Disconnection and reconnection: The morphological basis of (mal)adaptation to stress
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Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both humans and animal models has begun to identify morphological correlates of these functional changes. These include dendritic and synaptic reorganization, glial remodeling, and altered cell fate in cortical and subcortical structures. The emerging view is that stress induces a 'disconnection syndrome' whereby the transmission and integration of information that are critical for orchestrating appropriate physiological and behavioral responses are perturbed. High-resolution spatiotemporal mapping of the complete neural circuitry and identification of the cellular processes impacted by stress will help to advance discovery of strategies to reduce or reverse the burden of stress-related neuropsychiatric disorders.
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The effect of stress on neuronal morphology and functions varies across brain regions.
“In recent years, it has become increasingly clear that the effect of stress on neuronal morphology and functions varies across brain regions (53–56).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [53]
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Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541 · see citing works
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533 · see citing works
A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967 · see citing works
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402 · see citing works
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,287 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
Bechara, A., Tranel, D., & Damásio, H. (2000) · Brain · doi:10.1093/brain/123.11.2189 · Cited by 1,919 · see citing works
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521 · see citing works
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393 · see citing works
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
Why stress is bad for your brain
Sapolsky, R. M. (1996) · Science · doi:10.1126/science.273.5276.749 · Cited by 1,306 · see citing works
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works
Stress- and Allostasis-Induced Brain Plasticity
McEwen, B. S., & Gianaros, P. J. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100430 · Cited by 1,171 · see citing works
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068 · see citing works
Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
Jones, M. W., & Wilson, M. A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030402 · Cited by 1,036 · see citing works
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926 · see citing works
Benchenane, K., Peyrache, A., Khamassi, M., Tierney, P. L., Gioanni, Y., Battaglia, F. P., & Wiener, S. I. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.013 · Cited by 872 · see citing works
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858 · see citing works
Self-citationStarkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90079-f · Cited by 840 · see citing works
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 835 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 801 · see citing works
Karst, H., Berger, S., Turiault, M., Tronche, F., Schütz, G., & Joëls, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507572102 · Cited by 774 · see citing works
Radley, J. J., Sisti, H. M., Hao, J., Rocher, A. B., McCall, T., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.006 · Cited by 769 · see citing works
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760 · see citing works
Sousa, N., Lukoyanov, N. V., Madeira, M. D., Almeida, O. F. X., & Paula-Barbosa, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00050-6 · Cited by 758 · see citing works
Self-citationChronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.002 · Cited by 729 · see citing works
Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
Mitra, R., Jadhav, S., McEwen, B. S., Vyas, A., & Chattarji, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504011102 · Cited by 663 · see citing works
Aimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663 · see citing works
Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657 · see citing works
Stress prompts habit behavior in humans
Schwabe, L., & Wolf, O. T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0979-09.2009 · Cited by 606 · see citing works
The prefrontal cortex as a key target of the maladaptive response to stress
Cerqueira, J. J., Mailliet, F., Almeida, O. F. X., Jay, T. M., & Sousa, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4372-06.2007 · Cited by 599 · see citing works
Self-citationBessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · see citing works
Self-citationWellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594 · see citing works
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
