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Embryonic Origin of Postnatal Neural Stem Cells
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Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
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“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fuentealba et al., 2015
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Livet, J., Weissman, T. A., Kang, H., Draft, R. W., Lu, J., Bennis, R. A., Sanes, J. R., & Lichtman, J. W. (2007) · Nature · doi:10.1038/nature06293 · Cited by 1,876
The development of neural stem cells
Temple, S. (2001) · Nature · doi:10.1038/35102174 · Cited by 1,479
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,110
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“Two recent studies suggested that adult SVZ NSCs are regionally specified at an early embryonic stage and then remain largely quiescent until re-activation postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
Self-citationThe Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
“Curiously, this regional specification is already established in the embryo at very early stages of development (Fuentealba et al. 2015).”
BackgroundQuiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá-Martinez, F., Kupke, J., Zhao, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.040 · Cited by 399
The development and functions of multiciliated epithelia
Spassky, N., & Meunier, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.21 · Cited by 390
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 383
A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity
Knobloch, M., Pilz, G.-A., Ghesquière, B., Kovacs, W. J., Wegleiter, T., Moore, D. L., Hruzova, M., Zamboni, N., Carmeliet, P., & Jessberger, S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.029 · Cited by 334
“However, it needs to be noted that the classification of cellular clusters into clones according to spatial distance only assumes common lineage and does not ultimately prove the presence of cells of clonal origin as this would require an additional level of genetic lineage tracing (e.g., through genetic bookmarking a…”
MethodFaiz, M., Sachewsky, N., Gascón, S., Bang, K. W. A., Morshead, C. M., & Nagy, A. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.08.002 · Cited by 288
“Indeed, we know from previous studies that the striatum and cortex have distinct responses to injury (Fuentealba et al., 2015; Magnusson et al., 2014; Nato et al., 2015; Petit et al., 2001; Xu et al., 2001).”
ResultA Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.010 · Cited by 267
“5, precursors to adult SVZ neural progenitors remain largely quiescent until adulthood, and do not contribute to developmental olfactory bulb neurogenesis (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundResultInfluentialBuilding a lineage from single cells: genetic techniques for cell lineage tracking
Woodworth, M. B., Girskis, K. M., & Walsh, C. A. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.159 · Cited by 236
Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A., & Doetsch, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.044 · Cited by 248
“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation
Obernier, K., Cebrian-Silla, A., Thomson, M., Parraguez, J. I., Anderson, R., Guinto, C., Rodas Rodriguez, J., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.01.003 · Cited by 250
“Consistently, embryonic retroviral barcoding for lineage tracing has previously shown that the majority of clones of OB interneurons born at or after P28 are not clonally related to interneurons born before P28 (Fuentealba et al., 2015).”
InfluentialSelf-citationUzquiano, A., Kedaigle, A. J., Pigoni, M., Paulsen, B. D. S., Adiconis, X., Kim, K., Faits, T., Nagaraja, S., Antón-Bolaños, N., Gerhardinger, C., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.010 · Cited by 257
Shah, P. T., Stratton, J. A., Stykel, M. G., Abbasi, S., Sharma, S., Mayr, K. A., Koblinger, K., Whelan, P. J., & Biernaskie, J. (2018) · Cell · doi:10.1016/j.cell.2018.03.063 · Cited by 221
Engler, A., Zhang, R., & Taylor, V. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-89512-3_11 · Cited by 223
Yuzwa, S. A., Borrett, M. J., Innes, B. T., Voronova, A., Ketela, T., Kaplan, D. R., Bader, G. D., & Miller, F. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.017 · Cited by 205
Single-cell delineation of lineage and genetic identity in the mouse brain
Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Molinas, J. S. I., Frazel, P. W., Mohammadkhani, M., Machold, R. P., Mädler, S. C., et al. (2021) · Nature · doi:10.1038/s41586-021-04237-0 · Cited by 206
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198
“5.(47) The different regions of the adult V-SVZ arise from discrete germinal areas in the embryo.”
BackgroundIndividual human cortical progenitors can produce excitatory and inhibitory neurons
Delgado, R. N., Allen, D. E., Keefe, M. G., Mancia, W., Ziffra, R. S., Crouch, E. E., Álvarez-Buylla, A., & Nowakowski, T. J. (2021) · Nature · doi:10.1038/s41586-021-04230-7 · Cited by 211
Khacho, M., Clark, A., Svoboda, D. S., MacLaurin, J. G., Lagace, D. C., Park, D. S., & Slack, R. S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx217 · Cited by 199
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186
“Similarly, lineage tracing of embryonic precursors of adult NSCs suggests that individual NSCs might only be active for limited periods throughout adulthood (34).”
