The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Open accessAbstract
The myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry. We have assessed the dynamics of oligodendrocyte generation and myelination in the human brain. The number of oligodendrocytes in the corpus callosum is established in childhood and remains stable after that. Analysis of the integration of nuclear bomb test-derived (14)C revealed that myelin is exchanged at a high rate, whereas the oligodendrocyte population in white matter is remarkably stable in humans, with an annual exchange of 1/300 oligodendrocytes. We conclude that oligodendrocyte turnover contributes minimally to myelin modulation in human white matter and that this instead may be carried out by mature oligodendrocytes, which may facilitate rapid neural plasticity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition, birth dating of oligodendrocytes by analysis of integrated nuclear bomb test-derived 14C revealed that few oligodendrocytes were newly generated in shadow plaques of MS patients”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [22]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Birth dating of oligodendrocytes, by analysis of the integration of nuclear bomb test-derived14C into cells, provided evidence for the generation of only few new oligodendrocytes in the adult human corpus callosum (15), suggesting that adaptive myelination in the white matter of humans may be more limited as compared to mice.”
From BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions (2017) · cites this paper as [15]
The cited source says what the claim attributes to it.
In the citing paper
“Birth dating of oligodendrocytes, by analysis of the integration of nuclear bomb test-derived14C into cells, provided evidence for the generation of only few new oligodendrocytes in the adult human corpus callosum (15), suggesting that adaptive myelination in the white matter of humans may be more limited as compared to mice.”
From BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions (2017) · cites this paper as [15]
The cited source says what the claim attributes to it.
In the citing paper
“These data are in good agreement with the birth dating of oligodendrocytes by14C integration, which showed that the number of oligodendrocytes in the white matter is largely established during the first years, whereas gray matter oligodendrocytes continue to be generated in adulthood (15).”
From BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions (2017) · cites this paper as [15]
In the citing paper
“In the corpus callosum, oligodendrocyte numbers increase until age 5 years and are stable thereafter; a study of nuclear bomb test-derived 14C suggest that there is little turnover of oligodendrocytes after age 5 years217.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [217]
In the citing paper
“These and other studies have shown that myelination changes can occur in a time frame much less than the six-week intervention used here (Yeung et al., 2014; Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Yeung et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Self-citationDynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841
Self-citationTraining induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
White matter in learning, cognition, and psychiatric disorders
Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337
Extensive piano practicing has regionally specific effects on white matter development
Bengtsson, S. L., Nagy, Z., Skare, S., Forsman, L., Forssberg, H., & Ullén, F. (2005) · Nature Neuroscience · doi:10.1038/nn1516 · Cited by 1,193
Unbiased stereological estimation of the number of neurons in the human hippocampus
West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153
Diffusion tensor imaging of white matter tract evolution over the lifespan
Lebel, C., Gee, M., Camicioli, R., Wieler, M., Martin, W., & Beaulieu, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.094 · Cited by 1,100
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Neurogenesis in the striatum of the adult human brain
Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 536
Microglia in the context of multiple sclerosis
Zhang, X., Chen, F., Sun, M., Wu, N., Liu, B., Yi, X., Ge, R., & Fan, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1157287 · Cited by 36
Relevance of host tau in tau seeding and spreading in tauopathies
Ferrer, I., Zelaya, M. V., Aguiló, M., Carmona, M., López‐González, I., Andrés‐Benito, P., Lidón, L., Gavı́n, R., Garcia‐Esparcia, P., & del Rı́o, J. A. (2019) · Brain Pathology · doi:10.1111/bpa.12778 · Cited by 37
Nelson, M. B., O’Neil, S., Wisnowski, J. L., Hart, D., Sawardekar, S., Rauh, V., Perera, F. P., Andrews, H., Hoepner, L., Garcia, W. E., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2422-18.2019 · Cited by 41
Manukjan, N., Ahmed, Z., Fulton, D. J., Blankesteijn, W. M., & Foulquier, S. (2020) · Cells · doi:10.3390/cells9061545 · Cited by 35
Du, X., West, M., Cheng, W., Ewert, D. L., Li, W., Saunders, D., Towner, R. A., Floyd, R. A., & Kopke, R. D. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4159357 · Cited by 36
Cerina, M., Narayanan, V., Göbel, K., Bittner, S., Ruck, T., Meuth, P., Herrmann, A. M., Stangel, M., Gudi, V., Skripuletz, T., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.014 · Cited by 36
Regulators of Oligodendrocyte DifferentiationPreprint
Emery, B., & Wood, T. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041358 · Cited by 36
Marangon, D., Caporale, N., Boccazzi, M., Abbracchio, M. P., Testa, G., & Lecca, D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.748849 · Cited by 34
Melie‐García, L., Slater, D., Ruef, A., Sanabria-Díaz, G., Preisig, M., Kherif, F., Draganski, B., & Lutti, A. (2017) · Human Brain Mapping · doi:10.1002/hbm.23929 · Cited by 36
Oligodendrocytes and myelin: Active players in neurodegenerative brains?
Chen, J., Wang, F., Huang, N., Xiao, L., & Mei, F. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22867 · Cited by 37
Microglia: Senescence Impairs Clearance of Myelin Debris
Thériault, P., & Rivest, S. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.066 · Cited by 37
Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers
Mühlebner, A., van Scheppingen, J., de Neef, A., Bongaarts, A., Zimmer, T. S., Mills, J. D., Jansen, F. E., Spliet, W. G. M., Kršek, P., Zámečnı́k, J., et al. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa090 · Cited by 33
Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis
Traiffort, É., Morisset‐Lopez, S., Moussaed, M., & Zahaf, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073426 · Cited by 36
Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder
Peterson, B. S., Zargarian, A., Peterson, J. B., Goh, S., Sawardekar, S., Williams, S., Lythgoe, D. J., Zelaya, F. O., & Bansal, R. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.026 · Cited by 34
Age and Alzheimer’s Disease-Related Oligodendrocyte Changes in Hippocampal Subregions
DeFlitch, L., González‐Fernández, E., Crawley, I., & Kang, S. H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.847097 · Cited by 34
Macroglial diversity: white and grey areas and relevance to remyelination
Werkman, I. L., Lentferink, D. H., & Baron, W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03586-9 · Cited by 33
A neural stem cell paradigm of pediatric hydrocephalus
Duy, P. Q., RAKIC, P. T., Alper, S. L., Robert, S. M., Kundishora, A. J., Butler, W. E., Walsh, C. A., Šestan, N., Geschwind, D. H., Jin, S. C., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac341 · Cited by 32
Working Memory: From Neural Activity to the Sentient Mind
Jaffe, R. J., & Constantinidis, C. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210005 · Cited by 33
Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
Zhang, X., Huang, N., Xiao, L., Wang, F., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.760200 · Cited by 32
Palhol, J. S. C., Balia, M., Terán, F. S.-R., Labarchède, M., Gontier, É., & Battefeld, A. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00425-4 · Cited by 30
