The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Geroscience: Linking Aging to Chronic Disease
Open accessAbstract
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Chronological age is the major predictor for most of the diseases that account for the bulk of morbidity, mortality and health costs across low-, middle- and high-income countries2–7.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The Geroscience Hypothesis holds that these pillars of aging, including cellular senescence, tend to progress in concert and may be root-cause contributors to the pathophysiology of multiple diseases”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Old age is the greatest risk factor for the chronic diseases responsible for the majority of morbidity, mortality, and health-care costs worldwide (1, 2).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recent studies of animal models have established the veracity of the geroscience hypothesis (1).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Thus, PA and exercise may be considered central geriatric care interventions, that is, interventions that act on the cellular and molecular drivers of biological aging to decelerate the rates of aging, which constitute the basics of the geroscience field [633,634].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [634]
Experimental — accuracy not yet measured
The cited source says what the claim attributes to it.
In the citing paper
“Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“The recognition that old age is the greatest risk factor for most chronic diseases led to the geroscience hypothesis, which posits that therapeutically targeting fundamental aging mechanisms will successfully impact multiple chronic diseases because these diseases all share the same underlying mechanism (1).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“This hypothesis posits that by targeting a fundamental ageing process such as cellular senescence, multiple age-related disorders can be delayed, prevented, or alleviated as a group, instead of one-at-a-time.”
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, it could be argued that, as much of the basic biology of ageing seems largely conserved among many species with very different lifespans3,4,8, clocks that measure a universal cause or rate of ageing should function ubiquitously.”
From Measuring biological age using omics data (2022) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1–3.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“Evidence amassed in recent years indicates that aging science shows great promise as a method of extending health span (50)(51)(52)(53)(54)(55)(56).”
From Inconvenient Truths About Human Longevity (2019) · cites this paper as [51]
In the citing paper
“The somewhat surprising finding is that DNA damage has far-reaching effects on many aspects of cellular metabolism tied to aging, the so-called pillars of aging (Kennedy et al., 2014).”
From DNA damage-how and why we age? (2021) · cites this paper as Kennedy et al., 2014
In the citing paper
“Senescent cells expressing this phenotype can in turn promote a multitude of chronic health conditions and diseases, including insulin resistance, CVD, pulmonary arterial hypertension, chronic obstructive pulmonary disorder, emphysema, Alzheimer’s and Parkinson’s diseases, macular degeneration, osteoarthritis and cancer54,55.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [55]
In the citing paper
“Paramount among them is the accumulation of senescent cells in multiple tissues.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [87]
In the citing paper
“Thus, PA and exercise may be considered central geriatric care interventions, that is, interventions that act on the cellular and molecular drivers of biological aging to decelerate the rates of aging, which constitute the basics of the geroscience field [633,634].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [634]
In the citing paper
“The hallmarks of aging are interconnected (Kennedy et al., 2014; López-Otín et al., 2013; Zhang et al., 2015a), and age-associated perturbations of one can affect others.”
From The Aging Epigenome (2016) · cites this paper as Kennedy et al., 2014
In the citing paper
“Over the past decades, a large body of research has shown that the molecular and cellular decline of aging can be organized into several evolutionarily conserved hallmarks or pillars of aging (Kennedy et al., 2014; López-Otín et al., 2013).”
From The Aging Epigenome (2016) · cites this paper as Kennedy et al., 2014
In the citing paper
“time‐dependent loss of autophagy proficiency is thought to critically contribute to the aged phenotype (Lopez‐Otin et al, 2013; Kennedy et al, 2014; Lopez‐Otin & Kroemer, 2021)”
From Autophagy in major human diseases (2021) · cites this paper as Kennedy et al, 2014
In the citing paper
“The molecular causes of physical aging are thought to occur through the accumulation of cellular damage to mitochondrial DNA (mtDNA), telomeric ends, coding-DNA, and proteins (Kennedy et al, 2014).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Kennedy et al, 2014
In the citing paper
“Ageing is also characterized by the appearance of different chronic diseases such as sarcopenia, type 2 diabetes mellitus (T2DM), cardiovascular disease, hypercholesterolemia, hypertension or neurodegenerative diseases among others (Kennedy et al., 2014).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Kennedy et al., 2014
In the citing paper
“Ageing is multifactorial involving different molecular and cellular processes such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intracellular communication (Kennedy et al., 2014; Lopez-Otin et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Kennedy et al., 2014
In the citing paper
“The geroscience hypothesis posits that interventions that target key hallmarks of aging potentially can prevent, delay, or even reverse age-related conditions as a group (1).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [1]
In the citing paper
“Biological ageing is enormously complex and is thought to be driven by the interaction of multiple dysregulated cellular and biochemical processes3,4.”