Molecular and cellular dynamics of the developing human neocortex
Wang, L., Wang, C., Moriano, J., Chen, S., Zuo, G., Cebrián‐Silla, A., Zhang, S., Mukhtar, T., Wang, S., Song, M., et al. (2025) · Nature · doi:10.1038/s41586-024-08351-7 · Cited by 179
Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D. E., Pekosz, A. S., Klein, S. L., & Burd, I. D. (2017) · Nature Communications · doi:10.1038/ncomms14575 · Cited by 164
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
Baser, A., Skabkin, M. A., Kleber, S., Dang, Y., Balta, G. S. G., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., et al. (2019) · Nature · doi:10.1038/s41586-019-0888-x · Cited by 169
Stem cell quiescence: the challenging path to activation
Urbán, N., & Cheung, T. H. (2021) · Development · doi:10.1242/dev.165084 · Cited by 168
“In the subventricular zone niche in the brain, adult NSCs enter quiescence at mid-embryonic stages, which is much earlier than previously thought (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundBrain size and limits to adult neurogenesis
Paredes, M. F., Sorrells, S. F., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23896 · Cited by 148
“Recent work indicates that regional B1 cell specification occurs during very early stages of forebrain development (Fuentealba et al., 2015).”
BackgroundCebrián‐Silla, A., Nascimento, M. A., Redmond, S., Mansky, B., Wu, D., Obernier, K., Rodriguez, R. R., González-Granero, S., García‐Verdugo, J. M., Lim, D. A., et al. (2021) · eLife · doi:10.7554/elife.67436 · Cited by 148
Redmond, S., Figueres‐Oñate, M., Obernier, K., Nascimento, M. A., Parraguez, J. I., López‐Mascaraque, L., Fuentealba, L. C., & Álvarez-Buylla, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.088 · Cited by 128
“To study the lineage of single RG cells, we have previously used a library of retroviruses (QmGFP-OL), each encoding a unique 24-base pair DNAsequence, or”barcode” (Cepkoetal., 1995,1998; Golden et al., 1995; Fuentealba et al., 2015).”
BackgroundMethodInfluentialIdentification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Fu, N. Y., Rios, A. C., Pal, B., Law, C. W., Jamieson, P. R., Liu, R., Vaillant, F., Jackling, F. C., Liu, K. H., Smyth, G. K., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3471 · Cited by 141
Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt, M., Clavreul, S., Lalioti, M., Taraviras, S. L., Hippenmeyer, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.051 · Cited by 134
“, although B1 astrocytes are reactivable quiescent neuronal progenitors, multiciliated ependymal cells are postmitotic throughout life (Fuentealba et al., 2015; Furutachi et al., 2015; Shah et al., 2018; Spassky et al., 2005).”
Mechanisms of radial glia progenitor cell lineage progression
Beattie, R., & Hippenmeyer, S. (2017) · FEBS Letters · doi:10.1002/1873-3468.12906 · Cited by 136
Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
Engler, A., Rolando, C., Giachino, C., Saotome, I., Erni, A., Brien, C., Zhang, R., Zimber-Strobl, U., Radtke, F., Artavanis-Tsakonas, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.094 · Cited by 125
“In these distinct neurogenic niches, adult neural stem cells (NSCs) remain active and drive neurogenesis in rodents, non-human primates, and humans into adulthood (Doetsch, 2003; Doetsch et al., 1999; Ernst et al., 2014; Fuentealba et al., 2015; Furutachi et al., 2015; Spalding et al., 2013).”
Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S., & Fishell, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.011 · Cited by 113
“high complexity of the library, and the relatively low number of clones, cells sharing the same barcode are almost certainly siblings (Golden et al., 1995; Fuentealba et al., 2015).”
