The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Embryonic Origin of Postnatal Neural Stem Cells
Open accessAbstract
Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fuentealba et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Livet, J., Weissman, T. A., Kang, H., Draft, R. W., Lu, J., Bennis, R. A., Sanes, J. R., & Lichtman, J. W. (2007) · Nature · doi:10.1038/nature06293 · Cited by 1,876
The development of neural stem cells
Temple, S. (2001) · Nature · doi:10.1038/35102174 · Cited by 1,479
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,110
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 487
Adult Neurogenesis: Lessons from Crayfish and the Elephant in the Room
Beltz, B. S., Brenneis, G., & Benton, J. L. (2016) · Brain Behavior and Evolution · doi:10.1159/000447084 · Cited by 7
“…of NSCs in the subgranular and subventricular zones generating hippocampal and olfactory bulb neurons, respectively, suggest that these cells are relatively short-lived once activated, and undergo a limited number of divisions [Encinas et al., 2011; Calzolari et al., 2015; Fuentealba et al., 2015].”
BackgroundMetabolic Regulation and Related Molecular Mechanisms in Various Stem Cell Functions
Lee, H., & Hong, I. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200512105347 · Cited by 7
Paniagua‐Herranz, L., Menéndez‐Méndez, A., Gómez‐Villafuertes, R., Olivos-Oré, L. A., Fernández, J. M. B., Gualix, J., Pérez‐Sen, R., Delicado, E. G., Artalejo, A. R., Miras‐Portugal, M. T., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.007 · Cited by 7
“Altogether, these evidences suggest that at least part of the cerebellar NSC population may become quiescent, re-entering the cell cyclewhen required in adulthood, mimicking stem cells in the embryonic SVZ (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundFinding the Roots of Adult Neurogenesis
Kheirbek, M. A. (2015) · Cell · doi:10.1016/j.cell.2015.06.010 · Cited by 7
A developmental atlas of the mouse brain by single-cell mass cytometryPreprint
Deusen, A. L. V., Goggin, S. M., Williams, C. M., Keeler, A. B., Fread, K., Cheng, I., Deppmann, C. D., & Zunder, E. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.27.501794 · Cited by 7
Integrative single-cell transcriptomics clarifies adult neurogenesis and macroglia evolutionPreprint
Morizet, D., Foucher, I., Alunni, A., & Bally‐Cuif, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.27.530203 · Cited by 7
Embracing the heterogeneity of neural stem cells in the subventricular zone
Apostolou, S., & Donega, V. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102452 · Cited by 6
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration
Kanzawa, T., Nakajima, C., Sawada, M., & Sawamoto, K. (2025) · BioEssays · doi:10.1002/bies.70050 · Cited by 6
In vivo live imaging of postnatal neural stem cells
Marymonchyk, A., Malvaut, S., & Saghatelyan, A. (2021) · Development · doi:10.1242/dev.199778 · Cited by 7
Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ
Baur, K., García, C. C., Şan, Ş., von Hahn, M., Strelau, J., Hölzl‐Wenig, G., Mandl, C., & Ciccolini, F. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.01.008 · Cited by 6
Gomez, H. G., Castillo, J. G., Noguchi, H., Aguilar, D., Pleasure, S. J., & Yabut, O. (2019) · Biology Open · doi:10.1242/bio.039248 · Cited by 6
“5 neocortex, a time at which Type B1 cells are thought to be specified (Fuentealba et al., 2015; Furutachi et al., 2015), failed to generate Type B1 cells in the neonatal V-SVZ.”
Marcy, G., & Raineteau, O. (2019) · Stem Cells · doi:10.1002/stem.3071 · Cited by 7
Repurposing developmental mechanisms in the adult nervous system
Hunyara, J. L., & Kolodkin, A. L. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.04.006 · Cited by 6
Temporal-spatial Generation of Astrocytes in the Developing Diencephalon
Hong, W., Gong, P., Pan, X., Ren, Z., Liu, Y., Qi, G., Li, J.-L., Sun, W., Ge, W., Zhang, C., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01131-9 · Cited by 6
“5 by IUE remain largely quiescent 3 weeks after birth, similar to the adult progenitor B1 cells within the LV walls [41].”
Adult Neural Stem Cells: Constant Extension from Embryonic Ancestors
Cai, Y., & Yang, Z. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00396-3 · Cited by 6
“5), and are set aside for postnatal neurogenesis after diverging [2, 3].”
