Regulation of Ketone Body Metabolism and the Role of PPARα

Grabacka, Maja; Pierzchalska, Malgorzata; Dean, Matthew; Reiss, Krzysztof

doi:10.3390/ijms17122093

Cited by 305Peroxisome Proliferator-Activated ReceptorsDiet and metabolism studiesCancer, Lipids, and Metabolism

Regulation of Ketone Body Metabolism and the Role of PPARα

Open access

Grabacka, Maja, Pierzchalska, Malgorzata, Dean, Matthew, Reiss, Krzysztof·2016·International Journal of Molecular Sciences

DOI 10.3390/ijms17122093PMC PMC5187893

Open this paper in CoChat — free account Open PDF

Abstract

Ketogenesis and ketolysis are central metabolic processes activated during the response to fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome proliferator activated receptor α (PPARα) is one of the key transcription factors taking part in this regulation. PPARα is an important element in the metabolic network, where it participates in signaling driven by the main nutrient sensors, such as AMP-activated protein kinase (AMPK), PPARγ coactivator 1α (PGC-1α), and mammalian (mechanistic) target of rapamycin (mTOR) and induces hormonal mediators, such as fibroblast growth factor 21 (FGF21). This work describes the regulation of ketogenesis and ketolysis in normal and malignant cells and briefly summarizes the positive effects of ketone bodies in various neuropathologic conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms17122093