Gorabi, A. M., Kiaie, N., Barreto, G. E., Read, M. I., Tafti, S. H. A., & Sahebkar, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01663-0 · Cited by 121
Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories
Mirzadeh, Z., Kusne, Y. N., Duran‐Moreno, M., Cabrales, E., Gil‐Perotín, S., Ortiz, C., Chen, B., García‐Verdugo, J. M., Sanai, N., & Álvarez-Buylla, A. (2017) · Nature Communications · doi:10.1038/ncomms13759 · Cited by 121
Neural stem cells: developmental mechanisms and disease modeling
Zhao, X., & Moore, D. L. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2738-1 · Cited by 127
“During development, a subset of slowly-dividing NSCs are set aside to be the NSCs of the SVZ in the postnatal and adult brain (Fuentealba et al. 2015; Furutachi et al. 2015).”
BackgroundRoles of mitochondria in neuronal development
Son, G., & Han, J. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.11.226 · Cited by 121
“regions of the brain and maintained as adult NSCs (40,41).”
BackgroundNeural stem cell niche heterogeneity
Andreotti, J. P., da Silva, W. N., Costa, A. C., Picoli, C. C., Bitencourt, F. C. O., Coimbra-Campos, L. M. C., Resende, R. R., Magno, L. A. V., Romano‐Silva, M. A., Mintz, A., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.005 · Cited by 117
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou, Y. F., Bond, A. M., Shade, J. E., Zhu, Y., Davis, C.-H. O., Wang, X., Su, Y., Yoon, K., Phan, A. T., Chen, W. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.005 · Cited by 114
“Neural stem cells that will populate the adult SVZ are set aside and remain quiescent during development (Fuentealba et al., 2015; Furutachi et al., 2015).”
The emergence of the stem cell niche
Hicks, M. R., & Pyle, A. D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.07.003 · Cited by 114
“The brain houses at least two well-studied neural stem cell (NSC) niches in the subgranular zone in the hippocampal dentate gyrus and the subventricular zone around the lateral ventricles [6,7].”
Wide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106
“To directly determine the clonal relationship of clustered interneurons, we utilized an EnvA-pseudotyped retrovirus library carrying oligonucleotide sequence tags or barcodes (Cepko et al., 1995; Fuentealba et al., 2015; Jiang et al., 2013;WalshandCepko, 1992) (Figure3A).”
Matarredona, E. R., & Pastor, Á. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00779 · Cited by 110
Falk, S., & Götz, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.025 · Cited by 99
Therapeutic Plasticity of Neural Stem Cells
Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 105
“Thus, adult SVZ NSCs are regionally specified during the early embryonic stage and remain largely quiescent until, post-natally, they are re-activated (46, 47); they have intrinsic temporal programs linked to their positional characteristics (dorsal-ventral, rostral-caudal) (48) that guide differentiation in a cell-au…”
BackgroundTong, C. K., Fuentealba, L. C., Shah, J. K., Lindquist, R. A., Ihrie, R. A., Guinto, C. D., Rodas-Rodriguez, J. L., & Álvarez-Buylla, A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.08.013 · Cited by 114
“The V-SVZ is an extensive germinal layer on the walls of the lateral ventricles that includes components derived from the MGE, LGE, septum, and cortex (Merkle et al., 2007; Alvarez-Buylla et al., 2008; Fuentealba et al., 2015).”
BackgroundPotential Therapies by Stem Cell‐Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Luarte, A., Bátiz, L. F., Wyneken, Ú., & Lafourcade, C. (2016) · Stem Cells International · doi:10.1155/2016/5736059 · Cited by 100
“[173] L.”
Zhang, Y., Liu, G., Guo, T., Liang, X. G., Du, H., Yang, L., Bhaduri, A., Li, X., Xu, Z., Zhang, Z., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.027 · Cited by 89
“A recent lineage analysis using barcoded virus libraries confirmed this result and revealed that individual early cortical RGCs generate both PyNs and OB-INs in vivo (Fuentealba et al., 2015).”
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 106
Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche
Chang, E. H., Adorján, I., Mundim, M. V., Sun, B., Dizon, M. L. V., & Szele, F. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00332 · Cited by 92
Regulation of active and quiescent somatic stem cells by Notch signaling
Sueda, R., & Kageyama, R. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12626 · Cited by 88
“It has been shown that some neural stem cells become slowly dividing or quiescent during embryonic stages and remain as adult neural stem cells (Fuentealba et al., 2015; Furutachi et al., 2015) while others be‐ come quiescent postnatally (Berg et al., 2019).”
BackgroundChavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85
Raj, B., Gagnon, J. A., & Schier, A. F. (2018) · Nature Protocols · doi:10.1038/s41596-018-0058-x · Cited by 87
Bifari, F., Decimo, I., Pino, A., Llorens-Bobadilla, E., Zhao, S., Lange, C. M., Panuccio, G., Boeckx, B., Thienpont, B., Vinckier, S., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.10.020 · Cited by 89
Regulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 89
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H. (2018) · F1000Research · doi:10.12688/f1000research.12684.1 · Cited by 89
Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production
Tan, X., Liu, W. A., Zhang, X., Shi, W., Ren, S., Li, Z., Brown, K. N., & Shi, S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.023 · Cited by 88
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript insights into the embryonic origin and distinct properties of adult neural stem cells (Fuentealba et al., 2015).”
BackgroundStorer, M. A., Gallagher, D., Fatt, M. P., Simonetta, J. V., Kaplan, D. R., & Miller, F. D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.03.008 · Cited by 83
“We propose that these different long-term outcomes result fromdifferences in neural precursor cell-cycle state since, at the time of the IL-6 surge, embryonic NSCs were actively proliferating while post-natal NSCs were quiescent (Fuentealba et al., 2015; Furutachi et al., 2015; Yuzwa et al., 2017).”
BackgroundThe aged brain: genesis and fate of residual progenitor cells in the subventricular zone
Capilla‐González, V., Herranz‐Pérez, V., & García‐Verdugo, J. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00365 · Cited by 82
“It is known that NSCs within the SVZ derive from embryonic radial glia cells (Merkle et al., 2004; Kriegstein and Alvarez-Buylla, 2009; Morrens et al., 2012; Fuentealba et al., 2015).”
BackgroundMorizur, L., Chicheportiche, A., Gauthier, L., Daynac, M., Boussin, F. D., & Mouthon, M. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.005 · Cited by 81
“In contrast to their progeny, most adult NSCs are quiescent and a tight regulation of the balance between their quiescent and proliferative states appears essential for their long-term maintenance in neurogenic niches (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundGengatharan, A., Bammann, R. R., & Saghatelyan, A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00149 · Cited by 81
New neurons in adult brain: distribution, molecular mechanisms and therapies
Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 83
Stem cells in tissues, organoids, and cancers
Wang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03199-x · Cited by 80
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 81
Development of the mammalian main olfactory bulb
Tufo, C., Poopalasundaram, S., Dorrego-Rivas, A., Ford, M. C., Graham, A., & Grubb, M. S. (2022) · Development · doi:10.1242/dev.200210 · Cited by 75
“Cre-lox fate mapping of telencephalic neuroepithelium has revealed that the postnatal SVZ is populated by a heterogeneous pool of stem cells, derived from the MGE, LGE and embryonic cortex, which remain quiescent until activated in adulthood (Fuentealba et al., 2015; Young et al., 2007).”
BackgroundLepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 75
“Lifelong neurogenesis in the adult brain relies on a population of qNSCs set apart during development (Fuentealba et al , 2015; Furutachi et al , 2015; Falk et al , 2017).”
Cerrato, V., Parmigiani, E., Figueres‐Oñate, M., Betizeau, M., Aprato, J., Nanavaty, I. N., Berchialla, P., Luzzati, F., de’Sperati, C., López‐Mascaraque, L., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005513 · Cited by 64
Notch signaling as a master regulator of adult neurogenesis
Lampada, A., & Taylor, V. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179011 · Cited by 86
“5 and remain quiescent through the late stages of embryogenesis until postnatal and adult stages of life (Merkle et al., 2004; Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundAlonso, S. B., Reinert, J. K., Marichal, N., Massalini, S., Berninger, B., Kuner, T., & Calegari, F. (2019) · The EMBO Journal · doi:10.15252/embj.201798791 · Cited by 71
“Specifically, slowly dividing progenitors of embryonic origin (Fuentealba et al , 2015; Furutachi et al , 2015) become activated NSC (B1 cells) of the adult SVZ and give rise to intermediate progenitors (C cells) that produce neuroblasts (A cells) migrating through the rostral migratory stream…”
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62
Quiescent Neural Stem Cells for Brain Repair and Regeneration: Lessons from Model Systems
Otsuki, L., & Brand, A. H. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.02.002 · Cited by 68
Nucleotides in neuroregeneration and neuroprotection
Miras‐Portugal, M. T., Gómez‐Villafuertes, R., Gualix, J., Díaz‐Hernandéz, J. I., Artalejo, A. R., Ortega, F., Delicado, E. G., & Pérez‐Sen, R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.002 · Cited by 70
“The diverse and fine-tuned molecular and biochemical properties of stem cell types are essential for specific neurorepair, but it is also part of the difficulty for a feasible clinical application (Fuentealba et al., 2015; Merkle et al., 2014).”
