Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

DNA methylation patterns and epigenetic memory

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Human DNA methylomes at base resolution show widespread epigenomic differences

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,925

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451

Hunting for Darwin's gemmules and Lamarck's fluid: Transgenerational signaling and histone methylation

Choi, Y., & Mango, S. E. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.011 · Cited by 15

Influence of the Prader-Willi syndrome imprinting center on the DNA methylation landscape in the mouse brain

Brant, J. O., Riva, A., Resnick, J. L., & Yang, T. P. (2014) · Epigenetics · doi:10.4161/15592294.2014.969667 · Cited by 15

RA promotes proliferation of primordial germ cell‐like cells differentiated from porcine skin‐derived stem cells

Yan, H., Li, L., Liu, J., Wang, Y., Liu, X., Ge, W., Dyce, P. W., Li, L., Sun, X., Shen, W., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28454 · Cited by 15

Collaborations between CpG sites in DNA methylation

Song, Y., Ren, H., & Lei, J. (2017) · International Journal of Modern Physics B · doi:10.1142/s0217979217502435 · Cited by 16

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease

Tommasi, S., & Besaratinia, A. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16152791 · Cited by 15

NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis

B., L. Q. I., Bartsch, N., Kouzel, I. U., Busengdal, H., Richards, G. S., Steinmetz, P. R. H., & Rentzsch, F. (2023) · Nature Communications · doi:10.1038/s41467-023-39789-4 · Cited by 13

Recent advance in optical single-molecule detection of methylation modification and methyl-modifying enzymes

Han, Y., Yang, D., Jiang, S., Zhao, S., Ma, F., & Zhang, C. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117553 · Cited by 14

Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer

Kim, J. H., Lee, J., Im, S. S., Kim, B., Kim, E., Min, H.-J., Heo, J., Chang, E., Choi, K., Shin, D., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01231-0 · Cited by 15

Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation

Li, Y., Guo, X., Yao, H., Zhang, Z., & Zhao, H. (2024) · Epigenetics & Chromatin · doi:10.1186/s13072-024-00563-5 · Cited by 14

DNA methylation of the endothelin receptor B makes blue fish yellow

Fang, W., Blakkan, D., Byrne, A., Lee, G., Bashier, R., Fernald, R. D., & Alvarado, S. G. (2025) · Nature Communications · doi:10.1038/s41467-025-66936-w · Cited by 14

Oxidative Demethylation of DNA and RNA Mediated by Non‐Heme Iron‐Dependent Dioxygenases

Lu, L., Zhu, C., Xia, B., & Yi, C. (2014) · Chemistry - An Asian Journal · doi:10.1002/asia.201402148 · Cited by 15

Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation

Fujii, Y., Wakamori, M., Umehara, T., & Yokoyama, S. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12064 · Cited by 15

Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines

Zhang, C., Suo, J., Katayama, H., Wei, Y., Garcia‐Manero, G., & Hanash, S. (2016) · Clinical Proteomics · doi:10.1186/s12014-016-9115-z · Cited by 14

Antibody-Based Detection of Global Nuclear DNA Methylation in Cells, Tissue Sections, and Mammalian Embryos

Beaujean, N., Salvaing, J., Hadi, N. A. A., & Pennings, S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7481-8_4 · Cited by 14

Evolutionary dynamics of cancer: From epigenetic regulation to cell population dynamics—mathematical model framework, applications, and open problems

Lei, J. (2020) · Science China Mathematics · doi:10.1007/s11425-019-1629-7 · Cited by 14

Prader-Willi Syndrome: Molecular Mechanism and Epigenetic Therapy

Zhong, M., Chao, Y.-Q., & Zou, C. (2020) · Current Gene Therapy · doi:10.2174/1566523220666200424085336 · Cited by 14

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli

Qin, W., Brands, X., Matsumoto, H., Butler, J. M., Veer, C. V. ′., de Vos, A. F., Roelofs, J. J. T. H., Scicluna, B. P., & van der Poll, T. (2021) · Cells · doi:10.3390/cells11010082 · Cited by 13

Role of DNA De-methylation intermediate ‘5-hydroxymethylcytosine’ in ovarian cancer management: A comprehensive review

Bisht, D., Arora, A., & Sachan, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113674 · Cited by 16

CoxMKF: a knockoff filter for high-dimensional mediation analysis with a survival outcome in epigenetic studies

Tian, P., Yao, M., Huang, T., & Liu, Z. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac687 · Cited by 14

Perspectives in genetic prediction of Alzheimer's disease.

