Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

Décosterd, I., & Woolf, C. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00276-1 · Cited by 2,317 · see citing works

The Sensory Neurons of Touch

Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648 · see citing works

Neuronal circuitry for pain processing in the dorsal horn

Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475 · see citing works

Pain as a global public health priority

Goldberg, D. S., & McGee, S. J. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-770 · Cited by 1,471 · see citing works

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

Moore, K. A., Kohno, T., Karchewski, L. A., Scholz, J., Baba, H., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06724.2002 · Cited by 859 · see citing works

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

Li, L., Rutlin, M. L., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., Jankowski, M. P., Luo, W., Heintz, N., Koerber, H. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.027 · Cited by 760 · see citing works

Pharmacological studies on presynaptic inhibition

Eccles, J. C., Schmidt, R. F., & Willis, W. D. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007205 · Cited by 757 · see citing works

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

Yaksh, T. L. (1989) · Pain · doi:10.1016/0304-3959(89)90160-7 · Cited by 673 · see citing works

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582 · see citing works

Neural circuits for pain: Recent advances and current views

Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 481 · see citing works

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Häring, M., Zeisel, A., Hochgerner, H., Rinwa, P., Jakobsson, J. E. T., Lönnerberg, P., La Manno, G., Sharma, N., Borgius, L., Kiehn, O., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0141-1 · Cited by 470 · see citing works

The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord

Swett, J. E., & Woolf, C. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902310106 · Cited by 454 · see citing works

The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn

Todd, A. J., Hughes, D. I., Polgár, E., Nagy, G., Mackie, M., Ottersen, O. P., & Maxwell, D. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02406.x · Cited by 436 · see citing works

Central inhibitory action attributable to presynaptic depolarization produced by muscle afferent volleys

Eccles, J. C., Eccles, R. M., & Magni, F. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006798 · Cited by 419 · see citing works

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn

Abraira, V. E., Kuehn, E. D., Chirila, A. M., Springel, M. W., Toliver, A. A., Zimmerman, A. L., Orefice, L. L., Boyle, K. A., Bai, L., Song, B. J., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.010 · Cited by 409 · see citing works

Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord

Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407 · see citing works

Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn

Grudt, T. J., & Perl, E. R. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012890 · Cited by 402 · see citing works

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

Sathyamurthy, A., Johnson, K. R., Matson, K. J. E., Dobrott, C. I., Li, L., Ryba, A. R., Bergman, T. B., Kelly, M. C., Kelley, M. W., & Levine, A. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.003 · Cited by 370 · see citing works

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

Foster, E., Wildner, H., Tudeau, L., Haueter, S., Ralvenius, W. T., Jegen, M., Johannssen, H. C., Hösli, L., Haenraets, K., Ghanem, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.028 · Cited by 350 · see citing works

Dorsal Horn Circuits for Persistent Mechanical Pain

Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.029 · Cited by 327 · see citing works

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

Petitjean, H., Pawlowski, S. A., Fraine, S. L., Sharif, B., Hamad, D., Fatima, T., Berg, J., Brown, C. M., Jan, L.-Y., Ribeiro-da-Silva, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.080 · Cited by 326 · see citing works

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach

Yasaka, T., Tiong, S. Y. X., Hughes, D. I., Riddell, J. S., & Todd, A. J. (2010) · Pain · doi:10.1016/j.pain.2010.08.008 · Cited by 315 · see citing works

PGE2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons

Ahmadi, S., Lippross, S., Neuhuber, W., & Zeilhofer, H. U. (2001) · Nature Neuroscience · doi:10.1038/nn778 · Cited by 314 · see citing works

Presynaptic and postsynaptic inhibition of monosynaptic reflexes

Frank, K. (1957) · Medical Entomology and Zoology · Cited by 314 · see citing works

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

Lü, Y., Dong, H., Gao, Y., Gong, Y., Ren, Y., Gu, N., Zhou, S., Xia, N., Sun, Y., Ji, R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70026 · Cited by 287 · see citing works

Presynaptic inhibition of the spinal monosynaptic reflex pathway

Eccles, J. C., Schmidt, R. F., & Willis, W. D. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006886 · Cited by 284 · see citing works

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn

Baba, H., Ji, R., Kohno, T., Moore, K. A., Ataka, T., Wakai, A., Okamoto, M., & Woolf, C. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00236-7 · Cited by 274 · see citing works

Electrical Changes in Pre- and Postsynaptic Axons of the Giant Synapse of Loligo

Takeuchi, A., & Takeuchi, N. (1962) · The Journal of General Physiology · doi:10.1085/jgp.45.6.1181 · Cited by 273 · see citing works

Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain

Keller, A. F., Beggs, S., Salter, M. W., & Koninck, Y. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-27 · Cited by 262 · see citing works

Mechanical hyperalgesias in neuropathic pain patients: Dynamic and static subtypes

Ochoa, J. L., & Yarnitsky, D. (1993) · Annals of Neurology · doi:10.1002/ana.410330509 · Cited by 261 · see citing works

