Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 610

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

Open access
Farshidfar, Farshad, Zheng, Siyuan, Gingras, Marie-Claude, Newton, Yulia, Shih, Juliann, Robertson, A. Gordon, Hinoue, Toshinori, Hoadley, Katherine A., Gibb, Ewan A., Roszik, Jason, Covington, Kyle R., Wu, Chia-Chin, Shinbrot, Eve, Stransky, Nicolas, Hegde, Apurva, Yang, Ju Dong, Reznik, Ed, Sadeghi, Sara, Pedamallu, Chandra Sekhar, Ojesina, Akinyemi I., Hess, Julian M., Auman, J. Todd, Rhie, Suhn K., Bowlby, Reanne, Borad, Mitesh J., Akbani, Rehan, Allotey, Loretta K., Ally, Adrian, Alvaro, Domenico, Andersen, Jesper B., Appelbaum, Elizabeth L., Arora, Arshi, Auman, J. Todd, Balasundaram, Miruna, Balu, Saianand, Bardeesy, Nabeel, Bathe, Oliver F., Baylin, Stephen B., Beroukhim, Rameen, Berrios, Mario, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Borad, Mitesh J., Bowen, Jay, Bowlby, Reanne, Bragazzi, Maria Consiglia, Brooks, Denise, Cardinale, Vincenzo, Carlsen, Rebecca, Carpino, Guido, Carvalho, Andre L., Chaiteerakij, Roongruedee, Chandan, Vishal C., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Choe, Gina, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cordes, Matthew G., Covington, Kyle R., Crain, Daniel, Curley, Erin, De Rose, Agostino Maria, Defreitas, Timothy, Demchok, John A., Deshpande, Vikram, Dhalla, Noreen, Ding, Li, Evason, Kimberley, Farshidfar, Farshad, Felau, Ina, Ferguson, Martin L., Foo, Wai Chin, Franchitto, Antonio, Frazer, Scott, Fronick, Catrina C., Fulton, Lucinda A., Fulton, Robert S., Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gaudio, Eugenio, Gehlenborg, Nils, Genovese, Giannicola, Gerken, Mark, Getz, Gad, Giama, Nasra H., Gibbs, Richard A., Gingras, Marie-Claude, Giuliante, Felice, Grazi, Gian Luca, Hayes, D. Neil, Hegde, Apurva M., Heiman, David I., Hess, Julian M., Hinoue, Toshinori, Hoadley, Katherine A., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hutter, Carolyn M., Jefferys, Stuart R., Jones, Steven J.M., Jones, Corbin D., Kasaian, Katayoon, Kelley, Robin K., Kim, Jaegil, Kleiner, David E., Kocher, Jean-Pierre A., Kwong, Lawrence N., Lai, Phillip H., Laird, Peter W., Lawrence, Michael S., Leraas, Kristen M., Lichtenberg, Tara M., Lin, Pei, Liu, Wenbin, Liu, Jia, Lolla, Laxmi, Lu, Yiling, Ma, Yussanne, Mallery, David, Mardis, Elaine R., Marra, Marco A., Matsushita, Marcus M., Mayo, Michael, McLellan, Michael D., McRee, Autumn J., Meier, Sam, Meng, Shaowu, Meyerson, Matthew, Mieczkowski, Piotr A., Miller, Christopher A., Mills, Gordon B., Moore, Richard A., Morris, Scott, Mose, Lisle E., Moser, Catherine D., Mounajjed, Taofic, Mungall, Andrew J., Mungall, Karen, Murray, Bradley A., Naresh, Rashi, Newton, Yulia, Noble, Michael S., O’Brien, Daniel R., Ojesina, Akinyemi I., Parker, Joel S., Patel, Tushar C., Paulauskis, Joseph, Pedamallu, Chandra Sekhar, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Radenbaugh, Amie J., Ramirez, Nilsa C., Rathmell, W. Kimryn, Reznik, Ed, Rhie, Suhn K., Roach, Jeffrey, Roberts, Lewis R., Robertson, A. Gordon, Sadeghi, Sara, Saksena, Gordon, Sander, Chris, Schein, Jacqueline E., Schmidt, Heather K., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Shen, Ronglai, Sheth, Margi, Shi, Yan, Shih, Juliann, Shinbrot, Eve, Shroff, Rachna, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Soloway, Matthew G., Stoppler, Hubert, Stransky, Nicolas, Stuart, Josh, Sun, Qiang, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thorne, Leigh B., Torbenson, Michael S., Van Den Berg, David J., Veluvolu, Umadevi, Verhaak, Roel G.W., Voet, Doug, Wan, Yunhu, Wang, Zhining, Weinstein, John N., Weisenberger, Daniel J., Wheeler, David A., Wilson, Richard K., Wise, Lisa, Wong, Tina, Wu, Chia-Chin, Wu, Ye, Xi, Liu, Yang, Ju Dong, Yang, Liming, Zenklusen, Jean C., Zhang, Hailei, Zhang, Jiashan (Julia), Zheng, Siyuan, Zmuda, Erik, Zhu, Andrew X., Stuart, Josh M., Sander, Chris, Akbani, Rehan, Cherniack, Andrew D., Deshpande, Vikram, Mounajjed, Taofic, Foo, Wai Chin, Torbenson, Michael S., Kleiner, David E., Laird, Peter W., Wheeler, David A., McRee, Autumn J., Bathe, Oliver F., Andersen, Jesper B., Bardeesy, Nabeel, Roberts, Lewis R., Kwong, Lawrence N.·2017·Cell Reports
DOI 10.1016/j.celrep.2017.02.033
Open this paper in CoChat — free account

