Cited by 298Gut microbiota and healthImmune Response and InflammationT-cell and B-cell Immunology

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

Open access
Vatanen, Tommi, Kostic, Aleksandar D., d’Hennezel, Eva, Siljander, Heli, Franzosa, Eric A., Yassour, Moran, Kolde, Raivo, Vlamakis, Hera +17 more·2016·Cell

Integrity signals

Registry

Crossref · 10.1016/j.cell.2016.05.056

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  • LPS toxicity varies depending on lipid A composition, and this depends on bacterial species, strain and environmental conditions.

    “LPS toxicity varies depending on lipid A composition, and this depends on bacterial species, strain and environmental conditions [3–5].”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]

  • E. coli LPS induces a strong inflammatory response via MD2/TLR4, whereas B. dorei LPS does not, and B. dorei LPS can inhibit the inflammatory response to E. coli LPS.

    “E. coli LPS induces a strong inflammatory response via MD2/TLR4, whereas B. dorei LPS does not [5]. Moreover, because B. dorei LPS binds but does not activate the MD2/TLR4 receptor complex, it can inhibit the inflammatory response to E. coli LPS [5].”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]

  • Some LPS species are MD2/TLR4 antagonists and anti-inflammatory as a result of binding but not activating MD2 and/or TLR4.

    “Thus, some LPS species are MD2/TLR4 antagonists, and hence anti-inflammatory, as a result of binding but not activating MD2 and/or TLR4 [5].”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [5]

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Authors
Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., Peet, A., Tillmann, V., Uibo, R., Mokurov, S., Dorshakova, N., Ilonen, J., Virtanen, S. M., Szabo, S. J., Porter, J. A., Lähdesmäki, H., Huttenhower, C., Gevers, D., Cullen, T. W., Knip, M., & Xavier, R. J.
Corresponding author
Xavier, Ramnik J.
Venue
Cell
Publisher
Elsevier BV
Published
2016-06
Volume
165
Issue
6
Pages
1551
ISSN
0092-8674 (ISSN-L)
OpenAlex
W4239130026
Cited by
298
References
0
Citations by year
2026: 11 · 2025: 18 · 2024: 22 · 2023: 35 · 2022: 45 · 2021: 41 · 2020: 29 · 2019: 42 · 2018: 20 · 2017: 30 · 2016: 5
FWCI
13.81
Type
journal article
Language
en
Open access
Locations
Cell (publishedVersion)
Funders
Novo Nordisk Fonden (NNF11OC1014751)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
gut microbiota, lipopolysaccharide, immunogenicity, autoimmunity, type 1 diabetes, Bacteroides, immune tolerance, children

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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