From Measuring biological age using omics data (2022) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
Survivors of childhood and adolescent cancer: life-long risks and responsibilities
Robison, L. L., & Hudson, M. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3634 · Cited by 857
Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell · doi:10.1111/acel.12170 · Cited by 445
Is HIV a Model of Accelerated or Accentuated Aging?
Pathai, S., Bajillan, H., LANDAY, A. L., & High, K. P. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt168 · Cited by 437
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302
You Are What You Host: Microbiome Modulation of the Aging Process
Heintz, C., & Mair, W. (2014) · Cell · doi:10.1016/j.cell.2014.01.025 · Cited by 222
Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 209
Self-citation
Research works printed but not linked: 1
- Salvioli, 2013, Curr. Pharm. Des., 19, 1675
Cited by
Sorted by citations
Items 101–200 of 1,006
Senescence in COPD and Its Comorbidities
Barnes, P. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034314 · Cited by 278
Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
Keyes, B. E., Liu, S., Asare, A., Naik, S., Levorse, J., Polak, L., Lu, C. P., Nikolova, M., Pasolli, H. A., & Fuchs, E. (2016) · Cell · doi:10.1016/j.cell.2016.10.052 · Cited by 266
Chen, H.-Z., Wang, F., Gao, P., Pei, J.-F., Liu, Y., Xu, T.-T., Tang, X., Fu, W.-Y., Lu, J., Yan, Y.-F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308895 · Cited by 265
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257
Izquierdo, M., de Souto Barreto, P., Arai, H., Bischoff-Ferrari, H. A., Cadore, E. L., Cesari, M., Chen, L.-K., Coen, P. M., Courneya, K. S., Duque, G., et al. (2025) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100401 · Cited by 273
Saleh, H. A., Yousef, M. H., & Abdelnaser, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606069 · Cited by 269
The role of nutrition in inflammaging
Giosia, P. D., Stamerra, C. A., Giorgini, P., Jamialahamdi, T., Butler, A. E., & Sahebkar, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101596 · Cited by 262
Strianese, O., Rizzo, F. M., Ciccarelli, M., Galasso, G., D’Agostino, Y., Salvati, A., Giudice, C. D., Tesorio, P., & Rusciano, M. R. (2020) · Genes · doi:10.3390/genes11070747 · Cited by 269
Valenzano, D. R., Benayoun, B. A., Singh, P. P., Zhang, E., Etter, P. D., Hu, C., Clément‐Ziza, M., Willemsen, D., Cui, R., Harel, I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.008 · Cited by 245
Self-citationJeste, D. V., Palmer, B. W., Rettew, D. C., & Boardman, S. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14nr09599 · Cited by 256
Underlying features of epigenetic aging clocks in vivo and in vitro.