Šerý, O., Povová, J., & Balcar, V. J. (2014) · PubMed · Cited by 14

Nichtkanonische Basen im Genom: die regulative Informationsebene in der DNA

Carell, T., Kurz, M. Q., Müller, M., Rossa, M., & Spada, F. (2017) · Angewandte Chemie · doi:10.1002/ange.201708228 · Cited by 14

Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

Pacini, C., & Koziol, M. J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0073 · Cited by 14

Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome

Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 15

A Bisulfite-free Approach for Base-Resolution Analysis of Genomic 5-Carboxylcytosine

Ličytė, J., Gibas, P., Skardžiūtė, K., Stankevičius, V., Rukšėnaitė, A., & Kriukienė, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108155 · Cited by 15

Aberrant DNA methylation as a key modulator of cell death pathways: insights into cancer progression and other diseases

Zahoor, A., Khazer, R., Mehraj, I., Gani, U., Fayaz, F., Khanday, F. A., & Saleem, S. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01552-x · Cited by 13

Epigenetics: A link between toxicants and diseases

Romano, A. D. R. R., Pagiatakis, C., Gornati, R., Bernardini, G., & Papait, R. (2025) · iScience · doi:10.1016/j.isci.2025.112613 · Cited by 13

Investigating the Interplay between Myeloma Cells and Bone Marrow Stromal Cells in the Development of Drug Resistance: Dissecting the Role of Epigenetic Modifications

Schütt, J., Nägler, T. M., Schenk, T., & Brioli, A. (2021) · Cancers · doi:10.3390/cancers13164069 · Cited by 15

Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs

Xu, N., Liu, J., & Li, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.925416 · Cited by 13

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Zhang, H., Fu, H. E., Fang, H., Deng, Q., Huang, H., Hou, D., Wang, M., Yao, Q., Si, Q., Chen, R., et al. (2022) · Stem Cells International · doi:10.1155/2022/5015856 · Cited by 13

Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia

Humphries, S., Bond, D. R., Germon, Z. P., Keely, S., Enjeti, A. K., Dun, M. D., & Lee, H. J. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01566-x · Cited by 15

DNMT3a ‐mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF‐κB pathway

Cheng, P., Wei, H., Chen, H., Wang, Z., Mao, P., & Zhang, H. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18048 · Cited by 13

Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells

Ferrer, A. I., Sinha, G., Petryna, A., Gonzalez-Bermejo, R., Kenfack, Y., Adetayo, O., Patel, S. A., Hooda-Nehra, A., & Rameshwar, P. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01512-1 · Cited by 14

Genetic therapies and potential therapeutic applications of CRISPR activators in the eye

Ng, B., Kaukonen, M. K., McClements, M. E., Shamsnajafabadi, H., MacLaren, R. E., & Cehajic‐Kapetanovic, J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101289 · Cited by 13

Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input

Chen, D., Wang, Y., Mo, M., Zhang, J., Zhang, Y., Xu, Y., Liu, S. M., Chen, J., Ma, Y., Zhang, L., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz704 · Cited by 13

Rad50 mediates DNA demethylation to establish pluripotent reprogramming

Park, H., Cho, B., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0467-0 · Cited by 15

The eroding chromatin landscape of aging stem cells

Shi, C., Wang, L., & Sen, P. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.08.002 · Cited by 14

Modeling DNA Methylation Profiles through a Dynamic Equilibrium between Methylation and Demethylation

Riso, G. D., Fiorillo, D. F. G., Fierro, A., Cuomo, M., Chiariotti, L., Miele, G., & Cocozza, S. (2020) · Biomolecules · doi:10.3390/biom10091271 · Cited by 12

Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels

Ooi, S. K. T., Jiang, H., Kang, Y., & Allard, P. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8196 · Cited by 13

Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines

Foksiński, M., Zarakowska, E., Gackowski, D., Skonieczna, M., Gajda, K., Hudy, D., Szpila, A., Białkowski, K., Starczak, M., Wołowiec, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188856 · Cited by 13

Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis

Liu, W., Tan, S., Wang, Y., Zhang, F., Feng, Y., Ge, W., Dyce, P. W., Reiter, R. J., Shen, W., & Cheng, S. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12833 · Cited by 13

Early Life Stress: Nature and Nurture

Dallman, M. F. (2014) · Endocrinology · doi:10.1210/en.2014-1267 · Cited by 13

Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine

Yu, P., Ji, L., Lee, K. J., Yu, M., He, C., Ambati, S., McKinney, E. C., Jackson, C. L., Baile, C. A., Schmitz, R. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154949 · Cited by 13

In silico identification of enhancers on the basis of a combination of transcription factor binding motif occurrences

