Cited by 159Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Disconnection and reconnection: The morphological basis of (mal)adaptation to stress

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Sousa, Nuno, Almeida, Osborne F.X.·2012·Trends in Neurosciences

Abstract

Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both humans and animal models has begun to identify morphological correlates of these functional changes. These include dendritic and synaptic reorganization, glial remodeling, and altered cell fate in cortical and subcortical structures. The emerging view is that stress induces a 'disconnection syndrome' whereby the transmission and integration of information that are critical for orchestrating appropriate physiological and behavioral responses are perturbed. High-resolution spatiotemporal mapping of the complete neural circuitry and identification of the cellular processes impacted by stress will help to advance discovery of strategies to reduce or reverse the burden of stress-related neuropsychiatric disorders.

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Crossref · 10.1016/j.tins.2012.08.006

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  • The effect of stress on neuronal morphology and functions varies across brain regions.

    “In recent years, it has become increasingly clear that the effect of stress on neuronal morphology and functions varies across brain regions (53–56).”

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Authors
Sousa, N., & Almeida, O. F. X.
Affiliations
  • University of Minho (PT)
  • Max Planck Institute of Psychiatry (DE)
Corresponding author
Sousa, Nuno
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2012-12
Volume
35
Issue
12
Pages
742-751
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2102486166
Cited by
159
References
118
Citations by year
2026: 8 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 17 · 2020: 12 · 2019: 18 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 12 · 2014: 13 · 2013: 8
FWCI
0.69
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders
  • European Commission (238665, 259772)
  • Deutscher Akademischer Austauschdienst
  • National Science Council
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
stress, maladaptive stress response, dendritic reorganization, synaptic remodeling, cell fate, disconnection syndrome, neural circuits, stress-related neuropsychiatric disorders, cognitive impairment
MeSH terms
Adaptation, Physiological, Animals, Mental Disorders, Brain, Humans, Stress, Physiological, Stress, Psychological

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