The Gut Microbiome and Individual-Specific Responses to Diet
Open accessAbstract
Nutritional content and timing are increasingly appreciated to constitute important human variables collectively impacting all aspects of human physiology and disease. However, person-specific mechanisms driving nutritional impacts on the human host remain incompletely understood, while current dietary recommendations remain empirical and nonpersonalized. Precision nutrition aims to harness individualized bodies of data, including the human gut microbiome, in predicting person-specific physiological responses (such as glycemic responses) to food. With these advances notwithstanding, many unknowns remain, including the long-term efficacy of such interventions in delaying or reversing human metabolic disease, mechanisms driving these dietary effects, and the extent of the contribution of the gut microbiome to these processes. We summarize these conceptual advances, while highlighting challenges and means of addressing them in the next decade of study of precision medicine, toward generation of insights that may help to evolve precision nutrition as an effective future tool in a variety of "multifactorial" human disorders.
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Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods.
“Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods. 35-41”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [36]
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Diverse High-Fat Diets Drive Multi-Omic Reprogramming that Persists after Dietary ReversalPreprint
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- Authors
- Leshem, A., Segal, E., & Elinav, E.
- Affiliations
- Tel Aviv Sourasky Medical Center (IL)
- Weizmann Institute of Science (IL)
- German Cancer Research Center (DE)
- Corresponding author
- Segal, Eran
- Elinav, Eran
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2020-10-27
- Volume
- 5
- Issue
- 5
- ISSN
- 2379-5077 (ISSN-L)
- OpenAlex
- W3091358887
- Cited by
- 109
- References
- 173
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 15 · 2023: 20 · 2022: 18 · 2021: 16 · 2020: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSystems (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- gut microbiota, personalized nutrition, glycemic response, metabolic disorders, personalized medicine
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