Fang, Y., Wang, Y., Zhu, Q., Wang, J., & Li, G. (2016) · Scientific Reports · doi:10.1038/srep32476 · Cited by 12

Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice

Zarakowska, E., Czerwińska, J., Tupalska, A., Yousefzadeh, M., Gregg, S. Q., Croix, C. M. S., Niedernhofer, L. J., Foksiński, M., Gackowski, D., Szpila, A., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly012 · Cited by 12

The role of DNA demethylation in induction of stem cells

Ghazimoradi, M. H., & Farivar, S. (2020) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.12.005 · Cited by 13

Novo papel da proteína XPC na regulação dos complexos da cadeia de transporte de elétrons e desequilíbrio redox

Mori, M. P. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2015.tde-20072015-105008 · Cited by 13

Coordination of germ layer lineage choice by TET1 during primed pluripotencyPreprint

Luo, X., van der Veer, B. K., Sun, L., Bartoccetti, M., Boretto, M., Vankelecom, H. E. J., Khoueiry, R., & Koh, K. P. (2020) · Genes & Development · doi:10.1101/gad.329474.119 · Cited by 13

miR-29c-3p acts as a tumor promoter by regulating β-catenin signaling through suppressing DNMT3A, TET1 and HBP1 in ovarian carcinoma

Zhao, H., Feng, L., Cheng, R., Wu, M., Bai, X., Fan, L., & Liu, Y. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110936 · Cited by 12

Advances in the joint profiling technologies of 5mC and 5hmC

He, B., Yao, H., & Yi, C. (2024) · RSC Chemical Biology · doi:10.1039/d4cb00034j · Cited by 12

Modifying the maker: Oxygenases target ribosome biology

Zhuang, Q., Feng, T., & Coleman, M. L. (2015) · Translation · doi:10.1080/21690731.2015.1009331 · Cited by 12

DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase

Morales‐Ruíz, T., García‐Ortiz, M. V., Devesa-Guerra, I., Ruiz, L. R., Tejedor, J. R., Bayón, G. F., Sierra, M., Fraga, M. F., Ariza, R. R., & Roldán‐Arjona, T. (2017) · Epigenetics · doi:10.1080/15592294.2017.1414128 · Cited by 12

Epigenetic Quantification of DNA 5‐Hydroxymethylcytosine Using DNA Hybridization‐Based Single‐Molecule Immunofluorescent Imaging

Du, Y., Lai, Y., Liu, J., & Diao, J. (2021) · Small Methods · doi:10.1002/smtd.202100061 · Cited by 12

Epigenetic manipulation to improve mouse SCNT embryonic development

Li, Y., & Sun, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.932867 · Cited by 12

KDM2A interacts with estrogen receptor α to promote bisphenol A and S-induced breast cancer cell proliferation by repressing TET2 expression

Li, Z., Ren, Y., Li, X., & Wang, W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115132 · Cited by 12

ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine

Schlosberg, C., Wu, D. Y., Gabel, H. W., & Edwards, J. R. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz001 · Cited by 13

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H., & Akamatsu, W. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.018 · Cited by 12

DNA Methylation of Mouse Testes, Cardiac and Lung Tissue During Long-Term Microgravity Simulation

Loktev, S. S., & Ogneva, I. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-44468-w · Cited by 12

Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers

Aubuchon, L. N., & Verma, P. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103736 · Cited by 11

On correlative and causal links of replicative epimutations

Zhou, W., & Reizel, Y. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.08.008 · Cited by 13

AFM analysis of changes in nucleosome wrapping induced by DNA epigenetic modification

Kizaki, S., Suzuki, Y., Takenaka, T., Endo, M., & Sugiyama, H. (2014) · Biomaterials Science · doi:10.1039/c4bm00113c · Cited by 11

RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications

Shin, J. H., Xu, L., & Wang, D. (2016) · Transcription · doi:10.1080/21541264.2016.1168506 · Cited by 11

L-ascorbic acid and the evolution of multicellular eukaryotes

Edgar, J. A. (2019) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.06.001 · Cited by 11

Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations

Samoylova, E. M., & Baklaushev, V. P. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920090047 · Cited by 12

Transcriptome and DNA Methylation Profiles of Mouse Fetus and Placenta Generated by Round Spermatid Injection

Zhu, H., Sun, H., Yu, D., Li, T., Hai, T., Liu, C., Zhang, Y., Chen, Y., Dai, X., Li, Z., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.632183 · Cited by 11

Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Song, P. K., Li, Y., Wang, F., Pu, L., Bao, L., Gao, H., Zhu, C., Wang, M., & Tao, L. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01361-0 · Cited by 11

Propriétés et rôles biologiques des protéines TET au cours du développement et de l’hématopoïèse

Mahfoudhi, E., Secardin, L., Scourzic, L., Bernard, O., Vainchenker, W., & Plo, I. (2015) · médecine/sciences · doi:10.1051/medsci/20153103012 · Cited by 11

Chromatin dynamics in kidney development and function

Bechtel‐Walz, W., & Huber, T. B. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1884-y · Cited by 12

Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation

Vogt, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805388-1.00027-4 · Cited by 10

DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells

Chatterjee, B., Lin, M., Chen, S. C.-C., Peng, K.-L., Wu, M.-S., Tseng, M., Chen, Y., & Shen, C.-K. J. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.09.009 · Cited by 11

Possible involvement of DNA methylation in hippocampal synaptophysin gene expression during postnatal development of mice

Aizawa, S., & Yamamuro, Y. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104587 · Cited by 11

Epigenetic control of exercise adaptations in the equine athlete: Current evidence and future directions

Denham, J., McCluskey, M. J., Denham, M. M., Sellami, M., & Davie, A. J. (2020) · Equine Veterinary Journal · doi:10.1111/evj.13320 · Cited by 11

Analysis at the single-cell level indicates an important role of heterogeneous global DNA methylation status on the progression of lung adenocarcinoma

Chen, Q.-F., Gao, H., Pan, Q., Wang, Y.-J., & Zhong, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-02786-y · Cited by 11

Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization

Qu, K., Wang, C., Huang, L., Qin, X., Zhang, K., Qiu, J., & Wang, G. (2023) · APL Bioengineering · doi:10.1063/5.0141289 · Cited by 10

CpG Island Definition and Methylation Mapping of the T2T-YAO Genome

Xiao, M., Wei, R., Yu, J., Gao, C., Yang, F., & Zhang, L. (2024) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzae009 · Cited by 10

Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice

Carballo, L. G. H., Li, P., Senek, R., & Yan, Z. (2024) · The Journal of Physiology · doi:10.1113/jp285875 · Cited by 11

Integrative analysis of whole genome bisulfite and transcriptome sequencing reveals the effect of sodium butyrate on DNA methylation in the differentiation of bovine skeletal muscle satellite cells

Wang, X., Zhou, X., Li, C., Li, C., Shi, Y., Li, C.-J., & Kang, X. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110959 · Cited by 10

Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review

Liu, L., Ni, S., Zhang, L., Chen, Y., Xie, M., & Huang, X. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04179-z · Cited by 10

Resetting the epigenome: Methylation dynamics in cancer stem cells

Roy, A., Padhi, S. S., Khyriem, I., Nikose, S., Sankar, S. H. H., & Bharathavikru, R. S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.909424 · Cited by 10

Pan-cancer analysis of DNA epigenetic modifications by hydrophilic interaction liquid chromatography-tandem mass spectrometry

Hu, Y., Hong, X., Yuan, Z., Mu, J., Zhang, X., Fang, Z., Yuan, Y., Zheng, S. S., & Guo, C. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.108023 · Cited by 10

Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration

Si, T., Li, Z., Zhang, J., Su, S., Liu, Y., Chen, S., Peng, G.-H., Cao, J., & Zang, W. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1157893 · Cited by 9

Functional polymorphisms of the TET1 gene increase the risk of neuroblastoma in Chinese children

Chang, J., Lin, L., Zhou, C., Zhang, X., Yang, T., Wu, H., Zou, Y., & He, J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17820 · Cited by 10

Treating advanced cardiac damage in light chain amyloidosis: still an unmet need

Merlini, G., & Palladini, G. O. (2014) · Haematologica · doi:10.3324/haematol.2014.113464 · Cited by 10

SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells

Moriyama, T., Fujimitsu, Y., Yoshikai, Y., Sasano, T., Yamada, K., Murakami, M., Urano, T., Sugasawa, K., & Saitoh, H. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.004 · Cited by 10

More than a powerplant: the influence of mitochondrial transfer on the epigenome

Patananan, A. N., Sercel, A. J., & Teitell, M. A. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.11.006 · Cited by 11

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

Hahn, O., Stubbs, T. M., Reik, W., Grönke, S., Beyer, A., & Partridge, L. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007766 · Cited by 10

Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea

Ličytė, J., Kvederavičiūtė, K., Rukšėnaitė, A., Godliauskaitė, E., Gibas, P., Tomkutė, V., Petraitytė, G., Masevičius, V., Klimašauskas, S., & Kriukienė, E. (2022) · Open Biology · doi:10.1098/rsob.210302 · Cited by 9

