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Geroscience: Linking Aging to Chronic Disease
Open accessAbstract
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.
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“Chronological age is the major predictor for most of the diseases that account for the bulk of morbidity, mortality and health costs across low-, middle- and high-income countries2–7.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The Geroscience Hypothesis holds that these pillars of aging, including cellular senescence, tend to progress in concert and may be root-cause contributors to the pathophysiology of multiple diseases”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Old age is the greatest risk factor for the chronic diseases responsible for the majority of morbidity, mortality, and health-care costs worldwide (1, 2).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recent studies of animal models have established the veracity of the geroscience hypothesis (1).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
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In the citing paper
“The recognition that old age is the greatest risk factor for most chronic diseases led to the geroscience hypothesis, which posits that therapeutically targeting fundamental aging mechanisms will successfully impact multiple chronic diseases because these diseases all share the same underlying mechanism (1).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
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“This hypothesis posits that by targeting a fundamental ageing process such as cellular senescence, multiple age-related disorders can be delayed, prevented, or alleviated as a group, instead of one-at-a-time.”
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In the citing paper
“The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1–3.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [2]
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“Evidence amassed in recent years indicates that aging science shows great promise as a method of extending health span (50)(51)(52)(53)(54)(55)(56).”
From Inconvenient Truths About Human Longevity (2019) · cites this paper as [51]
In the citing paper
“The somewhat surprising finding is that DNA damage has far-reaching effects on many aspects of cellular metabolism tied to aging, the so-called pillars of aging (Kennedy et al., 2014).”
From DNA damage-how and why we age? (2021) · cites this paper as Kennedy et al., 2014
In the citing paper
“Senescent cells expressing this phenotype can in turn promote a multitude of chronic health conditions and diseases, including insulin resistance, CVD, pulmonary arterial hypertension, chronic obstructive pulmonary disorder, emphysema, Alzheimer’s and Parkinson’s diseases, macular degeneration, osteoarthritis and cancer54,55.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [55]
In the citing paper
“Paramount among them is the accumulation of senescent cells in multiple tissues.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [87]
In the citing paper
“Thus, PA and exercise may be considered central geriatric care interventions, that is, interventions that act on the cellular and molecular drivers of biological aging to decelerate the rates of aging, which constitute the basics of the geroscience field [633,634].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [634]
In the citing paper
“Thus, PA and exercise may be considered central geriatric care interventions, that is, interventions that act on the cellular and molecular drivers of biological aging to decelerate the rates of aging, which constitute the basics of the geroscience field [633,634].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [634]
In the citing paper
“The hallmarks of aging are interconnected (Kennedy et al., 2014; López-Otín et al., 2013; Zhang et al., 2015a), and age-associated perturbations of one can affect others.”
From The Aging Epigenome (2016) · cites this paper as Kennedy et al., 2014
In the citing paper
“Over the past decades, a large body of research has shown that the molecular and cellular decline of aging can be organized into several evolutionarily conserved hallmarks or pillars of aging (Kennedy et al., 2014; López-Otín et al., 2013).”
From The Aging Epigenome (2016) · cites this paper as Kennedy et al., 2014
In the citing paper
“time‐dependent loss of autophagy proficiency is thought to critically contribute to the aged phenotype (Lopez‐Otin et al, 2013; Kennedy et al, 2014; Lopez‐Otin & Kroemer, 2021)”
From Autophagy in major human diseases (2021) · cites this paper as Kennedy et al, 2014
In the citing paper
“The molecular causes of physical aging are thought to occur through the accumulation of cellular damage to mitochondrial DNA (mtDNA), telomeric ends, coding-DNA, and proteins (Kennedy et al, 2014).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Kennedy et al, 2014
In the citing paper
“Ageing is also characterized by the appearance of different chronic diseases such as sarcopenia, type 2 diabetes mellitus (T2DM), cardiovascular disease, hypercholesterolemia, hypertension or neurodegenerative diseases among others (Kennedy et al., 2014).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Kennedy et al., 2014
In the citing paper
“Ageing is multifactorial involving different molecular and cellular processes such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intracellular communication (Kennedy et al., 2014; Lopez-Otin et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Kennedy et al., 2014
In the citing paper
“The geroscience hypothesis posits that interventions that target key hallmarks of aging potentially can prevent, delay, or even reverse age-related conditions as a group (1).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [1]
In the citing paper
“Biological ageing is enormously complex and is thought to be driven by the interaction of multiple dysregulated cellular and biochemical processes3,4.”
