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Embryonic Origin of Postnatal Neural Stem Cells
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Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
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“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fuentealba et al., 2015
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Livet, J., Weissman, T. A., Kang, H., Draft, R. W., Lu, J., Bennis, R. A., Sanes, J. R., & Lichtman, J. W. (2007) · Nature · doi:10.1038/nature06293 · Cited by 1,876
The development of neural stem cells
Temple, S. (2001) · Nature · doi:10.1038/35102174 · Cited by 1,479
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,110
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
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Takahashi, H., Yoshihara, S., & Tsuboi, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00229 · Cited by 50
Ribeiro, M. F., Genebra, T., Rego, A. C., Rodrigues, C. M. P., & Solá, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1342-z · Cited by 50
Ontogeny of adult neural stem cells in the mammalian brain
Bond, A. M., Ming, G., & Song, H. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.002 · Cited by 51
“V-SVZ NSCs concomitantly downregulate expression of RC2 (Nestin), an RG marker, and increase GFAP expression around P6, the time when ependymal cells and B cells mature (Merkle, Tramontin, Garcı́a-Verdugo, & Alvarez-Buylla, 2004).”
BackgroundInfluentialMidbrain tectal stem cells display diverse regenerative capacities in zebrafish
Lindsey, B. W., Aitken, G., Tang, J., Khabooshan, M. A., Douek, A. M., Vandestadt, C., & Kaslin, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-40734-z · Cited by 48
Lee, C.-M. J., Zhou, L., Liu, J., Shi, J., Geng, Y., Liu, M., Wang, J., Su, X., Barad, N., Wang, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918883117 · Cited by 48
“The TAM-inducible CreER/LoxP system laid the foundations of significant discoveries in adult and embryonic neural stem cell fate mapping (2, 10, 11, 70), gene functions (71), as well as neuronal subtypes and activity-dependent neural circuitry (72–74).”
BackgroundOproescu, A.-M., Han, S., & Schuurmans, C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.642016 · Cited by 54
Kase, Y., Shimazaki, T., & Okano, H. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00122-x · Cited by 51
“NSCs are actively self-renewing, allowing the generation of a large number of neurons and glia during central nervous system development [35] and thus rapid cerebral development during the embryonic stage.”
BackgroundThe Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain
Gimeno, G. C., & Paridaen, J. T. M. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.885269 · Cited by 48
Magnusson, J. P., & Frisén, J. (2016) · Development · doi:10.1242/dev.133975 · Cited by 46
“In fact, individual neural stem cells in the subventricular zone may well spend most of their life in a quiescent state, becoming activated only for a few weeks of intense proliferation, followed by exhaustion of their stem cell potential (Fuentealba et al., 2015; Furutachi et al., 2015; Calzolari et al., 2015).”
BackgroundNeural lineage tracing in the mammalian brain
Ma, J., Shen, Z., Yu, Y., & Shi, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.013 · Cited by 46
Guo, T., Liu, G., Du, H., Wen, Y. F., Wei, S., Li, Z., Tao, G., Shang, Z., Song, X., Zhang, Z., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz018 · Cited by 45
“…this process continues postnatally in the subventricular zone (SVZ) and the rostral migratory stream (RMS) (Doetsch et al. 1999; Stenman et al. 2003; Kohwi et al. 2007; Long et al. 2007; Merkle et al. 2007; Ventura and Goldman 2007; Young et al. 2007; Xu et al. 2008; Fuentealba et al. 2015).”
BackgroundA Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors
Takahashi, H., Ogawa, Y., Yoshihara, S.-I., Asahina, R., Kinoshita, M., Kitano, T., Kitsuki, M., Tatsumi, K., Okuda, M., Tatsumi, K., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2783-15.2016 · Cited by 45
“Several subtypes of GCs are derived from distinct neural stem cells in the SVZ (Fuentealba et al., 2015).”