Liu, Z., Leung, D., Thrush, K., Zhao, W., Ratliff, S., Tanaka, T., Schmitz, L. L., Smith, J. A., Ferrucci, L., & Levine, M. E. (2020) · Aging Cell · doi:10.1111/acel.13229 · Cited by 227
Calorie Restriction and Aging in Humans
Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034601 · Cited by 239
A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
Rockwood, K. J., Blodgett, J. M., Theou, O., Sun, M., Feridooni, H. A., Mitnitski, A., Rose, R. A., Godin, J., Gregson, E., & Howlett, S. E. (2017) · Scientific Reports · doi:10.1038/srep43068 · Cited by 237
Epigenetics of Aging and Aging-Associated Diseases
Saul, D., & Kosinsky, R. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010401 · Cited by 247
Wine Flavonoids in Health and Disease Prevention
Fernandes, I., Pérez-Gregório, R., Soares, S., Mateus, N. F. D. C. B., & de Freitas, V. A. P. (2017) · Molecules · doi:10.3390/molecules22020292 · Cited by 241
Immune senescence, epigenetics and autoimmunity
Ray, D., & Yung, R. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.04.002 · Cited by 219
Demographic perspectives on the rise of longevity
Vaupel, J. W., Villavicencio, F., & Bergeron-Boucher, M.-P. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019536118 · Cited by 253
Rocca, W. A., Gazzuola-Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A., & Miller, V. M. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.08.002 · Cited by 229
A complex systems approach to aging biology
Cohen, A. A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M. E., Lipsitz, L. A., Olde Rikkert, M. G. M., Rutenberg, A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00252-6 · Cited by 221
Two-Step Senescence-Focused Cancer Therapies
Sieben, C. J., Sturmlechner, I., van de Sluis, B., & van Deursen, J. M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.006 · Cited by 222
Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging
Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203
Jin, K. (2014) · Aging and Disease · doi:10.14336/ad.2014.1210 · Cited by 232
Fülöp, T., Larbi, A., & Witkowski, J. M. (2019) · Gerontology · doi:10.1159/000497375 · Cited by 221
Waziry, R., Ryan, C. P., Corcoran, D. L., Huffman, K. M., Kobor, M. S., Kothari, M., Graf, G. H., Kraus, V. B., Kraus, W. E., Lin, D. T. S., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00357-y · Cited by 217
Crimmins, E. M., Thyagarajan, B., Levine, M. E., Weir, D. R., & Faul, J. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab016 · Cited by 213
Camell, C. D., Günther, P. S., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.006 · Cited by 216
IRE1 signaling exacerbates Alzheimer’s disease pathogenesis
Duran-Aniotz, C. A., Cornejo, V. H., Espinoza, S., Ardiles, Á. O., Medinas, D. B., Salazar, C., Foley, A., Gajardo, I., Thielen, P., Iwawaki, T., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1694-x · Cited by 216
Sierra, F. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025163 · Cited by 226
Self-citationEndoplasmic reticulum proteostasis impairment in aging
Martínez, G., Duran-Aniotz, C. A., Cabral‐Miranda, F., Vivar, J. P., & Hetz, C. A. (2017) · Aging Cell · doi:10.1111/acel.12599 · Cited by 213
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants
Pilling, L. C., Kuo, C.-L., Sicinski, K., Tamosauskaite, J., Kuchel, G. A., Harries, L. W., Herd, P., Wallace, R., Ferrucci, L., & Melzer, D. (2017) · Aging · doi:10.18632/aging.101334 · Cited by 211
Aging alters the immunological response to ischemic stroke
Ritzel, R. M., Lai, Y., Crapser, J. D., Patel, A. R., Schrecengost, A., Grenier, J. M., Mancini, N. S., Patrizz, A., Jellison, E. R., Morales‐Scheihing, D., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1859-2 · Cited by 214
Alternative splicing in aging and longevity
Bhadra, M., Howell, P., Dutta, S., Heintz, C., & Mair, W. B. (2020) · Human Genetics · doi:10.1007/s00439-019-02094-6 · Cited by 205
The chromatin accessibility signature of human immune aging stems from CD8+ T cells
Ucar, D., Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Uyar, A., Wu, T.-C., George, J., Stitzel, M. L., Palucka, A. K., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170416 · Cited by 200
Age-related deficit accumulation and the diseases of ageing