From Measuring biological age using omics data (2022) · cites this paper as [3]
In the citing paper
“Indeed, it could be argued that, as much of the basic biology of ageing seems largely conserved among many species with very different lifespans3,4,8, clocks that measure a universal cause or rate of ageing should function ubiquitously.”
From Measuring biological age using omics data (2022) · cites this paper as [3]
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
Survivors of childhood and adolescent cancer: life-long risks and responsibilities
Robison, L. L., & Hudson, M. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3634 · Cited by 857
Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell · doi:10.1111/acel.12170 · Cited by 445
Is HIV a Model of Accelerated or Accentuated Aging?
Pathai, S., Bajillan, H., LANDAY, A. L., & High, K. P. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt168 · Cited by 437
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302
You Are What You Host: Microbiome Modulation of the Aging Process
Heintz, C., & Mair, W. (2014) · Cell · doi:10.1016/j.cell.2014.01.025 · Cited by 222
Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 209
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Schmunk, L. J., Call, T. P., McCartney, D. L., Javaid, H., Hastings, W. J., Jovičević, V., Kojadinović, D., Tomkinson, N., Zlamalova, E., McGee, K. C., et al. (2025) · Aging Cell · doi:10.1111/acel.14444 · Cited by 25
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Simons, R. L., Ong, M. L., Lei, M., Klopack, E. T., Berg, M. T., Zhang, Y., Philibert, R. A., & Beach, S. R. H. (2021) · Journal of Aging and Health · doi:10.1177/08982643211043668 · Cited by 23
Güneşliol, B. E., Karaca, E., Ağagündüz, D., & Acar, Z. A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1952402 · Cited by 24
The Comprehensive Cancer Center
Aljurf, M., Majhail, N. S., Koh, M., Kharfan-Dabaja, M. A., & Chao, N. J. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-82052-7 · Cited by 24
Hernández-Silva, D., Cantón-Sandoval, J., Martínez-Navarro, F. J., Pérez‐Sánchez, H., de Oliveira, S., Mulero, V., Alcaraz‐Pérez, F., & Cayuela, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810468 · Cited by 25
Fournier, F., Diaz-Marin, R., Pilon, F., Neault, M., Juneau, R., Girouard, G., Wilson, A. M., Larrivée, B., Mallette, F. A., Crespo‐Garcia, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209973120 · Cited by 23
MLKL deficiency protects against low-grade, sterile inflammation in aged mice
Crutchfield, E. C. T., Garnish, S. E., Day, J. A., Anderton, H., Chiou, S., Hempel, A., Hall, C. M., Patel, K. M., Gangatirkar, P., Martin, K., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01121-4 · Cited by 23
Tang, B., Li, X., Wang, Y., Sjölander, A., Johnell, K., Thambisetty, M., Ferrucci, L., Reynolds, C. A., Finkel, D., Jylhävä, J., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00784-8 · Cited by 25
Pio‐Lopez, L., & Levin, M. G. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103585 · Cited by 23
Li, J., Gan‐Schreier, H., Zhu, X., Wang, W., Tuma‐Kellner, S., Liebisch, G., Stremmel, W., & Chamulitrat, W. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.09.001 · Cited by 23
Hibi, T., Ohtsuka, H., Shimasaki, T., Inui, S., Shibuya, M., Tatsukawa, H., Kanie, K., Yamamoto, Y., & Aiba, H. (2018) · Genes to Cells · doi:10.1111/gtc.12604 · Cited by 23
Wang, B., Han, L., Dai, S.-M., Li, X., Cai, W., Yang, D., Chen, L., Wang, N., Zhu, B., & Zhang, J. (2018) · BioMed Research International · doi:10.1155/2018/8541638 · Cited by 23