Navigating oligodendrocyte precursor cell aging in brain health
Leenders, F., Koole, L., Slaets, H., Tiane, A., van den Hove, D., & Vanmierlo, T. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111959 · Cited by 30
Patro, N., Naik, A. A., & Patro, I. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1065-1 · Cited by 30
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation
Jin, M., Li, Q., Gu, Y., Wan, B., Huang, J., Xu, X., Huang, R., & Zhang, Y. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14053 · Cited by 31
Donkels, C., Peters, M., Núñez, M. T. F., Nakagawa, J. M., Kirsch, M., Vlachos, A., Scheiwe, C. F., Schulze‐Bonhage, A., Prinz, M., Beck, J., et al. (2019) · Epilepsia · doi:10.1111/epi.16415 · Cited by 30
Martins‐Macedo, J., Lepore, A. C., Domingues, H. S., Salgado, A. J., Gomes, E. D., & Pinto, L. (2020) · Glia · doi:10.1002/glia.23922 · Cited by 31
More attention on glial cells to have better recovery after spinal cord injury
Hassanzadeh, S., Jalessi, M., Jameie, S. B., Khanmohammadi, M., Bagher, Z., Namjoo, Z., & Davachi, S. M. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2020.100905 · Cited by 30
Walczak, P., & Janowski, M. (2019) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000565 · Cited by 31
Astrocytes: From the Physiology to the Disease
Trujillo‐Estrada, L., Gómez-Arboledas, Á., Forner, S., Martini, A. C., Gutiérrez, A., Baglietto‐Vargas, D., & LaFerla, F. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190830110152 · Cited by 30
Many roles for oligodendrocyte precursor cells in physiology and pathology
Nishiyama, A., Serwanski, D. R., & Pfeiffer, F. (2021) · Neuropathology · doi:10.1111/neup.12732 · Cited by 31
Meningioma growth dynamics assessed by radiocarbon retrospective birth dating
Huttner, H. B., Bergmann, O., Salehpour, M., Cheikh, R. E., Nakamura, M., Tortora, A., Heinke, P., Coras, R., Englund, E. M., Eyüpoglu, I. Y., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.020 · Cited by 29
Self-citationBaud, O., & Saint-Faust, M. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004032 · Cited by 32
Neuroprotection of the preterm brain
Fleiss, B., & Gressèns, P. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64029-1.00015-1 · Cited by 32
Werner, H. B., Buscham, T. J., Eichel‐Vogel, M. A., & Siems, S. B. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.262569 · Cited by 28
Myelin plasticity modulates neural circuitry required for learning and behavior
Kato, D., & Wake, H. (2021) · Neuroscience Research · doi:10.1016/j.neures.2020.12.005 · Cited by 30
Fessel, J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01879-0 · Cited by 28
Rao, V. T. S., Khan, D., Jones, R. G., Nakamura, D. S., Kennedy, T. E., Cui, Q., Rone, M. B., Healy, L. M., Watson, R. L., Ghosh, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30020 · Cited by 28
Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?
Reiche, L., Küry, P., & Göttle, P. (2019) · Cells · doi:10.3390/cells8121591 · Cited by 28
Kusch, K., Uecker, M., Liepold, T., Möbius, W., Hoffmann, C., Neumann, H., Werner, H. B., & Jahn, O. (2017) · Proteomes · doi:10.3390/proteomes5010003 · Cited by 29
Baldassarro, V. A., Cescatti, M., Rocco, M. L., Aloe, L., Lorenzini, L., Giardino, L., & Calzà, L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1111170 · Cited by 26
Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
Mironova, Y. A., Dang, B., Heo, D., Xu, Y. K. T., Hsu, A. T.-W., von Bernhardi, J. E., Molina-Castro, G. C., Kim, A. A., LIN, J., Reich, D. S., et al. (2026) · Science · doi:10.1126/science.adu2896 · Cited by 28
Moyon, S., Holloman, M., & Salzer, J. L. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1114781 · Cited by 26
White matter alterations in Williams syndrome related to behavioral and motor impairments
Nir, A., & Barak, B. (2020) · Glia · doi:10.1002/glia.23868 · Cited by 26
Sampaio‐Baptista, C., Neyedli, H. F., Sanders, Z., Diosi, K., Havard, D., Huang, Y., Andersson, J., Lührs, M., Goebel, R., & Johansen‐Berg, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109890 · Cited by 26
