Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

DNA methylation patterns and epigenetic memory

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Human DNA methylomes at base resolution show widespread epigenomic differences

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,925

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

Li, X., Cao, G., Liu, X., Tang, T.-S., Guo, C., & Liu, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.852002 · Cited by 22

Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

Gyobu‐Motani, S., Yabuta, Y., Mizuta, K., Katou, Y., Okamoto, I., Kawasaki, M., Kitamura, A., Tsukiyama, T., Iwatani, C., Tsuchiya, H., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112962 · Cited by 21

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

Xue, Y., Chen, Y., Sun, S., Tong, X., Chen, Y., Tang, S., Wang, X., Bi, S., Qiu, Y., Zhao, Q., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240111 · Cited by 23

The expression patterns of DNA methylation reprogramming related genes are associated with the developmental competence of cloned embryos after zygotic genome activation in pigs

Huan, Y., Wang, H., Wu, Z., Zhang, J., Liu, Z., & He, H. (2015) · Gene Expression Patterns · doi:10.1016/j.gep.2015.04.001 · Cited by 22

DAZL regulates Tet1 translation in murine embryonic stem cells

Welling, M., Chen, H., Muñoz, J., Musheev, M. U., Kester, L. A., Junker, J. P., Mischerikow, N., Arbab, M., Kuijk, E., Silberstein, L., et al. (2015) · EMBO Reports · doi:10.15252/embr.201540538 · Cited by 22

Epigenetics mechanisms in renal development

Hilliard, S. A., & El-Dahr, S. S. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3228-x · Cited by 22

Epigenetic Control of Early Mouse Development

Lim, C. Y., Knowles, B. B., Solter, D., & Messerschmidt, D. M. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.05.002 · Cited by 23

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

Nishio, K., Belle, R., Katoh, T., Kawamura, A., Sengoku, T., Hanada, K., Ohsawa, N., Shirouzu, M., Yokoyama, S., & Suga, H. (2018) · ChemBioChem · doi:10.1002/cbic.201800047 · Cited by 22

Targeting ADP-ribosylation by PARP inhibitors in acute myeloid leukaemia and related disorders

Faraoni, I., Giansanti, M., Voso, M. T., Lo‐Coco, F., & Graziani, G. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.019 · Cited by 23

Effects of 2,3′,4,4′5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring’s oocytes in mice

He, Q., Wei, X.-Y., Han, X.-Y., Zhou, Q., Wang, H., Ding, N., Meng, X., Schatten, H., Sun, Q., & Liu, S. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02529-z · Cited by 22

CRISPR/dCas9 as a Therapeutic Approach for Neurodevelopmental Disorders: Innovations and Limitations Compared to Traditional Strategies

Ricci, R., & Colasante, G. (2021) · Developmental Neuroscience · doi:10.1159/000515845 · Cited by 23

Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases

Mao, L., Lu, J., Hou, Y., & Nie, T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1458848 · Cited by 23

Epigenetic Effects in Livestock Breeding

Yakovlev, A. F. (2018) · Russian Journal of Genetics · doi:10.1134/s1022795418080148 · Cited by 22

A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

Lei, J. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110196 · Cited by 23

Occupational exposure to organophosphate esters in e-waste dismantling workers: Risk assessment and influencing factors screening

Li, X., Wang, L., Wang, Y., Yao, Y., Zhang, P., Zhao, H., & Sun, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113707 · Cited by 22

The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine

Alagia, A., & Gullerová, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.915685 · Cited by 22

DNA methylation of HOX genes and its clinical implications in cancer

Hu, X., Wang, Y., Zhang, X., Li, C., Zhang, X., Yang, D., Liu, Y., & Li, L. (2023) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2023.104871 · Cited by 21

'Memory and molecular turnover,’ 30 years after inception

Meagher, R. B. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-37 · Cited by 21

5-Methylcytosine Recognition by Arabidopsis thaliana DNA Glycosylases DEMETER and DML3

Brooks, S. C., Fischer, R. L., Huh, J. H., & Eichman, B. F. (2014) · Biochemistry · doi:10.1021/bi5002294 · Cited by 21

Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer

Fernández‐Jiménez, N., Sklias, A., Ecsedi, S., Cahais, V., Esposti, D. D., Jay, A., Ancey, P., Woo, H. D., Hernández‐Vargas, H., & Herceg, Z. (2017) · Epigenetics · doi:10.1080/15592294.2017.1373919 · Cited by 23

The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism

Biamonti, G., Maita, L., & Montecucco, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00408 · Cited by 22

Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases

Norvil, A. B., Saha, D., Dar, M. S., & Gowher, H. (2019) · Genes · doi:10.3390/genes10050369 · Cited by 22

Bta-miR-10b Secreted by Bovine Embryos Negatively Impacts Preimplantation Embryo Quality

Lin, X., Pavani, K. C., Smits, K., Deforce, D. L. D., Heindryckx, B., Soom, A. V., & Peelman, L. J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00757 · Cited by 21

Methylation Detection and DNA Sequencing Based on Adsorption of Nucleobases on Silicene Nanoribbon

Li, Q., Liu, H., Tian, Y., Guo, J., Chen, G., & Lee, J. Y. (2020) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.0c01734 · Cited by 21

Thyroid Hormone Induces DNA Demethylation in Xenopus Tadpole Brain

Raj, S., Kyono, Y., Sifuentes, C. J., Arellanes-Licea, E. D. C., Subramani, A., & Denver, R. J. (2020) · Endocrinology · doi:10.1210/endocr/bqaa155 · Cited by 20

Molecular epigenetic switches in neurodevelopment in health and disease

Hoffmann, A., Zimmermann, C. A., & Spengler, D. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00120 · Cited by 22

Programming and Inheritance of Parental DNA Methylomes in Vertebrates

Ci, W., & Liu, J. (2015) · Physiology · doi:10.1152/physiol.00037.2014 · Cited by 21

Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency

Han, C., Deng, R., Mao, T., Luo, Y., Wei, B., Meng, P., Zhao, L. H., Zhang, Q., Quan, F., Liu, J., et al. (2018) · FEBS Journal · doi:10.1111/febs.14515 · Cited by 22

Covid-19 And Cancer: Insights Into Their Association And Influence On Genetic And Epigenetic Landscape

Ghosh, M. K., Kumar, S., Ganguly, K. K., Ghosh, P., Tabassum, S., Basu, B., & Basu, M. (2023) · Epigenomics · doi:10.2217/epi-2023-0052 · Cited by 22

MIR 29B mediates epigenetic mechanisms of HBG gene activation

Starlard‐Davenport, A., Smith, A., Vu, L. D., Li, Y., & Pace, B. S. (2019) · British Journal of Haematology · doi:10.1111/bjh.15870 · Cited by 20

Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease

Huang, Y., Chen, K., Lo, M., Cai, X.-Y., Chang, L., Kuo, Y.-H., Huang, W.-D., & Kuo, H. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.32773 · Cited by 20

Epigenetic changes in Mycobacterium tuberculosis and its host provide potential targets or biomarkers for drug discovery and clinical diagnosis

Sui, J., Qiao, W., Xiang, X., & Luo, Y. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106195 · Cited by 24

Paradigm shifts in animal epigenetics: Research on non‐model species leads to new insights into dependencies, functions and inheritance of DNA methylation

Vogt, G. (2022) · BioEssays · doi:10.1002/bies.202200040 · Cited by 21

Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models

Domingos, L. B., da Silva, N. R., Filho, A. J. M. C., Sales, A. J., Starnawska, A., & Joca, S. R. L. (2022) · Genes · doi:10.3390/genes13112165 · Cited by 19

Epigenetic mechanisms of bone cancer pain

Ni, C., Chen, L., Hua, B., Han, Z., Xu, L., Zhou, Q., Yao, M., & Ni, H. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110164 · Cited by 21

Isolation of Human Genomic DNA Sequences with Expanded Nucleobase Selectivity

Rathi, P., Maurer, S., Kubik, G., & Summerer, D. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b04807 · Cited by 20

5‐Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms

Lee, J. J., Vilain, R. E., Granter, S. R., Hu, N. R., Bresler, S. C., Xu, S., Frank, A., Mihm, M. C., Saw, R. P. M., Fletcher, C. D. �., et al. (2016) · Journal of Cutaneous Pathology · doi:10.1111/cup.12880 · Cited by 20

Dietary Restriction and Epigenetics: Part I.