BackgroundHu, X.-L., Chen, G., Zhang, S., Zheng, J., Wu, J., Bai, Q., Wang, Y., Li, J., Wang, H., Han, F., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.047 · Cited by 70
Borrett, M. J., Innes, B. T., Jeong, D., Tahmasian, N., Storer, M. A., Bader, G. D., Kaplan, D. R., & Miller, F. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108022 · Cited by 75
Neurogenesis From Embryo to Adult – Lessons From Flies and Mice
Mira, H., & Morante, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00533 · Cited by 71
Boareto, M., Iber, D., & Taylor, V. (2017) · Development · doi:10.1242/dev.152520 · Cited by 65
“In the peak neurogenic period, a few NSCs exit the cell cycle and become quiescent (qNSCs) (Furutachi et al., 2013, 2015; Fuentealba et al., 2015). qNSCs are only reactivated in the adult neurogenic niches.”
BackgroundInfluentialTranslating neural stem cells to neurons in the mammalian brain
Zahr, S. K., Kaplan, D. R., & Miller, F. D. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0411-9 · Cited by 67
Carradori, D., Eyer, J., Saulnier, P., Véronique Préat, A., & Rieux, A. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.032 · Cited by 66
“Adult SGZ-NSC could originate from the ventral hippocampus during the late fetal stage [21], while adult SVZ-NSC are regionally specified at an early embryonic stage [22,23].”
Mizrak, D., Bayin, N. S., Yuan, J., Liu, Z., Suciu, R. M., Niphakis, M. J., Ngo, N., Lum, K. M., Cravatt, B. F., Joyner, A. L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107805 · Cited by 59
“, 2014), with intrinsic regional identities defined during embryogenesis (Fuentealba et al., 2015), generating different olfactory bulb (OB) interneuron subtypes or glia depending on their location (Brill et al.”
Adult Neural Stem Cells: Born to Last
Morales, A. V., & Mira, H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00096 · Cited by 62
Neural crest lineage analysis: from past to future trajectory
Tang, W., & Bronner-Fraser, M. E. (2020) · Development · doi:10.1242/dev.193193 · Cited by 63
Regulation of CNS precursor function by neuronal chemokines
Watson, A. E. S., Goodkey, K., Footz, T. K., & Voronova, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134533 · Cited by 57
Harada, Y., Yamada, M., Imayoshi, I., Kageyama, R., Suzuki, Y., Kuniya, T., Furutachi, S., Kawaguchi, D., & Gotoh, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26605-0 · Cited by 56
Cole, A., Murray, S. S., & Xiao, J. (2016) · Stem Cells International · doi:10.1155/2016/9260592 · Cited by 56
“5 in murine embryogenesis [9].”
How a radial glial cell decides to become a multiciliated ependymal cell
Kyrousi, C., Lygerou, Z., & Taraviras, S. L. (2017) · Glia · doi:10.1002/glia.23118 · Cited by 59
“…embryonic stages, suggesting that RGCs committed to aNSCs are separated from the common pool of embryonic neural progenitor cells before E15 dpc. Interestingly, this pool of progenitors is maintained quiescent throughout embryogenesis and generates the majority of aNSCs (Fuentealba et al., 2015).”
BackgroundLineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells
Than-Trong, E., Kiani, B., Dray, N., Ortica, S., Simons, B., Rulands, S., Alunni, A., & Bally-Cuif, L. (2019) · Science Advances · doi:10.1126/sciadv.aaz5424 · Cited by 53
Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation
Ribeiro, M. F., Santos, A. A., Afonso, M. B., Rodrigues, P. M., Santos, S. S., Castro, R. E., Rodrigues, C. M. P., & Solá, S. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa165 · Cited by 56
Cascade diversification directs generation of neuronal diversity in the hypothalamus
Zhang, Y.-H., Xu, M., Shi, X., Sun, X., Mu, W., Wu, H., Wang, J., Li, S., Su, P., Gong, L., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.020 · Cited by 54
Targeting Adult Neurogenesis for Poststroke Therapy
Lu, J., Manaenko, A., & Hu, Q. (2017) · Stem Cells International · doi:10.1155/2017/5868632 · Cited by 54
“NSCs from medial wall produce calretinin (CalR) GCs and CalR PGCs [21] (Figure 1).”