Allogeneic mesenchymal stem cell therapy: A regenerative medicine approach to geroscience
Oliva, A. A., McClain‐Moss, L., Pena, A., Drouillard, A., & Hare, J. M. (2019) · Aging Medicine · doi:10.1002/agm2.12079 · Cited by 23
Vitamin D in physiological and pathological aging: Lesson from centenarians
Ferri, E., Casati, M., Cesari, M., Vitale, G., & Arosio, B. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09522-y · Cited by 23
Non-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective
Gessain, G., Blériot, C., & Ginhoux, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613116 · Cited by 24
Boyajian, J. L., Islam, P., Abosalha, A. K., Schaly, S., Thareja, R., Kassab, A., Arora, K., Santos, M., Shum-Tim, C., & Prakash, S. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.05 · Cited by 24
New insights into healthy ageing, inflammageing and frailty using metabolomics
Abdullah, G. A., Akpan, A., Phelan, M. M., & Wright, H. L. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1426436 · Cited by 22
Zonneveld, M. H., Kuhaili, N. A., Mooijaart, S. P., Slagboom, P. E., Jukema, J. W., Noordam, R., & Trompet, S. (2024) · GeroScience · doi:10.1007/s11357-024-01391-x · Cited by 21
Chen, Z., Cheang, I., Qu, Q., Zhu, X., Fu, Y., Gao, R., Zhou, Y., & Li, X. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105707 · Cited by 22
LI, S., Hamaya, R., Zhu, H., Chen, B. H., Pereira, A. C., Ivey, K. L., Rist, P. M., Manson, J. E., Dong, Y., & Sesso, H. D. (2026) · Nature Medicine · doi:10.1038/s41591-026-04239-3 · Cited by 27
New mechanisms driving muscle stem cell regenerative decline with aging
Sousa‐Victor, P., García‐Prat, L., & Muñoz‐Cánoves, P. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180041pm · Cited by 22
Júnior, G. R., Costa, N. D. S. X., Belotti, L., Alemany, A. A. S., Amato‐Lourenço, L. F., da Cunha, P. G., Duro, S. D. O., Ribeiro, S. P., Veras, M. M., Lopes, F. D. T. Q. D. S., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.139 · Cited by 22
Nieto, C., Tolentino‐Mayo, L., Monterrubio‐Flores, E., Medina, C., Patiño, S. R., Aguirre‐Hernández, R., & Barquera, S. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.07.016 · Cited by 26
How inflammaging diminishes adaptive immunity
Kasler, H. G., & Verdin, E. M. (2021) · Nature Aging · doi:10.1038/s43587-020-00021-3 · Cited by 22
Sola-Sevilla, N., Ricobaraza, A., Hernández-Alcoceba, R., Aymerich, M. S., Tordera, R. M., & Puerta, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063107 · Cited by 23
New Perspectives on Avian Models for Studies of Basic Aging Processes
Harper, J. M., & Holmes, D. J. (2021) · Biomedicines · doi:10.3390/biomedicines9060649 · Cited by 22
Family socioeconomic status and child telomere length among the Samburu of Kenya
Needham, B. L., Straight, B., Hilton, C. E., Olungah, C. O., & Lin, J. (2021) · Social Science & Medicine · doi:10.1016/j.socscimed.2021.114182 · Cited by 22
Gorostieta-Salas, E., Moreno-Blas, D., Gerónimo‐Olvera, C., Cisneros, B., Court, F. A., & Castro‐Obregón, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6682336 · Cited by 20
Crowder, S. L., Hoogland, A. I., Small, B. J., Carpenter, K. M., Fischer, S. M., Li, D., Kinney, A. Y., Welniak, T. L., Brownstein, N. C., Reich, R. R., et al. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.08.010 · Cited by 22
Langevin, S., Caspi, A., Barnes, J. C., Brennan, G. M., Poulton, R., Purdy, S. C., Ramrakha, S., Tanksley, P. T., Thorne, P. R., Wilson, G., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114402 · Cited by 29
