Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,925

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451

Epigenetic control of gene regulation during development and disease: A view from the retina

Corso‐Díaz, X., Jaeger, C., Chaitankar, V., & Swaroop, A. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.03.002 · Cited by 130

Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

Li, T., Wang, L., Du, Y., Xie, S., Yang, X., Lian, F., Zhou, Z., & Qian, C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky104 · Cited by 134

5-Hydroxymethylcytosine: A stable or transient DNA modification?

Hahn, M. A., Szabó, P. E., & Pfeifer, G. P. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.015 · Cited by 133

Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming

Lai, X., Li, Q., Wu, F., Lin, J., Chen, J., Zheng, H., & Guo, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00760 · Cited by 130

Patterns of DNA Methylation in Animals: An Ecotoxicological Perspective

Head, J. A. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu025 · Cited by 131

DNA methylation homeostasis in human and mouse development

Iurlaro, M., von Meyenn, F., & Reik, W. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.02.003 · Cited by 124

Whole-genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liverPreprint

Li, X., Liu, Y., Salz, T., Hansen, K. D., & Feinberg, A. P. (2016) · Genome Research · doi:10.1101/gr.211854.116 · Cited by 119

Epigenome editing technologies for discovery and medicine

McCutcheon, S. R., Rohm, D., Iglesias, N., & Gersbach, C. A. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02320-1 · Cited by 130

DNA Methylation in the Medial Prefrontal Cortex Regulates Alcohol-Induced Behavior and Plasticity

Barbier, E., Tapocik, J. D., Juergens, N., Pitcairn, C., Borich, A., Schank, J. R., Sun, H., Schuebel, K. E., Zhou, Z., Yuan, Q., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4571-14.2015 · Cited by 116

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

Takayama, K., Misawa, A., Suzuki, T., Takagi, K., Hayashizaki, Y., Fujimura, T., Homma, Y., Takahashi, S., Urano, T., & Inoue, S. (2015) · Nature Communications · doi:10.1038/ncomms9219 · Cited by 121

Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

Kowluru, R. A., Shan, Y., & Mishra, M. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.78 · Cited by 120

Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells

Dan, J., Rousseau, P., Hardikar, S., Veland, N., Wong, J., Autexier, C., & Chen, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.070 · Cited by 119

Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants

Lai, X., Stigliani, A., Vachon, G., Carles, C. C., Smaczniak, C., Zubieta, C., Kaufmann, K., & Parcy, F. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.10.010 · Cited by 124

TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer

López-Moyado, I. F., Ko, M., Hogan, P. G., & Rao, A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080223-044610 · Cited by 119

Playing TETris with DNA modifications

Delatte, B., Deplus, R., & Fuks, F. (2014) · The EMBO Journal · doi:10.15252/embj.201488290 · Cited by 118

Translational Perspective on Epigenetics in Cardiovascular Disease

van der Harst, P., Windt, L. J. D., & Chambers, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.067 · Cited by 118

The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination

Huang, G., Xiang, Z., Wu, H., He, Q., Dou, R., Lin, Z., Yang, C., Huang, S., Song, J., Di, Z., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69454 · Cited by 118

Origins of human disease: the chrono-epigenetic perspective

Oh, E. S., & Petronis, A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00348-6 · Cited by 108

Anti-aging properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments

Nie, X., Chen, Y., Li, W., & Lu, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112839 · Cited by 112

Zebrafish as a model to study the role of DNA methylation in environmental toxicology

Kamstra, J. H., Aleström, P., Kooter, J. M., & Legler, J. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3466-7 · Cited by 118

Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds

Rissman, E. F., & Adli, M. (2014) · Endocrinology · doi:10.1210/en.2014-1123 · Cited by 113

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis

Nakajima, H., & Kunimoto, H. (2014) · Cancer Science · doi:10.1111/cas.12484 · Cited by 117