BackgroundGLI3 Is Required for OLIG2+ Progeny Production in Adult Dorsal Neural Stem Cells
Embalabala, R., Brockman, A. A., Jurewicz, A., Kong, J. A., Ryan, K. E., Guinto, C. D., Álvarez-Buylla, A., Chiang, C. C., & Ihrie, R. A. (2022) · Cells · doi:10.3390/cells11020218 · Cited by 6
The state of the art in stem cell biology and regenerative medicine: the end of the beginning
Snyder, E. Y. (2017) · Pediatric Research · doi:10.1038/pr.2017.258 · Cited by 6
Ratz, M., von Berlin, L., Larsson, L., Martin, M., Westholm, J. O., Manno, G. L., Lundeberg, J., & Frisén, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.31.458418 · Cited by 6
Verkerke, M., Werkman, M. H., & Donega, V. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102533 · Cited by 5
Pastor-Alonso, O., Zahra, A. S., Kaske, B., García‐Moreno, F., Tetzlaff, F., Bockelmann, E., Grunwald, V., Martín‐Suárez, S., Riecken, K., Witte, O. W., et al. (2023) · The EMBO Journal · doi:10.1038/s44318-023-00011-2 · Cited by 9
“model proposed for V-SVZ NSCs (Fuentealba et al., 2015; Furutachi et al., 2015), yet on a different time scale.”
BackgroundWang, H., Zhou, C., Hou, M., Huang, H., & Sun, Y. W. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.677935 · Cited by 5
Fauser, M., Loewenbrück, K. F., Rangnick, J., Brandt, M., Hermann, A., & Storch, A. (2021) · Cells · doi:10.3390/cells10113021 · Cited by 6
Evolution of Neurosensory Cells and Systems
Fritzsch, B., & Elliott, K. L. (2022) · CRC Press eBooks · doi:10.1201/9781003092810 · Cited by 5
Adult neurogenesis research in China
Luo, X., Xu, M., & Guo, W. (2023) · Development Growth & Differentiation · doi:10.1111/dgd.12900 · Cited by 5
“It is widely recognized that both adult NSCs and embryonic NSCs originate from shared progenitor cells (Berg et al., 2019; Fuentealba et al., 2015; Furutachi et al., 2015; Luo et al., 2023).”
BackgroundHashimoto, Y., Gotoh, H., Ono, K., & Nomura, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-40599-2 · Cited by 5
Kriegstein, A. R., Subramanian, L., Obernier, K., & Álvarez-Buylla, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00031-x · Cited by 5
Expression of NFIA and NFIB within the murine spinal cord
Matuzelski, E., Harvey, T. J., Harkins, D., Nguyen, T. D., Ruitenberg, M. J., & Piper, M. (2020) · Gene Expression Patterns · doi:10.1016/j.gep.2020.119098 · Cited by 5
Transcription Factors of Direct Neuronal Reprogramming in Ontogenesis and Ex Vivo
Samoilova, E. M., Викторович, Б. В., & Baklaushev, V. P. (2021) · Molecular Biology · doi:10.1134/s0026893321040087 · Cited by 5
Ependymal and neural stem cells are close relatives
Lokka, G., Chantzara, A., Lygerou, Z., & Taraviras, S. L. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102574 · Cited by 4
Zheng, J., Chen, Y., Hu, Y., Zhu, Y., Lin, J., Xu, M., Zhang, Y., Song, W., & Chen, X. X. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003318 · Cited by 4
“Recent studies with advanced lineage-tracing methods have provided valuable insights on the clonal relationships among cells in the VZ during the development [6,14,28,29].”
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Shen, D., Wang, X., Liu, R.-H., Deng, H., Tong, S., Chen, J.-Y., Zhai, Z.-Y., Li, Y.-X., Lin, Y., Yang, F., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00624-9 · Cited by 4
“…1995; Price, 1987; Szele and Cepko, 1996), genetic multicolor labeling (Livet et al, 2007; Snippert et al, 2010), DNA barcode-based lineage tracing (Fuentealba et al, 2015; Golden et al, 1995; Harwell et al, 2015; Kirkwood et al, 1992; Lu et al, 2011; Mayer et al, 2015; Sultan et al, 2016; Walsh…”
Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms
Li, J., Godoy, M. I., Lu, Y., Zhang, A. J., Diamante, G., Rathbun, E. M., Tian, M., Ahn, I. S., Cebrián‐Silla, A., Álvarez-Buylla, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60895-y · Cited by 4
“The subpopulation of radial glia set aside to become adult type B cells divide slowly whereas other embryonic radial glia divide rapidly 6,7 .”
