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TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
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“Mouse and zebrafish models have also demonstrated a role for Tet2 and Tet3 in neutrophil mobility, phagocytosis and granule formation 140 .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [140]
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REVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502
Differential analysis of gene regulation at transcript resolution with RNA-seq
Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“…regions in gene expression, we assessed the genome-wide distribution of H3K4me1 (monomethylated lysine 4 on the histone H3 N-terminal tail) by chromatin immunoprecipitation and sequencing (ChIP-seq), since this is a modification known to mark enhancers (Heintzman et al., 2007, 2009).”
BackgroundHistone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints
Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.949802 · Cited by 1,125
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W. T. C., Bauer, C., Münzel, M., Wagner, M., Müller, M., Khan, F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.004 · Cited by 973
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897 · cited 3×
“1566 Cell Reports 15, 1566–1579, May 17, 2016 a 2016 The Author(s This is an open access article under the CC BY-NC-ND license (http:// and chromatin regulators (Pastor et al., 2013), TET activity also directly controls the recruitment of proteins or complexes to methylated DNA.”
BackgroundInfluentialSelf-citation
Research works printed but not linked: 42
- Abdel-Wahab, 2009, Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies, Blood, 114, 144, 10.1182/blood-2009-03-210039 · DOI · Paper page
- Amati, 2001, Function of the c-Myc oncoprotein in chromatin remodeling and transcription, Biochim. Biophys. Acta, 1471, M135
- An, 2015, Acute loss of TET function results in aggressive myeloid cancer in mice, Nat. Commun., 6, 10071, 10.1038/ncomms10071 · DOI
- Barozzi, 2014, Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers, Mol. Cell, 54, 844, 10.1016/j.molcel.2014.04.006 · DOI · Paper page
- Boyle, 2004, GO:TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes, Bioinformatics, 20, 3710, 10.1093/bioinformatics/bth456 · DOI · Paper page
- Cashman, 1992, Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons, Dev. Dyn., 194, 209, 10.1002/aja.1001940306 · DOI
- Chen, 2013, TET2 promotes histone O-GlcNAcylation during gene transcription, Nature, 493, 561, 10.1038/nature11742 · DOI · Paper page
- De Vita, 2014, Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis, PLoS ONE, 9, e96209, 10.1371/journal.pone.0096209 · DOI
- Deho’, 2014, Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities, J. Immunol., 193, 2196, 10.4049/jimmunol.1400516 · DOI
- Deplus, 2013, TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS, EMBO J., 32, 645, 10.1038/emboj.2012.357 · DOI · Paper page
- Gallant, 2009, Myc’s secret life without Max, Cell Cycle, 8, 3848, 10.4161/cc.8.23.10088 · DOI
- Garber, 2012, A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals, Mol. Cell, 47, 810, 10.1016/j.molcel.2012.07.030 · DOI · Paper page
- Hahn, 2013, Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis, Cell Rep., 3, 291, 10.1016/j.celrep.2013.01.011 · DOI
- Heinz, 2010, Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities, Mol. Cell, 38, 576, 10.1016/j.molcel.2010.05.004 · DOI · Paper page
- Hon, 2014, 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation, Mol. Cell, 56, 286, 10.1016/j.molcel.2014.08.026 · DOI · Paper page
- Huang, 2014, Connections between TET proteins and aberrant DNA modification in cancer, Trends Genet., 30, 464, 10.1016/j.tig.2014.07.005 · DOI
- Huang, 2014, Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells, Proc. Natl. Acad. Sci. USA, 111, 1361, 10.1073/pnas.1322921111 · DOI
- Iwasaki, 2006, The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages, Genes Dev., 20, 3010, 10.1101/gad.1493506 · DOI · Paper page
- Ko, 2010, Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2, Nature, 468, 839, 10.1038/nature09586 · DOI · Paper page