Ng, G. Y.-Q., Fann, D. Y., Jo, D., Sobey, C. G., & Arumugam, T. V. (2019) · PubMed · Cited by 20

Epigenetic States of Nephron Progenitors and Epithelial Differentiation

Adli, M., Parlak, M., Li, Y., & El-Dahr, S. S. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25048 · Cited by 21

Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains

Tang, Y., Han, S., Asakawa, T., Luo, Y., Han, X., Xiao, B., Dong, Q., & Wang, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s97456 · Cited by 20

The Regulation and Function of Fibroblast Growth Factor 8 and Its Function during Gonadotropin-Releasing Hormone Neuron Development

Chung, W. C. J., Linscott, M. L., Rodriguez, K. M., & Stewart, C. E. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00114 · Cited by 22

Correlation Between Altered DNA Methylation of Intergenic Regions of ITPR3 and Development of Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage

Kim, B. J., Kim, Y., Hong, E. P., Jeon, J. P., Yang, J. S., Choi, H. J., Kang, S. H., & Cho, Y. J. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.06.113 · Cited by 19

Quantification of Epigenetic DNA Modifications in the Subchromatin Structure Matrix Attachment Regions by Stable Isotope Dilution UHPLC-MS/MS Analysis

Zhang, R., Lai, W., & Wang, H. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04151 · Cited by 19

DNA methylation in cell plasticity and malignant transformation in liver diseases

Kim, M., Delgado, E. R., & Ko, S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108334 · Cited by 20

Targeting the epigenome with advanced delivery strategies for epigenetic modulators

Guha, S., Jagadeesan, Y., Pandey, M. M., Mittal, A., & Chitkara, D. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10710 · Cited by 22

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

Fong, K. S. K., Hufnagel, R. B., Khadka, V. S., Corley, M. J., Maunakea, A. K., Fogelgren, B., Ahmed, Z. M., & Lozanoff, S. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024109 · Cited by 20

DNA hydroxymethylation combined with carotid plaques as a novel biomarker for coronary atherosclerosis

Jiang, D., Wang, Y., Chang, G., Duan, Q., You, L., Sun, M., Hu, C., Gao, L., Wu, S., Tao, H., et al. (2019) · Aging · doi:10.18632/aging.101972 · Cited by 20

Reversible promoter methylation determines fluctuating expression of acute phase proteins

Zhang, S., Wang, M., Feng, J.-R., Chang, Y., Ji, S., & Wu, Y. (2020) · eLife · doi:10.7554/elife.51317 · Cited by 20

Epigenetic Regulation of Endothelial Cell Function by Nucleic Acid Methylation in Cardiac Homeostasis and Disease

Russell‐Hallinan, A., Watson, C. J., O’Dwyer, D., Grieve, D., & O’Neill, K. M. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07019-4 · Cited by 18

The neuroendocrine modulation of global DNA methylation in neuropsychiatric disorders

Müller, D., Grevet, E. H., da Silva, B. S., Charão, M. F., Rovaris, D. L., & Bau, C. H. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00924-y · Cited by 19

The Dnmt1 Intrinsically Disordered Domain Regulates Genomic Methylation During Development

Shaffer, B., McGraw, S., Xiao, S., Chan, D., Trasler, J. M., & Chaillet, J. R. (2014) · Genetics · doi:10.1534/genetics.114.173609 · Cited by 19

Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy

Oliński, R., Gackowski, D., & Cooke, M. S. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.11.002 · Cited by 19

DNA Methylation and Hydroxymethylation in Primary Colon Cancer and Synchronous Hepatic Metastasis

Udali, S., Santis, D. D., Ruzzenente, A., Moruzzi, S., Mazzi, F., Beschin, G., Tammen, S. A., Campagnaro, T., Pattini, P., Olivieri, O., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2017.00229 · Cited by 19

Ultrasensitive Determination of Rare Modified Cytosines Based on Novel Hydrazine Labeling Reagents

Yu, Y., Yuan, F., Zhang, X., Zhao, M., Zhou, Y., & Zhang, X. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03227 · Cited by 19

The Type I Interferon Axis in Systemic Autoimmune Diseases: From Molecular Pathways to Targeted Therapy