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

This adaptation spares glucose, facilitating sustained fat loss without loss of lean mass.
“This adaptation spares glucose, facilitating sustained fat loss without the loss of lean mass.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [75]
Ketone body production is crucial for energy provision during caloric restriction, reducing glucose demand and muscle breakdown.
“Ketone body production (ketogenesis) is crucial for energy provision during caloric restriction, as it reduces glucose demand and muscle breakdown.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [75]
Individuals with high PPAR-α expression or activity adapt more readily to fat oxidation, entering ketosis more efficiently.
“Individuals with high PPAR-α expression or activity adapt more readily to fat oxidation, entering ketosis more efficiently.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [75]
PPAR-α upregulates enzymes involved in ketogenesis, such as HMG-CoA synthase.
“PPAR-α is a transcription factor that upregulates enzymes involved in ketogenesis, such as HMG-CoA synthase.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [75]
Polymorphisms in the PPARA gene can affect the degree of ketogenic adaptation, influencing fat oxidation rates during caloric deficit.
“Polymorphisms in the PPARA gene can affect the degree of ketogenic adaptation, influencing fat oxidation rates during caloric deficit [75,76].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [75]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
Defining the role of mTOR in cancer
Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833 · see citing works
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works
The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations
Cleland, W. W. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)91800-6 · Cited by 2,092 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90211-6 · Cited by 1,911 · see citing works
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777 · see citing works
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758 · see citing works
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687 · see citing works
Brain Metabolism during Fasting*
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,650 · see citing works
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Pawlak, M., Lefebvre, P., & Staels, B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.039 · Cited by 1,578 · see citing works
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345 · see citing works
Fuel Metabolism in Starvation
Cahill, G. F. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111258 · Cited by 1,318 · see citing works
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232 · see citing works
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216 · see citing works
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,134 · see citing works
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106 · see citing works
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048 · see citing works
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036 · see citing works
Physiological roles of ketone bodies as substrates and signals in mammalian tissues.
Robinson, A. M., & Williamson, D. H. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.1.143 · Cited by 1,012 · see citing works
A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7473 · Cited by 943 · see citing works
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.316 · Cited by 897 · see citing works
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells
Riggs, M. G., WHITTAKER, R. G., Neumann, J. R., & Ingram, V. M. (1977) · Nature · doi:10.1038/268462a0 · Cited by 777 · see citing works
The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
Veech, R. L. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.007 · Cited by 759 · see citing works
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736 · see citing works
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Rardin, M. J., He, W., Nishida, Y., Newman, J. C., Carrico, C., Danielson, S. R., Guo, A., Gut, P., Sahu, A. K., Li, B., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.013 · Cited by 711 · see citing works
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works
Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., West, B. L., & Green, K. N. (2016) · Brain · doi:10.1093/brain/aww016 · Cited by 695 · see citing works
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif
Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Sujuti, H., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., & Yonezawa, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200665200 · Cited by 678 · see citing works
(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G
Taggart, A. K. P., Kero, J. T., Gan, X., Cai, T., Cheng, K., Ippolito, M. C., Ren, N., Kaplan, R. A., Wu, K., Wu, T.-J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500213200 · Cited by 651 · see citing works
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646 · see citing works
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works
Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state
Yoshino, A., Hovda, D. A., Kawamata, T., Katayama, Y., & Becker, D. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90755-k · Cited by 592 · see citing works
Branched-Chain Amino Acids: Enzyme and Substrate Regulation
Brosnan, J. T., & Brosnan, M. E. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.207s · Cited by 577 · see citing works
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Maalouf, M., Rho, J. M., & Mattson, M. P. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.002 · Cited by 575 · see citing works
A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
Dehouck, B., Fénart, L., Dehouck, M., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 568 · see citing works
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730870100 · Cited by 564 · see citing works
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Koo, S.-H., Satoh, H., Herzig, S., Lee, C.-H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., & Montminy, M. (2004) · Nature Medicine · doi:10.1038/nm1044 · Cited by 550 · see citing works
Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
Henderson, S. T., Vogel, J. L., Barr, L. J., Garvin, F., Jones, J. J., & Costantini, L. C. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-31 · Cited by 548 · see citing works
The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512 · see citing works
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
Schalm, S. S., Fingar, D. C., Sabatini, D. M., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00329-4 · Cited by 512 · see citing works
Effects of β-hydroxybutyrate on cognition in memory-impaired adults
Reger, M. A., Henderson, S. T., Hale, C. M., Cholerton, B., Baker, L. D., Watson, G. S., Hyde, K., Chapman, D., & Craft, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00087-3 · Cited by 510 · see citing works
Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
Oldendorf, W. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.6.1450 · Cited by 463 · cited 2× · see citing works
“The difficulties in crossing BBB are no concern for ketone bodies, which are efficiently absorbed through monocarboxylate transporters (MCT1, MCT2), the expression of which increases significantly during fasting [100,101].”
Background
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
Gurvich, N., Tsygankova, O. M., Meinkoth, J. L., & Klein, P. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0799 · Cited by 460 · see citing works
Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain
Schönfeld, P., & Reiser, G. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.128 · Cited by 457 · see citing works
Neuroprotective and disease-modifying effects of the ketogenic diet
Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00009 · Cited by 445 · see citing works
Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting
Hashimoto, T., Cook, W. S., Qi, C., Yeldandi, A. V., Reddy, J. K., & Rao, M. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910350199 · Cited by 444 · see citing works
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
Stafstrom, C. E., & Rho, J. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00059 · Cited by 440 · see citing works
