Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer

Brahmer, J. R., Tykodi, S. S., Chow, L. Q. M., Hwu, W.-J., Topalian, S. L., Hwu, P., Drake, C. G., Camacho, L. H., Kauh, J., Odunsi, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200694 · Cited by 7,945

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Wilkerson, M. D., & Hayes, D. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq170 · Cited by 5,645

Methylation of immune synapse genes modulates tumor immunogenicity

Berglund, A., Mills, M. N., Putney, R. M., Hamaidi, I., Mulé, J. J., & Kim, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci131234 · Cited by 54

The Innate Immune Signalling Pathways: Turning RIG-I Sensor Activation against Cancer

Iurescia, S., Fioretti, D., & Rinaldi, M. (2020) · Cancers · doi:10.3390/cancers12113158 · Cited by 55

Checkpoint immunotherapy in pediatrics: here, gone, and back again

Long, A. H., Morgenstern, D. A., Leruste, A., Bourdeaut, F., & Davis, K. L. (2022) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_349799 · Cited by 53

Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019

Gracia-Hernandez, M., Sotomayor, E. M., & Villagra, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.577571 · Cited by 54

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Desaulniers, D. M., Vasseur, P., Jacobs, A. C., Aguila, M. C., Ertych, N., & Jacobs, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010969 · Cited by 55

Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Vitiello, G. A. F., Ferreira, W. A. S., de Lima, V. C. C., & Medina, T. D. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.782852 · Cited by 59

RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

Stok, J. E., Oosenbrug, T., ter Haar, L. R., Gravekamp, D., Bromley, C. P., Zelenay, S., Sousa, C. R. E., & van der Veen, A. G. (2022) · The EMBO Journal · doi:10.15252/embj.2021109760 · Cited by 53

Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors

Wojcik, J. B., Marchione, D. M., Sidoli, S., Djedid, A., Lisby, A., Majewski, J., & Garcia, B. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3704 · Cited by 57

A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens

Minati, R., Perreault, C., & Thibault, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583287 · Cited by 55

Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma

Chai, P., Jia, R., Li, Y., Zhou, C., Gu, X., Yang, L., Shi, H., Tian, H., Lin, H., Yu, J., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101030 · Cited by 56

5-aza-2′-deoxycytidine potentiates anti-tumor immunity in colorectal peritoneal metastasis by modulating ABC A9-mediated cholesterol accumulation in macrophages

Shi, R., Zhao, K., Wang, T., Yuan, J., Zhang, D., Xiang, W., Qian, J., Luo, N., Zhou, Y., Tang, B., et al. (2021) · Theranostics · doi:10.7150/thno.66420 · Cited by 52

Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy

Zhang, H., Liu, K., Gong, Y., Zhu, W., Zhu, J., Pan, F., Chao, Y., Xiao, Z., Liu, Y., Wang, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121673 · Cited by 52

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Chan, K. L., Gomez, J., Cardinez, C., Kumari, N., Sparbier, C. E., Lam, E. Y. N., Yeung, M. M., Garciaz, S., Kuzich, J. A., Ong, D. M., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.007 · Cited by 52

Endogenous Retroelements and the Host Innate Immune Sensors

Mu, X. N., Ahmad, S., & Hur, S. (2016) · Advances in immunology · doi:10.1016/bs.ai.2016.07.001 · Cited by 56

Interplay between viruses and bacterial microbiota in cancer development

Vyshenska, D., Lam, K. C., Shulzhenko, N., & Morgun, A. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.003 · Cited by 49

Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target

Mustachio, L. M., Lu, Y., Kawakami, M., Roszik, J., Freemantle, S. J., Liu, X., & Dmitrovsky, E. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1752 · Cited by 52

Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1

Zhang, S., Li, J., Li, J., Yang, Y., Kang, X., Li, Y., Wu, X., Zhu, Q., Zhou, Y., & Hu, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-25073-9 · Cited by 51

The role of DNA-demethylating agents in cancer therapy

Mehdipour, P., Murphy, T., & Carvalho, D. D. D. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107416 · Cited by 55

Adenosine-to-inosine RNA editing in the immune system: friend or foe?