Fetal influence on the human brain through the lifespan
Walhovd, K., Krogsrud, S. K., Amlien, I., Sørensen, Ø., Wang, Y.-P., Bråthen, A., Overbye, K., Kransberg, J., Mowinckel, A., Magnussen, F., et al. (2024) · eLife · doi:10.7554/elife.86812 · Cited by 11
Nakafuku, M., & del Águila, Á. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.369 · Cited by 25
Weber, A. M., Zhang, Y., Kames, C., & Rauscher, A. (2019) · NMR in Biomedicine · doi:10.1002/nbm.4222 · Cited by 25
Jiang, Y., Armada, K., & Martin, J. H. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113015 · Cited by 26
White matter disturbances in phenylketonuria: Possible underlying mechanisms
Ferreira, B. K., Rodrigues, M. T., STRECK, E. L., Ferreira, G. C., & Schuck, P. F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24598 · Cited by 25
When glia meet induced pluripotent stem cells (iPSCs)
Li, L., & Shi, Y. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103565 · Cited by 24
Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics
Guyon, N., Zacharias, L. R., van Lunteren, J. A., Immenschuh, J., Fuzik, J., Märtin, A., Xuan, Y., Zilberter, M. Y., Kim, H., Meletis, K., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1848-20.2021 · Cited by 25
The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate
Boshans, L. L., Sherafat, A., & Nishiyama, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134593 · Cited by 24
Blanco‐Urrejola, M., Gaminde‐Blasco, A., Gamarra, M., de la Cruz, A., Vecino, E., Alberdi, E. M., & Baleriola, J. (2021) · Cells · doi:10.3390/cells10030632 · Cited by 24
Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination
Bloom, M. S., Orthmann‐Murphy, J. L., & Grinspan, J. B. (2022) · ASN NEURO · doi:10.1177/17590914221097510 · Cited by 25
Lange, S., Ebeling, M., Loye, A., Wanke, F., Siebourg‐Polster, J., Sudharshan, T. J. J., Völlmy, F., Kralik, J., Vidal, B., Hahn, K., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp7047 · Cited by 26
da Costa, G., Ribeiro, F. F., Sebastião, A. M., Muir, E. M., & Vaz, S. H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1003145 · Cited by 23
Dating the Heart: Exploring Cardiomyocyte Renewal in Humans
Graham, E. L., & Bergmann, O. (2016) · Physiology · doi:10.1152/physiol.00015.2016 · Cited by 22
Self-citationRemyelination: A Potential Therapeutic Strategy for Alzheimer’s Disease?
Sun, J., Zhou, H., Bai, F., Zhang, Z., & Ren, Q. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170036 · Cited by 22
Immunology of oligodendrocyte precursor cells in vivo and in vitro
Antel, J. P., Lin, Y. H., Cui, Q., Pernin, F., Kennedy, T. E., Ludwin, S. K., & Healy, L. M. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.006 · Cited by 23
Oligodendrocyte Progenitor Cells in the Tumor Microenvironment
Hide, T., & Komohara, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_8 · Cited by 23
Deciphering the physiopathology of neurodevelopmental disorders using brain organoids
Dionne, O., Sabatié, S., & Laurent, B. (2024) · Brain · doi:10.1093/brain/awae281 · Cited by 22
THE VERSATILE USES OF THE 14C BOMB PEAK
Kutschera, W. (2022) · Radiocarbon · doi:10.1017/rdc.2022.13 · Cited by 22
Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain
Radecki, D. Z., & Samanta, J. (2022) · Cells · doi:10.3390/cells11132101 · Cited by 21
Ionotropic glutamate receptor expression in human white matter
Christensen, P. C., Samadi‐Bahrami, Z., Pavlov, V., Stys, P. K., & Moore, G. R. W. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.030 · Cited by 21
Zhi, J.-J., Wu, S.-L., Wu, H., Ran, Q., Gao, X., Chen, J., Gu, X., Li, T., Wang, F., Xiao, L., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2130-22.2023 · Cited by 20
García‐Martínez, T., Gornatti, D. G., Ortiz, M., Cañellas, G., Heine‐Suñer, D., & Vives-Bauzá, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051886 · Cited by 20
Myelination may be impaired in neonates following birth asphyxia
Olivieri, B., Rampakakis, E., Gilbert, G., Fezoua, A., & Wintermark, P. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102678 · Cited by 19