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller‐Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4944 · Cited by 430 · see citing works
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J. M., & Stoffel, M. (2004) · Nature · doi:10.1038/nature03047 · Cited by 428 · see citing works
Ketone Bodies, Potential Therapeutic Uses
Veech, R. L., Chance, B., Kashiwaya, Y., Lardy, H. A., & Cahill, G. F. (2001) · IUBMB Life · doi:10.1080/152165401753311780 · Cited by 427 · see citing works
Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by <sup>13</sup> C Nuclear Magnetic Resonance Spectroscopy
Ebert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427 · see citing works
Purification and characterization of the AMP‐activated protein kinase
Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418 · see citing works
Parkinson's disease: Autoimmunity and neuroinflammation
VIRGILIO, A. D., Greco, A., Fabbrini, G., Inghilleri, M., Rizzo, M. I., Gallo, A., Conte, M., Rosato, C., Appiani, M. C., & VINCENTIIS, M. D. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.022 · Cited by 391 · see citing works
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378 · see citing works
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
Hegardt, F. G. (1999) · Biochemical Journal · doi:10.1042/bj3380569 · Cited by 375 · see citing works
PPARα is a key regulator of hepatic FGF21
Lundåsen, T., Hunt, M., Nilsson, L.-M., Sanyal, S., Angelin, B., Alexson, S., & Rudling, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.068 · Cited by 361 · see citing works
Malonyl-CoA: the regulator of fatty acid synthesis and oxidation
Foster, D. W. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63967 · Cited by 358 · see citing works
Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
Edmond, J., Robbins, R., Bergstrom, J. D., Cole, R. A., & de Vellis, J. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180407 · Cited by 357 · see citing works
Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
Mitchell, R. W., On, N. H., Del Bigio, M. R., Miller, D. W., & Hatch, G. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07245.x · Cited by 337 · see citing works
Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.
Nebeling, L. C., Miraldi, F. D., Shurin, S. B., & Lerner, E. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718495 · Cited by 312 · see citing works
Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study
VanItallie, T. B., Nonas, C., Rocco, A. D., Boyar, K. L., Hyams, K., & Heymsfield, S. B. (2005) · Neurology · doi:10.1212/01.wnl.0000152046.11390.45 · Cited by 300 · see citing works
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-5 · Cited by 299 · see citing works
The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma
Abdelwahab, M. G., Fenton, K. E., Preul, M. C., Rho, J. M., Lynch, A., Stafford, P., & Scheck, A. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036197 · Cited by 289 · see citing works
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
Pellerin, L., Halestrap, A. P., & Pierre, K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20307 · Cited by 269 · see citing works
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
Zuccoli, G., Marcello, N., Pisanello, A., Servadei, F., Vaccaro, S., Mukherjee, P., & Seyfried, T. N. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-33 · Cited by 266 · see citing works
Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1
Zupkovitz, G., Tischler, J., Posch, M., Sadzak, I., Ramsauer, K., Egger, G., Grausenburger, R., Schweifer, N., Chiocca, S., Decker, T., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01220-06 · Cited by 262 · see citing works
Transcription coactivators for peroxisome proliferator-activated receptors.
Yu, S.-T., & Reddy, J. (2007) · Biochimica et Biophysica Acta · doi:10.1016/j.bbalip.2007.01.008 · Cited by 252 · see citing works
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
Ahmed, K., Tunaru, S., & Offermanns, S. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.001 · Cited by 247 · see citing works
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat
Croset, M., BROSSARD, N., POLETTE, A., & Lagarde, M. (1999) · Biochemical Journal · doi:10.1042/bj3450061 · Cited by 247 · see citing works
Fatty Acid Oxidation and Ketogenesis by Astrocytes in Primary Culture
Auestad, N., Korsak, R. A., Morrow, J. W., & Edmond, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11435.x · Cited by 245 · see citing works
The Ketogenic Diet
Sinha, S. R., & Kossoff, E. H. (2005) · The Neurologist · doi:10.1097/01.nrl.0000160818.58821.d2 · Cited by 245 · see citing works
Energy Intake and Prostate Tumor Growth, Angiogenesis, and Vascular Endothelial Growth Factor Expression
Mukherjee, P., Sotnikov, A. V., Mangian, H. J., Zhou, J., Visek, W. J., & Clinton, S. K. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.6.512 · Cited by 237 · see citing works
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
Maurer, G. D., Brucker, D. P., Bähr, O., Harter, P. N., Hattingen, E., Walenta, S., Mueller‐Klieser, W., Steinbach, J. P., & Rieger, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-315 · Cited by 236 · see citing works
Distribution of mRNAs Encoding the Peroxisome Proliferator‐Activated Receptor α, β, and γ and the Retinoid X Receptor α, β, and γ in Rat Central Nervous System
Cullingford, T. E., Bhakoo, K. K., Peuchen, S., Dolphin, C. T., Patel, R., & Clark, J. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041366.x · Cited by 234 · see citing works
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
Stafford, P., Abdelwahab, M. G., ‍Kim, D. Y., Preul, M. C., Rho, J. M., & Scheck, A. C. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-74 · Cited by 224 · see citing works
Lysophosphatidylcholine as a Preferred Carrier Form of Docosahexaenoic Acid to the Brain
Lagarde, M., Bernoud‐Hubac, N., BROSSARD, N., Lemaitre-Delaunay, D., Thiès, F., Croset, M., & Lecerf, J. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:201 · Cited by 221 · see citing works
Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment
Deplanque, D., Gelé, P., Pétrault, O., Six, I., Furman, C., Bouly, M., Nion, S., Dupuis, B., Leys, D., Fruchart, J., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06264.2003 · Cited by 219 · see citing works
Peroxisome Proliferator-Activated Receptors, Coactivators, and Downstream Targets
Qi, C., Zhu, Y., & Reddy, J. K. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:187 · Cited by 216 · see citing works
FGF21 and the late adaptive response to starvation in humans
Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., Lee, H., Catana, C., Klibanski, A., Patwari, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83349 · Cited by 214 · see citing works
Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
Otto, C., Kaemmerer, U., Illert, B., Muehling, B., Pfetzer, N., Wittig, R., Voelker, H.-U., Thiede, A. H., & Coy, J. F. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-122 · Cited by 213 · see citing works
The Activity of Antiepileptic Drugs as Histone Deacetylase Inhibitors
Eyal, S., Yagen, B., Sobol, E., Altschuler, Y., Shmuel, M., & Bialer, M. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.00104.x · Cited by 207 · see citing works
The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect
Yudkoff, M., Daikhin, Y., Melø, T. M., Nissim, I., Sonnewald, U., & Nissim, I. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093722 · Cited by 202 · see citing works
Ketoacids? Good medicine?
Cahill, G. F., & Veech, R. L. (2003) · PubMed Central · Cited by 199 · see citing works
Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein
Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196 · see citing works
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
Prins, M. L., Fujima, L. S., & Hovda, D. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20633 · Cited by 194 · see citing works
Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Li, H., Gao, Z., Zhang, J., Ye, X., Xu, A., Ye, J., & Jia, W. (2012) · Diabetes · doi:10.2337/db11-0846 · Cited by 193 · see citing works
Oxidized Omega-3 Fatty Acids Inhibit NF-κB Activation Via a PPARα-Dependent Pathway
Mishra, A., Chaudhary, A. K., & Sethi, S. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137191.02577.86 · Cited by 188 · see citing works