Ishihara, R., Watanabe, R., Shiomi, M., Fujita, Y., Katsushima, M., Fukumoto, K., Yamada, S., & Hashimoto, M. (2025) · Biomolecules · doi:10.3390/biom15111586 · Cited by 20

Exploring epigenetic and microRNA approaches for γ-globin gene regulation

Starlard‐Davenport, A., Fitzgerald, A., & Pace, B. S. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211028195 · Cited by 20

Nuclear receptor subfamily 3 group c member 2 (NR3C2) is downregulated due to hypermethylation and plays a tumor-suppressive role in colon cancer

Li, X., Yang, A., Wen, P., Yuan, Y., Xiao, Z., Shi, H., & Wang, R. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04449-6 · Cited by 19

Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth

Cho, C., Lin, C., Huang, H.-H., Yang, W., Fei, C., Lin, H.-Y., Lee, M., & Yuan, H. S. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00065 · Cited by 18

Hypermethylation of TET1 Promoter Is a New Diagnosic Marker for Breast Cancer Metastasis

Sang, Y., Cheng, C., Tang, X., Zhang, M., & Lv, X. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.3.1197 · Cited by 18

A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation

Nguyen, H. P., Stewart, S. K., Kukwikila, M. N., Jones, S. F., Offenbartl‐Stiegert, D., Mao, S.-Q., Balasubramanian, S., Beck, S., & Howorka, S. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901139 · Cited by 18

A renewable DNA biosensor for sensitive detection of DNA methyltransferase activity based on cascade signal amplification

Liu, Y., Tu, Y., Wu, H., Zhang, H., Chen, H., Zhou, G., Wang, P., & Gu, Y. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128029 · Cited by 18

DNA methylation modulates allograft survival and acute rejection after renal transplantation by regulating the mTOR pathway

Zhu, C., Xiang, W., Li, B., Wang, Y., Feng, S., Wang, C., Chen, Y., Xie, W., Qu, L., Huang, H., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16183 · Cited by 18

A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline

Zhu, Q., Stöger, R. J., & Alberio, R. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00024 · Cited by 21

Epigenetic Alterations in Renal Cell Cancer With TKIs Resistance: From Mechanisms to Clinical Applications

Li, Q., Zhang, Z., Fan, Y., & Zhang, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.562868 · Cited by 18

Supplemental Herbal Choline Increases 5-hmC DNA on Whole Blood from Pregnant Ewes and Offspring

Roque-Jimenez, J. A., Martínez, G. D. M., Vázquez-Valladolid, A., Guerrero-González, M. D. L. L., Flores‐Ramírez, R., Pinos‐Rodríguez, J. M., Loor, J. J., Relling, A. E., & Lee-Rangel, H. A. (2020) · Animals · doi:10.3390/ani10081277 · Cited by 18

LIF maintains mouse embryonic stem cells pluripotency by modulating TET1 and JMJD2 activity in a JAK2-dependent manner

Wulansari, N., Sulistio, Y. A., Darsono, W. H. W., Kim, C., & Lee, S. (2021) · Stem Cells · doi:10.1002/stem.3345 · Cited by 17

DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells

Liu, Y., Xu, Z., Shi, J., Zhang, Y., Yang, S., Chen, Q., Song, C., Geng, S., Li, Q., Li, J., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105003 · Cited by 17

Regulation of main ncRNAs by polyphenols: A novel anticancer therapeutic approach

Zhang, L., Kang, Q., Kang, M., Jiang, S., Yang, F. W., Gong, J., Ou, G., & Wang, S. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155072 · Cited by 18

Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma

Lee, J. J., Cook, M. G., Mihm, M. C., Xu, S., Zhan, Q., Wang, T. J., Murphy, G. F., & Lian, C. G. (2015) · Oncotarget · doi:10.18632/oncotarget.6062 · Cited by 17

5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation

Kranzhöfer, D., Gilsbach, R., Grüning, B. A., Backofen, R., Nührenberg, T. G., & Hein, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166575 · Cited by 17

DNA repair and erasure of 5‐methylcytosine in vertebrates

Schomacher, L., & Niehrs, C. (2017) · BioEssays · doi:10.1002/bies.201600218 · Cited by 18

The destiny of the resistance/susceptibility against GCRV is controlled by epigenetic mechanisms in CIK cells

Shang, X., Yang, C., Wan, Q., Rao, Y., & Su, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03990-5 · Cited by 17

