Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making
Open accessAbstract
Effective evaluation of costs and benefits is a core survival capacity that in humans is considered as optimal, "rational" decision-making. This capacity is vulnerable in neuropsychiatric disorders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur. We report that chronic stress exposure in rodents produces abnormal evaluation of costs and benefits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sharply increased. Concomitantly, alterations in the task-related spike activity of medial prefrontal neurons correspond with increased activity of their striosome-predominant striatal projection neuron targets and with decreased and delayed striatal fast-firing interneuron activity. These effects of chronic stress on prefronto-striatal circuit dynamics could be blocked or be mimicked by selective optogenetic manipulation of these circuits. We suggest that altered excitation-inhibition dynamics of striosome-based circuit function could be an underlying mechanism by which chronic stress contributes to disorders characterized by aberrant decision-making under conflict. VIDEO ABSTRACT.
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- Authors
- Friedman, A., Homma, D., Bloem, B., Gibb, L. G., Amemori, K.-I., Hu, D., Delcasso, S., Truong, T. F., Yang, J., Hood, A. S., Mikofalvy, K. A., Beck, D. W., Nguyen, N., Nelson, E. D., Toro Arana, S. E., Vorder Bruegge, R. H., Goosens, K. A., & Graybiel, A. M.
- Affiliations
- McGovern Institute for Brain Research (US)
- Corresponding author
- Graybiel, Ann M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 171
- Issue
- 5
- Pages
- 1191-1205.e28
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5734095
- OpenAlex
- W2768620954
- Cited by
- 162
- References
- 46
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 17 · 2023: 14 · 2022: 21 · 2021: 24 · 2020: 23 · 2019: 16 · 2018: 9 · 2017: 2
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- NIH/NIMH (MH060379)
- CHDI Foundation (A-5552)
- Defense Advanced Research Projects Agency
- U.S. Army Research Office (W911NF-10-1-0059)
- Bachmann-Strauss Dystonia & Parkinson Foundation
- William N. & Bernice E. Bumpus Foundation (2013.1)
- Saks Kavanaugh Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chronic stress, decision-making, striosomes, medial prefrontal cortex, striatal interneurons, excitation-inhibition balance, cost-benefit analysis, optogenetics, high-risk behaviors, neuropsychiatric disorders
- MeSH terms
- Animals, Basal Ganglia, Decision Making, Interneurons, Male, Mice, Inbred C57BL, Neural Pathways, Stress, Physiological, Prefrontal Cortex, Rats, Long-Evans, Mice, Rats, Optogenetics
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