Cited by 207Mitochondrial Function and PathologySirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

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Finley, Lydia W.S., Haigis, Marcia C.·2009·Ageing Research Reviews

Abstract

Mitochondria are dynamic organelles that integrate environmental signals to regulate energy production, apoptosis and Ca(2+) homeostasis. Not surprisingly, mitochondrial dysfunction is associated with aging and the pathologies observed in age-related diseases. The vast majority of mitochondrial proteins are encoded in the nuclear genome, and so communication between the nucleus and mitochondria is essential for maintenance of appropriate mitochondrial function. Several proteins have emerged as major regulators of mitochondrial gene expression, capable of increasing transcription of mitochondrial genes in response to the physiological demands of the cell. In this review, we will focus on PGC-1alpha, SIRT1, AMPK and mTOR and discuss how these proteins regulate mitochondrial function and their potential involvement in aging, calorie restriction and age-related disease. We will also discuss the pathways through which mitochondria signal to the nucleus. Although such retrograde signaling is not well studied in mammals, there is growing evidence to suggest that it may be an important area for future aging research. Greater understanding of the mechanisms by which mitochondria and the nucleus communicate will facilitate efforts to slow or reverse the mitochondrial dysfunction that occurs during aging.

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Crossref · 10.1016/j.arr.2009.03.003

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Authors
Finley, L. W. S., & Haigis, M. C.
Affiliations
Harvard University (US)
Corresponding author
Haigis, Marcia C.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2009-07
Volume
8
Issue
3
Pages
173-188
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2049547722
Cited by
207
References
270
Citations by year
2026: 7 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 22 · 2013: 29 · 2012: 20
FWCI
1.58
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG032375)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
mitochondrial-nuclear communication, mitochondrial dysfunction, aging, caloric restriction, PGC-1α, SIRT1, AMPK, mTOR, mitochondrial gene expression, retrograde signaling, age-related diseases, mitochondrial biogenesis
MeSH terms
Aging, Animals, Cell Nucleus, Gene Expression Regulation, Humans, Mitochondria, Signal Transduction, Cellular Senescence, Active Transport, Cell Nucleus, Mitochondrial Proteins, Mitochondrial Diseases, Caloric Restriction

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