Super-Enhancers in the Control of Cell Identity and Disease

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Items 201–300 of 1,018

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    Xuhui Tong, Rong Tang, Jin Xu, Wei Wang, Yingjun Zhao, Xianjun Yu, Si Shi · 2022 · Signal Transduction and Targeted Therapy
  2. Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability
    Fei‐Long Meng, Zhou Du, Alexander Joel Federation, Jiazhi Hu, Qiao Wang, Kyong-Rim Kieffer-Kwon, Robin M. Meyers, Corina Amor, Caitlyn R. Wasserman, Donna S Neuberg et al. · 2014 · Cell
  3. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients
    De‐Chen Lin, Ming‐Rong Wang, Harold Phillip Koeffler · 2017 · Gastroenterology
  4. Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
    Preston R. Arnold, Andrew D. Wells, X.C. Li · 2020 · Frontiers in Cell and Developmental Biology
  5. The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
    Tasnim H. Beacon, Geneviève P. Delcuve, Camila L. Lopez, Gino Nardocci, Igor Kovalchuk, André J. van Wijnen, James Davie · 2021 · Clinical Epigenetics
  6. Identification of six new susceptibility loci for invasive epithelial ovarian cancer
    EMBRACE, Kuchenbaecker, Karoline B, GEMO Study Collaborators, Breast Cancer Family Registry, HEBON, KConFab Investigators, Australian Cancer Study (Ovarian Cancer Investigators), Australian Ovarian Cancer Study Group, the Consortium of Investigators of Modifiers of BRCA1 and BRCA2, Ramus, Susan J et al. · 2015 · Nature Genetics
  7. Bromodomain biology and drug discovery
    Nilesh Zaware, Ming‐Ming Zhou · 2019 · Nature Structural & Molecular Biology
  8. Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition
    Wang, Chaochen, Lee, Ji-Eun, Lai, Binbin, Macfarlan, Todd S., Xu, Shiliyang, Zhuang, Lenan, Liu, Chengyu, Peng, Weiqun, Ge, Kai · 2016 · Proceedings of the National Academy of Sciences
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  10. Functional inference of gene regulation using single-cell multi-omics
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  11. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis
    Jialiang Huang, Xin Liu, Dan Li, Zhen Shao, Hui Cao, Yuannyu Zhang, Eirini Trompouki, Teresa V. Bowman, Leonard Ira Zon, Guo‐Cheng Yuan et al. · 2016 · Developmental Cell
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  13. 50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms
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  14. MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
    Jakub Mieczkowski, April Cook, Sarah Bowman, Britta Mueller, Burak H. Alver, Sharmistha Kundu, Aimée M. Deaton, Jennifer A. Urban, Erica Larschan, Peter J. Park et al. · 2016 · Nature Communications
  15. The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma
    Jiyuan Zhang, Sofija Vlasevska, Victoria A. Wells, Sarah E. Nataraj, Antony B. Holmes, Romain Duval, Stefanie N. Meyer, Tongwei Mo, Katia Basso, Paul K. Brindle et al. · 2017 · Cancer Discovery
  16. RETRACTED: Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma
    Jian-Jun Xie, Yan-Yi Jiang, Yuan Ying Jiang, Chunquan Li, Mei Chee Lim, Ömer An, Anand Mayakonda, Ling‐Wen Ding, Lin Long, Chun Sun et al. · 2018 · Gastroenterology · Retracted
  17. Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
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  18. Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis
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  19. Dissecting super-enhancer hierarchy based on chromatin interactions
    Huang, Jialiang, Li, Kailong, Cai, Wenqing, Liu, Xin, Zhang, Yuannyu, Orkin, Stuart H., Xu, Jian, Yuan, Guo-Cheng · 2018 · Nature Communications
  20. Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1
    Eleni M. Tomazou, Nathan C. Sheffield, Christian Schmidl, Michael K. Schuster, Andreas Schönegger, Paul Datlinger, Stefan Kubicek, Christoph Bock, Heinrich Kovar · 2015 · Cell Reports
  21. Whole-genome sequencing of a sporadic primary immunodeficiency cohort
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  22. Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer
    Narsis Attar, Siavash K. Kurdistani · 2016 · Cold Spring Harbor Perspectives in Medicine
  23. Enhancer variants: evaluating functions in common disease
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  24. Nuclear compartmentalization as a mechanism of quantitative control of gene expression
    Prashant Bhat, Drew D. Honson, Mitchell Guttman · 2021 · Nature Reviews Molecular Cell Biology
  25. Enhancer redundancy in development and disease
    Evgeny Z. Kvon, Rachel Waymack, Mario Gad, Zeba Wunderlich · 2021 · Nature Reviews Genetics
  26. Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)
    Masaru Katoh · 2018 · International Journal of Molecular Medicine
  27. Identification of Novel Genetic Markers of Breast Cancer Survival
    Qi Jin Guo, Marjanka K. Schmidt, Peter L. Kraft, Sander Canisius, Constance Chen, Sofia Khan, Jonathan P. Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis et al. · 2015 · JNCI Journal of the National Cancer Institute
  28. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
    Paola A. Betancur, Brian J. Abraham, Ying Ying Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark A. Zarnegar, Angera H. Kuo, Kelly Marie McKenna, Yoko Kojima, Nicholas James Leeper et al. · 2017 · Nature Communications