Diagnostic and Prognostic Power of Active DNA Demethylation Pathway Intermediates in Acute Myelogenous Leukemia and Myelodysplastic Syndromes

Skalska-Bugała, A., Starczak, M., Szukalski, Ł., Gawroński, M., Siomek, A., Szpotan, J., Wołowiec, A., Zarakowska, E., Szpila, A., Jachalska, A., et al. (2022) · Cells · doi:10.3390/cells11050888 · Cited by 10

A causal association of ANKRD37 with human hippocampal volume

Xu, J., Xia, X., Li, Q., Dou, Y., Suo, X., Sun, Z., Liu, N., Han, Y., Sun, X., He, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01800-7 · Cited by 10

Epstein-Barr Virus Rta-Mediated Accumulation of DNA Methylation Interferes with CTCF Binding in both Host and Viral Genomes

Chen, Y., Chen, Y.-L., Chang, Y., Wu, C.-C., Ko, Y.-C., Tsao, S. W., Chen, J., & Lin, S. (2017) · Journal of Virology · doi:10.1128/jvi.00736-17 · Cited by 10

The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

Linowiecka, K., Guz, J., Dziaman, T., Urbanowska–Domańska, O., Zarakowska, E., Szpila, A., Szpotan, J., Skalska-Bugała, A., Mijewski, P., Siomek, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-56326-5 · Cited by 9

Recent advances in high-performance liquid chromatography tandem mass spectrometry techniques for analysis of DNA damage and epigenetic modifications

Chen, S., Lai, W., & Wang, H. (2024) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2024.503755 · Cited by 9

DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway

Fu, H., Gao, B., Zhou, X., Hao, Y., Liu, C., Lan, A., Tang, J., & Zhou, F. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00739-1 · Cited by 10

The Vindication of Lamarck? Epigenetics at the Intersection of Law and Mental Health

DeLisi, M., & Vaughn, M. G. (2015) · Behavioral Sciences & the Law · doi:10.1002/bsl.2206 · Cited by 11

DNA Methylation-Dependent Dysregulation of GABAergic Interneuron Functionality in Neuropsychiatric Diseases

Linde, J., & Zimmer‐Bensch, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.586133 · Cited by 11

Long non-coding ribonucleic acid H19 and ten-eleven translocation enzyme 1 messenger RNA expression levels in uterine fibroids may predict their postoperative recurrence

Zhan, X., Zhou, H., Sun, Y., Shen, B., & Chou, D. (2021) · Clinics · doi:10.6061/clinics/2021/e2671 · Cited by 9

Dynamic Enhancer Methylation - A Previously Unrecognized Switch for Tissue-Type Plasminogen Activator Expression

Magnusson, M., Lu, E., Larsson, P., Ulfhammer, E., Bergh, N., Carén, H., & Jern, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141805 · Cited by 9

TALEored Epigenetics: A DNA‐Binding Scaffold for Programmable Epigenome Editing and Analysis

Kubik, G., & Summerer, D. (2016) · ChemBioChem · doi:10.1002/cbic.201600072 · Cited by 9

Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken

Li, Y., Lei, X., Lü, H., Guo, W., Wu, S., Yin, Z., Sun, Q., & Yang, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02731 · Cited by 9

Examining the levels of acetylation, DNA methylation and phosphorylation in HIV-1 positive and multidrug-resistant TB-HIV patients

Marimani, M. D., Ahmad, A., Stacey, S. L., & Duse, A. G. (2020) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2020.09.023 · Cited by 9

An Improved Approach for Practical Synthesis of 5-Hydroxymethyl-2′-deoxycytidine (5hmdC) Phosphoramidite and Triphosphate

Yang, D., Chen, Z., Chi, M., Dong, Y., Pu, S., & Sun, Q. (2022) · Molecules · doi:10.3390/molecules27030749 · Cited by 9

Oxidative DNA demethylation mediated by Tet enzymes

Xu, G., & Wong, J. (2015) · National Science Review · doi:10.1093/nsr/nwv029 · Cited by 56

TET enzymes, TDG and the dynamics of DNA demethylation

Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623

Active DNA Demethylation in Development, Human Disease, and Cancer

Tricarico, R., & Bellacosa, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_21 · Cited by 2

The Molecular Basis of DNA Demethylation

Shi, M., & Shen, L. (2017) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-59786-7_3 · Cited by 2

Dynamic regulation of mammalian DNA methylation

Xiaoton, Y. (2014)