BackgroundLei, J., Vermillion, M. S., Jia, B., Xie, H., Xie, L. H., McLane, M. W., Sheffield, J. S., Pekosz, A. S., Brown, A. M., Klein, S. L., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.122678 · Cited by 46
A Population Phylogenetic View of Mitochondrial Heteroplasmy
Wilton, P., Zaidi, A. A., Makova, K. D., & Nielsen, R. (2018) · Genetics · doi:10.1534/genetics.118.300711 · Cited by 44
Neural stem cell heterogeneity through time and space in the ventricular-subventricular zone
Rushing, G. V., & Ihrie, R. A. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1407-1 · Cited by 50
Adult NSC diversity and plasticity: the role of the niche
Llorens-Bobadilla, E., & Martín-Villalba, A. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.008 · Cited by 45
HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells
Zweifel, S., Marcy, G., Giudice, Q. L., Li, D., Heinrich, C., Azim, K., & Raineteau, O. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.08.006 · Cited by 43
“This heterogeneity originates from early embryonic development (Fuentealba et al., 2015), and is intrinsically encoded by expression of selected transcription factors (TFs).”
BackgroundDelgado, R. N., & Lim, D. A. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.09.008 · Cited by 40
“After performing clonal analysis, they found that most individual V–SVZ NSCs generate either PGCs or GCs, but not both (Fuentealba et al., 2015).”
InfluentialUnique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells
Cebrián‐Silla, A., Alfaro‐Cervelló, C., Herranz‐Pérez, V., Kaneko, N., Park, D. H., Sawamoto, K., Álvarez-Buylla, A., Lim, D. A., & García‐Verdugo, J. M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.024 · Cited by 41
“5), remaining relatively quiescent until reactivated postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundInfluentialFalk, S., Bugeon, S., Ninkovic, J., Pilz, G.-A., Postiglione, M. P., Cremer, H., Knoblich, J. A., & Götz, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.009 · Cited by 39
“Remarkably, at least some of the aNSCs are derived from slowly dividing progenitor cells during embryonic development (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundInfluentialWu, X., Shen, Q., Zhang, Z., Zhang, D., Gu, Y., & Xing, D. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02399-2 · Cited by 42
“are mainly identified in two major regions: the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricle [1, 2].”
BackgroundGulaia, V. S., Kumeiko, V. V., Shved, N. A., Cicinskas, E., Александрович, Р. С., Ruzov, A. S., & Kagansky, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00388 · Cited by 39
“Adult neural stem cells (NSCs) represent a good model for quiescence investigation as almost all NSCs in the brain are quiescent (Fuentealba et al., 2015; Furutachi et al., 2015), so these cells are being extensively studied for deciphering the molecular mechanisms of dormant state.”
BackgroundBelmonte‐Mateos, C., & Pujades, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.781160 · Cited by 44
Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy
Wang, S., He, Q., Qu, Y., Yin, W., Zhao, R., Wang, X., Yang, Y., & Guo, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391313 · Cited by 41
“In newborns, a subgroup of RG cells act as NSCs, remaining mostly quiescent until activation after birth (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundZic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice andC. elegans
Tiveron, M.-C., Béclin, C., Murgan, S., Wild, S., Angelova, A., Marc, J., Coré, N., de Chevigny, A., Herrera, E., Bosio, A., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3888-16.2017 · Cited by 39
“This regionalization is already established during early time points of forebrain development (Fuentealba et al., 2015), when subsets of stem cells appear to be set aside in the cortex, striatum and septum.”
BackgroundInfluentialHuang, W., Bai, X., Stopper, L., Cătălin, B., Cartarozzi, L. P., Scheller, A., & Kirchhoff, F. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.06.015 · Cited by 38
Marco, B. D., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., de Almodóvar, C. R., Huang, E. J., & Alfonso, J. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108256 · Cited by 39
scClustViz – Single-cell RNAseq cluster assessment and visualization
Innes, B. T., & Bader, G. D. (2018) · F1000Research · doi:10.12688/f1000research.16198.2 · Cited by 47
“5 (Fuentealba et al ., 2015).”