Teker, H. T., Ceylani, T., Keskin, S., Samgane, G., Mansuroğlu, S., Baba, B., Allahverdi, H., Açıkgöz, E., & Gurbanov, R. (2023) · Biogerontology · doi:10.1007/s10522-023-10032-3 · Cited by 22
Defining exceptional cognition in older adults: A systematic review of cognitive super‐ageing
Powell, A., Page, Z. A., Close, J., Sachdev, P. S., & Brodaty, H. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.6034 · Cited by 22
IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans
Bannitz, R. F., Camara, H., De‐Souza, E. A., Pinto, S., Pinca, A. P. F., da Silva, R. C., Sato, V. N., Castilho, B. A., & Mori, M. A. (2016) · BMC Biology · doi:10.1186/s12915-016-0301-2 · Cited by 27
Inflammatory markers and overall survival in older adults with cancer
Nishijima, T. F., Deal, A. M., Lund, J. L., Nyrop, K. A., Muss, H. B., & Sanoff, H. K. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.08.004 · Cited by 22
The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects
Kuo, C., Joaquim, M., Kuchel, G. A., Ferrucci, L., Harries, L. W., Pilling, L. C., & Melzer, D. R. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz191 · Cited by 22
The potential for complex computational models of aging
Farrell, S., Stubbings, G., Rockwood, K. J., Mitnitski, A., & Rutenberg, A. D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111403 · Cited by 25
Santin, Y., Lopez, S., Ader, I., Andrieu, S., Blanchard, N., Carrière, A., Casteilla, L., Cousin, B., Davezac, N., Barreto, P. D. S., et al. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2020.43 · Cited by 20
Self-citationExercise reduces metabolic burden while altering the immune system in aged mice
Yoon, K. J., Ahn, A., Park, S. H., Kwak, S. H., Kwak, S. E., Lee, W., Yang, Y. R., Kim, M., Shin, H. M., Kim, H., et al. (2021) · Aging · doi:10.18632/aging.202312 · Cited by 23
Luthra, N. S., Clow, A., & Corcos, D. M. (2022) · Brain Sciences · doi:10.3390/brainsci12121695 · Cited by 20
Leite, M. M., Dutra, M. T., da Costa, M. V. G., Funghetto, S. S., Silva, A. D. O., de Lima, L. R., da Silva, I. C. R., Mota, M. R., & Stival, M. M. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111389 · Cited by 15
Metadata
- Authors
- Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T., & Sierra, F.
- Affiliations
- Buck Institute for Research on Aging (US)
- University of Pennsylvania (US)
- Stanford University (US)
- University of California, San Francisco (US)
- Institute of Neurological Sciences (IT)
- Northwestern University (US)
- Albert Einstein College of Medicine (US)
- VA Palo Alto Health Care System (US)
- Oklahoma City VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- National Institutes of Health (US)
- Corresponding author
- Kennedy, Brian K.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 4
- Pages
- 709-713
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4852871
- OpenAlex
- W2159914115
- Cited by
- 2,764
- References
- 15
- Citations by year
- 2026: 368 · 2025: 355 · 2024: 344 · 2023: 272 · 2022: 296 · 2021: 313 · 2020: 244 · 2019: 187 · 2018: 150 · 2017: 105 · 2016: 81 · 2015: 42 · 2014: 3
- FWCI
- 26.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG043080, R01AG033373, P01AG031782, R01AG024287, P01AG036695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- geroscience, aging, chronic disease, healthspan extension, aging interventions, dietary intervention, older adults
- MeSH terms
- Aging, Animals, Chronic Disease, Humans, Biomedical Research, Epigenesis, Genetic, Gene-Environment Interaction
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