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The transcription factor Bcl11a is essential for B-1a cell maintenance during aging

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The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4

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Transcriptional interferences ensure one olfactory receptor per ant neuron

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Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants

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Role of gene therapy in sickle cell disease

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Chromatin Profiling in Mouse Embryonic Germ Cells by CUT&RUN

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CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

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Therapeutic promise of CRISPR-Cas9 gene editing in sickle cell disease and β-thalassemia: A current review

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Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A

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Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic Targets

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Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis

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A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing

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Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

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Disease-Modifying Effect of HBS1L-MYB in HbE/β-Thalassemia Patients in Bangladeshi Population

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Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers

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High level of fetal-globin reactivation by designed transcriptional activator-like effector

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Differential Grainy head binding correlates with variation in chromatin structure and gene expression in Drosophila melanogaster

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Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition

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TR4 and BCL11A repress γ-globin transcription via independent mechanisms

Wang, Y., Myers, G., Yu, L., Deng, K., Balbin-Cuesta, G., Singh, S. A., Guan, Y., Khoriaty, R. N., & Engel, J. D. (2024) · Blood · doi:10.1182/blood.2024024599 · Cited by 5

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cellsPreprint

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ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expressionPreprint

Lan, X., Ren, R., Feng, R., Ly, L. C., Lan, Y., Zhang, Z., Aboreden, N. G., Qin, K., Horton, J. R., Grevet, J. D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.274324 · Cited by 4

Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent MiscarriagePreprint

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The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma

Chen, Y.-J. C., Bhaskara, G. B., Lu, Y., Lin, K., & Dent, S. Y. R. (2024) · Genes & Development · doi:10.1101/gad.351789.124 · Cited by 4

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathiesPreprint

Liu, J., Shen, Z., Park, S., Dong, Y., Yu, N., Zeng, J., Lee, H., Pate, B., Adamia, S., Vanuytsel, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676148 · Cited by 4

Quantification of human embryonic ζ-globin chains in Southeast Asian deletion (--SEA) carriers

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Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis)

Ibañez, V., Vaitkus, K., Ruiz, M. A., Lei, Z., Maienschein‐Cline, M., Arbieva, Z. H., & Lavelle, D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289860 · Cited by 4

The role of miR-129-5p in regulating γ-globin expression and erythropoiesis in β-thalassemia

li, J., Chen, M., Zhao, W., Lv, A., Lin, S., Zheng, Y., Cai, M., Lin, N., Xu, L., & Huang, H. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae180 · Cited by 3

Applications of genome editing technologies in the treatment of human diseases

Alshorman, J., Mehran, M. J., Tembo, K. M., Mostafavi, N., Bolideei, M., & Wang, Y. L. (2026) · Gene Therapy · doi:10.1038/s41434-026-00627-z · Cited by 3

miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation

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Beyond transfusions and transplants: genomic innovations rewriting the narrative of thalassemia

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ERH elicits cell lineage restriction in mammalian preimplantation development and differentiation from pluripotency via H3K9me3-heterochromatin

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Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation

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Targeting ZNF410 as a potential β-hemoglobinopathy therapy

Tumburu, L., & Thein, S. L. (2021) · Nature Genetics · doi:10.1038/s41588-021-00817-y · Cited by 3

ChromDL: a next-generation regulatory DNA classifier

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Activity of the pleiotropic drug resistance transcription factors Pdr1p and Pdr3p is modulated by binding site flanking sequences

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Regulation of N 6 ‐methyladenosine modification in erythropoiesis and thalassemia

Zheng, Y., Lin, S., Chen, M., Xu, L., & Huang, H. (2024) · Clinical Genetics · doi:10.1111/cge.14518 · Cited by 3

High-Efficiency Genomic Mapping of Chromatin-Associated Targets with CUT&RUN

Firestone, T. M., Venters, B. J., Novitzky, K., Albertorio-Sáez, L. M., Barnes, C. A., Fedder-Semmes, K. N., Hall, N. W., Hickman, A. R., Kaderli, M., Lin, C. P., et al. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5072-1_5 · Cited by 4

Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders

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A common TBP-binding site mutation elevates fetal hemoglobin levels by competitive globin switching change in β-thalassemia

Song, M., Wei, X., Luo, H., Wang, J., Ye, Y., Qin, L., Niu, C., Long, Y., Wang, X., Shao, C., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024013695 · Cited by 3

Sequential transcriptional programs underpin activation of hippocampal stem cells

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BCL11A-Related Intellectual Disability

Peron, A., Bradbury, K., Viskochil, D. H., & Dias, C. (2019) · Florence Research (University of Florence) · Cited by 3