BackgroundZimmermann, T., Maroso, M., Beer, A., Baddenhausen, S., Ludewig, S., Fan, W., Vennin, C., Loch, S., Berninger, B., Hofmann, C., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy258 · Cited by 53
“Even if adult NSCs and progenitors in the DG and SVZ share some cellular characteristics reflected by the expression of common specific transcription factors, they are clearly of different embryonic origin (Fuentealba et al. 2015; Berg et al. 2018) and are equipped with distinct transcriptional profiles (Hsieh 2012).”
BackgroundThyroid hormone regulation of neural stem cell fate: From development to ageing
Gothié, J. M., Vancamp, P., DEMENEIX, B. A., & Remaud, S. (2019) · Acta Physiologica · doi:10.1111/apha.13316 · Cited by 53
McLean, W. J., McLean, D. T., Eatock, R. A., & Edge, A. S. B. (2016) · Development · doi:10.1242/dev.139840 · Cited by 52
“*Authors for correspondence (eatock@uchicago.edu; albert_edge@meei.harvard.edu) A.S.B.E., 0000-0001-8641-755X D E V E LO P M E N T remained unresolved in several neural and non-neural stem cell compartments (Fuentealba et al., 2015).”
BackgroundNeural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
Morante‐Redolat, J. M., & Porlan, E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00102 · Cited by 50
“Notwithstanding their potential for generating differentiated progeny, NSC display a functional quiescence in adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and in contrast to other tissues, adult NSC can be found at different states of activation (Daynac et al.”
BackgroundEffects of Radiation Therapy on Neural Stem Cells
Michaelidesova, A. J., Konířová, J., Bartůněk, P., & Zı́ková, M. (2019) · Genes · doi:10.3390/genes10090640 · Cited by 55
Birkhoff, J. C., Huylebroeck, D., & Conidi, A. (2021) · Genes · doi:10.3390/genes12071037 · Cited by 52
Neural stem cell metabolism revisited: a critical role for mitochondria
Scandella, V., Petrelli, F., Moore, D. L., Braun, S. M. G., & Knobloch, M. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.008 · Cited by 55
“In both niches, NSCs that remain in adulthood originate from embryonic NSCs, which are set aside during embryonic and early postnatal development [20–22].”
BackgroundSabelström, H., Petri, R., Shchors, K., Jandial, R., Schmidt, C., Sacheva, R., Masic, S., Yuan, E., Fenster, T., Martinez, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.071 · Cited by 50
“Ventricularsubventricular zone (V-SVZ) stem cells expressing glial fibrillary acidic protein (GFAP) line the lateral ventricles and give rise to normal constituents, including doublecortin (DCX)-expressing neuroblasts that migrate along the rostral migratory stream and differentiate into olfactory bulb interneurons an…”
BackgroundBast, L., Calzolari, F., Strasser, M. K., Hasenauer, J., Theis, F. J., Ninkovic, J., & Marr, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.088 · Cited by 50
“, 2016), possibly since late embryonic times (Falk et al., 2017; Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundBalakrishnan, J., Kannan, S., & Govindasamy, A. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.003 · Cited by 53
Mercury Toxicity and Neurogenesis in the Mammalian Brain
Abbott, L. C., & Nigussie, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147520 · Cited by 51
“Some of the radial glial cells that are formed in early development become quiescent as the brain continues to develop and eventually form postnatal and adult NSCs in the subventricular zone (SVZ), located along the edges of the lateral ventricles [23,24].”
Background
Metadata
- Authors
- Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1644-1655
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4475276
- OpenAlex
- W1617074755
- Cited by
- 488
- References
- 55
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 29 · 2023: 43 · 2022: 43 · 2021: 51 · 2020: 62 · 2019: 58 · 2018: 45 · 2017: 47 · 2016: 35 · 2015: 15
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R37NS028478, NS-28478, R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural stem cells, neural progenitor cells, olfactory bulb, lateral ventricle, embryonic origin, regional specification, lineage tracing, quiescence, forebrain development, striatum, septum, cortex
- MeSH terms
- Animals, Embryo, Mammalian, Olfactory Bulb, Prosencephalon, Cell Lineage, Mice, Adult Stem Cells, Neural Stem Cells
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