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Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Endapally, Shreya, Frias, Donna, Grzemska, Magdalena, Gay, Austin, Tomchick, Diana R., Radhakrishnan, Arun·2019·Cell
DOI 10.1016/j.cell.2018.12.042PMC PMC6428426
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  • Sphingomyelin is concentrated in the outer leaflet of the PM and traps cholesterol, preventing its movement to the ER.

    “Sphingomyelin is concentrated in the outer leaflet of the PM and it traps cholesterol, preventing its movement to the ER (7, 30).”

    From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [30]

    The Introduction says sphingomyelin sequesters some plasma-membrane cholesterol, preventing its transport to the ER; the Discussion likewise describes a sphingomyelin-sequestered pool. Our copy does not establish the claim that sphingomyelin is concentrated in the outer leaflet. No page numbers are available for these passages. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Sphingomyelin can effectively sequester cholesterol.

    “consistent with the ability of sphingomyelin to effectively sequester cholesterol (Endapally et al, 2019).”

    From Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b (2021) · cites this paper as Endapally et al, 2019

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Metadata

Authors
Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R., & Radhakrishnan, A.
Venue
Cell
Publisher
Elsevier BV
Published
2019-02
Volume
176
Issue
5
Pages
1040-1053.e17
ISSN
0092-8674
DOI
10.1016/j.cell.2018.12.042
PMC
PMC6428426
Cited by
168
References
0
Language
en
Licence
Funders
  • Welch Foundation (I-1793)
  • American Heart Association (12SDG12040267)
  • NIH (HL20948)

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