Review: Regulation of the cancer epigenome by long non-coding RNAs

Forrest, M. E., & Khalil, A. M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.040 · Cited by 112

Lineage-specific functions of TET1 in the postimplantation mouse embryo

Khoueiry, R., Sohni, A., Thienpont, B., Luo, X., Velde, J. V., Bartoccetti, M., Boeckx, B., Zwijsen, A., Rao, A., Lambrechts, D., et al. (2017) · Nature Genetics · doi:10.1038/ng.3868 · Cited by 112

A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation

Duan, C., Wang, X., Xie, S., Pan, L., Miki, D., Tang, K., Hsu, C., Lei, M., Zhong, Y., Hou, Y., et al. (2016) · Cell Research · doi:10.1038/cr.2016.147 · Cited by 111

Rebooting the Epigenomes during Mammalian Early Embryogenesis

Xia, W., & Xie, W. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.005 · Cited by 114

Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants

Lee, H., Barraza‐Villarreal, A., Biessy, C., Duarte‐Salles, T., Sly, P. D., Ramakrishnan, U., Rivera, J. Á., Herceg, Z., & Romieu, I. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00061.2014 · Cited by 112

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

Zhang, W., Xia, W., Wang, Q., Towers, A. J., Chen, J., Gao, R., Zhang, Y., Yen, C., Lee, A. Y., Li, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.030 · Cited by 114

X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency

Pasque, V., Tchieu, J. H., Karnik, R., Uyeda, M. J., Dimashkie, A., Case, D., Papp, B., Bonora, G., Patel, S. G., Ho, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.040 · Cited by 108

Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma

Liu, J., Jiang, J., Mo, J., Liu, D., Cao, D., Wang, H., He, Y., & Wang, H. (2018) · Hepatology · doi:10.1002/hep.30146 · Cited by 108

The epigenetic implication in coronavirus infection and therapy

Atlante, S., Mongelli, A., Barbi, V., Martelli, F., Farsetti, A., & Gaetano, C. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00946-x · Cited by 112

CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

Nakagawa, T., Lv, L., Nakagawa, M., Yu, Y., Yu, C. Y., D’Alessio, A. C., Nakayama, K., Fan, H., Chen, X., & Xiong, Y. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.12.002 · Cited by 114

The dynamics of the stress neuromatrix

Sousa, N. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.196 · Cited by 111

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

Zeng, Y., Yao, B., Shin, J., Lin, L., Kim, N., Song, Q., Liu, S., Su, Y., Guo, J. U., Huang, L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.020 · Cited by 102

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Orlanski, S., Labi, V., Reizel, Y., Spiro, A., Lichtenstein, M., Levin-Klein, R., Koralov, S. B., Skversky‐Blocq, Y., Rajewsky, K., Cedar, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604365113 · Cited by 103

The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance

Tran, K. A., Dillingham, C. M., & Sridharan, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000831 · Cited by 110

Non‐canonical Bases in the Genome: The Regulatory Information Layer in DNA

Carell, T., Kurz, M. Q., Müller, M., Rossa, M., & Spada, F. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708228 · Cited by 104

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Qian, J., Guan, X., Xie, B., Xu, C., Niu, J., Tang, X., Li, C. H., Colecraft, H. M., Jaenisch, R., & Liu, X. S. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add4666 · Cited by 108

TET‐catalyzed oxidation of intragenic 5‐methylcytosine regulates CTCF‐dependent alternative splicing

Marina, R. J., Sturgill, D. M., Bailly, M. A., Thénoz, M., Varma, G., Prigge, M. F., Nanan, K. K., Shukla, S., Haque, N., & Oberdoerffer, S. (2015) · The EMBO Journal · doi:10.15252/embj.201593235 · Cited by 107

Epigenetic Regulation of Endothelial-to-Mesenchymal Transition in Chronic Heart Disease

Hulshoff, M. S., Xu, X., Krenning, G., & Zeisberg, E. M. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311276 · Cited by 102