Transcription factor Kruppel-like factor 5 positively regulates the expression of AarF domain containing kinase 4

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Comparison of transcriptome profiles of nucleated red blood cells in cord blood between preterm and full-term neonates

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A ChIP-exo screen of 887 PCRP transcription factor antibodies in human cellsPreprint

Lai, W. K. M., Mariani, L., Rothschild, G., Smith, E. R., Venters, B. J., Blanda, T. R., Kuntala, P. K., Bocklund, K., Mairose, J., Dweikat, S. N., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.08.140046 · Cited by 3

PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemiaPreprint

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High-efficiency HDR in immortalized cell lines by crude rAAV mediated donor template deliveryPreprint

Mehta, S., Buyanbat, A., Zheng, G., Liu, N., & Orkin, S. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.02.490359 · Cited by 3

Exhaustive identification of genome-wide binding events of transcriptional regulators with ICEBERGPreprint

Nordin, A., Pagella, P., Zambanini, G., & Cantù, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.29.547050 · Cited by 3

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance mattersPreprint

Felder, A.-K., Tjalsma, S. J. D., Verhagen, H. J. M. P., Majied, R., Verstegen, M. J. A. M., Verheul, T. C. J., Mohnani, R., Gremmen, R., Krijger, P. H. L., Philipsen, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.13.632719 · Cited by 3

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcomaPreprint

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Efficient Genome-Wide Chromatin Profiling by CUT&RUN with Low Numbers of Muscle Stem Cells

Ding, D., & Braun, T. W. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3036-5_28 · Cited by 2

The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase

Petrachkova, T., Солдаткина, О. И., Leduy, L., & Nepveu, A. (2024) · Biological Chemistry · doi:10.1515/hsz-2024-0088 · Cited by 2

Exploring Novel Strategies to Alleviate Symptoms of β-Globinopathies: Examining the Potential Role of Embryonic ε-globin Induction

Liu, J., Park, K., Shen, Z., Ye, Y., Lee, E., Herman, R. A., Zhu, X., Lu, W., Nuhfer, J., Bassal, M. A., et al. (2024) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2024.150861 · Cited by 2

A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression

Bao, X., Gao, Y., Chen, X., Wang, Z., Feng, X., Wang, L., Du, J., Ye, Y., Chen, F., Du, L., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00626-7 · Cited by 2

The induction effect of hydroxyurea and metformin on fetal globin in the K562 cell line

Eini, M., Safarpour, H., & Miri-Moghddam, E. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01184-8 · Cited by 1

Environmental PFOS and 6:2 Cl-PFESA Reshape Ferroptosis Vulnerability in Liver Cancer

Hong, J., Du, K., Wu, T., Wang, Z., Fang, J., Zhang, S., Zhang, W., Jiang, Y., Yu, H., Pan, T., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c16490 · Cited by 2

T cell development from expanded hematopoietic progenitors reveals initiation control by Lmo2 and Flt3L priming

Shin, B., Chang, S. J., MacNabb, B. W., Sidwell, T., Williams, B. A., & Rothenberg, E. V. (2026) · Science Immunology · doi:10.1126/sciimmunol.adw7765 · Cited by 2

BCL11A Polymorphism in Egyptian Children with β-Thalassemia: Relation to Phenotypic Heterogeneity

Salah, N. Y., Ali, H. G. A., Bassiouny, N., Salem, L. E. M. A., Taha, S., Youssef, M. K., Annaka, L., & Barakat, N. M. (2021) · Journal of Pediatric Genetics · doi:10.1055/s-0041-1728744 · Cited by 3

Gene therapies on the horizon for sickle cell disease: a clinician’s perspective

Butt, H., & Tisdale, J. F. (2024) · Expert Review of Hematology · doi:10.1080/17474086.2024.2386366 · Cited by 2

Identification of novel BCL11A variant in a patient with developmental delay and behavioural differences

Zha, J., Chen, Y., Cao, F., Zhong, J., Yu, X., & Wu, H. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10371 · Cited by 2

A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs

Conway, A. J., Rosanwo, T. O., Williamson, T. E., Landry, S. B., Kinney, M. A., Clark, M. A., Vo, L. T., Rowe, R. G., Marion, W., Zhang, Y., et al. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.105264 · Cited by 2

Recent advances of CRISPR/Cas9 gene editing in the treatment of β-thalassemia

Xie, Q., Lei, S.-Y., Qu, C., Wu, H., Liu, Y., Huang, P., & Teng, S. (2022) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2022-0109 · Cited by 2