Morrison, B. E., Rahman, A. A., Lai, N., Albright, J., Urquhart, P., & Webb, A. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.219050 · Cited by 4
Транскрипционные факторы прямого пронейронального репрограммирования в онтогенезе и ex vivo
Samoilova, E. M., Викторович, Б. В., & Baklaushev, V. P. (2021) · Molecular Biology · doi:10.31857/s0026898421050086 · Cited by 4
Bagnoli, S., Chiavacci, E., Cellerino, A., & Tozzini, E. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043650 · Cited by 4
Pecoraro, S., Verkerke, M., Sluijs, J. A., Hof, B. V. H., van der Pol, S. M. A., van Strien, M. E., van der Kant, R., de Vries, C. J. M., de Vries, H. E., van de Berg, W. D. J., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.06.017 · Cited by 4
Aging of the ventricular-subventricular zone neural stem cell niche
Merson, T. D. (2020) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2020.07.001 · Cited by 4
Saldivia, N., Salazar, K., Cifuentes, M., Espinoza, F., Harrison, F. E., & Nualart, F. (2024) · Glia · doi:10.1002/glia.24498 · Cited by 4
“5 and remain quiescent until reactivation at the adult stage (Fuentealba et al., 2015).”
BackgroundCasasbuenas, D. L., Kortebi, I., Gora, C., Scott, E., Gomes, C., Oliveira, M. S., Sharma, T., Daniele, E., Olfat, A., Gibbs, R., et al. (2024) · Glia · doi:10.1002/glia.24578 · Cited by 5
The impact of different modes of neuronal migration on brain evolution
García‐Moreno, F., & Molnár, Z. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00025-0 · Cited by 4
Illumination of neural development by in vivo clonal analysis
Xu, M., Wang, J., Guo, X., Li, T., Kuang, X., & Wu, Q. (2018) · Cell Regeneration · doi:10.1016/j.cr.2018.09.001 · Cited by 4
Li, J., Godoy, M. I., Zhang, A. J., Diamante, G., Ahn, I. S., Cebrián‐Silla, A., Álvarez-Buylla, A., Yang, X., Novitch, B. G., & Zhang, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.14.528567 · Cited by 4
A specific olfactory bulb interneuron subtype Tpbg/5T4 generated at embryonic and neonatal stages
Tsuboi, A. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1427378 · Cited by 3
“…in superficial GCs nearby the MC layer (G IIIM ) based on their location and dendritic morphology (Imamura et al., 2006; Yoshihara et al., 2012; Fuentealba et al., 2015), while CalR GCs are in the other superficial GCs (G III ) with a different cell lineage from Tpbg/5T4 (Merkle et al., 2014;…”
BackgroundInfluentialGenerating neurons in the embryonic and adult brain: compared principles and mechanisms
Chouly, M., & Bally‐Cuif, L. (2024) · Comptes Rendus Biologies · doi:10.5802/crbiol.167 · Cited by 4
Regulation of neural stem cells by innervating neurons
Dittmann, N. L., Chen, L., & Voronova, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16287 · Cited by 3
“The lateral SVZ in the adult mammalian brain originates from the embryonic lateral gan - glionic eminence (LGE), defined by γ - glutamylcysteine synthetase 2-positive (Gsh2) + cells (Young et al., 2007 ), whereas the septal SVZ NPCs originates from septal progenitors, which express zinc finger protein ZIC1 (Fuentealba…”
InfluentialApplications and Possible Mechanisms of ULK4 in Brain: Implications for Neuropsychiatric Disorders
Luo, W., Wang, J., & Chen, J. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin31350 · Cited by 3
Nato, G., Fogli, M., Marichal, N., Cerrato, V., Turrini, G., Proserpio, V., Ghia, I., Zanotto, G., Molineris, I., Bergami, M., et al. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.103015 · Cited by 4
Effects of thyroid disruption on neural cells stem fate in the mouse brain
Valcárcel-Hernández, V., Butruille, L., & Remaud, S. (2025) · La Presse Médicale · doi:10.1016/j.lpm.2025.104312 · Cited by 3
Gupta, R., Abdulazeez, A. M., Kedhim, M., Alkhathami, A. G., Malathi, H., Kundlas, M., Maharana, L., Chauhan, A. S., Alnajar, M. J., & Hammoodi, H. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05430-2 · Cited by 5
“In the postnatal and adult brain, a subgroup of slowly dividing NSCs is designated as the NSCs and neuroepithelial cells of the SVZ throughout development [84].”