Sahay, A., Wilson, D. A., & Hen, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.012 · Cited by 514 · see citing works
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
北村, 貴., Saitoh, Y., Takashima, N., Murayama, A., Niibori, Y., Ageta, H., Sekiguchi, M., Sugiyama, H., & Inokuchi, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.020 · Cited by 489 · see citing works
Ottersen, O. P. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902050104 · Cited by 474 · see citing works
Antidepressants recruit new neurons to improve stress response regulation
Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471 · see citing works
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2009 · Cited by 469 · see citing works
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458 · see citing works
Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease
Starkman, M. N., Giordani, B., Gebarski, S. S., Berent, S., Schork, M. A., & Schteingart, D. E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00203-6 · Cited by 455 · see citing works
Motivational influences on cognitive control: Behavior, brain activation, and individual differences
Locke, H., & Braver, T. S. (2008) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.8.1.99 · Cited by 450 · see citing works
Sapolsky, R. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01228.1985 · Cited by 403 · see citing works
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works
Corticosteroid hormones in the central stress response: Quick-and-slow
de Kloet, E. R., Karst, H., & Joëls, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.002 · Cited by 391 · see citing works
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Mizoguchi, K., Ishige, A., Aburada, M., & Tabira, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00105-2 · Cited by 369 · see citing works
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr, M., Valentine, G. W., Li, X., Gourley, S. L., Taylor, J. R., & Duman, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.006 · Cited by 341 · see citing works
Mild, Short-term Stress Alters Dendritic Morphology in Rat Medial Prefrontal Cortex
Brown, S. M., Henning, S., & Wellman, C. L. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi048 · Cited by 335 · see citing works
Goldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works
Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus
Stein-Behrens, B., Mattson, M., Chang, I., Yeh, M., & Sapolsky, R. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05373.1994 · Cited by 327 · see citing works
Dissociation of mechanisms underlying syllogistic reasoning
Goel, V., Buchel, C., Frith, C., & Dolan, R. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0636 · Cited by 325 · see citing works
RADLEY, J., ROCHER, A., JANSSEN, W., HOF, P., MCEWEN, B., & MORRISON, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.008 · Cited by 323 · see citing works
Sullivan, R. M., & Gratton, A. P. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00038-5 · Cited by 321 · see citing works
Maroun, M., & Richter-Levin, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04406.2003 · Cited by 293 · see citing works
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289 · see citing works
DAVIS, M., Walker, D. L., & LEE, Y. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48289.x · Cited by 280 · see citing works
Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders
Pacák, K. (2001) · Endocrine Reviews · doi:10.1210/er.22.4.502 · Cited by 280 · see citing works
Frodl, T., Jäger, M., Smajstrlova, I., Born, C., Bottlender, R., Palladino, T., Reiser, M., Möller, H.-J., & Meisenzahl, E. M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0840 · Cited by 279 · see citing works
Molecular and Cellular Approaches to Memory Allocation in Neural Circuits
Silva, A. J., Zhou, Y., Rogerson, T., Shobe, J. L., & Balaji, J. (2009) · Science · doi:10.1126/science.1174519 · Cited by 266 · see citing works
Sotiropoulos, I., Catania, C., Pinto, L., Silva, R., Pollerberg, G. E., Takashima, A., Sousa, N. J., & Almeida, O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-11.2011 · Cited by 265 · see citing works
Self-citationManzanares, P. A. R., Isoardi, N. A., Carrer, H. F., & Molina, V. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-05.2005 · Cited by 262 · see citing works
Figueiredo, H. F., Bruestle, A., Bodie, B., Dolgas, C. M., & Herman, J. P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02932.x · Cited by 251 · see citing works
Stress-Induced Dendritic Remodeling in the Prefrontal Cortex is Circuit Specific
Shansky, R. M., Hamo, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp003 · Cited by 248 · see citing works
Differential involvement of left prefrontal cortexin inductive and deductive reasoning
Goel, V. (2004) · Cognition · doi:10.1016/j.cognition.2004.03.001 · Cited by 247 · see citing works
Corticosteroids Operate as a Switch between Memory Systems
Schwabe, L., Schächinger, H., de Kloet, E. R., & Oitzl, M. S. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21278 · Cited by 217 · see citing works