THE KETOGENIC DIET IN EPILEPSY
PETERMAN, M. G. (1925) · JAMA · doi:10.1001/jama.1925.02660520007003 · Cited by 184 · see citing works
Metabolic therapy: A new paradigm for managing malignant brain cancer
Seyfried, T. N., Flores, R. E., Poff, A. M., D’Agostino, D. P., & Mukherjee, P. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.015 · Cited by 182 · see citing works
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase
Turko, I. V., Marcondes, S., & Murad, F. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2289 · Cited by 182 · see citing works
Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
Mukherjee, P., El‐Abbadi, M. M., Kasperzyk, J. L., Ranes, M. K., & Seyfried, T. N. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600298 · Cited by 178 · see citing works
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
Huang, D., Li, T., Wang, L., Zhang, L., Yan, R., Li, K., Xing, S., Wu, G., Hu, L., Jia, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.109 · Cited by 172 · see citing works
Clinical review: Ketones and brain injury
White, H. T., & Venkatesh, B. (2011) · Critical Care · doi:10.1186/cc10020 · Cited by 171 · see citing works
Identification of a Peroxisome Proliferator-responsive Element Upstream of the Human Peroxisomal Fatty Acyl Coenzyme A Oxidase Gene
Varanasi, U., Chu, R., Huang, Q. M., Castellon, R., Yeldandi, A. V., & Reddy, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2147 · Cited by 169 · see citing works
mTOR signaling in tumorigenesis
Xu, K. L., Liu, P., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.007 · Cited by 167 · see citing works
Fatty acid transport into the brain: Of fatty acid fables and lipid tails
Mitchell, R. W., & Hatch, G. M. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.007 · Cited by 167 · see citing works
Medium‐chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte‐neuron lactate and ketone body shuttle systems
Thévenet, J., Marchi, U. D., Domingo, J. S., Christinat, N., Bultot, L., Lefebvre, G. C., Sakamoto, K., Descombes, P., Masoodi, M., & Wiederkehr, A. (2016) · The FASEB Journal · doi:10.1096/fj.201500182 · Cited by 167 · see citing works
Effect of β-Hydroxybutyrate, a Cerebral Function Improving Agent, on Cerebral Hypoxia, Anoxia and Ischemia in Mice and Rats
Suzuki, M., Suzuki, M., Sato, K., Dohi, S., Sato, T., Matsuura, A., & Hiraide, A. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.87.143 · Cited by 160 · see citing works
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling
Kang, H., Fan, J., Lin, R., Elf, S., Ji, Q., Zhao, L., Jin, L., Seo, J. H., Shan, C., Arbiser, J. L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.037 · Cited by 158 · see citing works
Ketone body synthesis in the brain: possible neuroprotective effects
Guzmán, M., & Blázquez, C. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.05.001 · Cited by 152 · see citing works
Glucose and lactate supply to the synapse
Barros, L. F., & Deitmer, J. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.002 · Cited by 148 · see citing works
Regulation of ketogenesis and clinical aspects of the ketotic state
McGarry, J. D., & Foster, D. W. (1972) · Metabolism · doi:10.1016/0026-0495(72)90059-5 · Cited by 146 · see citing works
Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury
Robertson, C., Scafidi, S., McKenna, M. C., & Fiskum, G. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.030 · Cited by 143 · see citing works
A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fastingPreprint
Hugo, S. E., Cruz-Garcia, L., Karanth, S., Anderson, R. M., Stainier, D. Y. R., & Schlegel, A. (2012) · Genes & Development · doi:10.1101/gad.180968.111 · Cited by 141 · see citing works
Pekmeability Changes in the Blood-Brain Barrier: Causes and Consequences
Pardridge, W. M., Connor, J. D., Crawford, I. L., & Oldendorf, W. H. (1975) · Critical Reviews in Toxicology · doi:10.3109/10408447509079857 · Cited by 138 · see citing works
Metabolic and inflammatory adaptation of reactive astrocytes: role of PPARs
Iglesias, J., Morales, L., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9833-2 · Cited by 137 · see citing works
Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
Cimini, A., Benedetti, E., Cristiano, L., Sebastiani, P., D’Amico, M. A., D’Angelo, B., & Loreto, S. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.043 · Cited by 129 · see citing works
The AMP‐Activated Protein Kinase Is Involved in the Regulation of Ketone Body Production by Astrocytes
Blázquez, C., Woods, A., CEBALLOS, M. L. D., Carling, D., & Guzmán, M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731674.x · Cited by 129 · see citing works
Leukotriene B4 Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist
Narala, V. R., Adapala, R. K., Suresh, M. V., Brock, T. G., Peters-Golden, M., & Reddy, R. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085118 · Cited by 126 · cited 1× · see citing works
“Arachidonic acid derived inflammatory mediators, such as leukotrienes LTB4 and LTA4 are natural PPARα agonists [158].”
Background
Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells
Martinez‐Outschoorn, U., Zhao, L., Whitaker‐Menezes, D., Howell, A., Lisanti, M. P., & Sotgia, F. (2012) · Cell Cycle · doi:10.4161/cc.22136 · Cited by 125 · see citing works
Ketone bodies inhibit the viability of human neuroblastoma cells
SKINNER, R. S., Trujillo, A., Ma, X., & Beierle, E. A. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2008.10.042 · Cited by 119 · see citing works
DNA Binding-Independent Induction of I B Gene Transcription by PPAR
Delerive, P., Bosscher, K. D., Berghe, W. V., Fruchart, J., Haegeman, G., & Staels, B. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.5.0826 · Cited by 116 · see citing works
The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders
Cullingford, T. E. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.008 · Cited by 115 · see citing works
Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinasePreprint
Lustig, Y., Ruas, J. L., Estall, J. L., Lo, J. C., Devarakonda, S., Laznik, D., Choi, J. H., Ono, H., Olsen, J. V., & Spiegelman, B. M. (2011) · Genes & Development · doi:10.1101/gad.2054711 · Cited by 115 · see citing works
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α
Scuderi, C., Valenza, M., Stecca, C., Esposito, G., Carratù, M. R., & Steardo, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-49 · Cited by 112 · see citing works
Quantitative Proteomics Reveals That Enzymes of the Ketogenic Pathway Are Associated with Prostate Cancer Progression
Saraon, P., Cretu, D., Musrap, N., Karagiannis, G. S., Batruch, I., Drabovich, A. P., van der Kwast, T., Mizokami, A., Morrissey, C. M., Jarvi, K. A., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.023887 · Cited by 112 · see citing works
Histone deacetylases: complex transducers of nuclear signals
Johnson, C. A., & Turner, B. M. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0299 · Cited by 110 · see citing works
Caloric restriction reduces growth of mammary tumors and metastases
Lorenzo, M. S. D., Baljinnyam, E., Vatner, D. E., Abarzúa, P., Vatner, S. F., & Rabson, A. B. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr107 · Cited by 109 · see citing works
The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury
Prins, M. L., & Matsumoto, J. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046706 · Cited by 107 · see citing works
Role of Carnitine Palmitoyltransferase I in the Control of Ketogenesis in Primary Cultures of Rat Astrocytes
Blázquez, C., Sánchez, C., Velasco, G., & Guzmán, M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041597.x · Cited by 105 · see citing works
Cerebral Metabolic Response to Traumatic Brain Injury Sustained Early in Development: A 2-Deoxy-D-Glucose Autoradiographic Study
Thomas, S., Prins, M. L., Samii, M., & Hovda, D. A. (2000) · Journal of Neurotrauma · doi:10.1089/089771500415409 · Cited by 105 · see citing works
Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy
Chang, H. T., Olson, L. K., & Schwartz, K. A. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-47 · Cited by 105 · see citing works
Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. I. Regulation of branched chain alpha-ketoacid metabolism.