Presynaptic inhibition of spinal sensory feedback ensures smooth movement

Fink, A. J. P., Croce, K. R., Huang, Z. J., Abbott, L. F., Jessell, T. M., & Azim, E. (2014) · Nature · doi:10.1038/nature13276 · Cited by 260 · see citing works

Modular Organization of Excitatory Circuits between Neurons of the Spinal Superficial Dorsal Horn (Laminae I and II)

Lü, Y., & Perl, E. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0102-05.2005 · Cited by 255 · see citing works

Two types of synaptic glomeruli and their distribution in laminae I–III of the rat spinal cord

Ribeiro‐da‐Silva, A., & Coimbra, A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902090205 · Cited by 235 · see citing works

Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?

Field, M. J., Bramwell, S. R., Hughes, J. M., & Singh, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00111-6 · Cited by 209 · see citing works

Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons

Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 208 · see citing works

The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

Rutlin, M. L., Ho, C.-Y., Abraira, V. E., Cassidy, C., Bai, L., Woodbury, C. J., & Ginty, D. D. (2014) · Cell · doi:10.1016/j.cell.2014.11.038 · Cited by 183 · see citing works

Subpopulations of gabaergic neurons in laminae i–iii of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin

Laing, I., Todd, A. J., Heizmann, C. W., & Schmidt, H. H. H. W. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90065-5 · Cited by 177 · see citing works

Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings

Moehring, F., Halder, P., Seal, R. P., & Stucky, C. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.019 · Cited by 155 · see citing works

Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers

Light, A. R., Perl, E. R., & Réthelyi, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902070409 · Cited by 153 · see citing works

Morphological, neurochemical and electrophysiological features of parvalbumin‐expressing cells: a likely source of axo‐axonic inputs in the mouse spinal dorsal horn

Hughes, D. I., Sikander, S., Kinnon, C. M., Boyle, K. A., Watanabe, M., Callister, R. J., & Graham, B. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235655 · Cited by 151 · see citing works

Loss of Neurons from Laminas I-III of the Spinal Dorsal Horn Is Not Required for Development of Tactile Allodynia in the Spared Nerve Injury Model of Neuropathic Pain

Polgár, E., Hughes, D. I., Arham, A. Z., & Todd, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1490-05.2005 · Cited by 151 · see citing works

GABA and Glycine in Synaptic Glomeruli of the Rat Spinal Dorsal Horn

Todd, A. J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01543.x · Cited by 148 · see citing works

Sciatic Chronic Constriction Injury Produces Cell-Type-Specific Changes in the Electrophysiological Properties of Rat Substantia Gelatinosa Neurons

Balasubramanyan, S., Stemkowski, P. L., Stebbing, M. J., & Smith, P. A. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00087.2006 · Cited by 147 · see citing works

Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn

Maxwell, D. J., Belle, M. D. C., Cheunsuang, O., Stewart, A., & Morris, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.140996 · Cited by 144 · see citing works

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Dhandapani, R., Arokiaraj, C. M., Taberner, F. J., Pacifico, P., Raja, S., Nocchi, L., Portulano, C., Franciosa, F., Maffei, M., Hussain, A. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04049-3 · Cited by 127 · see citing works

Moving From an Averaged to Specific View of Spinal Cord Pain Processing Circuits

Graham, B. A., Brichta, A. M., & Callister, R. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00581.2007 · Cited by 111 · see citing works

Vasoactive intestinal polypeptide increases in areas of the dorsal horn of the spinal cord from which other neuropeptides are depleted following peripheral axotomy

Shehab, S. A. S., & Atkinson, M. E. (1986) · Experimental Brain Research · doi:10.1007/bf00238861 · Cited by 102 · see citing works

Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I–II of the ipsilateral spinal dorsal horn

Polgár, E., & Todd, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.009 · Cited by 95 · see citing works

P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn

Hughes, D. I., Mackie, M., Nagy, G., Riddell, J. S., Maxwell, D. J., Szabó, G., Erdélyi, F., Veress, G., Szűcs, P., Antal, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503646102 · Cited by 93 · see citing works

Electron microscopic observations on the synaptic contacts of group Ia muscle spindle afferents in the cat lumbosacral spinal cord

Conradi, S., Cullheim, S., Gollvik, L., & Kellerth, J. ‐. (1983) · Brain Research · doi:10.1016/0006-8993(83)91330-6 · Cited by 91 · see citing works

Dermatomes and the central organization of dermatomes and body surface regions in the spinal cord dorsal horn in rats

Takahashi, Y., Chiba, T., Kurokawa, M., & Aoki, Y. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10669 · Cited by 89 · see citing works

Ultrastructural changes of the central scalloped (C1) primary afferent endings of synaptic glomeruli in the substantia gelatinosa Rolandi of the rat after peripheral neurotomy

Castro‐Lopes, J. M., Coimbra, A., Grant, G., & Arvidsson, J. (1990) · Journal of Neurocytology · doi:10.1007/bf01188402 · Cited by 88 · see citing works