Nakahama, T., & Kawahara, Y. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03466-2 · Cited by 51

Technologies for targeting DNA methylation modifications: Basic mechanism and potential application in cancer

Wang, J., Yang, J., Li, D., & Li, J. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188454 · Cited by 53

Human endogenous retroviruses in cancer: Expression, regulation and function (Review)

Gao, Y., Yu, X., & Chen, T. (2020) · Oncology Letters · doi:10.3892/ol.2020.12382 · Cited by 56

Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments

Ngo, C., & Postel-Vinay, S. C. (2022) · Biomedicines · doi:10.3390/biomedicines10030650 · Cited by 54

Biomarkers for Response to Immune Checkpoint Blockade

Ganesan, S., & Mehnert, J. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033604 · Cited by 51

Investigating the Potential Roles of SINEs in the Human Genome

Zhang, X.-O., Pratt, H., & Weng, Z. (2021) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111620-100736 · Cited by 55

Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Spiliopoulou, P., Spear, S., Mirza, H., Garner, I., McGarry, L., Freile, F. G., Cheng, Z., Ennis, D. P., Iyer, N., McNamara, S., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0743 · Cited by 50

H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer

Baratchian, M., Tiwari, R., Khalighi, S., Chakravarthy, A., Yuan, W., Berk, M. P., Li, J., Guerinot, A., Bono, J. S. D., Makarov, V., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114324119 · Cited by 51

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

Pan, D., Bao, X., Hu, M., Jiao, M., Li, F., & Li, C. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3523 · Cited by 54

Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells

Jang, H. J., Shah, N. M., Maeng, J. H., Liang, Y., Basri, N. L., Ge, J., Qu, X., Mahlokozera, T., Tzeng, S., Williams, R. B., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01880-x · Cited by 58

The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

Zhao, H., Ning, S., Nolley, R., Scicinski, J. J., Oronsky, B. T., Knox, S. J., & Peehl, D. M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0312-z · Cited by 56

Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma

Nakaoka, T., Saito, Y., & Saito, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061111 · Cited by 51

Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re‐Visiting the “Gene‐Battery” Model

Sundaram, V., & Wang, T. (2017) · BioEssays · doi:10.1002/bies.201700155 · Cited by 50

Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS

Lee, J., Chiang, C., & Gack, M. U. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2019.0015 · Cited by 50

Interferons: role in cancer therapy

Abdolvahab, M. H., Darvishi, B., Zarei, M., Majidzadeh-A, K., & Farahmand, L. (2020) · Immunotherapy · doi:10.2217/imt-2019-0217 · Cited by 50

Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma

Carrasco-Leon, A., Ezponda, T., Meydan, C., Valcárcel, L. V., Ordoñez, R., Kulis, M., Garate, L., Miranda, E., Segura, V., Guruceaga, E., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01147-y · Cited by 50

Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia

Egan, G., Khan, D. H., Lee, J. B., Mirali, S., Zhang, L., & Schimmer, A. D. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1227 · Cited by 52

TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment

Mao, J., Zhang, Q., Wang, Y., Yang, Z., Xu, L., Ma, X., Guan, D., Zhou, J., Liu, J., Wu, X., et al. (2022) · EMBO Reports · doi:10.15252/embr.202152984 · Cited by 51

Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use

Abbotts, R., Dellomo, A. J., & Rassool, F. V. (2022) · Cancers · doi:10.3390/cancers14112640 · Cited by 54

Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity

Ning, H., HUANG, S. H., Yang, L., Zhi, R., Yan, H., Jin, J., Hu, Z., Guo, K., Liu, J., Yang, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34253-1 · Cited by 53

Mechanisms of low MHC I expression and strategies for targeting MHC I with small molecules in cancer immunotherapy

Kong, S., Zhang, J., Wang, L., Li, W., Guo, H., Weng, Q., He, Q., Lou, H., Ding, L., & Yang, B. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217432 · Cited by 50

Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications

Wang, X., Luo, X., Xiao, R., Liu, X., Zhou, F., Jiang, D., Bai, J., Cui, M., You, L., & Yupei, Z. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02334-4 · Cited by 59

Interplay Between Inflammation and Epigenetic Changes in Cancer

Maiuri, A. R., & O’Hagan, H. M. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.09.002 · Cited by 48

Algorithms for Drug Sensitivity Prediction

Niz, C. D., Rahman, R., Zhao, X., & Pal, R. (2016) · Algorithms · doi:10.3390/a9040077 · Cited by 50

Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System

Kawasaki, T., & Kawai, T. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.08.004 · Cited by 52

Endogenous retroviruses are associated with hippocampus-based memory impairment

Sankowski, R., Strohl, J. J., Huerta, T. S., Nasiri, E., Mazzarello, A. N., d’Abramo, C., Cheng, K. F., Staszewski, O., Prinz, M., Huerta, P. T., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1822164116 · Cited by 49

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Janelle, V., Rulleau, C., Testa, S. D., Carli, C., & Delisle, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00276 · Cited by 52