WILLIAMSON, J. R., Wałajtys-Rode, E., & Coll, K. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86514-6 · Cited by 104 · see citing works
SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
Hirschey, M. D., Shimazu, T., Capra, J. A., Pollard, K. S., & Verdin, E. M. (2011) · Aging · doi:10.18632/aging.100339 · Cited by 104 · see citing works
Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide
Scuderi, C., Esposito, G., Blasio, A., Valenza, M., Arietti, P., Steardo, L., Carnuccio, R., Filippis, D. D., Petrosino, S., Iuvone, T., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01267.x · Cited by 101 · see citing works
THE INHIBITION OF MALIGNANT CELL GROWTH BY KETONE BODIES
Magee, B. A., Potezny, N., Rofe, A. M., & Conyers, R. A. J. (1979) · Immunology and Cell Biology · doi:10.1038/icb.1979.54 · Cited by 101 · see citing works
A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth
Feyter, H. M. D., Behar, K. L., Rao, J. U., Madden-Hennessey, K., Ip, K. L., Hyder, F., Drewes, L. R., Geschwind, J.-F. H., de Graaf, R. A., & Rothman, D. L. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now088 · Cited by 99 · see citing works
Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes
Xu, J., Chavis, J. A., Racke, M. K., & Drew, P. D. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.04.019 · Cited by 98 · see citing works
A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα
Meertens, L. M., Miyata, K., Cechetto, J. D., Rachubinski, R. A., & Capone, J. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6972 · Cited by 97 · see citing works
Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy
Phoenix, K. N., Vumbaca, F., Fox, M. M., Evans, R., & Claffey, K. P. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0647-z · Cited by 97 · see citing works
Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders
Drew, P. D., Xu, J., Storer, P. D., Chavis, J. A., & Racke, M. K. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.003 · Cited by 96 · see citing works
EPILEPSY IN ADULTS
Barborka, C. J. (1930) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1930.02220110066004 · Cited by 96 · see citing works
The ketogenic diet for the treatment of malignant glioma
Woolf, E. C., & Scheck, A. C. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046797 · Cited by 96 · see citing works
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues
Tisdale, M. J., & Brennan, R. A. (1983) · British Journal of Cancer · doi:10.1038/bjc.1983.38 · Cited by 91 · see citing works
The Role of Inflammation in Brain Cancer
Sowers, J. L., Johnson, K. M., Conrad, C. C., Patterson, J. T., & Sowers, L. C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_4 · Cited by 90 · see citing works
Implementing A Ketogenic Diet Based on Medium-chain Triglyceride Oil in Pediatric Patients with Cancer
Nebeling, L. C., & Lerner, E. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00189-1 · Cited by 89 · see citing works
Glucagon activates mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase in vivo by decreasing the extent of succinylation of the enzyme
Quant, P. A., Tubbs, P. K., & Brand, M. D. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15291.x · Cited by 87 · see citing works
Ten-Year Single-Center Experience of the Ketogenic Diet: Factors Influencing Efficacy, Tolerability, and Compliance
Wibisono, C., Rowe, N., Beavis, E., Kepreotes, H., Mackie, F., Lawson, J. A., & Cardamone, M. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.12.018 · Cited by 86 · see citing works
New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae
Pohl, J., Ring, A., Herrmann, T. R. W., & Stremmel, W. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004341 · Cited by 86 · see citing works
Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE
Kostiuk, M. A., Keller, B. O., & Berthiaume, L. G. (2010) · The FASEB Journal · doi:10.1096/fj.09-149765 · Cited by 83 · see citing works
Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes
Cristiano, L., Bernardo, A., & Ceru`, M. P. (2001) · Journal of Neurocytology · doi:10.1023/a:1016525716209 · Cited by 80 · see citing works
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration
Marcondes, S., Turko, I. V., & Murad, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141222598 · Cited by 78 · see citing works
Hydroxycarboxylic and oxocarboxylic acids in urine:products from branched-chain amino acid degradation and from ketogenesis
Liebich, H. M., & Först, C. (1984) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(84)80031-6 · Cited by 77 · see citing works
Peroxisome proliferator‐activated receptor‐α agonist fenofibrate regulates IL‐12 family cytokine expression in the CNS: relevance to multiple sclerosis
Xu, J., Racke, M. K., & Drew, P. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04875.x · Cited by 76 · see citing works
Regulation of P450 4A expression by peroxisome proliferator activated receptors
Johnson, E. F., Hsu, M., Savas, Ü., & Griffin, K. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00282-2 · Cited by 74 · see citing works
Ketogenesis in isolated rat liver mitochondria I. Relationships with the citric acid cycle and with the mitochondrial energy state
Lopes-Cardozo, M., & van den Bergh, S. G. (1972) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(72)90092-8 · Cited by 71 · see citing works
Relationship between central and peripheral fatty acids in humans
Guest, J., Garg, M. L., BILGIN, A. A. B., & Grant, R. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-79 · Cited by 69 · see citing works
Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases
Van, A. L., Sakayori, N., Hachem, M., Belkouch, M., Picq, M., Lagarde, M., Osumi, N., & Bernoud‐Hubac, N. (2016) · Biochimie · doi:10.1016/j.biochi.2016.07.011 · Cited by 66 · see citing works
Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1
Nadal, A., Marrero, P. F., & Haro, D. (2002) · Biochemical Journal · doi:10.1042/bj20020598 · Cited by 65 · see citing works
PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings
Puligheddu, M., Pillolla, G., Melis, M., Lecca, S., Marrosu, F., Montis, M. G. D., Scheggi, S., Carta, G., Murru, E., Aroni, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064541 · Cited by 65 · see citing works
Succinylation and inactivation of 3-hydroxy-3-methylglutaryl-CoA synthase by succinyl-CoA and its possible relevance to the control of ketogenesis
Lowe, D. M., & Tubbs, P. K. (1985) · Biochemical Journal · doi:10.1042/bj2320037 · Cited by 63 · see citing works
Peroxisome Proliferator-Activated Receptor-α Contributes to the Anti-Inflammatory Activity of Glucocorticoids
Cuzzocrea, S., Bruscoli, S., Mazzon, E., Crisafulli, C., Donato, V., Paola, R. D., Velardi, E., Esposito, E., Nocentini, G., & Riccardi, C. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.041475 · Cited by 62 · see citing works
3‐Oxo acid coenzyme A transferase activity in brain and tumors of the nervous system1
Fredericks, M. R., & Ramsey, R. B. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb06581.x · Cited by 60 · see citing works
Hormonal regulation of ketone-body metabolism in man.
Alberti, K. G. M. M., Johnston, D. G., Gill, A., Barnes, A., & Ørskov, H. (1978) · PubMed · Cited by 59 · see citing works
Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
Motojima, K. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00046-7 · Cited by 55 · see citing works
The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
Cullingford, T. E., Dolphin, C. T., & Sato, H. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00014-x · Cited by 54 · see citing works
Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism
Sánchez‐Alvarez, R., Martinez‐Outschoorn, U., Zhao, L., Lamb, R., Hulit, J., Howell, A., Sotgia, F., Rubin, E., & Lisanti, M. P. (2013) · Cell Cycle · doi:10.4161/cc.23109 · Cited by 54 · see citing works
Mapping Cerebral Glucose Metabolism During Spatial Learning: Interactions of Development and Traumatic Brain Injury
Prins, M. L., & Hovda, D. A. (2001) · Journal of Neurotrauma · doi:10.1089/089771501750055758 · Cited by 53 · see citing works
Peroxisome proliferator-activated receptor δ is a specific sensor for teratogenic valproic acid derivatives
Lampen, A., Carlberg, C., & Nau, H. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01423-6 · Cited by 53 · see citing works
Metabolic and Regulatory Roles of Leucine in Neural Cells
