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Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling
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“In Drosophila , muscle specific knockdown of complex I subunit NDUFS1/ND75 extends longevity in an UPR mt -dependent fashion 164 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [164]
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“elegans, where RNAi-mediated knockdown of cytochrome c oxidase-1 subunit Vb in neurons activates the UPR autonomously in neurons and nonautonomously in the gut (Durieux et al., 2011).”
InfluentialPharmacological approaches to restore mitochondrial function
Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
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“For instance, the increased replicative lifespan associated with mitochondrial perturbation in yeast is abrogated when genes involved in the retrograde response are disrupted (Kirchman et al., 1999), and the prolonged lifespan resulting from electron transport chain (ETC) perturbation in C.”
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
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The mitochondrial basis of aging
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Mitonuclear communication in homeostasis and stress
Quirós, P. M., Mottis, A., & Auwerx, J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.23 · Cited by 787
Metadata
- Authors
- Owusu-Ansah, E., Song, W., & Perrimon, N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 155
- Issue
- 3
- Pages
- 699-712
- ISSN
- 0092-8674
- PMC
- PMC3856681
- Cited by
- 391
- References
- 10
- Language
- en
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