Roadmap toward subtype-specific vulnerabilities in adult glioma
Feng, J. H., Zhang, Y., Li, J., & Fan, X. (2022) · Holistic Integrative Oncology · doi:10.1007/s44178-022-00022-9 · Cited by 3
Heterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone
Rushing, G. V., Bollig, M. K., & Ihrie, R. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-24108-7_1 · Cited by 4
Saito, T. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34436-8_6 · Cited by 3
Mechanisms of neurogenesis and angiogenesis in ischaemic stroke: literature review
Koroleva, E. S., & Alifirova, V. M. (2021) · Annals of Clinical and Experimental Neurology · doi:10.54101/acen.2021.3.7 · Cited by 4
Fate Through Fat: Neutral Lipids as Regulators of Neural Stem Cells
Hamilton, L. K., & Fernandes, K. J. L. (2017) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-49343-5_5 · Cited by 3
Neuronal migration in the postnatal brain
Sawada, M., & Sawamoto, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00021-3 · Cited by 4
Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage
Tanaka, A., Ishida, S., Fuchigami, T., Hayashi, Y., Kuroda, A., Ikenaka, K., Fukazawa, Y., & Hitoshi, S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa200 · Cited by 3
Deciphering Adult Neural Stem Cells with Single-Cell Sequencing
Liu, Y., Zhu, Y., Shi, Y., Liu, X., Su, W., & Zhuo, Y. (2023) · Stem Cells and Development · doi:10.1089/scd.2022.0234 · Cited by 3
Marcy, G., Foucault, L., Babina, E., Texeraud, E., Zweifel, S., Heinrich, C., Hernández‐Vargas, H., Parras, C. M., Jabaudon, D., & Raineteau, O. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.20.492790 · Cited by 3
Solana-Orts, A., Belenguer, G., Ballester‐Lurbe, B., Gómez, O., Pérez‐Roger, I., Terrado, J., Poch, E., & Bizy, A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1612177 · Cited by 2
Chen, Z., Cai, M., Wang, Y., Li, X., He, Y., Pu, H., Huang, J., Ye, L., Yang, R., Jing, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65705-z · Cited by 5
Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer
Tanaka, Y., Sakahara, M., Yamanaka, H., Natsume, Y., Kusama, D., Kumegawa, K., Yoshikawa, H., Abe, Y., Okabayashi, K., Matui, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67979-9 · Cited by 3
“Protein synthesis is the most energy-consuming process in cells, and its low rate is the key to effectively maintain the stem cell pool 68 – 70 .”
Yammine, S. Z., Burns, I., Gosio, J., Peluso, A., Merritt, D. M., Innes, B. T., Coles, B. L. K., Yan, W. R., Bader, G. D., Morshead, C. M., et al. (2023) · Stem Cells and Development · doi:10.1089/scd.2023.0038 · Cited by 3
“Regionalization of neuronal-subtype specification has been reported for GFAP -expressing dNSCs [45–47].”
Arx revisited: involved in the development of GABAergic interneurons
Tsuboi, A., & Yoshihara, S.-I. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1563515 · Cited by 4
Every cell every gene all at once: Systems genetic approaches toward corticogenesis
Wu, B., Li, J., & Jin, X. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103034 · Cited by 2
Harland, A. J., & Perks, C. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104749 · Cited by 2
Zaritsky, R., Kumari, E., Velloso, F. J., Lemenze, A. D., Husain, S., & Levison, S. W. (2025) · Biomolecules · doi:10.3390/biom15101438 · Cited by 2
“NSCs arise in the SVZ during mid-embryonic development [6] and divide asymmetrically [7] to produce intermediate progenitors (Transit Amplifying Progenitors; TAPs) [8], originally called “Type C cells”, which then become lineage-restricted to form terminally differentiated cells [8].”