Transient loss of terminals from non-peptidergic nociceptive fibers in the substantia gelatinosa of spinal cord following chronic constriction injury of the sciatic nerve

Bailey, A. L., & Ribeiro‐da‐Silva, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.051 · Cited by 85 · see citing works

Dorsal root potentials and afferent input to the spinal cord in rats with an experimental peripheral neuropathy

Laird, J. M. A., & Bennett, G. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90893-e · Cited by 83 · see citing works

Impaired Excitatory Drive to Spinal Gabaergic Neurons of Neuropathic Mice

Leitner, J., Westerholz, S., Heinke, B., Forsthuber, L., Wunderbaldinger, G., Jäger, T., Gruber-Schoffnegger, D., Braun, K., & Sandkühler, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073370 · Cited by 68 · see citing works

Synaptic architecture of glomeruli in superficial dorsal horn of rat spinal cord, as shown in serial reconstructions

Ribeiro‐da‐Silva, A., Pignatelli, D., & Coimbra, A. (1985) · Journal of Neurocytology · doi:10.1007/bf01258448 · Cited by 66 · see citing works

A Putative Relay Circuit Providing Low-Threshold Mechanoreceptive Input to Lamina I Projection Neurons via Vertical Cells in Lamina II of the Rat Dorsal Horn

Yasaka, T., Tiong, S. Y., Polgár, E., Watanabe, M., Kumamoto, E., Riddell, J. S., & Todd, A. J. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-3 · Cited by 59 · see citing works

Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling

Cordero‐Erausquin, M., Allard, S., Dolique, T., Bachand, K., Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22179 · Cited by 51 · see citing works

Reduction of Transmitter Output by Depolarization

Hubbard, J. I., & Willis, W. D. (1962) · Nature · doi:10.1038/1931294a0 · Cited by 50 · see citing works

Presynaptic inhibition of the monosynaptic reflex pathway in kittens

Eccles, R. M., & Willis, W. D. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007066 · Cited by 47 · see citing works

Relative numbers of several types of synaptic connections in the substantia gelatinosa of the cat spinal cord

Duncan, D., & Morales, R. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901820403 · Cited by 45 · see citing works

Immunostaining for Homer reveals the majority of excitatory synapses in laminae I–III of the mouse spinal dorsal horn

Gutièrrez‐Mecinas, M., Kuehn, E. D., Abraira, V. E., Polgár, E., Watanabe, M., & Todd, A. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.009 · Cited by 44 · see citing works

Synaptic relationships between hair follicle afferents and neurones expressing GABA and glycine‐like immunoreactivity in the spinal cord of the rat

Watson, A. H. D., Hughes, D. I., & Bazzaz, A. A. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10410 · Cited by 42 · see citing works

Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse

Graham, B. A., Tadros, M. A., Schofield, P. R., & Callister, R. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206326 · Cited by 34 · see citing works

Do central terminals of intact myelinated primary afferents sprout into the superficial dorsal horn of rat spinal cord after injury to a neighboring peripheral nerve?

Shehab, S. A. S., SPIKE, R. C., & Todd, A. J. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20147 · Cited by 32 · see citing works

Synaptic interactions between the terminals of slow‐adapting type II mechanoreceptor afferents and neurones expressing γ‐aminobutyric acid‐ and glycine‐like immunoreactivity in the rat spinal cord

Watson, A. H. D. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20043 · Cited by 17 · see citing works

Properties of spinal lamina III GABAergic neurons in naïve and in neuropathic mice

Gassner, M., Leitner, J., Gruber-Schoffnegger, D., Forsthuber, L., & Sandkühler, J. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00294.x · Cited by 16 · see citing works

A harmonized atlas of mouse spinal cord cell types and their spatial organization

Russ, D. E., Cross, R. B. P., Li, L., Koch, S. C., Matson, K. J. E., Yadav, A., Alkaslasi, M. R., Lee, D. I., Le Pichon, C. E., Menon, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25125-1 · Cited by 255 · see citing works

Central neuropathic pain

Rösner, J., de Andrade, D. C., Davis, K. D., Gustin, S. M., Kramer, J. L. K., Seal, R. P., & Finnerup, N. B. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00484-9 · Cited by 146 · see citing works

MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model

Wen, Q., Wang, Y., Pan, Q., Tian, R., Zhang, D., Qin, G.-C., Zhou, J.-Y., & Chen, L.-X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02342-5 · Cited by 128 · see citing works

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

Peirs, C., Dallel, R., & Todd, A. J. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02159-1 · Cited by 131 · see citing works

Neuroplasticity related to chronic pain and its modulation by microglia

Hiraga, S.-I., Itokazu, T., Nishibe, M., & Yamashita, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00199-6 · Cited by 98 · see citing works

Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord

Hughes, D. I., & Todd, A. J. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00936-0 · Cited by 88 · see citing works