Crochemore, C., Lu, J., Wu, Y., Liposits, Z., Sousa, N., Holsboer, F., & Almeida, O. F. X. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001679 · Cited by 210 · see citing works
Self-citationExperience Dictates Stem Cell Fate in the Adult Hippocampus
Dranovsky, A., Picchini, A. M., Moadel, T., Sisti, A. C., Yamada, A., Kimura, S., Leonardo, E. D., & Hen, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.022 · Cited by 207 · see citing works
French, S. J., & Totterdell, S. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10191 · Cited by 202 · see citing works
Hippocampal volume reduction and HPA-system activity in major depression
Colla, M., Kronenberg, G., Deuschle, M., Meichel, K., Hagen, T., Bohrer, M., & Heuser, I. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.06.011 · Cited by 200 · see citing works
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
Krugers, H. J., Hoogenraad, C. C., & Groc, L. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2913 · Cited by 197 · see citing works
Make mild moments memorable: add a little arousal
McGaugh, J. L. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.06.001 · Cited by 196 · see citing works
Visuospatial processing and the right-hemisphere interpreter
Corballis, P. M. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00103-9 · Cited by 193 · see citing works
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · see citing works
Interactive Effects of Stress and Aging on Structural Plasticity in the Prefrontal Cortex
Bloss, E. B., Janssen, W. G. M., McEwen, B. S., & Morrison, J. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0759-10.2010 · Cited by 185 · see citing works
Stress-induced changes in human decision-making are reversible
Soares, J. M., Sampaio, A., Ferreira, L. M., Santos, N. C., Marques, F., Palha, J. A., Cerqueira, J. J., & Sousa, N. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.59 · Cited by 183 · see citing works
Self-citationFrench, S. J., & Totterdell, S. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00150-7 · Cited by 180 · see citing works
Cerqueira, J., Taipa, R. J. F., Uylings, H. B. M., Almeida, O. F. X., & Sousa, N. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl108 · Cited by 171 · see citing works
Self-citationGlucocorticoids act on glutamatergic pathways to affect memory processes
Sandi, C. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.01.006 · Cited by 162 · see citing works
Sapolsky, R. M., Meaney, M. J., & McEwen, B. S. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90261-5 · Cited by 158 · see citing works
Dissociation of the morphological correlates of stress‐induced anxiety and fear
Pêgo, J. M., Morgado, P. F., Pinto, L., Cerqueira, J., Almeida, O. F. X., & Sousa, N. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06112.x · Cited by 146 · see citing works
Self-citationNMDA Receptor Blockade Alters Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex
Martin, K. P., & Wellman, C. L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr021 · Cited by 138 · see citing works
The Neurobiology of Anxiety Disorders: Brain Imaging, Genetics, and Psychoneuroendocrinology
Martin, E. I., Ressler, K. J., Binder, E. B., & Nemeroff, C. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.05.004 · Cited by 132 · see citing works
Maggio, N., & Segal, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1901-09.2009 · Cited by 119 · see citing works
Landfield, P. W., Thibault, O., Mazzanti, M. L., Porter, N. M., & Kerr, D. S. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230914 · Cited by 118 · see citing works
Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction
Wilber, A. A., Walker, A. G., Southwood, C. J., Farrell, M. R., Lin, G. L., Rebec, G. V., & Wellman, C. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.070 · Cited by 115 · see citing works
Endocrine disturbances in depression
Tichomirowa, M. A., Keck, M. E., Schneider, H. J., Páez-Pereda, M., Renner, U., Holsboer, F., & Stalla, G. K. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345535 · Cited by 111 · see citing works
Cerqueira, J., Catania, C., Sotiropoulos, I., Schubert, M. I., Kalisch, R., Almeida, O. F. X., Auer, D. P., & Sousa, N. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.01.003 · Cited by 106 · see citing works
Self-citationEffects of stress and corticosterone on activity and plasticity in the amygdala
Kavushansky, A., & Richter‐Levin, G. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21058 · Cited by 106 · see citing works
Sousa, N., Almeida, O. F. X., Holsboer, F., Paula-Barbosa, M. M., & Madeira, M. D. (1998) · Stress · doi:10.3109/10253899809167288 · Cited by 105 · see citing works
Self-citationSpecific impairments of rule induction in different frontal lobe subgroups
Reverberi, C., Lavaroni, A., Gigli, G. L., Škrap, M., & Shallice, T. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.06.008 · Cited by 104 · see citing works