The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment

Ebrahimi, V., & Hashemi, A. (2021) · Trends in Peptide and Protein Sciences · doi:10.22037/tpps.v6i.34202 · Cited by 2

The Novel Role of the B-Cell Lymphoma/Leukemia 11A (BCL11A) Gene in β-Thalassaemia Treatment

Lai, M. I., & Ahmed, N. H. M. (2022) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x23666230123140926 · Cited by 3

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancerPreprint

Chen, Z., Arai, E., Khan, O., Zhang, Z., Ngiow, S. F., He, Y. M., Huang, H., Manne, S., Cao, Z., Baxter, A. E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.20.087379 · Cited by 2

ZNF410 represses fetal globin by devoted control of CHD4/NuRDPreprint

Vinjamur, D. S., Yao, Q., Cole, M. A., McGuckin, C., Ren, C., Zeng, J., Hossain, M., Luk, K., Wolfe, S. A., Pinello, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.272856 · Cited by 2

Novel lentiviral vectors for gene therapy of sickle cell disease combining gene addition and gene silencing strategiesPreprint

Brusson, M., Chalumeau, A., Martinucci, P., Romano, O., Poletti, V., Scaramuzza, S., Ramadier, S., Masson, C., Ferrari, G., Mavilio, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.31.522279 · Cited by 2

Targeting RUNX1 in Macrophages Facilitates Cardiac RecoveryPreprint

Amrute, J., Zhu, A., Pai, Y.-L., Hector-Greene, M., An, Y., Kim, K. R., Sheth, M. U., Padmanabhan, A., Lee, C. Y., Yamawaki, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.25.665779 · Cited by 4

RNA-seq analysis reveals candidate genes associated with proliferation, invasion, and migration in BCL11A knockdown B-NHL cell lines

Yin, J., Xie, X., Quan, Y., Wang, Z., Liu, S., Su, Q., Che, F., & Wang, L. (2023) · Annals of Hematology · doi:10.1007/s00277-023-05247-w · Cited by 1

Connecting the dots from let-7 to HIC2 to HBG

Dean, A. (2024) · Blood · doi:10.1182/blood.2024024191 · Cited by 1

Transcriptional regulators of fetal hemoglobin

dos Santos, G. P., Rabi, L. T., Bezerra, A. A., da Cunha, M. R., Iatecola, A., & Fernandes, V. A. R. (2024) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2024.06.001 · Cited by 1

Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis

Belmokhtar, I., Belmokhtar, K. Y., Lhousni, S., Charif, M., Sidqi, Z., Seddik, R., Choukri, M. A., Bellaoui, M., & Boulouiz, R. (2024) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2024.110840 · Cited by 1

Une approche CRISPR/Cas pour traiter les β-hémoglobinopathies

Brusson, M., & Miccio, A. (2025) · médecine/sciences · doi:10.1051/medsci/2024191 · Cited by 2

In vivo deletion of a GWAS-identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in β-thalassemia

Deleuze, V., Stephen, T., Salma, M., Orfeo, C., Jorna, R., Maas, A., Barroca, V., Arcangeli, M.-L., Lecellier, C., Andrieu‐Soler, C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-94222-8 · Cited by 2

Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites

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BCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy

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Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications

Jang, Y., Eom, Y. J., Gwak, S.-H., Koh, Y., Han, J., Rim, Y. A., Nam, Y., & Ju, J. H. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04825-1 · Cited by 2

BCL11A-triggered IFI6 inhibition reduces glioma cell resistance to temozolomide by promoting ferroptosis

Xu, H., Lü, J., Wu, L., Wang, H., Guo, Q., & Zhang, H. (2025) · Neurological Research · doi:10.1080/01616412.2025.2592118 · Cited by 1

HbF-inducing gene therapies for the β-hemoglobinopathies: implications for future pregnancies

Gavillet, M., Legardeur, H., Adam, C. J. M., Renella, R., Dashraath, P., & Baud, D. (2026) · Blood Red Cells & Iron · doi:10.1016/j.brci.2026.100047 · Cited by 2

DNA methylation matters: methylation of the γ-globin ( HBG ) gene promoters is required for postnatal silencing of HbF

Ginder, G. D., Shang, S., & Williams, D. C. (2026) · Blood · doi:10.1182/blood.2025031153 · Cited by 1

miRNA-Mediated Regulation of γ-Globin to β-Globin Switching: Therapeutic Potential in β-Hemoglobinopathies

Alotaibi, D., Aldagdog, F., Alramadhan, S. I., Almuhaidib, B., Asiri, N., Almodhi, L., Alshabaan, M., Alborhan, R., Vatte, C., Mohiuddin, S. S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031203 · Cited by 2

Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymorphisms Identified by GWAS, and Advances in γ-Globin Editing: An Updated Overview

Márquez-Benitez, Y., Osorio-Garzón, V. I., Bernal, J. E., & Briceño, I. (2026) · Genes · doi:10.3390/genes17020135 · Cited by 1

Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

Mao, X., Tokamov, S. A., Pahmeier, F., Lari, A., Xu, J., Harris, E., & Glaunsinger, B. A. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117028 · Cited by 1

CRISPR in Thalassemia: Global Research Trend Analysis

Saboor, M., Alblooshi, M. J., Alkaabi, A. A., Soozaei, F. R., & Alketbi, M. H. (2026) · Hemoglobin · doi:10.1080/03630269.2026.2634815 · Cited by 1

Circ_0001428 regulates erythropoiesis and γ-globin expression via activating the ATF4-BCL11A axis in β-thalassemia

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A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

Arcanjo, G. D. S., Silva, A. P., Diniz, M. V., Domingos, I. F., Pereira-Martins, D. A., Araújo, A. B., França, T. S. S., Anjos, A. C., Araújo, A. D. S., Belini-Junior, E., et al. (2026) · British Journal of Haematology · doi:10.1111/bjh.70489 · Cited by 1

New Gene Therapy Strategy for β-Thalassemia

Liang, D., Schmidt‐Wolf, I. G. H., & Pu, J. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11132-6 · Cited by 1

Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy

Arji, S., Shen, Z., Welch, S., ElMahdaoui, F., Bahadur, A., Lee, E., Lee, H., Wu, S.-C. P., Konshina, E., Ayubali, B., et al. (2026) · Biomarker Research · doi:10.1186/s40364-026-00911-5 · Cited by 1

Thérapie génique pour la drépanocytose : avancées et obstacles

Cavazzana, M. (2023) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2023.06.015 · Cited by 1

Mechanistic and Biological Perspectives on Erythropoiesis

Bresnick, E. H., Papayannopoulou, T., & Migliaccio, A. R. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104286 · Cited by 1

Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia

Luo, H., Wang, J., Qin, L., Zhang, X., Liu, H., Niu, C., Song, M., Shao, C., Xu, P., Yu, M., et al. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.10.015 · Cited by 1

Hotspots and status of Fetal Alpha-Thalassemia from 2009 to 2023: a bibliometric analysis

Li, Q., Li, X., he, S. T., & Li, J. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1467760 · Cited by 1

Plasma metabolomic signatures for copy number variants and COVID-19 risk loci in Northern Finland populations

De, T., Coin, L., Herberg, J. A., Johnson, M. R., & Järvelin, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-94839-9 · Cited by 1

Pleiotropic Effects of Polymorphisms in the BCL11A Gene on Laboratory Parameters in Sickle Cell Anemia

Oliveira, A. M. D. J., Fiuza, L. M., Figueiredo, C. V. B., da Guarda, C. C., Santiago, R. P., Yahouédéhou, S. C. M. A., Carvalho, S. P., Pacheco, A. P., Lyra, I. M., Adôrno, E. V., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110458 · Cited by 1

A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells

Kim, J., & Dean, A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.023 · Cited by 1

Bcl11a and the Correlated Key Genes Ascribable to Globin Switching: An In-silico Study

Modarressi, M. H., Motlagh, F. M., Soleimanpour‐Lichaei, H. R., Emami, A., Kadkhoda, S., Shamsara, M., & Rasti, A. (2022) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x22666220617125731 · Cited by 1

The roles of the transcription factor B-cell CLL/Lymphoma 11A (BCL11A) in erythroid cells

Yang, L. (2022) · UNSWorks (University of New South Wales, Sydney, Australia) · doi:10.26190/unsworks/3412

New Strategies to Define Regulators of Fetal Hemoglobin

Orkin, S. H. (2010) · Blood · doi:10.1182/blood.v116.21.sci-17.sci-17 · Cited by 1

Identification Of BCL11A Structure-Function Domains For Fetal Hemoglobin Silencing

Xu, J., Bauer, D. E., Peng, C., Smith, E. C., & Orkin, S. H. (2013) · Blood · doi:10.1182/blood.v122.21.435.435 · Cited by 3

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.08.001 · Cited by 143

Control of Hemoglobin Switching by BCL11A.

Xu, J., Sankaran, V. G., Fujiwara, Y., & Orkin, S. H. (2009) · Blood · doi:10.1182/blood.v114.22.5.5 · Cited by 4