Getting in Touch with Mechanical Pain Mechanisms

Hill, R. Z., & Bautista, D. M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.03.004 · Cited by 78 · see citing works

K+ Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain

Smith, P. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.566418 · Cited by 71 · see citing works

Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn

Smith, K. M., Browne, T. J., Davis, O. C., Coyle, A., Boyle, K. A., Watanabe, M., Dickinson, S. A., Iredale, J. A., Gradwell, M. A., Jobling, P., et al. (2019) · eLife · doi:10.7554/elife.49190 · Cited by 57 · see citing works

Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain

Yousefpour, N., Locke, S., Deamond, H., Wang, C., Marques, L., Louis, M. S., Ouellette, J., Khoutorsky, A., Koninck, Y. D., & Ribeiro‐da‐Silva, A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112010 · Cited by 66 · see citing works

Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J. S., Hughes, D. I., Ulven, T., Hudson, B. D., Ulven, E. R., Dekker, N., et al. (2022) · eLife · doi:10.7554/elife.73777 · Cited by 57 · see citing works

Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits

Comitato, A., & Bardoni, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010414 · Cited by 57 · see citing works

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain

Chirila, A. M., Rankin, G., Tseng, S.-Y., Emanuel, A. J., Chavez‐Martinez, C. L., Zhang, D., Harvey, C. D., & Ginty, D. D. (2022) · Cell · doi:10.1016/j.cell.2022.10.012 · Cited by 55 · see citing works

Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain

Cao, B., Scherrer, G., & Chen, L. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.027 · Cited by 51 · see citing works

Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways

Stachowski, N. J., & Dougherty, K. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052667 · Cited by 51 · see citing works

Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain

Nelson, T. S., Sinha, G. P., dos Santos, D. F. D. S., Jukkola, P. I., Prasoon, P., Winter, M. K., McCarson, K. E., Smith, B. N., & Taylor, B. K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204515119 · Cited by 48 · see citing works

Multiscale Computer Model of the Spinal Dorsal Horn Reveals Changes in Network Processing Associated with Chronic Pain

Medlock, L., Sekiguchi, K., Hong, S., Durá-Bernal, S., Lytton, W. W., & Prescott, S. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1199-21.2022 · Cited by 41 · see citing works

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

Löken, L. S., Braz, J. M., Etlin, A., Sadeghi, M., Bernstein, M. X., Jewell, M. E., Steyert, M. R., Kuhn, J., Hamel, K. A., Llewellyn‐Smith, I. J., et al. (2021) · eLife · doi:10.7554/elife.59751 · Cited by 44 · see citing works

Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn

Gradwell, M. A., Boyle, K. A., Browne, T. J., Bell, A. M., Leonardo, J., Reyes, F. S. P., Dickie, A. C., Smith, K. M., Callister, R. J., Dayas, C. V., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002422 · Cited by 39 · see citing works

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Boyle, K. A., Polgár, E., Gutièrrez‐Mecinas, M., Dickie, A. C., Cooper, A. H., Bell, A. M., Jumolea, E., Casas-Benito, A., Watanabe, M., Hughes, D. I., et al. (2023) · eLife · doi:10.7554/elife.86633 · Cited by 43 · see citing works

Excitatory and Inhibitory Neurons of the Spinal Cord Superficial Dorsal Horn Diverge in Their Somatosensory Responses and Plasticity in Vivo

Sullivan, S. J., & Sdrulla, A. D. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1860-21.2021 · Cited by 37 · see citing works

Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain

Polgár, E., Dickie, A. C., Gutièrrez‐Mecinas, M., Bell, A. M., Boyle, K. A., Quillet, R., Rashid, E. A., Clark, R. A., German, M. T., Watanabe, M., et al. (2022) · Pain · doi:10.1097/j.pain.0000000000002677 · Cited by 37 · see citing works

Parabrachial Calca neurons drive nociplasticity

Condon, L. F., Yu, Y., Park, S., Cao, F., Pauli, J. L., Nelson, T. S., & Palmiter, R. D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114057 · Cited by 38 · see citing works

TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current

Yoo, S., Santos, C., Reynders, A., Marics, I., Malapert, P., Gaillard, S., Charron, A., Ugolini, S., Rossignol, R., Khallouqi, A. E., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109884 · Cited by 32 · see citing works

Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn

Gradwell, M. A., Ozeri-Engelhard, N., Eisdorfer, J. T., Laflamme, O. D., Gonzalez, M., Upadhyay, A., Medlock, L., Shrier, T., Patel, K., Aoki, A., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.027 · Cited by 32 · see citing works

Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition

Arokiaraj, C. M., Leone, M. J., Kleyman, M., Chamessian, A. G., Noh, M., Phan, B. N., Lopes, B. C., Corrigan, K. A., Cherupally, V. K., Yeramosu, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114876 · Cited by 31 · see citing works

Transgenic Cross-Referencing of Inhibitory and Excitatory Interneuron Populations to Dissect Neuronal Heterogeneity in the Dorsal Horn

