The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs
Open accessAbstract
N 6 -methyladenosine (m 6 A) is the most abundant internal modification of mRNAs and is implicated in all aspects of post-transcriptional RNA metabolism. However, little is known about m 6 A modifications to circular (circ) RNAs. We developed a computational pipeline (AutoCirc) that, together with depletion of ribosomal RNA and m 6 A immunoprecipitation, defined thousands of m 6 A circRNAs with cell-type-specific expression. The presence of m 6 A circRNAs is corroborated by interaction between circRNAs and YTHDF1/YTHDF2, proteins that read m 6 A sites in mRNAs, and by reduced m 6 A levels upon depletion of METTL3, the m 6 A writer. Despite sharing m 6 A readers and writers, m 6 A circRNAs are frequently derived from exons that are not methylated in mRNAs, whereas mRNAs that are methylated on the same exons that compose m 6 A circRNAs exhibit less stability in a process regulated by YTHDF2. These results expand our understanding of the breadth of m 6 A modifications and uncover regulation of circRNAs through m 6 A modification.
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Citations
Cites
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Self-citationCirc-ZNF609 is a circular RNA that can be translated and functions in myogenesis
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“Transposable Elements are Enriched in the Flanking Regions of m6A-circRNAs Reverse complementary sequence in transposable elements (TEs) in the flanking regions of circRNAs promote the formation of circRNAs (Ashwal-Fluss et al., 2014; Chen et al., 2017; Liang and Wilusz, 2014; Zhang et al., 2014).”
BackgroundResultInfluentialExtensive translation of circular RNAs driven by N6-methyladenosine
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Cited by
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Metadata
- Authors
- Zhou, C., Molinie, B., Daneshvar, K., Pondick, J. V., Wang, J., Van Wittenberghe, N., Xing, Y., Giallourakis, C. C., & Mullen, A. C.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 20
- Issue
- 9
- Pages
- 2262-2276
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2752229407
- Cited by
- 428
- References
- 13
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- gold
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