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Embryonic Origin of Postnatal Neural Stem Cells
Open accessAbstract
Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
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“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fuentealba et al., 2015
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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
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“Two recent studies suggested that adult SVZ NSCs are regionally specified at an early embryonic stage and then remain largely quiescent until re-activation postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
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Self-citationThe Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
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“Curiously, this regional specification is already established in the embryo at very early stages of development (Fuentealba et al. 2015).”
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Metadata
- Authors
- Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1644-1655
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4475276
- OpenAlex
- W1617074755
- Cited by
- 488
- References
- 55
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 29 · 2023: 43 · 2022: 43 · 2021: 51 · 2020: 62 · 2019: 58 · 2018: 45 · 2017: 47 · 2016: 35 · 2015: 15
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R37NS028478, NS-28478, R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural stem cells, neural progenitor cells, olfactory bulb, lateral ventricle, embryonic origin, regional specification, lineage tracing, quiescence, forebrain development, striatum, septum, cortex
- MeSH terms
- Animals, Embryo, Mammalian, Olfactory Bulb, Prosencephalon, Cell Lineage, Mice, Adult Stem Cells, Neural Stem Cells
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