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

Rajagopalan, K. N., Chen, X., Weinberg, D. N., Chen, H., Majewski, J., Allis, C. D., & Lü, C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021795118 · Cited by 50

Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

Kumar, R., Mendonca, J., Owoyemi, O., Boyapati, K., Thomas, N., Kanacharoen, S., Coffey, M. R., Topiwala, D., Gomes, C., Özbek, B., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3607 · Cited by 50

High rate of complete responses to immune checkpoint inhibitors in patients with relapsed or refractory Hodgkin lymphoma previously exposed to epigenetic therapy

Falchi, L., Sawas, A., Deng, C., Amengual, J. E., Colbourn, D. S., Lichtenstein, E., Khan, K. A., Schwartz, L. H., & O’Connor, O. A. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0363-1 · Cited by 49

Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities

Tien, F., Lu, H., Lin, S., & Tsai, H.-C. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-022-00893-0 · Cited by 51

A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

Guo, H., Feng, R.-X., Zhang, Y., Yu, Y., Lu, W., Liu, J.-J., Yang, S., Zhao, C., Zhang, Z.-L., Yu, S., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101592 · Cited by 50

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects

Gambacorta, V., Gnani, D., Vago, L., & Micco, R. D. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00207 · Cited by 49

Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs

Ku, Y., Park, J., Cho, R., Lee, Y.-K., Park, H.-M., Kim, M. A., Hur, K., Byun, S. Y., Liu, J., Lee, Y.-S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016289118 · Cited by 49

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

Kitsou, K. S., Kotanidou, A. N., Paraskevis, D. N., Karamitros, T., Katzourakis, A., Tedder, R. S., Hurst, T. P., Sapounas, S., Kotsinas, A., Gorgoulis, V. G., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01260-21 · Cited by 47

Emerging roles for endogenous retroviruses in immune epigenetic regulation*

Buttler, C. A., & Chuong, E. B. (2021) · Immunological Reviews · doi:10.1111/imr.13042 · Cited by 54

Epigenetics in normal and malignant hematopoiesis: An overview and update 2017

Goyama, S., & Kitamura, T. (2017) · Cancer Science · doi:10.1111/cas.13168 · Cited by 53

Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia

Huang, Y., Zhang, Q., Lubas, M., Yang, Y., Yalçın, F., Efe, I. E., Xia, P., Motta, E., Buonfiglioli, A., Lehnardt, S., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0666-20.2020 · Cited by 48

Reactivated endogenous retroviruses promote protein aggregate spreading

Liu, S., Heumüller, S.-E., Hossinger, A., Müller, S. A., Buravlova, O., Lichtenthaler, S. F., Denner, P., & Vorberg, I. M. (2023) · Nature Communications · doi:10.1038/s41467-023-40632-z · Cited by 48

Progresses in biomarkers for cancer immunotherapy

Lin, X., Zong, C., Zhang, Z., Fang, W., & Xu, P. (2023) · MedComm · doi:10.1002/mco2.387 · Cited by 50

Inverted Alu repeats: friends or foes in the human transcriptome

Lee, K., Ku, J., Ku, D., & Kim, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01177-3 · Cited by 48

DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development

Li, S., Park, J., Guan, Y., Chung, K., Shrestha, R., Palmer, M. B., & Suszták, K. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018070687 · Cited by 47

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response

Dhanwani, R., Takahashi, M., Mathews, I. T., Lenzi, C., Romanov, A., Watrous, J. D., Pieters, B. C. H., Hedrick, C. C., Benedict, C. A., Linden, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3688 · Cited by 48

Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers

Steiner, M. C., Marston, J. L., Iñiguez, L., Bendall, M. L., Chiappinelli, K. B., Nixon, D. F., & Crandall, K. A. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3975 · Cited by 48

Ancient Adversary – HERV-K (HML-2) in Cancer

Dervan, E., Bhattacharyya, D. D., McAuliffe, J. D., Khan, F. H., & Glynn, S. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.658489 · Cited by 46

Machine Learning in Epigenomics: Insights into Cancer Biology and Medicine

Arslan, E., Schulz, J., & Rai, K. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188588 · Cited by 50

Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability

Guo, P., Liu, Y., Geng, F., Daman, A. W., Liu, X., Zhong, L., Ravishankar, A., Lis, R., Durán, J. G. B., Itkin, T., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00795-7 · Cited by 48

An analysis of the role of HnRNP C dysregulation in cancers

Mo, L., Meng, L., Huang, Z.-C., Yi, L., Yang, N., & Li, G. (2022) · Biomarker Research · doi:10.1186/s40364-022-00366-4 · Cited by 50