Mouton, L., Ribeiro, M., Mouthon, M., Boumezbeur, F., Bihan, D. L., Ricard, D., Boussin, F. D., & Verrelle, P. (2020) · Neuromethods · doi:10.1007/978-1-0716-0856-2_11 · Cited by 2
Synaptogenesis in the adult CNS—olfactory system
Mizrahi, A., & Vinograd, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00011-9 · Cited by 2
Influence des morphogènes sur la régionalisation de la zone sous-ventriculaire postnatale
Angonin, D., Marcy, G., & Raineteau, O. (2015) · médecine/sciences · doi:10.1051/medsci/20153111010 · Cited by 2
Regeneration in the Olfactory Bulb
Malvaut, S., & Saghatelyan, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.23883-2 · Cited by 2
Lysophospholipid Signalling and the Tumour Microenvironment
Ng, W., & Morokoff, A. P. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-47189-7_8 · Cited by 2
Insights into the mechanism of adult neurogenesis - an interview with Arturo Álvarez-Buylla
Escalante‐Alcalde, D., & Chimal‐Monroy, J. (2020) · The International Journal of Developmental Biology · doi:10.1387/ijdb.200297de · Cited by 2
Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis
von Berlin, L., Westholm, J. O., Ratz, M., & Frisén, J. (2022) · Hippocampus · doi:10.1002/hipo.23482 · Cited by 2
“This is opposed to the previously suggested “sequential” model where unknown progenitor cells produce cell types of different lineages in a stepwise manner (Kriegstein & Alvarez-Buylla, 2009) and to the “set aside” model where a part of the embryonic progenitor cells is set aside for later adult neurogenesis (Fuenteal…”
BackgroundResultSato, T., Okumura, M., Takahashi, J., Kokubu, T., Tanabe, M., Onda, A., Komatsu, T., Sakuta, K., Sakai, K., Umehara, T., et al. (2023) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2023.102603 · Cited by 2
Azim, K., Calzolari, F., Cantone, M., Akkermann, R., Vera, J., Hartung, H., Başak, O., Butt, A. M., & Küry, P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.18.423285 · Cited by 2
Dehler, S., Kremer, L. P. M., Cerrizuela, S., Stiehl, T., Weinmann, J., Abendroth, H., Kleber, S., Laure, A., Andari, J. E., Anders, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.05.434064 · Cited by 2
Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell QuiescencePreprint
Geben, L. C., Brockman, A. A., Chalkley, M. L., Sweet, S. R., Gallagher, J. E., Scheuing, A. L., Simerly, R. B., Ess, K. C., Irish, J. M., & Ihrie, R. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.14.528513 · Cited by 2
Proneural genes form a combinatorial code to diversify neocortical neural progenitor cellsPreprint
Moffat, A., Oproescu, A.-M., Okawa, S., Han, S., Vasan, L., Ghazale, H., Dennis, D. J., Zinyk, D. L., Guillemot, F., del Sol, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.29.551096 · Cited by 2
“Additional supporting evidence includes the demonstration that adult neural stem cells (NSCs) are derived from a small pool of embryonic aRG that are set aside in dormancy in the early embryo (Fuentealba et al. 2015; Furutachi et al. 2015).”
BackgroundNeurogenesis in the postnatal V-SVZ and the origin of interneuron diversity
Álvarez-Buylla, A., Merkle, F. T., Fuentealba, L. C., & Cebrián‐Silla, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00022-9 · Cited by 1
Olfactory system embryonic development
Figueres‐Oñate, M., & López‐Mascaraque, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23739-3.00016-x · Cited by 1
Human endothelial cells promote a human neural stem cell type B phenotype via Notch signaling
Gutierrez, B., Liu, T. C., Rodriguez, C., Pastor-Alonso, O., Lambing, H., Paredes, M. F., & Flanagan, L. A. (2025) · Nature Communications · doi:10.1038/s41467-025-60194-6 · Cited by 3
“Of note, studies in rodents indicate that adult type B cells are generated prenatally, and the hNSPCs in our in vitro studies were derived from prenatal stages 86 .”
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
Morizet, D., & Bally‐Cuif, L. (2025) · BioEssays · doi:10.1002/bies.70041 · Cited by 3
“5 [60, 61], although quiescence acquisition seems to be postnatal in the dorsal wall of the ventricle [62].”
Simão, A. L., Santos, S. S., Moreira, J. A. F., Silva, F. J. D. C., Oliveira, R., Roxo, C., Santos, M., Vaz, A. R., Brites, D. M. T. O., Silva, M. F. B., et al. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167997 · Cited by 1
Gao, J., Tian, Q., LI, S.-H., Zheng, L., & Zhou, Y. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70303 · Cited by 1
“Maternal HFD during pregnancy and lactation may disrupt stem cell fate regulation by altering the intrauterine environment at critical stages of development [8, 9].”