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
Marinopoulou, E., Biga, V., Sabherwal, N., Miller, A., Desai, J., Adamson, A. D., & Papalopulu, N. (2021) · iScience · doi:10.1016/j.isci.2021.103198 · Cited by 33
“In particular, it was shown that a subpopulation of embryonic neural progenitors is ‘set aside’ during early embryonic development and remains in a quiescent state that later contributes to the adult NSC pool (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundNovel Perspectives on the Development of the Amygdala in Rodents
Aerts, T., & Seuntjens, E. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.786679 · Cited by 36
Sultan, K. T., Han, Z., Zhang, X., Xianyu, A., Li, Z., Huang, K., & Shi, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.033 · Cited by 40
Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo
Figueres‐Oñate, M., Sánchez-Villalón, M., Sánchez‐González, R., & López‐Mascaraque, L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.010 · Cited by 37
“, 2014), although clone size varies among clonal analyses (Calzolari et al., 2015; Fuentealba et al., 2015).”
BackgroundNew Neurons in the Post-ischemic and Injured Brain: Migrating or Resident?
Nemirovich-Danchenko, N. M., & Khodanovich, M. Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00588 · Cited by 38
Donega, V., van der Geest, A. T., Sluijs, J. A., van Dijk, R. E., Wang, C. C., Başak, O., Pasterkamp, R. J., & Hol, E. M. (2022) · Nature Communications · doi:10.1038/s41467-022-28626-9 · Cited by 36
scClustViz – Single-cell RNAseq cluster assessment and visualization
Innes, B. T., & Bader, G. D. (2018) · F1000Research · doi:10.12688/f1000research.16198.1 · Cited by 36
Role of Astrocytes in the Neurogenic Niches
Schneider, J., Karpf, J., & Beckervordersandforth, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_2 · Cited by 36
Adult hypothalamic neurogenesis and sleep–wake dysfunction in aging
Kostin, A., Alam, A., McGinty, D., & Alam, M. N. (2020) · SLEEP · doi:10.1093/sleep/zsaa173 · Cited by 33
Kremer, L. P. M., Cerrizuela, S., Dehler, S., Stiehl, T., Weinmann, J., Abendroth, H., Kleber, S., Laure, A., Andari, J. E., Anders, S., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.07.001 · Cited by 34
Mosaic Subventricular Origins of Forebrain Oligodendrogenesis
Azim, K., Berninger, B., & Raineteau, O. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00107 · Cited by 33
“5 (Fuentealba et al., 2015).”
BackgroundShimada, I. S., Somatilaka, B. N., Hwang, S., Anderson, A. G., Shelton, J. M., Rajaram, V., Konopka, G., & Mukhopadhyay, S. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.03.011 · Cited by 36
GemC1 is a critical switch for neural stem cell generation in the postnatal brain
Lalioti, M., Kaplani, K., Lokka, G., Georgomanolis, T., Kyrousi, C., Dong, W., Dunbar, A., Parlapani, E., Damianidou, E., Spassky, N., et al. (2019) · Glia · doi:10.1002/glia.23690 · Cited by 32
“Lineage tracing experiments have shown that the majority of adult NSCs' precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundInfluentialMaintenance of neural stem cell positional identity by mixed-lineage leukemia 1
Delgado, R. N., Mansky, B., Ahanger, S. H., Lu, C., Andersen, R., Dou, Y., Álvarez-Buylla, A., & Lim, D. A. (2020) · Science · doi:10.1126/science.aba5960 · Cited by 32
Molecular Mechanisms of Neurogenic Aging in the Adult Mouse Subventricular Zone
Lupo, G., Gioia, R., Nisi, P. S., Biagioni, S., & Cacci, E. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519829040 · Cited by 35
DNA barcodes evolve for high-resolution cell lineage tracing
Masuyama, N., Mori, H., & Yachie, N. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.05.014 · Cited by 31
Notch Signaling and Embryonic Development: An Ancient Friend, Revisited
Reichrath, J., & Reichrath, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34436-8_2 · Cited by 34
Wu, K.-Y., Tang, F., Lee, D., Zhao, Y., Song, H., Zhu, X., Mei, L., & Xiong, W. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1520-19.2020 · Cited by 33
“NeuroD6-Cre (also called Nex-Cre) mice were kindly provided by Klaus-Armin Nave (Goebbels et al., 2006).”
MethodCalvo‐Ochoa, E., Byrd-Jacobs, C. A., & Fuss, S. H. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03334-2 · Cited by 35
Micali, N., Kim, S.-K., Diaz-Bustamante, M., Stein-O’Brien, G., Seo, S., Shin, J.-H., Rash, B. G., Ma, S., Wang, Y., Olivares, N. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107599 · Cited by 31
“It has been shown in the mouse that olfactory bulb (OB) interneurons generated postnatally share common embryonic progenitors with cortical projection neurons in vivo (Fuentealba et al., 2015) and in vitro (Cai et al., 2013).”