Live imaging of remyelination in the adult mouse corpus callosum
Bottes, S., & Jessberger, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025795118 · Cited by 22
Coherent, time-shifted patterns of microstructural plasticity during motor-skill learning
Azzarito, M., Emmenegger, T. M., Ziegler, G., Huber, E., Grabher, P., Callaghan, M. F., Thompson, A. J., Friston, K. J., Weiskopf, N., Killeen, T., et al. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120128 · Cited by 20
ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function
Cho, C. H., Deyneko, I. V., Cordova-Martinez, D., Vazquez, J., Maguire, A. S., Diaz, J. R., Carbonell, A. U., Tindi, J. O., Cui, M., Fleysher, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43438-1 · Cited by 20
Cortical cellular diversity and development in schizophrenia
Price, A. J., Jaffe, A. E., & Weinberger, D. R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0775-8 · Cited by 23
What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?
Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000208000 · Cited by 21
Multiple Sclerosis: Basic and Clinical
Buzzard, K. A., Chan, W. H., Kilpatrick, T. J., & Murray, S. S. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_8 · Cited by 26
A timeline of oligodendrocyte death and proliferation following experimental subarachnoid hemorrhage
Peng, K., Koduri, S., Ye, F., Yang, J., Keep, R. F., Xi, G., & Hua, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13812 · Cited by 19
Intrinsic organization of the corpus callosum
Barbaresi, P., Fabri, M., Lorenzi, T., Sagrati, A., & Morroni, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1393000 · Cited by 20
Built to Adapt: Mechanisms of Cognitive Flexibility in the Human Brain
Hauptman, M., Liu, Y., & Bedny, M. (2024) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-120621-042108 · Cited by 20
Hypothalamic neuronal-glial crosstalk in metabolic disease
Nguyen, L. T., & Dodd, G. T. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00026-1 · Cited by 22
Alzheimer’s disease: an axonal injury disease?
Liang, D., & Zhang, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1264448 · Cited by 21
Vitantonio, A. T., Dimovasili, C., Mortazavi, F., Vaughan, K. L., Mattison, J. A., & Rosene, D. L. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.05.005 · Cited by 18
Novel roles of oligodendrocyte precursor cells in the developing and damaged brain
Maki, T. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12358 · Cited by 18
Lukoshe, A., van den Bosch, G. E., van der Lugt, A., Kushner, S. A., Hokken‐Koelega, A. C. S., & White, T. J. H. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx052 · Cited by 18
Why monkeys do not get multiple sclerosis (spontaneously)
Bove, R. M. (2018) · Evolution Medicine and Public Health · doi:10.1093/emph/eoy002 · Cited by 19
Seeing Is Believing: Myelin Dynamics in the Adult CNS
Swire, M., & ffrench‐Constant, C. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.005 · Cited by 18
Pfeiffer, F. (2022) · Cells · doi:10.3390/cells11121954 · Cited by 17
Davies, M. R., Greenberg, Z., van Vuurden, D. G., Cross, C., Zannettino, A. C. W., Bardy, C., & Wardill, H. R. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.013 · Cited by 17
Revisit the Candidacy of Brain Cell Types as the Cell(s) of Origin for Human High-Grade Glioma
Shao, F., & Liu, C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00048 · Cited by 17
From mice to mind: Strategies and progress in translating neuroregeneration
Burns, T. C., & Verfaillie, C. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.041 · Cited by 17
Engineering of Adult Neurogenesis and GliogenesisPreprint
Berninger, B., & Jessberger, S. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018861 · Cited by 17
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain · doi:10.1093/brain/awae293 · Cited by 16
“22 26-28 These findings promoted a debate on the origins of new internodes that might derive from different cellular sources depending on the nature, extent, duration and potentially age of the demyelinating insult.”
