Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder
Open accessAbstract
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions and behavior but convincing evidence of its role in AUD is lacking. Here, we show that gut dysbiosis is associated with metabolic alterations that affect behavioral (depression, sociability) and neurobiological (myelination, neurotransmission, inflammation) processes involved in alcohol addiction. By transplanting the gut microbiota from AUD patients to mice, we point out that the production of ethanol by specific bacterial genera and the reduction of lipolysis are associated with a lower hepatic synthesis of β-hydroxybutyrate (BHB), which thereby prevents the neuroprotective effect of BHB. We confirm these results in detoxified AUD patients, in which we observe a persisting ethanol production in the feces as well as correlations among low plasma BHB levels and social impairments, depression, or brain white matter alterations.
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Several clinical studies reported that probiotics have a role in modulating mood and social functioning.
“In addition, several clinical studies reported that probiotics have a role in modulating mood and social functioning [26].”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as [26]
The Discussion links gut microbiota with sociability and depression-related behavior, but does not report clinical studies of probiotics modulating mood or social functioning. A search for “probiotics” found only an exclusion criterion in Experimental Model and Subject Details: participants who had recently taken probiotics were excluded. The paper’s findings about gut microbiota and fecal microbiota transplantation do not establish the attributed claim about probiotics. (LLM, conf=0.76)
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- Authors
- Leclercq, S., Le Roy, T., Furgiuele, S., Coste, V., Bindels, L. B., Leyrolle, Q., Neyrinck, A. M., Quoilin, C., Amadieu, C., Petit, G., Dricot, L., Tagliatti, V., Cani, P. D., Verbeke, K., Colet, J.-M., Stärkel, P., de Timary, P., & Delzenne, N. M.
- Affiliations
- UCLouvain (BE)
- University of Mons (BE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- KU Leuven (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Delzenne, Nathalie M.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 33
- Issue
- 2
- Pages
- 108238
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3092783202
- Cited by
- 178
- References
- 95
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 44 · 2023: 32 · 2022: 29 · 2021: 20 · 2020: 1
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lirias (submittedVersion, cc-by-nc-nd)
- ORBi UMONS (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- European Regional Development Fund
- Fonds Baillet Latour
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- alcoholism, gut microbiota, beta-hydroxybutyrate, gut dysbiosis, sociability, depression, lipolysis, hepatic ketogenesis, myelination, white matter, neuroinflammation, neurotransmission, fecal microbiota transplantation
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Ethanol, Alcoholism, Animals, Anti-Bacterial Agents, Bacteria, Behavior, Animal, Brain, Depression, Homeostasis, Humans, Inflammation, Intestines, Lipolysis, Liver, Male, Mice, Inbred C57BL, Myelin Sheath, Permeability, Social Behavior, Tissue Donors, 3-Hydroxybutyric Acid, Metabolic Networks and Pathways, Diet, Ketogenic, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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