Borrett, M. J., Innes, B. T., Tahmasian, N., Bader, G. D., Kaplan, D. R., & Miller, F. D. (2022) · eNeuro · doi:10.1523/eneuro.0271-21.2021 · Cited by 31
“…NSCs originate from a subset of RPs that are set aside during mid-to-late embryogenesis (Fuentealba, et al., 2015; Furutachi et al., 2015), coincident with acquisition of a slowly-proliferating/quiescent-like cell cycle state (Fuentealba et al., 2015; Furutachi et al., 2015; Yuzwa et al., 2017).”
BackgroundInfluentialEncoding and decoding time in neural development
Toma, K., Wang, T., & Hanashima, C. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12257 · Cited by 30
“However, there is a minor population of neural stem cells that maintains neurogenic potential until the postnatal stage, during which they contribute to postnatal neurogenesis (Fuentealba et al. 2015; Furutachi et al. 2015).”
BackgroundEpigenetic cues modulating the generation of cell‐type diversity in the cerebral cortex
Amberg, N., Laukoter, S., & Hippenmeyer, S. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14601 · Cited by 29
L‐type voltage‐gated calcium channels in stem cells and tissue engineering
Tan, Y., Fei, D., He, X., Dai, J., Xu, R., Xu, X., Wu, J., & Li, B. (2019) · Cell Proliferation · doi:10.1111/cpr.12623 · Cited by 29
Mechanisms of Cortical Differentiation
Adnani, L., Han, S., Li, S., Mattar, P. A., & Schuurmans, C. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.005 · Cited by 33
Recent advances in tissue stem cells
Fu, X., He, Q., Tao, Y., Wang, M., Wang, W., Wang, Y., Yu, Q. C., Zhang, F., Zhang, X., Chen, Y., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2007-8 · Cited by 30
“Lineage tracing studies have shown that adult V-SVZ NSCs are derived from Vcam1 RGPs during embryonic neurogenesis (Fuentealba et al., 2015; Furutachi et al., 2015; Hu et al., 2017).”
BackgroundSinnaeve, J., Mobley, B. C., & Ihrie, R. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.029 · Cited by 28
Reawakening the sleeping beauty in the adult brain: neurogenesis from parenchymal glia
Péron, S., & Berninger, B. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.07.004 · Cited by 28
Qin, S., Ware, S. M., Waclaw, R. R., & Campbell, K. (2017) · Neural Development · doi:10.1186/s13064-017-0090-5 · Cited by 28
“Unlike the locally born projection neurons [11, 12, 13], OB interneurons are generated caudal to the bulb within the ventral telencephalon, largely the lateral ganglionic eminence (LGE) and septum, from embryonic day 12 (E12) until birth and subsequently from the postnatal and adult SVZ, which represents the derivativ…”
InfluentialEndogenous neural precursor cells in health and disease
Bacigaluppi, M., Sferruzza, G., Butti, E., Ottoboni, L., & Martino, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146619 · Cited by 29
García-González, D., Dumitru, I., Zuccotti, A., Yen, T.-Y., Herranz-Pérez, V., Tan, L. L., Neitz, A., García-Verdugo, J., Kuner, R., Alfonso, J., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0823-4 · Cited by 24
Lineage-resolved atlas of the developing human cortex
Keefe, M. G., Steyert, M. R., & Nowakowski, T. J. (2025) · Nature · doi:10.1038/s41586-025-09033-8 · Cited by 30
Dray, N., Than‐Trong, E., & Bally‐Cuif, L. (2020) · BioEssays · doi:10.1002/bies.202000228 · Cited by 26
Neural Stem Cells in the Adult Olfactory Bulb Core Generate Mature Neurons in Vivo
Defteralı, Ç., Moreno‐Estellés, M., Crespo, C., Díaz‐Guerra, E., Díaz‐Moreno, M., Vergaño‐Vera, E., Nieto‐Estévez, V., Hurtado‐Chong, A., Consiglio, A., Mira, H., et al. (2021) · Stem Cells · doi:10.1002/stem.3393 · Cited by 30
“There are at least 10 subtypes of interneurons generated from SVZ NSCs, as detected using a combination of cell markers and morphological analyses.(9,10,69,75,76) Using a cell marker approach, we detected”
MethodVisualization of individual cell division history in complex tissues using iCOUNT
Denoth‐Lippuner, A., Jaeger, B. N., Liang, T., Royall, L. N., Chie, S. E., Buthey, K., Machado, D., Korobeynyk, V. I., Kruse, M., Munz, C. M., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.08.012 · Cited by 32
“Recently, substantial progress has been made to derive full lineage tree information from individual cells using barcoding techniques (Baron and van Oudenaarden, 2019; Fuentealba et al., 2015; Gao et al., 2014; Kalhor et al., 2018; Mayer et al., 2015; McKenna et al., 2016).”
