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Although abundant in tumor tissue, mast cells have no effect on immunological micro‐milieu or growth of HPV‐induced or transplanted tumors

Ghouse, Shanawaz Mohammed, Polikarpova, Anastasia, Muhandes, Lina, Dudeck, Jan, Tantcheva-Poór, Iliana, Hartmann, Karin, Lesche, Matthias, Dahl, Andreas, Eming, Sabine, Müller, Werner, Behrendt, Rayk, Roers, Axel·2018·Cell Reports
DOI 10.1016/j.celrep.2017.12.010
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Abstract

High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.

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Metadata

Authors
Ghouse, S. M., Polikarpova, A., Muhandes, L., Dudeck, J., Tantcheva-Poór, I., Hartmann, K., Lesche, M., Dahl, A., Eming, S., Müller, W., Behrendt, R., & Roers, A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2018-01
Volume
22
Issue
1
Pages
27-35
ISSN
2211-1247
DOI
10.1016/j.celrep.2017.12.010
Cited by
20
References
1
Language
en
Licence
Funders
  • Deutsche Forschungsgemeinschaft (RO2133/7, RO2133/3, RO2133/4)
  • Seventh Framework Programme (317445)

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