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Although abundant in tumor tissue, mast cells have no effect on immunological micro‐milieu or growth of HPV‐induced or transplanted tumors

Ghouse, Shanawaz Mohammed, Polikarpova, Anastasia, Muhandes, Lina, Dudeck, Jan, Tantcheva-Poór, Iliana, Hartmann, Karin, Lesche, Matthias, Dahl, Andreas, Eming, Sabine, Müller, Werner, Behrendt, Rayk, Roers, Axel·2018·Cell Reports
DOI 10.1016/j.celrep.2017.12.010
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Abstract

High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.

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Research works printed but not linked: 44

  1. Abraham, 2010, Mast cell-orchestrated immunity to pathogens, Nat. Rev. Immunol., 10, 440, 10.1038/nri2782 · DOI · Paper page
  2. Antsiferova, 2013, Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis, J. Immunol., 191, 6147, 10.4049/jimmunol.1301350 · DOI · Paper page
  3. Benoist, 2002, Mast cells in autoimmune disease, Nature, 420, 875, 10.1038/nature01324 · DOI
  4. Bergot, 2014, HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells, PLoS Pathog., 10, e1004466, 10.1371/journal.ppat.1004466 · DOI
  5. Bischoff, 2007, Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data, Nat. Rev. Immunol., 7, 93, 10.1038/nri2018 · DOI
  6. Chervenick, 1969, Decreased neutrophils and megakaryocytes in anemic mice of genotype W/W, J. Cell. Physiol., 73, 25, 10.1002/jcp.1040730104 · DOI
  7. Dalton, 2012, The roles of mast cells in anticancer immunity, Cancer Immunol. Immunother., 61, 1511, 10.1007/s00262-012-1246-0 · DOI
  8. Dawicki, 2007, New and emerging roles for mast cells in host defence, Curr. Opin. Immunol., 19, 31, 10.1016/j.coi.2006.11.006 · DOI · Paper page
  9. Dimitriadou, 1997, Mast cell-tumor cell interactions: for or against tumour growth and metastasis?, Anticancer Res., 17, 1541
  10. Dudeck, 2011, Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens, Immunity, 34, 973, 10.1016/j.immuni.2011.03.028 · DOI
  11. Feyerabend, 2011, Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity, Immunity, 35, 832, 10.1016/j.immuni.2011.09.015 · DOI
  12. Feyerabend, 2016, Of Mouse Models of Mast Cell Deficiency and Metabolic Syndrome, Cell Metab., 24, 1, 10.1016/j.cmet.2016.06.019 · DOI
  13. Gabrilovich, 2012, Coordinated regulation of myeloid cells by tumours, Nat. Rev. Immunol., 12, 253, 10.1038/nri3175 · DOI · Paper page
  14. Galinsky, 2008, Mast cells and cancer--no longer just basic science, Crit. Rev. Oncol. Hematol., 68, 115, 10.1016/j.critrevonc.2008.06.001 · DOI
  15. Galli, 2005, Mast cells in the development of adaptive immune responses, Nat. Immunol., 6, 135, 10.1038/ni1158 · DOI
  16. Gerber, 1999, VEGF is required for growth and survival in neonatal mice, Development, 126, 1149, 10.1242/dev.126.6.1149 · DOI
  17. Gounaris, 2007, Mast cells are an essential hematopoietic component for polyp development, Proc. Natl. Acad. Sci. USA, 104, 19977, 10.1073/pnas.0704620104 · DOI
  18. Hanahan, 2012, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Cancer Cell, 21, 309, 10.1016/j.ccr.2012.02.022 · DOI · Paper page
  19. Hershko, 2011, Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis, Immunity, 35, 562, 10.1016/j.immuni.2011.07.013 · DOI
  20. Huizinga, 1995, W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity, Nature, 373, 347, 10.1038/373347a0 · DOI
  21. Katz, 2011, Mast cell deficiency, a game of kit and mouse, Immunity, 35, 668, 10.1016/j.immuni.2011.11.004 · DOI
  22. Khazaie, 2011, The significant role of mast cells in cancer, Cancer Metastasis Rev., 30, 45, 10.1007/s10555-011-9286-z · DOI