Vancamp, P., Blay, K. L., Butruille, L., Sébillot, A., Boelen, A., DEMENEIX, B. A., & Remaud, S. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.01.002 · Cited by 28
“SVZNSCs originate from radial glia of the embryonic ventricular zone (VZ)-SVZ (Fuentealba et al., 2015; Merkle et al., 2004).”
BackgroundWhat Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?
Bond, A. M., Ming, G., & Song, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.891713 · Cited by 28
Doeppner, T. R., Herz, J., Bähr, M., Tonchev, A. B., & Stoykova, A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1104-y · Cited by 24
Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
Coller, H. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190014 · Cited by 33
Insights into the Biology and Therapeutic Applications of Neural Stem Cells
Harris, L., Zalucki, O. H., Piper, M., & Heng, J. I. (2016) · Stem Cells International · doi:10.1155/2016/9745315 · Cited by 26
“While this hypothesis would predict that B1 cells are specified during the early postnatal period when aRG cells become depleted, both Fuentealba and colleagues [126] and Furutachi and colleagues [31] used label-retention assays, such as thymidine analog injections, to demonstrate that the majority of B1 cells became…”
Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells
Van, A. L., Hachem, M., Lagarde, M., & Bernoud‐Hubac, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174240 · Cited by 25
Rhee, Y., Yi, S., Kim, J. Y., Chang, M., Jo, A.-Y., Kim, J., Park, C., Cho, J., Choi, Y., Sun, W., et al. (2016) · Scientific Reports · doi:10.1038/srep32025 · Cited by 26
Cataldi, S., Arcuri, C., Hunot, S., Mecca, C., Codini, M., Laurenti, M. E., Ferri, I., Loreti, E., Garcia‐Gil, M., Traina, G., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00031 · Cited by 26
“Adult neurogenesis has many common characteristics with embryonal neurogenesis and parallelisms are possible (Kriegstein and Alvarez-Buylla, 2009; Fuentealba et al., 2015).”
BackgroundDorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57KIP2/Dacapo
Otsuki, L., & Brand, A. H. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.02.015 · Cited by 26
“Once activated, quiescent NSCs in the brain generate different types of progeny in a region-specific manner (Fuentealba et al., 2015).”
BackgroundInfluentialFabra-Beser, J., de Araújo, J. A. M., Coelho, D. M., Goff, L. A., Costa, M. R., Müller, U., & Gil, C. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2905-20.2021 · Cited by 24
“The extent in which different subpopulations of RGCs contribute directly to the generation of cellular diversity in the neocortex is a controversial topic (Franco et al., 2012; Fuentealba et al., 2015; García-Moreno and Molnár, 2015; Gil-Sanz et al., 2015).”
BackgroundA novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis
Baur, K., Abdullah, Y., Mandl, C., Hölzl‐Wenig, G., Shi, Y., Schmidt-Edelkraut, U., Khatri, P. R., Hagenston, A. M., Irmler, M., Beckers, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154078 · Cited by 22
“It is known that quiescent adult NSCs include slow-cycling radial glia progenitors which enter quiescence at mid-development (Fuentealba et al , 2015; Furu-tachi et al , 2015; Hu et al , 2017; Yuzwa et al , 2017).”