  29. Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
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  30. MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification
    Mark W. Zimmerman, Yu Liu, Shuning He, Adam David Durbin, Brian J. Abraham, John B. Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang et al. · 2017 · Cancer Discovery
  31. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
    Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar, Tomoyuki Koga, Yarui Diao, Ramya Raviram, Feng Liu, Kristen M. Turner, Huijun Yang, Elizabeth Brunk et al. · 2019 · Nature
  32. Genetic, Epigenetic, and Environmental Contributions to Neural Tube Closure
    Jonathan J. Wilde, Juliette R. Petersen, Lee Ann Niswander · 2014 · Annual Review of Genetics
  33. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
    Rhamy Zeid, Matthew A. Lawlor, Evon Poon, Jaime M. Reyes, Mariateresa Fulciniti, Michael A. Lopez, Thomas G. Scott, Behnam Nabet, Michael A. Erb, Georg E. Winter et al. · 2018 · Nature Genetics
  34. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Yuan Ying Jiang, Yan-Yi Jiang, Jian‐Jun Xie, Anand Mayakonda, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chunquan Li, Moli Huang, Ling‐Wen Ding et al. · 2018 · Nature Communications
  35. Evaluating Enhancer Function and Transcription
    Andrew R. Field, Karen Adelman · 2020 · Annual Review of Biochemistry
  36. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells
    Tahsin Stefan Barakat, Florian Halbritter, Man Zhang, André F. Rendeiro, Elena Perenthaler, Christoph Bock, Ian Chambers · 2018 · Cell stem cell
  37. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
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  38. Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines
    Qin Cao, Christine Anyansi, Xihao Sherlock Hu, Liangliang Xu, Lei Xiong, Wenshu Tang, Myth T.S. Mok, Chao Cheng, Xiaodan Fan, Mark Gerstein et al. · 2017 · Nature Genetics
  39. Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma
    Lindsay M. LaFave, Vinay K. Kartha, Sai Ma, Kevin Meli, Isabella S. Del Priore, Caleb A. Lareau, Santiago Naranjo, Peter M.K. Westcott, Fabiana M. Duarte, Venkat Sankar et al. · 2020 · Cancer Cell
  40. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
    Remi Stevelink, Ciarán Campbell, Siwei Chen, Bassel W Abou-Khalil, Oluyomi M. Adesoji, Zaid Afawi, Elisabetta Amadori, Alison Anderson, Joseph Anderson, Danielle Molinari Andrade et al. · 2023 · Nature Genetics
  41. Treg cells in health and autoimmune diseases: New insights from single cell analysis
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  42. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
    Gerard L. Brien, David Remillard, Junwei Shi, Matthew L. Hemming, Jonathon Chabon, Kieran J. Wynne, Eugène Dillon, Gerard Cagney, Guido van Mierlo, Marijke P. A. Baltissen et al. · 2018 · eLife
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  44. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
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  45. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
    NBCS Collaborators, Lang Wu, kConFab/AOCS Investigators, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K. Bolla, Xiao‐Ou Shu et al. · 2018 · Nature Genetics
  46. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma
    Yan-Yi Jiang, De‐Chen Lin, Anand Mayakonda, Masaharu Hazawa, Ling‐Wen Ding, Wen-Wen Chien, Liang Xu, Ye Chen, Jin‐Fen Xiao, William T. Senapedis et al. · 2016 · Gut
  47. Genetic determinants of co-accessible chromatin regions in activated T cells across humans
    Gate, Rachel E., Cheng, Christine S., Aiden, Aviva P., Siba, Atsede, Tabaka, Marcin, Lituiev, Dmytro, Machol, Ido, Gordon, M. Grace, Subramaniam, Meena, Shamim, Muhammad et al. · 2018 · Nature Genetics
  48. Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex
    Zhijie Liu, Daria Merkurjev, Feng Yang, Wenbo Li, Soohwan Oh, Meyer J. Friedman, Xiaoyuan Song, Feng Zhang, Qi Ma, Kenneth A. Ohgi et al. · 2014 · Cell
  49. Integrated genomic analyses of de novo pathways underlying atypical meningiomas
    Akdes Serin Harmancı, Mark W. Youngblood, Victoria Elizabeth Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Durán, Zeynep Erson-Omay, Leon D. Kaulen, Tong Ihn Lee, Brian J. Abraham et al. · 2017 · Nature Communications
  50. CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
    Wang, Qianhao, Xiong, Haiqing, Ai, Shanshan, Yu, Xianhong, Liu, Yaxi, Zhang, Jiejie, He, Aibin · 2019 · Molecular Cell
  51. Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
    Di Micco, Raffaella, Fontanals-Cirera, Barbara, Low, Vivien, Ntziachristos, Panagiotis, Yuen, Stephanie K., Lovell, Claudia D., Dolgalev, Igor, Yonekubo, Yoshiya, Zhang, Guangtao, Rusinova, Elena et al. · 2014 · Cell Reports
  52. Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation
    Rui R. Catarino, Alexander Stark · 2018 · Genes & Development
  53. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
    Holger Heyn, Enrique Vidal, Humberto J. Ferreira, Miguel Vizoso, Sergi Sayols, Antonio Gómez, Sebastián Morán, Raquel Boqué-Sastre, Sònia Guil, Anna Martínez‐Cardús et al. · 2016 · Genome biology