Oligodendrogenesis in Evolution, Development and Adulthood
Hu, H., Gao, T., Zhao, J., & Li, H. (2025) · Glia · doi:10.1002/glia.70033 · Cited by 16
Wintermark, P., Lapointe, A., Steinhorn, R. H., Rampakakis, E., Burhenne, J., Meid, A. D., Bajraktari‐Sylejmani, G., Khairy, M. A., Altit, G., Adamo, M.-T., et al. (2023) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2023.113879 · Cited by 16
Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science
Malfatti, M. A., Buchholz, B. A., Enright, H. A., Stewart, B. J., Ognibene, T. J., McCartt, A. D., Loots, G. G., Zimmermann, M., Scharadin, T. M., Cimino, G. D., et al. (2019) · Toxics · doi:10.3390/toxics7020027 · Cited by 16
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor
Chen, K., Park, E., & Abd‐Elrahman, K. S. (2025) · Molecular Pharmacology · doi:10.1016/j.molpha.2025.100027 · Cited by 15
Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?
Barton, S. K., Gregory, J. M., Chandran, S., & Turner, B. J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00124 · Cited by 18
Kieser, T. J., Santschi, N., Nowack, L., Axer, A., Kehr, G., Albrecht, S., & Gilmour, R. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00319 · Cited by 15
Glucocorticosteroids Effects on Brain Development in the Preterm Infant: A Role for Microglia?
Zinni, M., Pansiot, J., Billion, E., Baud, O., & Mairesse, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210517112913 · Cited by 15
Beyond IQ: The Importance of Metacognition for the Promotion of Global Wellbeing
Varshney, L. R., & Barbey, A. K. (2021) · Journal of Intelligence · doi:10.3390/jintelligence9040054 · Cited by 15
The Diameters of Cortical Axons and Their Relevance to Neural Computing
Innocenti, G. M., Carlén, M., & Dyrby, T. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801393-9.00015-3 · Cited by 17
Stokowy, T., Polushina, T. V., Sønderby, I. E., Karlsson, R., Giddaluru, S., Hellard, S. L., Bergen, S. E., Sullivan, P. F., Andreassen, O. A., Djurovic, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25280-4 · Cited by 15
Longitudinal changes in choline concentration and associated factors in human breast milk
Wu, T., Lan, Q.-Y., Tian, F., Xiong, X., Yang, M.-T., Huang, S., Chen, X.-Y., Kuchan, M. J., Li, X., Zhao, Y., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.07.016 · Cited by 14
Small sample Accelerator Mass Spectrometry for biomedical applications
Salehpour, M., Håkansson, K., & Possnert, G. (2015) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2015.04.047 · Cited by 14
Self-citation
Metadata
- Authors
- Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., Druid, H., & Frisén, J.
- Affiliations
- Karolinska Institutet (SE)
- Centre National de la Recherche Scientifique (FR)
- Uppsala University (SE)
- National Institutes of Health (US)
- Karolinska University Hospital (SE)
- Corresponding author
- Frisén, Jonas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 4
- Pages
- 766-774
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2044216636
- Cited by
- 541
- References
- 49
- Citations by year
- 2026: 42 · 2025: 46 · 2024: 47 · 2023: 53 · 2022: 43 · 2021: 66 · 2020: 39 · 2019: 56 · 2018: 33 · 2017: 47 · 2016: 42 · 2015: 26
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Funders
- Cancerfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocyte generation, myelination, corpus callosum, white matter, neuroplasticity, human brain development
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Carbon Isotopes, Child, Child, Preschool, Corpus Callosum, Humans, Infant, Middle Aged, Myelin Sheath, Neuronal Plasticity, Oligodendroglia, Nuclear Weapons, Young Adult, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