HERVs and Cancer—A Comprehensive Review of the Relationship of Human Endogenous Retroviruses and Human Cancers

Stricker, E., Peckham‐Gregory, E. C., & Scheurer, M. E. (2023) · Biomedicines · doi:10.3390/biomedicines11030936 · Cited by 48

TIP60 represses activation of endogenous retroviral elements

Rajagopalan, D., Tirado-Magallanes, R., Bhatia, S. S., Teo, W. S., Sian, S., Hora, S., Lee, K. K., Zhang, Y., Jadhav, S. P., Wu, Y., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky659 · Cited by 47

The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy

Mendez, L., Posey, R. R., & Pandolfi, P. P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01162 · Cited by 46

Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

Chen, M., Hu, S., Li, Y., Jiang, T., Jin, H., & Feng, L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00347-9 · Cited by 47

Sequence-Specific Sensing of Nucleic Acids

Vabret, N., Bhardwaj, N., & Greenbaum, B. D. (2017) · Trends in Immunology · doi:10.1016/j.it.2016.10.006 · Cited by 45

Endogenized viral sequences in mammals

Parrish, N. F., & Tomonaga, K. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.03.002 · Cited by 46

Epi‐immunotherapy for cancers: rationales of epi‐drugs in combination with immunotherapy and advances in clinical trials

Xu, Y., Li, P., Liu, Y., Xin, D., Lei, W., Liang, A., Han, W., & Qian, W. (2022) · 癌症：英文版 · doi:10.1002/cac2.12313 · Cited by 47

Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer

Gomez, S., Cox, O. L., Walker, R. R., Rentia, U., Hadley, M. M., Arthofer, E., Diab, N., Grundy, E. E., Kanholm, T., McDonald, J. I., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004974 · Cited by 47

Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses

Wang, L., Tracy, L., Su, W., Yang, F., Yu, F., Silverman, N. S., & Zhang, Z. Z. (2022) · Nature Genetics · doi:10.1038/s41588-022-01214-9 · Cited by 42

TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

Leonova, K. I., Safina, A. F., Nesher, E., Sandlesh, P., Pratt, R. N., Burkhart, C. A., Lipchick, B. C., Gitlin, I. I., Frangou, C. G., Koman, I. E., et al. (2018) · eLife · doi:10.7554/elife.30842 · Cited by 41

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

Zhang, G., Wu, L. W., Mender, I., Barzily-Rokni, M., Hammond, M. R., Ope, O., Cheng, C., Vasilopoulos, T., Randell, S., Sadek, N. L., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2773 · Cited by 44

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

Rajshekar, S., Yao, J., Arnold, P. K., Payne, S. G., Zhang, Y., Bowman, T. V., Schmitz, R. J., Edwards, J. R., & Goll, M. G. (2018) · eLife · doi:10.7554/elife.39658 · Cited by 45

CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer

Morra, F., Merolla, F., Criscuolo, D., Insabato, L., Giannella, R., Ilardi, G., Cerrato, A., Visconti, R., Staibano, S., & Celetti, A. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1087-1 · Cited by 45

Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice

Gao, J., Cheng, Y., Hao, H., Yin, Y., Xue, J., Zhang, Q., Li, L., Liu, J., Xie, Z., Yu, S., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1338-2 · Cited by 45

High RIG‐I expression in ovarian cancer associates with an immune‐escape signature and poor clinical outcome

Wolf, D. G. F., Fiegl, H., Zeimet, A. G., Wieser, V. E., Marth, C., Sprung, S., Sopper, S., Hartmann, G., Reimer, D., & Boesch, M. (2019) · International Journal of Cancer · doi:10.1002/ijc.32818 · Cited by 45

Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review

Haibe, Y., Husseini, Z. E., Sayed, R. E., & Shamseddine, A. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176176 · Cited by 45

Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses

Mikhalkevich, N., O’Carroll, I. P., Tkavc, R., Lund, K., Sukumar, G., Dalgard, C. L., Johnson, K. R., Li, W., Wang, T., Nath, A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009305 · Cited by 43

PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma

Tao, H., Jin, C., Zhou, L., Deng, Z., Li, X., Dang, W., Fan, S., Li, B., Ye, F., Lu, J., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1082 · Cited by 44

Targeting the epigenome in malignant pleural mesothelioma

McLoughlin, K. C., Kaufman, A. S., & Schrump, D. S. (2017) · Translational Lung Cancer Research · doi:10.21037/tlcr.2017.06.06 · Cited by 45