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1978-z · Cited by 99

The Epigenetic Landscape of Alcoholism

Krishnan, H. R., Sakharkar, A. J., Teppen, T. L., Berkel, T. D. M., & Pandey, S. C. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00003-2 · Cited by 103

Orchestration of H3K27 methylation: mechanisms and therapeutic implication

Pan, M., Hsu, M., Chen, L., & Hung, W. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2596-8 · Cited by 111

miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma

Wu, H., Zhang, W., Wu, Z., Liu, Y., Shi, Y., Gong, J., Shen, W., & Liu, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1281-7 · Cited by 99

Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

Liu, Z., Shen, J., Barfield, R., Schwartz, J. D., Baccarelli, A., & Lin, X. (2021) · Journal of the American Statistical Association · doi:10.1080/01621459.2021.1914634 · Cited by 99

Repair of naturally occurring mismatches can induce mutations in flanking DNA

Chen, J., Miller, B., & Furano, A. V. (2014) · eLife · doi:10.7554/elife.02001 · Cited by 99

Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence

Yoon, K., Vissers, C. B., Ming, G., & Song, H. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802117 · Cited by 96

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Wang, M., & Ibeagha-Awemu, E. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.613636 · Cited by 105

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity

Tanaka, S., Ise, W., Inoue, T., Ito, A., Ono, C., Shima, Y., Sakakibara, S., Nakayama, M., Fujii, K., Miura, I., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0700-y · Cited by 96

Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

van der Wijst, M. G. P., Muralidhar, V., Chen, H., Xu, G., Plösch, T., & Rots, M. G. (2015) · Epigenetics · doi:10.1080/15592294.2015.1062204 · Cited by 98

Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review

Wang, B., Yang, Q., Harris, C. L., Nelson, M. L., Busboom, J. R., Zhu, M. J., & Du, ‬. (2016) · Meat Science · doi:10.1016/j.meatsci.2016.04.003 · Cited by 96

Cell totipotency: molecular features, induction, and maintenance

Lu, F., & Zhang, Y. (2015) · National Science Review · doi:10.1093/nsr/nwv009 · Cited by 96

Aberrant miRNA promoter methylation and EMT‐involving miRNAs in breast cancer metastasis: Diagnosis and therapeutic implications

Zare, M., Bastami, M., Solali, S., & Alivand, M. R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26116 · Cited by 92

DNA methylation, environmental exposures and early embryo development

Breton‐Larrivée, M., Elder, E., & McGraw, S. (2019) · Animal Reproduction · doi:10.21451/1984-3143-ar2019-0062 · Cited by 101

Gadd45a promotes DNA demethylation through TDG

Li, Z., Gu, T., Weber, A. R., Shen, J., Li, B.-Z., Xie, Z., Yin, R., Guo, F., Liu, X., Tang, F., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv283 · Cited by 101

Epigenetic correlates of neonatal contact in humans

Moore, S. R., McEwen, L. M., Quirt, J., Morin, A. M., Mah, S. M., Barr, R. G., Boyce, W. T., & Kobor, M. S. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001213 · Cited by 95

DNAmod: the DNA modification database

Sood, A. J., Viner, C., & Hoffman, M. M. (2019) · Journal of Cheminformatics · doi:10.1186/s13321-019-0349-4 · Cited by 91

Epigenetics and locust life phase transitions

Ernst, U., Hiel, M. B. V., Depuydt, G., Boerjan, B., LOOF, A. D., & Schoofs, L. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107078 · Cited by 93

Epigenetics in the pathogenesis of RA

Ospelt, C., Gay, S., & Klein, K. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0621-5 · Cited by 97

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy

Duraisamy, A. J., Mishra, M., Kowluru, A., & Kowluru, R. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24548 · Cited by 91

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs

Noh, K., Wang, H., Kim, H. R., Wenderski, W., Fang, F., Li, C. H., Dewell, S. B., Hughes, S. H., Melnick, A. M., Patel, D. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.017 · Cited by 93

The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity

Provençal, N., Booij, L., & Tremblay, R. E. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.111401 · Cited by 101

Epigenetic Modification in Coronary Atherosclerosis

Rizzacasa, B., Amati, F., Romeo, F., Novelli, G., & Mehta, J. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.043 · Cited by 88

Epigenetic regulation of rice flowering and reproduction

Shi, J., Dong, A., & Shen, W. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00803 · Cited by 87

DNA methylation: old dog, new tricks?