Rockwood, K., & Howlett, S. E. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.04.005 · Cited by 198
Nrf2: Molecular and epigenetic regulation during aging
Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 199
Sex Differences in Myocardial and Vascular Aging
Ji, H., Kwan, A. C., Chen, M. T., Ouyang, D., Ebinger, J. E., Bell, S. P., Niiranen, T., Bello, N. A., & Cheng, S. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319902 · Cited by 210
Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20790-0 · Cited by 199
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.03.008 · Cited by 195
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, M. G., Biondi, F., et al. (2015) · Nutrients · doi:10.3390/nu7042589 · Cited by 198
Self-citationChange in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis
Belsky, D. W., Huffman, K. M., Pieper, C. F., Shalev, I., & Kraus, W. E. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx096 · Cited by 185
Dietary Anti-Aging Polyphenols and Potential Mechanisms
Luo, J., Si, H., Jia, Z., & Liu, D. (2021) · Antioxidants · doi:10.3390/antiox10020283 · Cited by 203
Recent Patterns of Multimorbidity Among Older Adults in High-Income Countries
Ofori‐Asenso, R., Chin, K. L., Curtis, A. J., Zomer, E., Zoungas, S., & Liew, D. (2018) · Population Health Management · doi:10.1089/pop.2018.0069 · Cited by 193
Reducing Senescent Cell Burden in Aging and Disease
Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.005 · Cited by 177
Romero, Y., Bueno, M., Ramírez, R., Álvarez, D., Sembrat, J., Goncharova, E. A., Rojas, M. M., Selman, M., Mora, A. L., & Pardo, A. (2016) · Aging Cell · doi:10.1111/acel.12514 · Cited by 193
Aging and InflammationPreprint
Singh, A., Schurman, S. H., Bektas, A., Kaileh, M., Roy, R., Wilson, D. M., Sen, R., & Ferrucci, L. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041197 · Cited by 201
Kulkarni, A. S., Brutsaert, E. F., Anghel, V., Zhang, K., Bloomgarden, N., Pollak, M., Mar, J. C., Hawkins, M., Crandall, J. P., & Barzilai, N. (2018) · Aging Cell · doi:10.1111/acel.12723 · Cited by 183
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction
Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184
Simons, R. L., Lei, M., Klopack, E. T., Beach, S. R. H., Gibbons, F. X., & Philibert, R. A. (2020) · Social Science & Medicine · doi:10.1016/j.socscimed.2020.113169 · Cited by 197
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182
Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary
Walston, J. D., Bandeen‐Roche, K., Buta, B. J., Bergman, H., Gill, T. M., Morley, J. E., Fried, L. P., Robinson, T. N., Afilalo, J., Newman, A. B., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15928 · Cited by 180
Anti-senescence compounds: A potential nutraceutical approach to healthy aging
Gurău, F., Baldoni, S., Prattichizzo, F., Espinosa, E., Amenta, F., Procopio, A. D., Albertini, M. C., Bonafè, M., & Olivieri, F. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.001 · Cited by 179
Teissier, T., & Boulanger, É. (2019) · Biogerontology · doi:10.1007/s10522-019-09808-3 · Cited by 187
Marcucci, G., Domazetovic, V., Nediani, C., Ruzzolini, J., Favre, C., & Brandi, M. L. (2023) · Antioxidants · doi:10.3390/antiox12020373 · Cited by 200
Geroscience and the trans-NIH Geroscience Interest Group, GSIG
Sierra, F., & Kohanski, R. (2017) · GeroScience · doi:10.1007/s11357-016-9954-6 · Cited by 186
Self-citationThe dog aging project: translational geroscience in companion animals
Kaeberlein, M. R., Creevy, K. E., & Promislow, D. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9638-7 · Cited by 186
Osteosarcopenia: A case of geroscience
Kirk, B., Saedi, A. A., & Duque, G. (2019) · Aging Medicine · doi:10.1002/agm2.12080 · Cited by 178
Shahidehpour, R. K., Higdon, R. E., Crawford, N. G., Neltner, J. H., Ighodaro, E. T., Patel, E., Price, D., Nelson, P. T., & Bachstetter, A. D. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.12.003 · Cited by 173
The World Goes Bats: Living Longer and Tolerating Viruses
Gorbunova, V., Seluanov, A., & Kennedy, B. K. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.013 · Cited by 162
Self-citationRamalingam, M., Kim, H., Lee, Y., & Lee, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00348 · Cited by 180