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids
Vassalou, S., Lalioti, M., Giaimo, R. D., Taraviras, S. L., Cappello, S., & Kyrousi, C. (2025) · EMBO Reports · doi:10.1038/s44319-025-00621-3 · Cited by 1
“In mice, it has been shown that ECs and aNSCs are generated through a common glial lineage (Fuentealba et al, 2015; Merkle et al, 2004; Spassky et al, 2005).”
Riya, P. A., Jose, R., Meera, V., Basu, B., Suresh, S., Aryasree, R., Jyothi, N. P., Parvathy, S., Dhanesh, S. B., Sanalkumar, R., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2511800123 · Cited by 1
“5 to 15.5 (67, 68).”
InfluentialBeyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma
Fogli, M., Nato, G., Peretto, P. M., Buffo, A., & Luzzati, F. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1737065 · Cited by 2
Lao, Z.-K., & Xu, N. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00546-4 · Cited by 1
Varela-Martínez, I., Pipicelli, F., & Hippenmeyer, S. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102487 · Cited by 1
Wang, B. S., Karamboulas, K., Tahmasian, N., Dennis, D. J., Kaplan, D. R., & Miller, F. D. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102967 · Cited by 1
“This model is based upon label-retaining studies identifying a population of slowly proliferating, set-aside embryonic RPs that generate the adult lateral V-SVZ NSC pool (Fuentealba et al., 2015; Furutachi et al., 2015).”
Zhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.021 · Cited by 1
A Butterfly Effect on Neural Stem Cells
Vanderhaeghen, P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.015 · Cited by 1
“Viral lineage-tracing experiments have shown that SEZ aNSCs originate in the embryo from ventricular progenitors (Fuentealba et al., 2015) within the lateral ganglionic eminence (LGE), a region of the ventral telencephalon that contains a particularly high diversity of progenitors The embryonic…”
BackgroundThe Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution
Nomura, T., Gotoh, H., & Ono, K. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2380-z · Cited by 1
Resident Neural Stem Cell Niches and Regeneration: The Splendors and Miseries of Adult Neurogenesis
Baklaushev, V. P., Yusubalieva, G. M., Samoilova, E. M., & Викторович, Б. В. (2022) · Russian Journal of Developmental Biology · doi:10.1134/s1062360422030080 · Cited by 1
“5 (Fuentealba et al., 2015).”
BackgroundInfluentialNeural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment
Sharma, K., Puranik, N., & Yadav, D. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230512121416 · Cited by 1
Edwards, A. J., & Beltz, B. S. (2024) · Neural Development · doi:10.1186/s13064-024-00185-3 · Cited by 1
“However, a number of studies in mice have demonstrated that hippocampal and olfactory bulb neural stem cells have a limited life-span in vivo [8, 12, 13], and not the long-term self-renewal that has been proposed.”
BackgroundMorphological classification of radial glia–like cells in the postnatal mouse subventricular zone
Yoshida, R., & Mori, T. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16503 · Cited by 1
“Both type B1 cells and hippocampal NSCs (called type 1 cells or R cells) are descendants of radial glia and have a long basal process (Fuentealba et al., 2015; Furutachi et al., 2015; Merkle et al., 2004; Mirzadeh et al., 2008; Olpe & Jessberger, 2023; Yeh et al., 2023).”
McRae, H. M., Leong, M. P.-Y., Bergamasco, M., Garnham, A. L., Hu, Y., Corbett, M. A., Whitehead, L. W., El-Saafin, F., Sheikh, B. N., Wilcox, S., et al. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011428 · Cited by 1
An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance
Okazaki, T., & Gotoh, Y. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.006 · Cited by 1
Les hormones thyroïdiennes régulent le destin des cellules souches neurales
Remaud, S., & DEMENEIX, B. A. (2019) · Biologie Aujourd hui · doi:10.1051/jbio/2019007 · Cited by 1
Metadata
- Authors
- Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1644-1655
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4475276
- OpenAlex
- W1617074755
- Cited by
- 488
- References
- 55
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 29 · 2023: 43 · 2022: 43 · 2021: 51 · 2020: 62 · 2019: 58 · 2018: 45 · 2017: 47 · 2016: 35 · 2015: 15
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R37NS028478, NS-28478, R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural stem cells, neural progenitor cells, olfactory bulb, lateral ventricle, embryonic origin, regional specification, lineage tracing, quiescence, forebrain development, striatum, septum, cortex
- MeSH terms
- Animals, Embryo, Mammalian, Olfactory Bulb, Prosencephalon, Cell Lineage, Mice, Adult Stem Cells, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