- Ko, 2011, Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice, Proc. Natl. Acad. Sci. USA, 108, 14566, 10.1073/pnas.1112317108 · DOI · Paper page
- Ko, 2015, TET proteins and 5-methylcytosine oxidation in hematological cancers, Immunol. Rev., 263, 6, 10.1111/imr.12239 · DOI
- Langmead, 2012, Fast gapped-read alignment with Bowtie 2, Nat. Methods, 9, 357, 10.1038/nmeth.1923 · DOI · Paper page
- Leoni, 2015, Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis, Eur. J. Haematol., 95, 566, 10.1111/ejh.12537 · DOI
- Li, 2009, The Sequence Alignment/Map format and SAMtools, Bioinformatics, 25, 2078, 10.1093/bioinformatics/btp352 · DOI · Paper page
- Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
- Lu, 2014, Role of Tet proteins in enhancer activity and telomere elongation, Genes Dev., 28, 2103, 10.1101/gad.248005.114 · DOI
- Mayoral, 2010, Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors, Methods Mol. Biol., 667, 205, 10.1007/978-1-60761-811-9_14 · DOI
- Mayoral, 2011, MiR-221 influences effector functions and actin cytoskeleton in mast cells, PLoS ONE, 6, e26133, 10.1371/journal.pone.0026133 · DOI
- Ostuni, 2013, Latent enhancers activated by stimulation in differentiated cells, Cell, 152, 157, 10.1016/j.cell.2012.12.018 · DOI · Paper page
- Paul, 2015, Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors, Cell, 163, 1663, 10.1016/j.cell.2015.11.013 · DOI · Paper page
- Qi, 2013, Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates, Immunity, 39, 97, 10.1016/j.immuni.2013.06.012 · DOI
- Quinlan, 2010, BEDTools: a flexible suite of utilities for comparing genomic features, Bioinformatics, 26, 841, 10.1093/bioinformatics/btq033 · DOI · Paper page
- Rishi, 2010, CpG methylation of half-CRE sequences creates C/EBPalpha binding sites that activate some tissue-specific genes, Proc. Natl. Acad. Sci. USA, 107, 20311, 10.1073/pnas.1008688107 · DOI
- Rusca, 2012, MiR-146a and NF-κB1 regulate mast cell survival and T lymphocyte differentiation, Mol. Cell. Biol., 32, 4432, 10.1128/MCB.00824-12 · DOI
- Song, 2011, Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine, Nat. Biotechnol., 29, 68, 10.1038/nbt.1732 · DOI
- Soucie, 2012, In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells, Blood, 120, 4846, 10.1182/blood-2011-12-397588 · DOI
- Tahiliani, 2009, Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1, Science, 324, 930, 10.1126/science.1170116 · DOI · Paper page
- Trapnell, 2012, Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks, Nat. Protoc., 7, 562, 10.1038/nprot.2012.016 · DOI
- Tsai, 1991, Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor, Proc. Natl. Acad. Sci. USA, 88, 6382, 10.1073/pnas.88.14.6382 · DOI
- Wu, 2011, Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells, Nature, 473, 389, 10.1038/nature09934 · DOI · Paper page
- Yamanaka, 1997, Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice, Proc. Natl. Acad. Sci. USA, 94, 13187, 10.1073/pnas.94.24.13187 · DOI · Paper page
- Zhang, 2008, Model-based analysis of ChIP-Seq (MACS), Genome Biol., 9, R137, 10.1186/gb-2008-9-9-r137 · DOI · Paper page
Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Clonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
Dnmt3a restrains mast cell inflammatory responses
Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616420114 · Cited by 138
Decoding the role of TET family dioxygenases in lineage specification
Wu, X., Li, G., & Xie, R. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0228-7 · Cited by 43
Metadata
- Authors
- Montagner, S., Leoni, C., Emming, S., Della Chiara, G., Balestrieri, C., Barozzi, I., Piccolo, V., Togher, S., Ko, M., Rao, A., Natoli, G., & Monticelli, S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 15
- Issue
- 7
- Pages
- 1566-1579
- ISSN
- 2211-1247
- PMC
- PMC5584687
- Cited by
- 93
- References
- 17
- Language
- en
- Update notices
- erratum (2017-08-15)
- Licence
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (156875)
- Novartis Foundation
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- Montagner, S., Leoni, C., Emming, S., Della Chiara, G., Balestrieri, C., Barozzi, I., Piccolo, V., Togher, S., Ko, M., Rao, A., Natoli, G., & Monticelli, S. (2016). TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Reports. https://doi.org/10.1016/j.celrep.2016.04.044