 · 2021: 43 · 2020: 54 · 2019: 68 · 2018: 24 · 2017: 48 · 2016: 39 · 2015: 39 · 2014: 37 · 2013: 5
FWCI: 21.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 373 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Agence Nationale de la Recherche (07-Physio 002-01)
Institut National de la Santé et de la Recherche Médicale
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: intestinal epithelium, circadian clock, gut microbiota, Toll-like receptors, RORα, NR1D1, PPARα, JNK, IKKβ, NF-κB, AP-1, prediabetes, corticosterone, intestinal homeostasis
MeSH terms: Animals, Corticosterone, Ileum, Intestinal Mucosa, Male, Mice, Inbred C57BL, NF-kappa B, Toll-Like Receptors, Mice, Metagenome, Nuclear Receptor Subfamily 1, Group D, Member 1, Nuclear Receptor Subfamily 1, Group F, Member 1

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Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

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