Ding, Y., Zuo, Y., Zhang, B., Fan, Y., Xu, G., Cheng, Z., Ma, S., Fang, S., Tian, A., Gao, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.047 · Cited by 200
Association of Depression and Anxiety With the Accumulation of Chronic Conditions
Bobo, W. V., Grossardt, B. R., Virani, S., Sauver, J. L. S., Boyd, C. M., & Rocca, W. A. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.9817 · Cited by 186
Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.008 · Cited by 173
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., et al. (2017) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx015 · Cited by 173
Self-citationIdentification of 12 genetic loci associated with human healthspan
Zenin, A., Tsepilov, Y., Sharapov, S., Getmantsev, E., Menshikov, L. I., Fedichev, P. O., & Aulchenko, Y. (2019) · Communications Biology · doi:10.1038/s42003-019-0290-0 · Cited by 170
Emerging roles of lactate in acute and chronic inflammation
Fang, Y., Li, Z., Yang, L., Li, W., Wang, Y., Kong, Z., Miao, J., Chen, Y., Bian, Y., & Zeng, L. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01624-8 · Cited by 186
Inflammaging and human longevity in the omics era
Monti, D., Ostan, R., Borelli, V., Castellani, G., & Franceschi, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.008 · Cited by 169
Self-citationThe African turquoise killifish: A research organism to study vertebrate aging and diapause
Hu, C., & Brunet, A. (2018) · Aging Cell · doi:10.1111/acel.12757 · Cited by 174
Self-citationCardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 172
Where Metabolism Meets Senescence: Focus on Endothelial Cells
Sabbatinelli, J., Prattichizzo, F., Olivieri, F., Procopio, A. D., Rippo, M. R., & Giuliani, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01523 · Cited by 173
Stress-induced biological aging: A review and guide for research priorities
Polsky, L. R., Rentscher, K. E., & Carroll, J. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.016 · Cited by 193
Urfer, S. R., Kaeberlein, T. L., Mailheau, S., Bergman, P. J., Creevy, K. E., Promislow, D. E. L., & Kaeberlein, M. (2017) · GeroScience · doi:10.1007/s11357-017-9972-z · Cited by 158
The Business of Anti-Aging Science
de Magalhães, J. P., Stevens, M., & Thornton, D. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.07.004 · Cited by 174
Sahu, A., Mamiya, H., Shinde, S. N., Cheikhi, A., Winter, L., Vo, N. V., Stolz, D. B., Roginskaya, V. Y., Tang, W., Croix, C. M. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07253-3 · Cited by 178
Self-citationPerrott, K. M., Wiley, C. D., Desprez, P.-Y., & Campisi, J. (2017) · GeroScience · doi:10.1007/s11357-017-9970-1 · Cited by 163
Self-citationDiscovery, development, and future application of senolytics: theories and predictions
Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., & Kirkland, J. L. (2020) · The FEBS Journal · doi:10.1111/febs.15264 · Cited by 160
60 years of healthy aging: On definitions, biomarkers, scores and challenges
Behr, L. C., Simm, A., Kluttig, A., & Großkopf, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101934 · Cited by 184
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163
The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda
Moffitt, T. E., Belsky, D. W., Danese, A., Poulton, R., & Caspi, A. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw191 · Cited by 117
The companion dog as a model for human aging and mortality
Hoffman, J. M., Creevy, K. E., Franks, A. M., O'Neill, D. G., & Promislow, D. (2018) · Aging Cell · doi:10.1111/acel.12737 · Cited by 172
d’Avila, J. C., Siqueira, L. D., Mazeraud, A., Azevedo, E. P., Foguel, D., Castro-Faria-Neto, H. C., Sharshar, T., Chrétien, F., & Bozza, F. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1059-y · Cited by 168
A single-cell transcriptomic landscape of primate arterial aging
Zhang, W., Zhang, S., Yan, P., Ren, J., Song, M., Li, J., Lei, J., Pan, H., Wang, S., Ma, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15997-0 · Cited by 165
DCAF1 regulates Treg senescence via the ROS axis during immunological aging
Guo, Z., Wang, G., Wu, B., Chou, W.-C., Cheng, L., Zhou, C., Lou, J., Wu, D., Su, L., Zheng, J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136466 · Cited by 163