Browne, T. J., Gradwell, M. A., Iredale, J. A., Madden, J. F., Callister, R. J., Hughes, D. I., Dayas, C. V., & Graham, B. A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00032 · Cited by 30 · see citing works

Spinoparabrachial projection neurons form distinct classes in the mouse dorsal horn

Browne, T. J., Smith, K. M., Gradwell, M. A., Iredale, J. A., Dayas, C. V., Callister, R. J., Hughes, D. I., & Graham, B. A. (2021) · Pain · doi:10.1097/j.pain.0000000000002194 · Cited by 29 · see citing works

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

García‐Magro, N., Negredo, P., Martín, Y. B., Núñez, Á., & Avendaño, C. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01161-y · Cited by 28 · see citing works

Parabrachial neurons promote nociplastic pain

Palmiter, R. D. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.07.002 · Cited by 29 · see citing works

A bioinspired tactile scanner for computer haptics

Li, H., Lin, J., Lin, S., Zhong, H., Jiang, B., Liu, X., Wu, W., Li, W., Iranmanesh, E., Zhou, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51674-2 · Cited by 27 · see citing works

Primary afferent-driven presynaptic inhibition of C-fiber inputs to spinal lamina I neurons

Fernandes, E. C., Pechincha, C., Luz, L. L., Kókai, É., Szűcs, P., & Safronov, B. V. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101786 · Cited by 25 · see citing works

Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons

Rankin, G., Chirila, A. M., Emanuel, A. J., Zhang, Z., Woolf, C. J., Drugowitsch, J., & Ginty, D. D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113718 · Cited by 24 · see citing works

Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model

Heuvel, F. O., Ouali-Alami, N., Aousji, O., Pogatzki-Zahn, E., Zahn, P., Wilhelm, H., Deshpande, D., Khatamsaz, E., Catanese, A., Woelfle, S., et al. (2023) · Molecular Autism · doi:10.1186/s13229-023-00552-7 · Cited by 10 · see citing works

Modulation of SK Channels via Calcium Buffering Tunes Intrinsic Excitability of Parvalbumin Interneurons in Neuropathic Pain: A Computational and Experimental Investigation

Ma, X., Miraucourt, L. S., Qiu, H., Sharif‐Naeini, R., & Khadra, A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0426-23.2023 · Cited by 23 · see citing works

PKCγ interneurons, a gateway to pathological pain in the dorsal horn

Artola, A., Voisin, D. L., & Dallel, R. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02162-6 · Cited by 23 · see citing works

Reviewing the case for compromised spinal inhibition in neuropathic pain

Gradwell, M. A., Callister, R. J., & Graham, B. A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02090-0 · Cited by 21 · see citing works

Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aβ-fiber electrical stimulation

Fan, W., & Sdrulla, A. D. (2020) · Pain · doi:10.1097/j.pain.0000000000001836 · Cited by 21 · see citing works

The structure of sensory afferent compartments in health and disease

Middleton, S. J., Pérez-Sánchez, J., & Dawes, J. M. (2021) · Journal of Anatomy · doi:10.1111/joa.13544 · Cited by 19 · see citing works

Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons

Qiu, H., Miraucourt, L. S., Petitjean, H., Xu, M., Theriault, C., Davidova, A., Soubeyre, V., Poulen, G., Lonjon, N., Vachiéry-Lahaye, F., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2403777121 · Cited by 19 · see citing works

Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord

Davis, O., Dickie, A. C., Mustapa, M., Boyle, K. A., Browne, T. J., Gradwell, M. A., Smith, K. M., Polgár, E., Bell, A. M., Kókai, É., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38605-9 · Cited by 19 · see citing works

An electrophysiologist’s guide to dorsal horn excitability and pain

Rivera‐Arconada, I., Baccei, M. L., Lopez-Garcia, J. A., & Bardoni, R. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1548252 · Cited by 18 · see citing works

Defining populations of dorsal horn interneurons

Graham, B. A., & Hughes, D. I. (2020) · Pain · doi:10.1097/j.pain.0000000000002067 · Cited by 18 · see citing works

Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord

Quillet, R., Gutièrrez‐Mecinas, M., Polgár, E., Dickie, A. C., Boyle, K. A., Watanabe, M., & Todd, A. J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1294994 · Cited by 17 · see citing works

Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations

Fan, W., Sullivan, S. J., & Sdrulla, A. D. (2022) · Molecular Pain · doi:10.1177/17448069221079559 · Cited by 16 · see citing works

Network model of nociceptive processing in the superficial spinal dorsal horn reveals mechanisms of hyperalgesia, allodynia, and spinal cord stimulation

Gilbert, J. E., Zhang, T. C., Esteller, R., & Grill, W. M. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00186.2023 · Cited by 16 · see citing works

The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states

Upadhyay, A., Gradwell, M. A., Vajtay, T. J., Conner, J., Sanyal, A. A., Azadegan, C., Patel, K., Thackray, J. K., Bohic, M., Imai, F., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115556 · Cited by 15 · see citing works

Presynaptic gating of monkey proprioceptive signals for proper motor action

Tomatsu, S., Kim, G.-H., Kubota, S., & Seki, K. (2023) · Nature Communications · doi:10.1038/s41467-023-42077-w · Cited by 13 · see citing works

Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice

Zou, Y., Ho, I. H. T., Jiang, Y., Li, Z., Luo, Q., Ng, L. H. L., Jin, T., Li, Q., Qin, F., Tan, L., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adk8096 · Cited by 13 · see citing works

Proprioception revisited: where do we stand?