Murín, R., & Hamprecht, B. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9444-4 · Cited by 51 · see citing works
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism
Rando, G., Tan, C. K., Khaled, N., Montagner, A., Leuenberger, N., Bertrand‐Michel, J., Paramalingam, E., Guillou, H., & Wahli, W. (2016) · eLife · doi:10.7554/elife.11853 · Cited by 51 · see citing works
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases?
Hoffmann, K., Czapp, M., & Löscher, W. (2008) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.04.019 · Cited by 50 · see citing works
The regulation of FGF21 gene expression by metabolic factors and nutrients
Erickson, A., & Moreau, R. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0016 · Cited by 50 · see citing works
On the Mechanism of Ketogenesis and Its Control
Huth, W., Jonas, R., WUNDERLICH, I., & Seubert, W. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02476.x · Cited by 49 · see citing works
Skeletal muscle PGC‐1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice
Svensson, K., Albert, V., Cardel, B., Salatino, S., & Handschin, C. (2016) · The FASEB Journal · doi:10.1096/fj.201500128 · Cited by 49 · see citing works
Human Mitochondrial NAD(P)+–Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion
Chang, Y., Gao, H., Chiang, C., Wang, W., Huang, S., Ku, C.-F., Liu, G., & Hung, H. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.385 · Cited by 48 · see citing works
Peroxisome Proliferator-Activated Receptor-α Activation Inhibits Langerhans Cell Function
Dubrac, S., Stoitzner, P., Pirkebner, D., Elentner, A., Schoonjans, K., Auwerx, J. H., Saeland, S., Hengster, P., Fritsch, P. O., Romani, N., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4362 · Cited by 47 · see citing works
Control of Ketogenesis from Amino Acids. IV. Tissue Specificity in Oxidation of Leucine, Tyrosine, and Lysine1
Noda, C., & Ichihara, A. (1976) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131371 · Cited by 46 · see citing works
Effect of Dietary Energy Restriction on Vascular Density during Mammary Carcinogenesis
Thompson, H. J., McGinley, J. N., Spoelstra, N. S., Jiang, W., Zhu, Z., & Wolfe, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0787 · Cited by 46 · see citing works
PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia
Xuan, A., Chen, Y., Long, D., Zhang, M., Ji, W., Zhang, W., Liu, J., Hong, L.-P., He, X., & Chen, W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8882-7 · Cited by 46 · see citing works
Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
König, B., Koch, A. H., Giggel, K., Dordschbal, B., Eder, K., & Stangl, G. I. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.002 · Cited by 46 · see citing works
PPARα agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS‐treated macrophages
Paukkeri, E., Leppänen, T., Sareila, O., Vuolteenaho, K., Kankaanranta, H., & Moilanen, E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707477 · Cited by 44 · see citing works
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
Stemmer, K., Zani, F., Habegger, K. M., Neff, C., Kotzbeck, P., Bauer, M., Yalamanchilli, S., Azad, A., Lehti, M., Martins, P. J. F., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3668-7 · Cited by 44 · see citing works
Role of neuron-glia interaction in the regulation of brain glucose utilization.
Pellerin, L., Bonvento, G., Chatton, J., Pierre, K., & Magistretti, P. J. (2002) · PubMed · Cited by 43 · see citing works
Mechanisms of catecholamine effects on ketogenesis
Bahnsen, M. K., Burrin, J. M., Johnston, D. G., Pernet, A., Walker, M., & Alberti, K. G. M. M. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.2.e173 · Cited by 42 · see citing works
Gene expression of fatty acid transport and binding proteins in the blood–brain barrier and the cerebral cortex of the rat: Differences across development and with different DHA brain status
Pélerin, H., Jouin, M., Lallemand, M.-S., Alessandri, J., Cunnane, S. C., Goustard, B., & Guesnet, P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.07.004 · Cited by 41 · see citing works
Anticonvulsant Effect of Time-Restricted Feeding in a Pilocarpine-Induced Seizure Model: Metabolic and Epigenetic Implications
Landgrave-Gómez, J., Mercado-Gómez, O. F., Vázquez-García, M., Molina, V., Córdova-Dávalos, L. E., Arriaga-Ávila, V. S., Miranda-Martínez, A., & Guevara‐Guzmán, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00007 · Cited by 39 · see citing works
Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells
Grabacka, M., Wilk, A. M., Antończyk, A., Banks, P., Walczyk-Tytko, E., Dean, M. J., Pierzchalska, M., & Krzysztof Reiss, F. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00005 · Cited by 39 · see citing works
Self-citation
Human ketone body production and utilization studied using tracer techniques: Regulation by free fatty acids, insulin, catecholamines, and thyroid hormones
Keller, U. B., Lustenberger, M., Müller‐Brand, J., Gerber, P. P. G., & Stauffacher, W. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050306 · Cited by 38 · see citing works
Effect of PPARα activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes
Murakami, K., Bujo, H., Unoki‐Kubota, H., & Saitō, Y. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.037 · Cited by 38 · see citing works
Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist
Januszewicz, E., Pająk, B., Gajkowska, B., Samluk, Ł., Djavadian, R. L., Hinton, B. T., & Nałęcz, K. A. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.08.020 · Cited by 38 · see citing works
Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells
Hildebrandt, L. A., Spennetta, T. L., Elson, C. E., & Shrago, E. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.1.c22 · Cited by 38 · see citing works
The role of leucine in ketogenesis in starved rats
Thomas, L. K., Ittmann, M., & Cooper, C. (1982) · Biochemical Journal · doi:10.1042/bj2040399 · Cited by 37 · see citing works
Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate
Dueregger, A., Schöpf, B., Eder, T., Hoefer, J., Gnaiger, E., Aufinger, A., Kenner, L., Perktold, B., Ramoner, R. E., Klocker, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135704 · Cited by 36 · see citing works
KTX 0101: A Potential Metabolic Approach to Cytoprotection in Major Surgery and Neurological Disorders
Smith, S. L., Heal, D. J., & Martin, K. F. (2005) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00265.x · Cited by 36 · see citing works
β‐Hydroxybutyric Acid Inhibits Growth Hormone‐Releasing Hormone Synthesis and Secretion Through the GPR 109A/Extracellular Signal‐Regulated 1/2 Signalling Pathway in the Hypothalamus
Fu, S., Liu, B., Wang, J. ‐., Xue, W., Liu, H. ‐., Zeng, Y., Huang, B., Li, S. ‐., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12256 · Cited by 35 · see citing works
Ketone-body metabolism in glioma and neuroblastoma cells.
Patel, M. S., Russell, J. J., & Gershman, H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7214 · Cited by 34 · see citing works
Utilization of ketone bodies and glucose by established neural cell lines
Roeder, L. M., Poduslo, S. E., & Tildón, J. T. (1982) · Journal of Neuroscience Research · doi:10.1002/jnr.490080412 · Cited by 33 · see citing works
The Hepatocyte Nuclear Factor 4 (HNF-4) Represses the Mitochondrial HMG-CoA Synthase Gene
guez, J. C. R. X., Ortiz, J. A., Hegardt, F. G., & Haro, D. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8032 · Cited by 32 · see citing works
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene
Rodríguez, J. C., Ortiz, J. A., Hegardt, F. G., & Haro, D. (1997) · Biochemical Journal · doi:10.1042/bj3260587 · Cited by 32 · see citing works
Modulation of Fatty Acid Metabolism by Glucagon in Man: II. Effects in Insulin-deficient Diabetics
Schade, D. S., & Eaton, R. P. (1975) · Diabetes · doi:10.2337/diab.24.5.510 · Cited by 30 · see citing works
[2,4-13C]β-hydroxybutyrate Metabolism in Astrocytes and C6 Glioblastoma Cells
Eloqayli, H., Melø, T. M., Haukvik, A., & Sonnewald, U. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0485-3 · Cited by 24 · see citing works
Very Long Chain Fatty Acid β-Oxidation in Astrocytes: Contribution of the ABCD1-Dependent and -Independent Pathways
Morita, M., Shinbo, S., 朝日彰子, & Imanaka, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00411 · Cited by 22 · see citing works