Turning back time with emerging rejuvenation strategies
Mahmoudi, S., Xu, L., & Brunet, A. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0206-0 · Cited by 171
Self-citationHallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Carrero, D., Soria-Valles, C., & López-Otín, C. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024711 · Cited by 153
Tolahunase, M., Sagar, R., & Dada, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7928981 · Cited by 172
Alpha-Ketoglutarate dietary supplementation to improve health in humans
Gyanwali, B., Lim, Z. X., Soh, J., Lim, C., Guan, S. P., Goh, J., Maier, A. B., & Kennedy, B. K. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.11.003 · Cited by 167
Self-citationMediterranean diet and inflammaging within the hormesis paradigm
Martucci, M., Ostan, R., Biondi, F., Bellavista, E., Fabbri, C., Bertarelli, C., Salvioli, S., Capri, M., Franceschi, C., & Santoro, A. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux013 · Cited by 167
Self-citationMitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles
Picca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040805 · Cited by 161
Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis
Yang, Z., Lin, H., Jiang, G.-H., Chu, Y.-H., Gao, J.-H., Tong, Z.-J., & Wang, Z. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1935-8 · Cited by 192
Graf, G. H., Crowe, C. L., Kothari, M., Kwon, D., Manly, J. J., Turney, I. C., Valeri, L., & Belsky, D. W. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwab281 · Cited by 150
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.019 · Cited by 162
Nutritional Vulnerability in Older Adults: A Continuum of Concerns
Starr, K. N. P., McDonald, S. R., & Bales, C. W. (2015) · Current Nutrition Reports · doi:10.1007/s13668-015-0118-6 · Cited by 169
Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers
Diebel, L., & Rockwood, K. J. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01097-9 · Cited by 160
Defining the age-dependent and tissue-specific circadian transcriptome in male mice
Wolff, C. A., Gutierrez‐Monreal, M. A., Meng, L., Zhang, X., Douma, L. G., Costello, H. M., Douglas, C. M., Ebrahimi, E., Pham, A. T., Oliveira, A. C. D. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111982 · Cited by 158
Zhang, Z., Schlamp, F., Huang, L., Clark, H., & Brayboy, L. (2020) · Reproduction · doi:10.1530/rep-19-0330 · Cited by 150
Regenerative decline of stem cells in sarcopenia
Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147
Heterochromatin: an epigenetic point of view in aging
Lee, J., Kim, E. W., Croteau, D. L., & Bohr, V. A. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00497-4 · Cited by 164
Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential
Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148
Metadata
- Authors
- Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T., & Sierra, F.
- Affiliations
- Buck Institute for Research on Aging (US)
- University of Pennsylvania (US)
- Stanford University (US)
- University of California, San Francisco (US)
- Institute of Neurological Sciences (IT)
- Northwestern University (US)
- Albert Einstein College of Medicine (US)
- VA Palo Alto Health Care System (US)
- Oklahoma City VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- National Institutes of Health (US)
- Corresponding author
- Kennedy, Brian K.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 4
- Pages
- 709-713
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4852871
- OpenAlex
- W2159914115
- Cited by
- 2,764
- References
- 15
- Citations by year
- 2026: 368 · 2025: 355 · 2024: 344 · 2023: 272 · 2022: 296 · 2021: 313 · 2020: 244 · 2019: 187 · 2018: 150 · 2017: 105 · 2016: 81 · 2015: 42 · 2014: 3
- FWCI
- 26.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG043080, R01AG033373, P01AG031782, R01AG024287, P01AG036695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- geroscience, aging, chronic disease, healthspan extension, aging interventions, dietary intervention, older adults
- MeSH terms
- Aging, Animals, Chronic Disease, Humans, Biomedical Research, Epigenesis, Genetic, Gene-Environment Interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