Shadrach, J. L., Gomez‐Frittelli, J., & Kaltschmidt, J. A. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.02.003 · Cited by 16 · see citing works

Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia

Veshchitskii, A. A., & Merkulyeva, N. S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105634 · Cited by 12 · see citing works

Neural signaling in neuropathic pain: A computational modeling perspective

Ma, X., & Khadra, A. (2024) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2024.100509 · Cited by 10 · see citing works

Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord

Quillet, R., Dickie, A. C., Polgár, E., Gutièrrez‐Mecinas, M., Bell, A. M., Goffin, L., Watanabe, M., & Todd, A. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-32720-3 · Cited by 11 · see citing works

Making connections: recent advances in spinal cord dorsal horn circuitry

Smith, K. M., & Ross, S. E. (2020) · Pain · doi:10.1097/j.pain.0000000000001980 · Cited by 10 · see citing works

GABAA and Glycine Receptor-Mediated Inhibitory Synaptic Transmission onto Adult Rat Lamina IIi PKCγ-Interneurons: Pharmacological but Not Anatomical Specialization

Khoueiry, C. E., Alba‐Delgado, C., Antri, M., Gutièrrez‐Mecinas, M., Todd, A. J., Artola, A., & Dallel, R. (2022) · Cells · doi:10.3390/cells11081356 · Cited by 11 · see citing works

The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice

Zhi, Y., Cao, F., Su, X.-J., Shu-wen, G., Zheng, H.-N., Jiang, J., Su, L., Liu, J., Wang, Y., Zhang, Y., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.875726 · Cited by 10 · see citing works

In Vivo Measurements Reveal that Both Low- and High-frequency Spinal Cord Stimulation Heterogeneously Modulate Superficial Dorsal Horn Neurons

Kuo, S.-W., Zhang, T. C., Esteller, R., & Grill, W. M. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.04.010 · Cited by 10 · see citing works

The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation

Graham, R. D., Bruns, T. M., Duan, B., & Lempka, S. F. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13211 · Cited by 12 · see citing works

Presynaptic Interactions between Trigeminal and Cervical Nociceptive Afferents Supplying Upper Cervical Lamina I Neurons

Fernandes, E. C., Carlos-Ferreira, J., Luz, L. L., & Safronov, B. V. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0025-22.2022 · Cited by 9 · see citing works

Synchronous firing of dorsal horn neurons at the origin of dorsal root reflexes in naïve and paw-inflamed mice

Lucas‐Romero, J., Rivera‐Arconada, I., & Lopez-Garcia, J. A. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1004956 · Cited by 9 · see citing works

Differential expression of Na+/K+/Cl− cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents

Javdani, F., Hegedűs, K., Miranda, C. O., Hegyi, Z., Holló, K., & Antal, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68638-3 · Cited by 9 · see citing works

Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord

Nakagawa, T., Yasaka, T., Nakashima, N., Takeya, M., Oshita, K., Tsuda, M., Yamaura, K., & Takano, M. (2020) · Molecular Brain · doi:10.1186/s13041-020-00666-6 · Cited by 9 · see citing works

Central sensitization of dorsal root potentials and dorsal root reflexes: An in vitro study in the mouse spinal cord.

Vicente‐Baz, J., Lopez-Garcia, J. A., & Rivera‐Arconada, I. (2021) · European Journal of Pain · doi:10.1002/ejp.1864 · Cited by 9 · see citing works

Molecular and Electrophysiological Characterization of Dorsal Horn Neurons in a GlyT2-iCre-tdTomato Mouse Line

He, X., Liu, P., Zhang, X., Jiang, Z., Gu, N., Wang, Q., & Lü, Y. (2021) · Journal of Pain Research · doi:10.2147/jpr.s296940 · Cited by 8 · see citing works

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses

Lezgiyeva, K., Liu, J., Nguyen, K., DeLisle, M. M., Ko, F. C., Fullam, S., Obeidat, A. M., Turecek, J., Alkislar, I., Lehnert, B. P., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.06.014 · Cited by 7 · see citing works

Diverse roles and modulations of IA in spinal cord pain circuits

Clerc, N., & Moqrich, A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110588 · Cited by 7 · see citing works