  54. Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF
    Kang, Kyuho, Park, Sung Ho, Chen, Janice, Qiao, Yu, Giannopoulou, Eugenia, Berg, Karen, Hanidu, Adedayo, Li, Jun, Nabozny, Gerald, Kang, Keunsoo et al. · 2017 · Immunity
  55. SEdb: a comprehensive human super-enhancer database
    Yong Jiang, Fengcui Qian, Xuefeng Bai, Yuejuan Liu, Qiuyu Wang, Bo Ai, Xiaole Han, Shanshan Shi, Jian Zhang, Xuecang Li et al. · 2018 · Nucleic Acids Research
  56. CDK9: a signaling hub for transcriptional control
    Curtis W. Bacon, Iván D’Orso · 2018 · Transcription
  57. mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
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  58. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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  59. Architecture of gene regulatory networks controlling flower development in Arabidopsis thaliana
    Dijun Chen, Wenhao Yan, Liang-Yu Fu, Kerstin Kaufmann · 2018 · Nature Communications
  60. CDK7 inhibitors as anticancer drugs
    Georgina P. Sava, Hailing Fan, R. Charles Coombes, Laki Buluwela, Simak Ali · 2020 · Cancer and Metastasis Reviews
  61. CRISPR Reveals a Distal Super-Enhancer Required for Sox2 Expression in Mouse Embryonic Stem Cells
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  62. HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models
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  63. Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
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  67. Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis
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  74. Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells
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  77. MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
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  79. Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
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  80. Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex
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  81. CD4 T cell differentiation in type 1 diabetes
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  82. Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
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  83. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
    Paloma Cejas, Yotam Drier, Koen M.A. Dreijerink, Lodewijk A.A. Brosens, Vikram Deshpande, Charles B. Epstein, Elfi B. Conemans, Folkert H.M. Morsink, Mindy Kim Graham, Gerlof Dirk Valk et al. · 2019 · Nature Medicine
  84. Targeting Cancer Cells with BET Bromodomain Inhibitors
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  85. Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients
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  87. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
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  88. TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines
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  89. Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions
    Michael J. D. Brand, Angelina M. Measures, Brian G. Wilson, Wilian Augusto Cortopassi, Rikki P. Alexander, Matthias Höss, David S. Hewings, Timothy P. C. Rooney, Robert S. Paton, Stuart J. Conway · 2014 · ACS Chemical Biology
  90. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
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  91. Genome-Wide Prediction and Validation of Intergenic Enhancers in Arabidopsis Using Open Chromatin Signatures
    Bo Zhu, Wenli Zhang, Tao Zhang, Liu B, Jiming Jiang · 2015 · The Plant Cell
  92. The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations
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  93. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
    GEMO Study Collaborators, Laura Fachal, EMBRACE Collaborators, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen et al. · 2020 · Nature Genetics
  94. EP300 Selectively Controls the Enhancer Landscape of MYCN -Amplified Neuroblastoma
    Adam David Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M. Shendy, Stephanie Nance, Anand G. Patel et al. · 2021 · Cancer Discovery
  95. Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth
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  96. The many lives of KATs — detectors, integrators and modulators of the cellular environment
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  97. Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer
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  98. A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity
    D’Alessio, Ana C., Fan, Zi Peng, Wert, Katherine J., Baranov, Petr, Cohen, Malkiel A., Saini, Janmeet S., Cohick, Evan, Charniga, Carol, Dadon, Daniel, Hannett, Nancy M. et al. · 2015 · Stem Cell Reports
  99. MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner
    Rodrigo L. dos Santos, Luca Tosti, Aliaksandra Radzisheuskaya, Isabel Martín Caballero, Keisuke Kaji, Brian Hendrich, José Silva · 2014 · Cell stem cell
  100. Rewiring cancer drivers to activate apoptosis
    Sai P. Gourisankar, A. Krokhotin, Wenzhi Ji, Xiaofan Liu, Chiung-Ying Chang, Samuel H. Kim, Zhengnian Li, Wendy Wenderski, Juste Simanauskaite, Haopeng Yang et al. · 2023 · Nature