  23. Lilla, 2011, Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice, Blood, 118, 6930, 10.1182/blood-2011-03-343962 · DOI · Paper page
  24. Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol., 15, 550, 10.1186/s13059-014-0550-8 · DOI · Paper page
  25. Mantovani, 2008, Cancer-related inflammation, Nature, 454, 436, 10.1038/nature07205 · DOI · Paper page
  26. Marichal, 2013, Mast cells: potential positive and negative roles in tumor biology, Cancer Immunol. Res., 1, 269, 10.1158/2326-6066.CIR-13-0119 · DOI
  27. Marshall, 2004, Mast-cell responses to pathogens, Nat. Rev. Immunol., 4, 787, 10.1038/nri1460 · DOI
  28. Marshall, 2004, Mast cells in innate immunity, J. Allergy Clin. Immunol., 114, 21, 10.1016/j.jaci.2004.04.045 · DOI
  29. Nigrovic, 2008, Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy, Am. J. Pathol., 173, 1693, 10.2353/ajpath.2008.080407 · DOI · Paper page
  30. Öhrvik, 2016, Mast cells promote melanoma colonization of lungs, Oncotarget, 7, 68990, 10.18632/oncotarget.11837 · DOI · Paper page
  31. Otsuka, 2011, Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity, PLoS ONE, 6, e25538, 10.1371/journal.pone.0025538 · DOI
  32. Paul, 2016, Mast cells have no impact on cutaneous leishmaniasis severity and related Th2 differentiation in resistant and susceptible mice, Eur. J. Immunol., 46, 114, 10.1002/eji.201545613 · DOI
  33. Peschke, 2014, IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation, Cell Rep., 8, 1300, 10.1016/j.celrep.2014.07.046 · DOI
  34. Pittoni, 2011, Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers, Cancer Res., 71, 5987, 10.1158/0008-5472.CAN-11-1637 · DOI
  35. Puddington, 1994, Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis, Immunity, 1, 733, 10.1016/S1074-7613(94)80015-4 · DOI
  36. Rabenhorst, 2012, Mast cells play a protumorigenic role in primary cutaneous lymphoma, Blood, 120, 2042, 10.1182/blood-2012-03-415638 · DOI
  37. Rodewald, 2012, Widespread immunological functions of mast cells: fact or fiction?, Immunity, 37, 13, 10.1016/j.immuni.2012.07.007 · DOI · Paper page
  38. Scholten, 2008, Mast cell-specific Cre/loxP-mediated recombination in vivo, Transgenic Res., 17, 307, 10.1007/s11248-007-9153-4 · DOI
  39. Soucek, 2007, Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors, Nat. Med., 13, 1211, 10.1038/nm1649 · DOI
  40. Starkey, 1988, Mast-cell-deficient W/Wv mice exhibit a decreased rate of tumor angiogenesis, Int. J. Cancer, 42, 48, 10.1002/ijc.2910420110 · DOI
  41. Theoharides, 2004, Mast cells: the Jekyll and Hyde of tumor growth, Trends Immunol., 25, 235, 10.1016/j.it.2004.02.013 · DOI
  42. Wasiuk, 2012, Mast cells impair the development of protective anti-tumor immunity, Cancer Immunol. Immunother., 61, 2273, 10.1007/s00262-012-1276-7 · DOI
  43. Willenborg, 2014, Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis, J. Invest. Dermatol., 134, 2005, 10.1038/jid.2014.12 · DOI
  44. Wu, 2010, Fast and SNP-tolerant detection of complex variants and splicing in short reads, Bioinformatics, 26, 873, 10.1093/bioinformatics/btq057 · DOI · Paper page

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Metadata

Authors
Ghouse, S. M., Polikarpova, A., Muhandes, L., Dudeck, J., Tantcheva-Poór, I., Hartmann, K., Lesche, M., Dahl, A., Eming, S., Müller, W., Behrendt, R., & Roers, A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2018-01
Volume
22
Issue
1
Pages
27-35
ISSN
2211-1247
DOI
10.1016/j.celrep.2017.12.010
Cited by
20
References
1
Language
en
Licence
Funders
  • Deutsche Forschungsgemeinschaft (RO2133/7, RO2133/3, RO2133/4)
  • Seventh Framework Programme (317445)

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