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain

Wong, C., Rodriguez-Hernandez, L. D., Lister, K. C., Gu, N., Cai, W., Hooshmandi, M., Fan, J., Brown, N., Nguyen, V., Ribeiro‐da‐Silva, A., et al. (2024) · Brain · doi:10.1093/brain/awae275 · Cited by 6 · see citing works

Glial cells in neuropathic pain

Berta, T., Khoutorsky, A., Xu, J., & Ji, R. (2026) · Physiological Reviews · doi:10.1152/physrev.00034.2025 · Cited by 7 · see citing works

Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain

Targowska‐Duda, K. M., Peters, D., Marcus, J. S., Zribi, G., Toll, L., & Ozawa, A. (2023) · Pain · doi:10.1097/j.pain.0000000000003068 · Cited by 6 · see citing works

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Lister, K. C., Wong, C., Uttam, S., Parisien, M., Stecum, P., Brown, N., Cai, W., Ho-Tieng, D., Hooshmandi, M., Gu, N., et al. (2026) · eLife · doi:10.7554/elife.100451.3 · Cited by 6 · see citing works

Elucidating afferent-driven presynaptic inhibition of primary afferent input to spinal laminae I and X

Krotov, V., Agashkov, K., Romanenko, S., Halaidych, O., Andrianov, Y., Safronov, B. V., Belan, P. V., & Voitenko, N. V. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1029799 · Cited by 6 · see citing works

Nicotinic receptor modulation of primary afferent excitability with selective regulation of Aδ-mediated spinal actions

Shreckengost, J., Halder, M., Mena-Avila, E., Garcia-Ramirez, D. L., Quevedo, J. N., & Hochman, S. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00228.2020 · Cited by 6 · see citing works

Multimodal Sensory Control of Motor Performance by Glycinergic Interneurons of the Spinal Cord Deep Dorsal HornPreprint

Gradwell, M. A., Ozeri-Engelhard, N., Eisdorfer, J. T., Laflamme, O. D., Gonzalez, M., Upadhyay, A., Aoki, A., Shrier, T., Gandhi, M., Abbas-Zadeh, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.21.492933 · Cited by 6 · see citing works

Altered Intrinsic Properties and Inhibitory Connectivity in Aged Parvalbumin-Expressing Dorsal Horn Neurons

Gradwell, M. A., Smith, K. M., Dayas, C. V., Smith, D. W., Hughes, D. I., Callister, R. J., & Graham, B. A. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.834173 · Cited by 5 · see citing works

Electrophysiological and Morphological Features of Rebound Depolarization Characterized Interneurons in Rat Superficial Spinal Dorsal Horn

Zhu, M., Yan, Y., Cao, X., Zeng, F., Xu, G. G., Shen, W., Li, F., Luo, L., Wang, Z., Zhang, Y., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.736879 · Cited by 5 · see citing works

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Boyle, K. A., Polgár, E., Gutièrrez‐Mecinas, M., Dickie, A. C., Cooper, A. H., Bell, A. M., Jumolea, E., Casas-Benito, A., Watanabe, M., Hughes, D. I., et al. (2023) · eLife · doi:10.7554/elife.86633.3 · Cited by 5 · see citing works

Sex-related exacerbation of injury-induced mechanical hypersensitivity in GAD67 haplodeficient mice

Charron, A., Pepino, L., Malapert, P., Debrauwer, V., Castets, F., Salio, C., & Moqrich, A. (2023) · Pain · doi:10.1097/j.pain.0000000000003012 · Cited by 5 · see citing works

Changes in motor outputs after spinal cord injury

Mahrous, A. A., Shelton, O., Birch, D. V., & Tysseling, V. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819260-3.00011-1 · Cited by 5 · see citing works

Novel aspects of signal processing in lamina I

Safronov, B. V., & Szűcs, P. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109858 · Cited by 4 · see citing works

Neurochemical atlas of the rabbit spinal cord

Veshchitskii, A. A., Shkorbatova, P. Y., & Merkulyeva, N. S. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02842-z · Cited by 4 · see citing works

Parvalbumin protein controls inhibitory tone in the spinal cordPreprint

Qiu, H., Miraucourt, L. S., Petitjean, H., Davidova, A., Levesque-Damphousse, P., Estall, J. L., & Sharif‐Naeini, R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.15.508019 · Cited by 4 · see citing works

Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain

Zhang, X., Millecamps, M., & Kania, A. (2023) · Molecular Pain · doi:10.1177/17448069231170546 · Cited by 3 · see citing works

Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord

Browne, T. J., Smith, K. M., Gradwell, M. A., Dayas, C. V., Callister, R. J., Hughes, D. I., & Graham, B. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-73620-4 · Cited by 3 · see citing works

A molecular and spinal circuit basis for the functional segregation of itch and pain

Noh, M., Corrigan, K. A., Williams, S.-P. G., Peirs, C., Leone, M. J., Headrick, D. J., Guvercin, M., Lee, S., Phan, B. N., Zhao, X., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.029 · Cited by 3 · see citing works

Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy

Reedich, E. J., Genry, L. T., Singer, M. A., Cavarsan, C. F., Avila, E. M., Boudreau, D. M., Brennan, M. C., Garrett, A. M., Dowaliby, L., Detloff, M. R., et al. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25108 · Cited by 3 · see citing works

A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity

Farah, A., Patel, R., Poplawski, P., Wastie, B. J., Tseng, M., Barry, A. M., Daifallah, O., Dubb, A., Paul, I., Cheng, H. L., et al. (2024) · Brain · doi:10.1093/brain/awae302 · Cited by 3 · see citing works

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signallingPreprint

Boyle, K. A., Polgár, E., Gutièrrez‐Mecinas, M., Dickie, A. C., Cooper, A. H., Bell, A. M., Jumolea, M. E., Casas-Benito, A., Watanabe, M., Hughes, D. I., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.10.528013 · Cited by 3 · see citing works

Calcium buffering tunes intrinsic excitability of spinal dorsal horn parvalbumin-expressing interneurons: A computational modelPreprint

Ma, X., Miraucourt, L. S., Qiu, H., Sharif‐Naeini, R., & Khadra, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.05.531043 · Cited by 3 · see citing works

Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon

Ganley, R. P., Sousa, M., Ji, G., Ranucci, M., Beccarini, C., Werder, K., Pietrafesa, F., d‘Aquin, S., Akyüz, T., Hubli, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71289-z · Cited by 2 · see citing works

Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies

Krotov, V., & Kopach, O. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01642-1 · Cited by 2 · see citing works

GABAergic and Glycinergic Inhibition in Pain Pathways

Zeilhofer, H. U., & Ganley, R. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24133-3 · Cited by 2 · see citing works

Decoding touch

Gradwell, M. A., Bohic, M., & Abraira, V. E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819260-3.00008-1 · Cited by 2 · see citing works

Establishment of a Magnetically Controlled Scalable Nerve Injury Model

Yang, T., Liu, X., Cao, R., Zhou, X., Li, W., Wu, W., Yu, W., Zhang, X., Guo, Z., & Cui, S. (2024) · Advanced Science · doi:10.1002/advs.202405265 · Cited by 2 · see citing works

Spinal cord homeostatic plasticity gates mechanical allodynia in chronic painPreprint

Cao, B., Scherrer, G., & Chen, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.10.475704 · Cited by 2 · see citing works

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Lister, K. C., Wong, C., Uttam, S., Parisien, M., Stecum, P., Brown, N., Cai, W., Ho-Tieng, D., Hooshmandi, M., Gu, N., et al. (2026) · eLife · doi:10.7554/elife.100451 · Cited by 2 · see citing works

Precision cutaneous stimulation in freely moving micePreprint

Parkes, I., Schorscher-Petcu, A., Gan, Q., & Browne, L. E. (2025) · eLife · doi:10.7554/elife.106033 · Cited by 3 · see citing works

The neuronal cell types of the spinal cord

Koch, S. C., & Levine, A. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819260-3.00005-6 · Cited by 2 · see citing works

Glutamatergic and GABAergic Synapses in the Human Spinal Dorsal Horn Revealed With Immunohistochemistry

Davis, O., Todd, A. J., & Price, T. J. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70091 · Cited by 1 · see citing works

Spinal dorsal horn GABAergic neuron activation underlies electroacupuncture analgesia in inflammatory pain

Zheng, H., Sun, X., Chen, J., Deng, L., Li, Y., Wang, X., Su, Y., Jing, X., & Zhang, Z. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.060 · Cited by 1 · see citing works

Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation

Medlock, L., & Prescott, S. A. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.1691-25.2026 · Cited by 1 · see citing works

Morphological, neurochemical and electrophysiological features of parvalbumin‐expressing cells: a likely source of axo‐axonic inputs in the mouse spinal dorsal horn

Hughes, D. I., Sikander, S., Kinnon, C. M., Boyle, K. A., Watanabe, M., Callister, R. J., & Graham, B. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235655 · Cited by 151 · see citing works

The cellular and synaptic architecture of local circuits in the spinal dorsal horn

Yasaka, T. (2018) · PAIN RESEARCH · doi:10.11154/pain.33.10

Peripheral nerve injury reallocates primary afferent input through spinal parvalbumin microcircuitsPreprint

Qiu, H., Wildner, H., Zeilhofer, H. U., Dallel, R., Peirs, C., & Sharif‐Naeini, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.15.737290 · Cited by 1 · see citing works

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

Petitjean, H., Pawlowski, S. A., Fraine, S. L., Sharif, B., Hamad, D., Fatima, T., Berg, J., Brown, C. M., Jan, L.-Y., Ribeiro-da-Silva, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.080 · Cited by 326 · see citing works

Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn

Gradwell, M. A., Boyle, K. A., Browne, T. J., Bell, A. M., Leonardo, J., Reyes, F. S. P., Dickie, A. C., Smith, K. M., Callister, R. J., Dayas, C. V., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002422 · Cited by 39 · see citing works