Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

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Establishing, maintaining and modifying DNA methylation patterns in plants and animals

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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The ground state of embryonic stem cell self-renewal

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CpG islands and the regulation of transcription

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DNA methylation: roles in mammalian development

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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A decade of exploring the cancer epigenome—biological and translational implications

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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Cancer epigenomics: DNA methylomes and histone-modification maps

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

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DNA Modification Mechanisms and Gene Activity During Development

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High sensitivity mapping of methylated cytosines

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Global epigenomic reconfiguration during mammalian brain development

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Mutation in TET2 in Myeloid Cancers

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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TET enzymes, TDG and the dynamics of DNA demethylation

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UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

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DNA-binding factors shape the mouse methylome at distal regulatory regions

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Demethylation of the zygotic paternal genome

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A map of the cis-regulatory sequences in the mouse genome

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

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Charting a dynamic DNA methylation landscape of the human genome

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X inactivation, differentiation, and DNA methylation

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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JmjC-domain-containing proteins and histone demethylation

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How Are Alkynes Scrambled?

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Epigenetic reprogramming in mouse primordial germ cells

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Epigenetic Reprogramming in Plant and Animal Development

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

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The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

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Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

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Active DNA demethylation: many roads lead to Rome

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Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

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Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

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A unique regulatory phase of DNA methylation in the early mammalian embryo

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The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

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Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

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Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution

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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system

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Cyclical DNA methylation of a transcriptionally active promoter

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Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

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TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

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Influence of Metabolism on Epigenetics and Disease

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Epigenetic events in mammalian germ-cell development: reprogramming and beyond

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

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The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

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5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

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Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

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5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

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Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

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Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

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Active DNA Demethylation Mediated by DNA Glycosylases

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Germline DNA Demethylation Dynamics and Imprint Erasure through 5-hydroxymethylcytosine

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Acquired mutations in TET2 are common in myelodysplastic syndromes

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The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing

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Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

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Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

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Reprogramming towards pluripotency requires AID-dependent DNA demethylation

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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

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Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

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Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

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DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

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