Abstract

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.celrep.2017.02.033

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Cited by

Metadata

Authors
Farshidfar, F., Zheng, S., Gingras, M.-C., Newton, Y., Shih, J., Robertson, A. G., Hinoue, T., Hoadley, K. A., Gibb, E. A., Roszik, J., Covington, K. R., Wu, C.-C., Shinbrot, E., Stransky, N., Hegde, A., Yang, J. D., Reznik, E., Sadeghi, S., Pedamallu, C. S., Ojesina, A. I., Hess, J. M., Auman, J. T., Rhie, S. K., Bowlby, R., Borad, M. J., Akbani, R., Allotey, L. K., Ally, A., Alvaro, D., Andersen, J. B., Appelbaum, E. L., Arora, A., Auman, J. T., Balasundaram, M., Balu, S., Bardeesy, N., Bathe, O. F., Baylin, S. B., Beroukhim, R., Berrios, M., Bodenheimer, T., Boice, L., Bootwalla, M. S., Borad, M. J., Bowen, J., Bowlby, R., Bragazzi, M. C., Brooks, D., Cardinale, V., Carlsen, R., Carpino, G., Carvalho, A. L., Chaiteerakij, R., Chandan, V. C., Cherniack, A. D., Chin, L., Cho, J., Choe, G., Chuah, E., Chudamani, S., Cibulskis, C., Cordes, M. G., Covington, K. R., Crain, D., Curley, E., De Rose, A. M., Defreitas, T., Demchok, J. A., Deshpande, V., Dhalla, N., Ding, L., Evason, K., Farshidfar, F., Felau, I., Ferguson, M. L., Foo, W. C., Franchitto, A., Frazer, S., Fronick, C. C., Fulton, L. A., Fulton, R. S., Gabriel, S. B., Gardner, J., Gastier-Foster, J. M., Gaudio, E., Gehlenborg, N., Genovese, G., Gerken, M., Getz, G., Giama, N. H., Gibbs, R. A., Gingras, M.-C., Giuliante, F., Grazi, G. L., Hayes, D. N., Hegde, A. M., Heiman, D. I., Hess, J. M., Hinoue, T., Hoadley, K. A., Holbrook, A., Holt, R. A., Hoyle, A. P., Huang, M., Hutter, C. M., Jefferys, S. R., Jones, S. J. M., Jones, C. D., Kasaian, K., Kelley, R. K., Kim, J., Kleiner, D. E., Kocher, J.-P. A., Kwong, L. N., Lai, P. H., Laird, P. W., Lawrence, M. S., Leraas, K. M., Lichtenberg, T. M., Lin, P., Liu, W., Liu, J., Lolla, L., Lu, Y., Ma, Y., Mallery, D., Mardis, E. R., Marra, M. A., Matsushita, M. M., Mayo, M., McLellan, M. D., McRee, A. J., Meier, S., Meng, S., Meyerson, M., Mieczkowski, P. A., Miller, C. A., Mills, G. B., Moore, R. A., Morris, S., Mose, L. E., Moser, C. D., Mounajjed, T., Mungall, A. J., Mungall, K., Murray, B. A., Naresh, R., Newton, Y., Noble, M. S., O’Brien, D. R., Ojesina, A. I., Parker, J. S., Patel, T. C., Paulauskis, J., Pedamallu, C. S., Penny, R., Perou, C. M., Perou, A. H., Pihl, T., Radenbaugh, A. J., Ramirez, N. C., Rathmell, W. K., Reznik, E., Rhie, S. K., Roach, J., Roberts, L. R., Robertson, A. G., Sadeghi, S., Saksena, G., Sander, C., Schein, J. E., Schmidt, H. K., Schumacher, S. E., Shelton, C., Shelton, T., Shen, R., Sheth, M., Shi, Y., Shih, J., Shinbrot, E., Shroff, R., Simons, J. V., Sipahimalani, P., Skelly, T., Sofia, H. J., Soloway, M. G., Stoppler, H., Stransky, N., Stuart, J., Sun, Q., Tam, A., Tan, D., Tarnuzzer, R., Thiessen, N., Thorne, L. B., Torbenson, M. S., Van Den Berg, D. J., Veluvolu, U., Verhaak, R. G. W., Voet, D., Wan, Y., Wang, Z., Weinstein, J. N., Weisenberger, D. J., Wheeler, D. A., Wilson, R. K., Wise, L., Wong, T., Wu, C.-C., Wu, Y., Xi, L., Yang, J. D., Yang, L., Zenklusen, J. C., Zhang, H., Zhang, J. (., Zheng, S., Zmuda, E., Zhu, A. X., Stuart, J. M., Sander, C., Akbani, R., Cherniack, A. D., Deshpande, V., Mounajjed, T., Foo, W. C., Torbenson, M. S., Kleiner, D. E., Laird, P. W., Wheeler, D. A., McRee, A. J., Bathe, O. F., Andersen, J. B., Bardeesy, N., Roberts, L. R., & Kwong, L. N.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2017-03
Volume
18
Issue
11
Pages
2780-2794
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2017.02.033
OpenAlex
W2603204749
Cited by
610
References
8
FWCI
58.12
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.