Glutamate Spillover Promotes the Generation of NMDA Spikes
Chalifoux, J. R., & Carter, A. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2777-11.2011 · Cited by 103 · see citing works
Patel, P. D., Katz, M., Karssen, A. M., & Lyons, D. M. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.003 · Cited by 102 · see citing works
van Eekelen, J. A. M., Bohn, M. C., & de Kloet, E. R. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90111-u · Cited by 101 · see citing works
MacLullich, A. M. J., Ferguson, K. J., Wardlaw, J. M., Starr, J. M., Deary, I. J., & Seckl, J. R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2610 · Cited by 100 · see citing works
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Behl, C., Trapp, T., Skutella, T., & Holsboer, F. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01442.x · Cited by 98 · see citing works
Bhatnagar, S., VINING, C., & DENSKI, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.050 · Cited by 93 · see citing works
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Holsboer, F., Bender, W., Benkert, O., Klein, H. E., & Schmauss, M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92755-5 · Cited by 90 · see citing works
Perez‐Cruz, C., Keuker, J. I. H., Heilbronner, U., Fuchs, E., & Flügge, G. (2007) · Neural Plasticity · doi:10.1155/2007/46276 · Cited by 90 · see citing works
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Scheurich, A., Fellgiebel, A., Schermuly, I., Bauer, S., Wölfges, R., & Müller, M. J. (2007) · Psychological Medicine · doi:10.1017/s0033291707002206 · Cited by 76 · see citing works
Lu, J., Goula, D., Sousa, N., & Almeida, O. F. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00421-4 · Cited by 71 · see citing works
Self-citationRiedemann, T., Patchev, A. V., Cho, K., & Almeida, O. F. X. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-2 · Cited by 62 · see citing works
Self-citationPerez‐Cruz, C., Simon, M., Czéh, B., Flügge, G., & Fuchs, E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06622.x · Cited by 51 · see citing works
Glucocorticoid Regulation of Astrocytic Fate and Function
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Self-citation[3H]Dexamethasone binding in the limbic brain of the fetal rat
Meaney, M. J., Sapolsky, R. M., Aitken, D. H., & McEwen, B. S. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90054-9 · Cited by 36 · see citing works
Lee, Y. A., Poirier, P., Otani, S., & Goto, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.039 · Cited by 30 · see citing works
Nuclear and cytosolic androgen receptor levels in the limbic brain of neonatal male and female rats.
Meaney, M. J., Aitken, D. H., Jensen, L. K., Mcginnis, M. Y., & Mcewen, B. S. (1985) · Brain Research · doi:10.1016/0165-3806(85)90039-2 · Cited by 28 · see citing works
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Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
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Friedman, A., Homma, D., Bloem, B., Gibb, L. G., Amemori, K.-I., Hu, D., Delcasso, S., Truong, T. F., Yang, J., Hood, A. S., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.017 · Cited by 162 · see citing works
Lebares, C. C., Guvva, E. V., Olaru, M., Sugrue, L. P., Staffaroni, A. M., Delucchi, K. L., Kramer, J. H., Ascher, N. L., & Harris, H. W. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.4108 · Cited by 131 · see citing works
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Fine, R., Zhang, J., & Stevens, H. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.35 · Cited by 96 · see citing works
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The Role of Stress in Obsessive-Compulsive Disorder: A Narrative Review
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Wang, J., Huang, C., Luo, G., Xiao, Y., Guo, G., Quan, D., & Zheng, H. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.03.006 · Cited by 8 · see citing works
- Authors
- Sousa, N., & Almeida, O. F. X.
- Affiliations
- University of Minho (PT)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Sousa, Nuno
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 35
- Issue
- 12
- Pages
- 742-751
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2102486166
- Cited by
- 159
- References
- 118
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 17 · 2020: 12 · 2019: 18 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 12 · 2014: 13 · 2013: 8
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission (238665, 259772)
- Deutscher Akademischer Austauschdienst
- National Science Council
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, maladaptive stress response, dendritic reorganization, synaptic remodeling, cell fate, disconnection syndrome, neural circuits, stress-related neuropsychiatric disorders, cognitive impairment
- MeSH terms
- Adaptation, Physiological, Animals, Mental Disorders, Brain, Humans, Stress, Physiological, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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