Spruijt, C. G., & Vermeulen, M. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2910 · Cited by 100

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

Qin, W., Scicluna, B. P., & van der Poll, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.696280 · Cited by 91

TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures

Shukla, V., Samaniego‐Castruita, D., Dong, Z., González‐Avalos, E., Yan, Q., Sarma, K., & Rao, A. (2021) · Nature Immunology · doi:10.1038/s41590-021-01087-w · Cited by 88

A Sensitive Approach to Map Genome-wide 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution

Sun, Z., Dai, N., Borgaro, J. G., Quimby, A., Sun, D., Junior, I. R. C., Zheng, Y., Zhu, Z., & Guan, S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.035 · Cited by 86

Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs

Cruvinel, E. M., Budinetz, T. H., Germain, N., Chamberlain, S., Lalande, M., & Martins‐Taylor, K. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu187 · Cited by 85

Active DNA demethylation by DNA repair: Facts and uncertainties

Schuermann, D., Weber, A. R., & Schär, P. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.013 · Cited by 87

Epigenetic reprogramming during spermatogenesis and male factor infertility

McSwiggin, H., & O’Doherty, A. (2018) · Reproduction · doi:10.1530/rep-18-0009 · Cited by 84

The Epigenetics of the Endocannabinoid System

Meccariello, R., Santoro, A., D’Angelo, S., Morrone, R., Fasano, S., Viggiano, A., & Pierantoni, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031113 · Cited by 89

PRDM14: a unique regulator for pluripotency and epigenetic reprogramming

Nakaki, F., & Saitou, M. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.04.003 · Cited by 87

DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR

Micevic, G., Muthusamy, V., Damsky, W., Theodosakis, N., Liu, X., Meeth, K. M., Wingrove, E., Santhanakrishnan, M., & Bosenberg, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.010 · Cited by 86

Aberrant DNA methylation reprogramming in bovine SCNT preimplantation embryos

Zhang, S., Chen, X., Wang, F., An, X., Tang, B., Zhang, X., Sun, L., & Li, Z. (2016) · Scientific Reports · doi:10.1038/srep30345 · Cited by 84

Principles and Challenges of Applying Epigenetic Epidemiology to Psychology

Jones, M. J., Moore, S. R., & Kobor, M. S. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033653 · Cited by 94

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H., et al. (2019) · Kidney International · doi:10.1016/j.kint.2019.02.020 · Cited by 87

Regulation of hematopoietic development by ZBTB transcription factors

Maeda, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2035-x · Cited by 88

The Gut Microbiota and their Metabolites: Potential Implications for the Host Epigenome

Mischke, M., & Plösch, T. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_3 · Cited by 86

Postnatal DNA demethylation and its role in tissue maturation

Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04456-6 · Cited by 83

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency

Rulands, S., Lee, H. J., Clark, S. J., Angermueller, C., Smallwood, S. A., Krueger, F., Mohammed, H., Dean, W., Nichols, J., Rugg‐Gunn, P. J., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.06.012 · Cited by 86

Comprehensive evaluation of the Infinium human MethylationEPIC v2 BeadChip

Kaur, D., Lee, S. M., Goldberg, D., Spix, N. J., Hinoue, T., Li, H., Dwaraka, V. B., Smith, R. C., Shen, H., Liang, G., et al. (2023) · Epigenetics Communications · doi:10.1186/s43682-023-00021-5 · Cited by 86

Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease

Gordon, J. A. R., Stein, J. L., Westendorf, J. J., & van Wijnen, A. J. (2015) · Bone · doi:10.1016/j.bone.2015.03.011 · Cited by 85

Structure of DNMT1 RFTS domain in complex with ubiquitin

Qian, C. (2017) · Worldwide Protein Data Bank · doi:10.2210/pdb5ydr/pdb · Cited by 82

High resolution mapping of modified DNA nucleobases using excision repair enzymesPreprint

Bryan, D. S., Ransom, M., Adane, B., York, K. T., & Hesselberth, J. R. (2014) · Genome Research · doi:10.1101/gr.174052.114 · Cited by 81

Epigenetic modifications in diabetes

Kowluru, R. A., & Mohammad, G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154920 · Cited by 86

Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals

Jacobs, M. N., Marczylo, E. L., Guerrero‐Bosagna, C., & Rüegg, J. (2017) · Annual Review of Environment and Resources · doi:10.1146/annurev-environ-102016-061111 · Cited by 81

The roles of TET family proteins in development and stem cells

Yang, J., Bashkenova, N., Zang, R., Huang, X., & Wang, J. (2020) · Development · doi:10.1242/dev.183129 · Cited by 80

Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

Lan, J., Rajan, N., Bizet, M., Penning, A., Singh, N. K., Guallar, D., Calonne, E., Greci, A. L., Bonvin, E., Deplus, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18729-6 · Cited by 75

Theory Uncovers an Unusual Mechanism of DNA Repair of a Lesioned Adenine by AlkB Enzymes

Wang, B., Usharani, D., Li, C., & Shaik, S. S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja507934g · Cited by 79

Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood

Ebner, N. C., Lin, T., Muradoglu, M., Weir, D. H., Plasencia, G. M., Lillard, T. S., Pournajafi-Nazarloo, H., Cohen, R. A., Sue Carter, C., & Connelly, J. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.01.008 · Cited by 79

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Lees, J. G., Gardner, D. K., & Harvey, A. J. (2017) · Stem Cells International · doi:10.1155/2017/2874283 · Cited by 81

ROS1-Dependent DNA Demethylation Is Required for ABA-Inducible NIC3 Expression

Kim, J., Lim, J. Y., Shin, H., Kim, B., Yoo, S.-D., Kim, W. T., & Huh, J. H. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.18.01471 · Cited by 77

Drugging the pain epigenome

Niederberger, E., Resch, E., Parnham, M. J., & Geißlinger, G. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.68 · Cited by 77

Stem cells in tissues, organoids, and cancers

Wang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03199-x · Cited by 80

NLRP3 Activation Was Regulated by DNA Methylation Modification during Mycobacterium tuberculosis Infection

Wei, M., Wang, L., Wu, T., Xi, J., Han, Y.-Z., Yang, X., Zhang, D., Fang, Q., & Tang, B. (2016) · BioMed Research International · doi:10.1155/2016/4323281 · Cited by 76

Charting oxidized methylcytosines at base resolution

Wu, H., & Zhang, Y. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3071 · Cited by 76

Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking

Sakharkar, A. J., Kyzar, E. J., Gavin, D. P., Zhang, H., Chen, Y., Krishnan, H. R., Grayson, D. R., & Pandey, S. C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107679 · Cited by 75

Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

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Man, X., Li, Q., Wang, B., Zhang, H., Zhang, S., & Li, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.916725 · Cited by 75

Oxidative DNA demethylation mediated by Tet enzymes

Xu, G., & Wong, J. (2015) · National Science Review · doi:10.1093/nsr/nwv029 · Cited by 56

TET enzymes, TDG and the dynamics of DNA demethylation

Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623

Active DNA Demethylation in Development, Human Disease, and Cancer

Tricarico, R., & Bellacosa, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_21 · Cited by 2

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Dynamic regulation of mammalian DNA methylation

Xiaoton, Y. (2014)