Regulation of microglia function by neural stem cells
de Almeida, M. M. A., Goodkey, K., & Voronova, A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1130205 · Cited by 26
“Finally, some embryonic NPCs divide more slowly and contribute to the establishment of the adult neurogenic niches (Fuentealba et al., 2015; Furutachi et al., 2015; Yuzwa et al., 2017).”
BackgroundMarcy, G., Foucault, L., Babina, E., Capeliez, T., Texeraud, E., Zweifel, S., Heinrich, C., Hernández‐Vargas, H., Parras, C. M., Jabaudon, D., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7553 · Cited by 25
Neural Progenitor Cells and the Hypothalamus
Makrygianni, E. A., & Chrousos, G. P. (2023) · Cells · doi:10.3390/cells12141822 · Cited by 30
“B cells remain mostly quiescent; however, quiescent and actively selfrenewing B cells are essentially present simultaneously in the SVZ [1,42,43].”
BackgroundLive Imaging of Adult Neural Stem Cells in Rodents
Ortega, F., & Costa, M. R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00078 · Cited by 23
Luca, C. D., Virtuoso, A., Papa, M., Certo, F., Barbagallo, G. M. V., & Altieri, R. (2022) · Cells · doi:10.3390/cells11081349 · Cited by 27
“These relatively quiescent NSC (also known as B1 cells) can be stimulated to become rapidly dividing progenitors (the so-called C cells) that could furtherly differentiate towards A cells (migrating neuronal precursors) [21,22].”
BackgroundQuaresima, S., Istiaq, A., Jono, H., Cacci, E., Ohta, K., & Lupo, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.845567 · Cited by 26
The neural stem cell secretome across neurodevelopment
Dause, T. J., Denninger, J. K., Smith, B. M., & Kirby, E. D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114142 · Cited by 26
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
Frederico, B., Martins, I., Chapela, D., Gasparrini, F., Chakravarty, P., Ackels, T., Piot, C., Almeida, B., Carvalho, J., Ciccarelli, A., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.07.012 · Cited by 22
“Adult NSCs and ependymal cells share a common lineage, both emerging from radial glia (Aimone et al., 2014; Fuentealba et al., 2015; Ortiz-A´lvarez et al., 2019).”
BackgroundMitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain
Büeler, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073342 · Cited by 26
“Nestin+/Sox2+ NPC and DCX+ neuroblasts persisted in the brain of old people, and their numbers were reduced in brains from patients with both MCI and AD when compared to age-matched controls [152].”
BackgroundInfluentialYuizumi, N., Harada, Y., Kuniya, T., Sunabori, T., Koike, M., Wakabayashi, M., Ishihama, Y., Suzuki, Y., Kawaguchi, D., & Gotoh, Y. (2021) · Stem Cells · doi:10.1002/stem.3359 · Cited by 23
“aside during development and later become adult neural stem cells (NSCs) in the mouse subventricular zone (SVZ).(5,6) This subpopulation of NPCs (designated the embryonic origin of adult NSCs) must be maintained for a longer period in order to subserve life-long neuro-”
BackgroundHuang, H., Zhao, C., Hu, Q., Liu, Q., Sun, Y.-M., Chen, C., Huang, H., Zhou, C., & Wu, Y. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02550-3 · Cited by 23
Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis
Liu, J., Wu, X., & Lü, Q. (2022) · Development · doi:10.1242/dev.199985 · Cited by 19
Zhang, C., Xue, P., Zhang, H., Tan, C., Zhao, S., Li, X., Sun, L., Zheng, H., Wang, J., Zhang, B., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1072341 · Cited by 24
“As adults, B1 cells undergo symmetric division to complete cell self-renewal or undergo asymmetric division to form intermediate progenitors (C cells), which further generate neuroblasts (A cells) (Ponti et al., 2013; Fuentealba et al., 2015; Obernier et al., 2018).”
BackgroundVerma, R., Chen, X., Xin, D. E., Luo, Z., Ogurek, S., Xin, M., Rao, R., Berry, K., & Lu, Q. R. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-1577 · Cited by 23
Neural stem cell heterogeneity in the mammalian forebrain
Adams, K. V., & Morshead, C. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.005 · Cited by 26
“These dNSCs become activated postnatally, as revealed by reduced BrdU intensity at PND45, although the findings have not been correlated with cell cycle analysis (Fuentealba et al., 2015).”
Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats
Bălşeanu, T. A., Grigore, M. M., Pinosanu, L. R., SLEVIN, M. A., Hermann, D. M., Glăvan, D., & Popa‐Wagner, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00732 · Cited by 22
MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors
Ma, H., Su, L., Xia, W., Wang, W., Tan, G., & Jiao, J. (2021) · EMBO Reports · doi:10.15252/embr.202052150 · Cited by 23
“The function of the brain is precisely regulated by many genes and epigenetic regulators (Haubensak et al, 2003; Noctor et al, 2004; Fuentealba et al, 2015).”
Reilein, A. R., Kogan, H. V., Misner, R., Park, K. S., & Kalderon, D. (2021) · eLife · doi:10.7554/elife.69749 · Cited by 20
Jeong, D., Casasbuenas, D. L., Gengatharan, A., Edwards, K. M., Saghatelyan, A., Kaplan, D. R., Miller, F. D., & Yuzwa, S. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108257 · Cited by 23
Interneuron Progenitor Transplantation to Treat CNS Dysfunction
Chohan, M. O., & Moore, H. M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00064 · Cited by 23
“With refined knowledge of neurodevelopment (Merkle and Alvarez-Buylla, 2006; Muotri and Gage, 2006; Fuentealba et al., 2015) studies carried out over the past two decades have now begun to offer mechanistic insights and renewed evidence for the therapeutic efficacy of cell transplantation in CNS…”
BackgroundDonega, V., Marcy, G., Giudice, Q. L., Zweifel, S., Angonin, D., Fiorelli, R., Abrous, D. N., Rival‐Gervier, S., Koehl, M., Jabaudon, D., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.030 · Cited by 23
“5 (Fuentealba et al., 2015; Furutachi et al., 2015).”
ResultPhysiological Interactions between Microglia and Neural Stem Cells in the Adult Subependymal Niche
Sirerol-Piquer, M. S., Belenguer, G., Morante‐Redolat, J. M., Duart-Abadía, P., Pérez‐Villalba, A., & Fariñas, I. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.009 · Cited by 23
Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
Meng, H., Yu, H., Zhang, K., Yi, X., Meng, X., Kang, E., Wu, S., Deng, W., & Wang, Y. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01206-1 · Cited by 23
“Recent studies suggested another “set-aside” model which supposes that embryonic NSCs acquire different fates at early developmental stages, with some developing into different brain regions and one sub-group remaining dormant and becoming adult NSCs in the postnatal stage [9, 10].”
BackgroundDevelopment of GABAergic Interneurons in the Human Cerebral Cortex
Marín, Ó. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70136 · Cited by 22
“Furthermore, some olfactory bulb interneurons are produced from pallial progenitors in both rodents and humans (Cai et al. 2013; Delgado et al. 2022; Fuentealba et al. 2015; Kohwi et al. 2007; Young et al. 2007) and can be potentially mis-taken for cortical interneurons without the appropriate…”
Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain
Radecki, D. Z., & Samanta, J. (2022) · Cells · doi:10.3390/cells11132101 · Cited by 21
Autophagy drives the conversion of developmental neural stem cells to the adult quiescent state
Calatayud-Baselga, I., Casares-Crespo, L., Franch-Ibáñez, C., Guijarro-Nuez, J., Sanz, P., & Mira, H. (2023) · Nature Communications · doi:10.1038/s41467-023-43222-1 · Cited by 23
Metadata
- Authors
- Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1644-1655
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4475276
- OpenAlex
- W1617074755
- Cited by
- 488
- References
- 55
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 29 · 2023: 43 · 2022: 43 · 2021: 51 · 2020: 62 · 2019: 58 · 2018: 45 · 2017: 47 · 2016: 35 · 2015: 15
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R37NS028478, NS-28478, R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural stem cells, neural progenitor cells, olfactory bulb, lateral ventricle, embryonic origin, regional specification, lineage tracing, quiescence, forebrain development, striatum, septum, cortex
- MeSH terms
- Animals, Embryo, Mammalian, Olfactory Bulb, Prosencephalon, Cell Lineage, Mice, Adult Stem Cells, Neural Stem Cells
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