A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring†

Lei, J., Nie, Q. H., & Chen, D. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy050 · Cited by 17

Chemistry‐Driven Epigenetic Investigation of Histone and DNA Modifications

Sueoka, T., Koyama, K., Hayashi, G., & Okamoto, A. (2018) · The Chemical Record · doi:10.1002/tcr.201800040 · Cited by 17

Maternal and Cord Blood Folate Concentrations Are Inversely Associated with Fetal DNA Hydroxymethylation, but Not DNA Methylation, in a Cohort of Pregnant Canadian Women

Plumptre, L., Tammen, S. A., Sohn, K., Masih, S. P., Visentin, C., Aufreiter, S., Malysheva, O., Schroder, T. H., Ly, A., Berger, H. M., et al. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz232 · Cited by 17

DNA methyltransferase 3 participates in behavioral phase change in the migratory locust

Hou, L., Wang, X., Yang, P., Li, B., Lin, Z., Kang, L., & Wang, X. (2020) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2020.103374 · Cited by 17

Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine

Zhang, W., Liu, S., Han, D., & He, Z. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.034 · Cited by 17

Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi

Li, W., Zhang, T., & Ding, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv979 · Cited by 17

MicroRNA22-5p targets ten-eleven translocation and regulates estrogen receptor 2 expression in infertile women with minimal/mild endometriosis during implantation window

Xiao, L. Y., Pei, T., Huang, W., Zhou, M., Fu, J., Tan, J., Liu, T., Song, Y., & Yang, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234086 · Cited by 17

Role of oxygen sensing and hypoxia-inducible factors in orchestrating innate immune responses

Low, J. T., Kim, Y., Matsushita, M., & Ho, P. (2025) · Nature Immunology · doi:10.1038/s41590-025-02317-1 · Cited by 18

Human menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagy

Zhou, S., Liu, Y., Zhang, Q., Xu, H., Fang, Y., Chen, X., Fu, J., Yuan, Y., Li, Y., Yuan, L., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03278-8 · Cited by 16

Activation, decommissioning, and dememorization: enhancers in a life cycle

Wu, X., Wu, X., & Xie, W. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.04.005 · Cited by 15

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2

Wang, Z., Liu, J., Qiu, X., Zhang, D., Inuzuka, H., Chen, L., Chen, H., Xie, L., Kanıskan, H. Ü., Chen, X., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c06023 · Cited by 16

Role of Epigenetics for the Efficacy of Cisplatin

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DNA methylation and its role in the trophoblast cell lineage

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Nucleosome dynamics and maintenance of epigenetic states of CpG islands

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The Role of DNA Methylation in Transcriptional Regulation of Pro-Nociceptive Genes in Rat Trigeminal Ganglia

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Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

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DAT1 Gene Methylation as an Epigenetic Biomarker in Attention Deficit Hyperactivity Disorder: A Commentary

Tonelli, E., Pascale, E., Troianiello, M., D’Addario, C., & Adriani, W. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00444 · Cited by 17

TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation

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Epigenetics of Aberrant Cardiac Wound Healing

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Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

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Long Noncoding RNAs and Mitochondrial Homeostasis in the Development of Diabetic Retinopathy

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TETs Link Hydrogen Sulfide to Immune Tolerance

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Early-life adversity-induced long-term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals

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Transcriptional and epigenetic control in mouse pluripotency: lessons from in vivo and in vitro studies

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Ten-eleven translocation proteins and their role beyond DNA demethylation – what we can learn from the fly

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Search for an epigenetic biomarker in ADHD diagnosis, based on the DAT1 gene 5’-UTR methylation: a new possible approach

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Single-Cell Epigenomics in Cancer: Charting a Course to Clinical Impact

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Oxidative DNA demethylation mediated by Tet enzymes

Xu, G., & Wong, J. (2015) · National Science Review · doi:10.1093/nsr/nwv029 · Cited by 56

TET enzymes, TDG and the dynamics of DNA demethylation

Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623

Active DNA Demethylation in Development, Human Disease, and Cancer

Tricarico, R., & Bellacosa, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_21 · Cited by 2

The Molecular Basis of DNA Demethylation

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Dynamic regulation of mammalian DNA methylation

Xiaoton, Y. (2014)