Overview of DNA methylation in adult diffuse gliomas

Aoki, K., & Natsume, A. (2019) · Brain Tumor Pathology · doi:10.1007/s10014-019-00339-w · Cited by 45

A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors

Gaillard, S. L., ZAHURAK, M. L., Sharma, A. R., Durham, J. N., Reiss, K. A., Sartorius-Mergenthaler, S., Downs, M., Anders, N. M., Ahuja, N., Rudek, M. A., et al. (2019) · Cancer · doi:10.1002/cncr.32138 · Cited by 44

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation

Stolz, P., Mantero, A. S., Tvardovskiy, A., Ugur, E., Wange, L. E., Mulholland, C. B., Cheng, Y., Wierer, M., Enard, W., Schneider, R., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac642 · Cited by 43

Single-cell RNA sequencing highlights the functional role of human endogenous retroviruses in gallbladder cancer

Wang, J., Ren, M., Yu, J., Hu, M., Wang, X., Ma, W., Jiang, X., & Cui, J. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104319 · Cited by 46

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Ishiguro, K., Kitajima, H., Niinuma, T., Ishida, T., Maruyama, R., Ikeda, H., Hayashi, T., Sasaki, H., Wakasugi, H., Nishiyama, K., et al. (2018) · Haematologica · doi:10.3324/haematol.2018.191262 · Cited by 45

G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma

Kelly, G., Al‐Ejeh, F., McCuaig, R., Casciello, F., Kamal, N. A., Ferguson, B., Pritchard, A. L., Ali, S. S., da Silva, I. P., Wilmott, J. S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3463 · Cited by 43

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension

Taylor, S., Isobe, S., Cao, A., Contrepois, K., Benayoun, B. A., Jiang, L., Wang, L., Melemenidis, S., Ozen, M. O., Otsuki, S., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0446oc · Cited by 43

The next generation of DNMT inhibitors

Mehdipour, P., Chen, R. E., & Carvalho, D. D. D. (2021) · Nature Cancer · doi:10.1038/s43018-021-00271-z · Cited by 43

DNA hypomethylation leads to cGAS‐induced autoinflammation in the epidermis

Beck, M. A., Fischer, H., Grabner, L., Groffics, T., Winter, M., Tangermann, S., Meischel, T., Zaussinger‐Haas, B., Wagner, P., Fischer, C., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108234 · Cited by 44

An Epigenetic Perspective on Intra-Tumour Heterogeneity: Novel Insights and New Challenges from Multiple Fields

Beyes, S., Bediaga, N. G., & Zippo, A. (2021) · Cancers · doi:10.3390/cancers13194969 · Cited by 44

DNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy

Huang, K. C., Chiang, S., Ke, T., Chen, T.-W., Hu, C.-H., Yang, P.-C., Chang, H.-Y., Liang, J., Chen, W. T., & Chao, K. S. C. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1989790 · Cited by 42

Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer

Grillo, G., Keshavarzian, T., Linder, S., Arlidge, C., Mout, L., Nand, A., Teng, M., Qamra, A., Zhou, S., Kron, K. J., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0331 · Cited by 42

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling

Chomiak, A. A., Tiedemann, R. L., Liu, Y., Kong, X., Cui, Y., Wiseman, A. K., Thurlow, K. E., Cornett, E. M., Topper, M. J., Baylin, S. B., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk4423 · Cited by 44

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas

Wu, J., Castro, L. N. G., Battaglia, S., Farran, C. A. E., D’Antonio, J. P., Miller, T. E., Suvà, M. L., & Bernstein, B. (2024) · Nature Cancer · doi:10.1038/s43018-024-00865-3 · Cited by 48

Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications

Ma, C., Cheng, J., Gu, J. H., & Wang, Q. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00373-5 · Cited by 56

Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L., Snyder, A., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.chromepi15-b32 · Cited by 1

Abstract 4019: Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy

Chiappinelli, K. B., Stone, M. L., Topper, M. J., Murphy, L. M., Strissel, P. L., Strick, R., Zahnow, C. A., & Baylin, S. B. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-4019

Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Strick, R., Strissel, P. L., Baylin, S. B., & Chiappinelli, K. B. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1122160 · Cited by 37

Immunomodulation of ovarian cancer by DNMTi and expression of endogenous retroviruses

Natoli, M. (2019) · doi:10.25560/89688

A New Molecular Mechanism Underlying the Antitumor Effect of DNA Methylation Inhibitors via an Antiviral Immune Response

Saito, Y., Nakaoka, T., & Saito, H. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.08.005 · Cited by 5