Flagged first, then by citations

3 of the 209 references couldn’t be matched to a known paper.

Sorted by citations

PPAR control of metabolism and cardiovascular functions
Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 960 · see citing works
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation
Schiliro, C., & Firestein, B. L. (2021) · Cells · doi:10.3390/cells10051056 · Cited by 631 · see citing works
Very-Low-Calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases: Systematic Review and Consensus Statement from the Italian Society of Endocrinology (SIE)
Caprio, M., Infante, M., Moriconi, E., Armani, A., Fabbri, A., Mantovani, G., Mariani, S., Lubrano, C., Poggiogalle, E., Migliaccio, S., et al. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01061-2 · Cited by 283 · see citing works
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease
Torres, J. A., Kruger, S. L., Broderick, C., Amarlkhagva, T., Agrawal, S., Dodam, J. R., Mrug, M. M., Lyons, L. A., & Weimbs, T. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.012 · Cited by 223 · see citing works
Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health
Miller, V. J., Villamena, F. A., & Volek, J. S. (2018) · Journal of Nutrition and Metabolism · doi:10.1155/2018/5157645 · Cited by 200 · see citing works
Diet and exercise in NAFLD/NASH: Beyond the obvious
Semmler, G., Datz, C., Reiberger, T., & Trauner, M. A. (2021) · Liver International · doi:10.1111/liv.15024 · Cited by 183 · see citing works
Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder
Leclercq, S., Le Roy, T., Furgiuele, S., Coste, V., Bindels, L. B., Leyrolle, Q., Neyrinck, A. M., Quoilin, C., Amadieu, C., Petit, G., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108238 · Cited by 178 · see citing works
Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases
Moffett, J. R., Puthillathu, N., Vengilote, R., Jaworski, D. M., & Namboodiri, A. M. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.580167 · Cited by 182 · see citing works
Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
Chen, G., Xiong, S., Qiao, J., van Gestel, C. A. M., van Straalen, N. M., Roelofs, D., Sun, L., & Qiu, H. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158666 · Cited by 166 · see citing works
PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
Todisco, S., Santarsiero, A., Convertini, P., Stefano, G. D., Gilio, M., Iacobazzi, V., & Infantino, V. (2022) · Biology · doi:10.3390/biology11050792 · Cited by 153 · see citing works
RETRACTED ARTICLE: Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
Wu, Q., Li, J., Li, Z., Sun, S., Zhu, S., Wang, L., Wu, J., Yuan, J., Zhang, Y., Sun, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1210-3 · Cited by 137 · see citing works
Retracted
Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry
Longo, R., Peri, C., Cricrì, D., Coppi, L., Caruso, D., Mitro, N., Fabiani, E. D., & Crestani, M. (2019) · Nutrients · doi:10.3390/nu11102497 · Cited by 117 · see citing works
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo
Bayraktar, E. C., Baudrier, L., Özerdem, C., Lewis, C. A., Chan, S. H., Kunchok, T., Abu-Remaileh, M., Cangelosi, A. L., Sabatini, D. M., Birsoy, K., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816656115 · Cited by 112 · see citing works
Ketogenic diets, physical activity and body composition: a review
Ashtary‐Larky, D., Bagheri, R., Bavi, H., Baker, J. S., Moro, T., Mancin, L., & Paoli, A. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002609 · Cited by 114 · see citing works
Cardioprotective Potential of an SGLT2 Inhibitor Against Doxorubicin-Induced Heart Failure
Oh, C., Cho, S., Jang, J., Kim, H., Chun, S., Choi, M., Park, S., & Ko, Y. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0180 · Cited by 109 · see citing works
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases
Jiang, Z., Yin, X., Wang, M., Chen, T., Wang, Y., Gao, Z., & Wang, Z. (2022) · Aging and Disease · doi:10.14336/ad.2021.1217 · Cited by 109 · see citing works
Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer
Hwang, C. Y., Choe, W., Yoon, K., Ha, J., Kim, S. S., Yeo, E., & Kang, I. (2022) · Nutrients · doi:10.3390/nu14224932 · Cited by 105 · see citing works
Ketosis-prone diabetes (Flatbush diabetes): an emerging worldwide clinically important entity
Lebovitz, H. E., & Banerji, M. A. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1075-4 · Cited by 98 · see citing works
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma
Wang, Y.-H., Liu, C.-L., Chiu, W., Twu, Y., & Liao, Y. (2019) · Cancers · doi:10.3390/cancers11121876 · Cited by 89 · see citing works
Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease
Mooli, R. G. R., & Ramakrishnan, S. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.946474 · Cited by 84 · see citing works
Diverse Metabolic Reactions Activated During 58-hr Fasting are Revealed by Non-Targeted Metabolomic Analysis of Human Blood
Teruya, T., Chaleckis, R., Takada, J., Yanagida, M., & Kondoh, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-36674-9 · Cited by 86 · see citing works
Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate
Hinds, T. D., Creeden, J. F., Gordon, D. M., Stec, D. F., Donald, M. C., & Stec, D. E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.594574 · Cited by 85 · see citing works
Glioblastoma Microenvironment and Cellular Interactions
Crivii, C. B., Boşca, A. B., Melincovici, C. S., Constantin, A.-M., Mărginean, M. V., Dronca, E., Suflețel, R. T., Gonciar, D., Bungărdean, R. M., & Şovrea, A. S. (2022) · Cancers · doi:10.3390/cancers14041092 · Cited by 82 · see citing works
Inflammasomes: Pandora’s box for sepsis
Kumar, V. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s178084 · Cited by 85 · see citing works
The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence
Virtuoso, A., Giovannoni, R., Luca, C. D., Gargano, F., Cerasuolo, M., Maggio, N., Lavitrano, M., & Papa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073301 · Cited by 80 · see citing works
Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research
Berardo, C., Pasqua, L. G. D., Cagna, M., Richelmi, P., Vairetti, M., & Ferrigno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249646 · Cited by 80 · see citing works
Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways
Snaebjornsson, M. T., & Schulze, A. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0065-6 · Cited by 77 · see citing works
The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism
Zhang, S., & Xie, C. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.07.003 · Cited by 76 · see citing works
Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial
He, X., Parenti, M., Grip, T., Domellöf, M., Lönnerdal, B. L., Hernell, O., Timby, N., & Slupsky, C. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-36292-5 · Cited by 76 · see citing works
Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue
Hinds, T. D., Kipp, Z. A., Xu, M., Yiannikouris, F. B., Morris, A. J., Stec, D. F., Wahli, W., & Stec, D. E. (2021) · Cells · doi:10.3390/cells11010004 · Cited by 71 · see citing works
RETRACTED ARTICLE: Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
Wu, Q., Sun, S., Li, Z., Yang, Q., Li, B., Zhu, S., Wang, L., Wu, J., Yuan, J., Wang, C., et al. (2018) · Adipocyte · doi:10.1080/21623945.2018.1551688 · Cited by 70 · see citing works
Retracted
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells
Kim, J. T., Li, C., Weiss, H. L., Zhou, Y., Liu, C., Wang, Q., & Evers, B. M. (2019) · Cells · doi:10.3390/cells8091106 · Cited by 70 · see citing works
Fasting: From Physiology to Pathology
Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 71 · see citing works
Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders
Morris, G., Maes, M. H. J., Berk, M., Carvalho, A. F., & Puri, B. K. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2019.13 · Cited by 67 · see citing works
The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer
Mohammadifard, N., Haghighatdoost, F., Rahimlou, M., Rodrigues, A., Gaskarei, M. A. K., Okhovat, P., de Oliveira, C., Silveira, É. A., & Sarrafzadegan, N. (2022) · Nutrients · doi:10.3390/nu14173499 · Cited by 62 · see citing works
Metabolomics and transcriptomics based multi-omics integration reveals radiation-induced altered pathway networking and underlying mechanism
Maan, K., Baghel, R., Dhariwal, S., Sharma, A., Bakhshi, R., & Rana, P. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00305-5 · Cited by 66 · see citing works
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis
Fan, S., Lin, C., Wei, Y., Yeh, S., Tsai, Y., Lee, A. C., Lin, W., & Wang, P. (2021) · Aging Cell · doi:10.1111/acel.13510 · Cited by 65 · see citing works
Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration
Cheng, Y., Gregorich, Z. R., Prajnamitra, R. P., Lundy, D. J., Ma, T.-Y., Huang, Y., Lee, Y.-C., Ruan, S., Lin, J.-H., Lin, P.-J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.061960 · Cited by 65 · see citing works
Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging
Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2022) · Food & Function · doi:10.1039/d2fo02688k · Cited by 69 · see citing works
Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy
Chou, Y., Ma, J., Su, X., & Zhong, Y. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01415-3 · Cited by 63 · see citing works
Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis
Harbeson, D. J., Francis, F., Bao, W., Amenyogbe, N., & Kollmann, T. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01918 · Cited by 62 · see citing works
Ketogenic Diet in the Treatment of Gliomas and Glioblastomas
Bello, S. D., Valdemarin, F., Martinuzzi, D., Filippi, F., Gigli, G. L., & Valente, M. (2022) · Nutrients · doi:10.3390/nu14183851 · Cited by 62 · see citing works
Short-Chain Fatty Acids in the Metabolism of Heart Failure – Rethinking the Fat Stigma
Palm, C. L., Nijholt, K. T., Bakker, B. M., & Westenbrink, B. D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.915102 · Cited by 61 · see citing works
Sodium‐glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter‐organ crosstalk
Kim, J. H., Lee, M., Kim, S. H., Kim, S. R., Lee, B., Kang, E. S., Cha, B., Cho, J. W., & Lee, Y. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13577 · Cited by 60 · see citing works
Continuous Ketone Monitoring Consensus Report 2021
Nguyen, K. T., Xu, N. Y., Zhang, J. Y., Shang, T., Basu, A., Bergenstal, R. M., CASTORINO, K. N., Chen, K. Y., Kerr, D. E., Koliwad, S. K., et al. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211042656 · Cited by 56 · see citing works
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming
Chong, D., Gu, Y., Zhang, T., Xu, Y., Bu, D., Chen, Z., Xu, N., Li, L., Zhu, X., Wang, H., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00447-6 · Cited by 56 · see citing works
The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines
Sherrier, M. C., & Li, H. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz145 · Cited by 56 · see citing works
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage
Wang, Z., Tian, L., Du, M., Zhang, L., Xu, L., Song, H., & Zhang, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.12.011 · Cited by 54 · see citing works
Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling
Misto, A., Provensi, G., Vozella, V., Passani, M. B., & Piomelli, D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.014 · Cited by 53 · see citing works
PPARα at the crossroad of metabolic–immune regulation in cancer
Zeng, W., Yin, X., Jiang, Y., Jin, L., & Liang, W. P. (2021) · FEBS Journal · doi:10.1111/febs.16181 · Cited by 52 · see citing works
The effects of oleoylethanolamide, an endogenous PPAR‐α agonist, on risk factors for NAFLD: A systematic review
Tutunchi, H., Ostadrahimi, A., Saghafi‐Asl, M., & Maleki, V. (2019) · Obesity Reviews · doi:10.1111/obr.12853 · Cited by 50 · see citing works
Diagnosis by Volatile Organic Compounds in Exhaled Breath from Patients with Gastric and Colorectal Cancers
Chung, J., Akter, S., Han, S., Shin, Y., Choi, T., Kang, I., & Kim, S. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010129 · Cited by 49 · see citing works
Pathways of Non-enzymatic Lysine Acylation
Baldensperger, T., & Glomb, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664553 · Cited by 45 · see citing works
Ketogenesis alleviates TNFα-induced apoptosis and inflammatory responses in intestinal cells
Kim, J. T., Napier, D. L., Kim, J., Li, C., Lee, E. Y., Weiss, H. L., Wang, Q., & Evers, B. M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.032 · Cited by 47 · see citing works
Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor
Lou, W., Zhang, M.-D., Chen, Q., Bai, T., Hu, Y., Gao, F., Li, J., Lv, X., Zhang, Q., & Chang, F. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01627-9 · Cited by 46 · see citing works
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue—Relationship between AMPK and Glycolysis
Kalezic, A., Udicki, M., Srdić, B., Aleksic, M., Korać, A., Janković, A., & Korać, B. (2021) · Cancers · doi:10.3390/cancers13112731 · Cited by 43 · see citing works
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer
Wang, Y.-H., Suk, F., & Liao, Y. (2020) · Cancers · doi:10.3390/cancers12071797 · Cited by 43 · see citing works
Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review
Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works
The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis
Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 41 · see citing works
ChREBP Reciprocally Regulates Liver and Plasma Triacylglycerol Levels in Different Manners
Iizuka, K., Takao, K., Kato, T., Horikawa, Y., & Takeda, J. (2018) · Nutrients · doi:10.3390/nu10111699 · Cited by 41 · see citing works
Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease
Semmler, G., Datz, C., & Trauner, M. A. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0364 · Cited by 42 · see citing works
Induced Ketosis as a Treatment for Neuroprogressive Disorders: Food for Thought?
Morris, G., Puri, B. K., Carvalho, A. F., Maes, M. H. J., Berk, M., Ruusunen, A. A., & OLIVE, L. S. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa008 · Cited by 41 · see citing works
Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model
Riedel, E. O., Hinrichs, A., Kemter, E., Dahlhoff, M., Backman, M., Rathkolb, B., Prehn, C. P., Adamski, J., Renner, S., Blutke, A., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.100978 · Cited by 40 · see citing works
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
Li, H., Ma, Z., Zhai, Y., Lv, C., Yuan, P., Zhu, F. Y., Wei, L., Li, Q., & Qi, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01255 · Cited by 40 · see citing works
Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease
Gross, T. J., Doran, E. W., Cheema, A. K., Head, E., Lott, I. T., & Mapstone, M. E. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22716 · Cited by 39 · see citing works
Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases
Bae, H. R., Leung, P. S. C., Hodge, D. L., Fenimore, J. M., Jeon, S.-M., Thovarai, V., Dzutsev, A., Welcher, A. A., Boedigheimer, M. J., Damore, M. A., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102436 · Cited by 39 · see citing works
AMPK-Targeted Effector Networks in Mycobacterial Infection
Jo, E., Silwal, P., & Yuk, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00520 · Cited by 38 · see citing works
The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation
Martines, A.-C. M. F., van Eunen, K., Reijngoud, D., & Bakker, B. M. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005461 · Cited by 37 · see citing works
Studying non-alcoholic fatty liver disease: the ins and outs of in vivo, ex vivo and in vitro human models
Green, C., Parry, S. A., Gunn, P. J., Ceresa, C. D. L., Rosqvist, F., Piché, M., & Hodson, L. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0038 · Cited by 37 · see citing works
Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos
Sangalli, J. R., Sampaio, R. V., del Collado, M., da Silveira, J. C., De, T. H. C., Perecin, F., Smith, L. C., & Meirelles, F. V. (2018) · Scientific Reports · doi:10.1038/s41598-018-31822-7 · Cited by 37 · see citing works
In vitro human colonic microbiota utilises D-β-hydroxybutyrate to increase butyrogenesis
Sasaki, K., Sasaki, D., Hannya, A., Tsubota, J., & Kondo, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-65561-5 · Cited by 37 · see citing works
Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts
Jung, J. G., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_12 · Cited by 38 · see citing works
Immunometabolic Changes in Glia – A Potential Role in the Pathophysiology of Obesity and Diabetes
Robb, J. L., Morrissey, N. A., Potter, P. G. W., Smithers, H. E., Beall, C., & Ellacott, K. L. J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.021 · Cited by 35 · see citing works
Apatinib induces 3‐hydroxybutyric acid production in the liver of mice by peroxisome proliferator‐activated receptor α activation to aid its antitumor effect
Feng, S., Wang, H., Wang, Y., Sun, R., Xie, Y., Zhou, Z., Wang, H., Aa, J., Zhou, F., & Wang, G. (2019) · Cancer Science · doi:10.1111/cas.14168 · Cited by 33 · see citing works
The Effect of Hyperlipidemia on the Course of Diabetic Retinopathy—Literature Review
Bryl, A., Mrugacz, M., Falkowski, M., & Zorena, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102761 · Cited by 33 · see citing works
The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows
Puppel, K., Gołębiewski, M., Solarczyk, P., Grodkowski, G., Slósarz, J., Kunowska-Slósarz, M., Balcerak, M., Przysucha, T., Kalińska, A., & Kuczyńska, B. (2019) · BMC Veterinary Research · doi:10.1186/s12917-019-2131-2 · Cited by 31 · see citing works
Dysregulation of Ketone Body Metabolism Is Associated With Poor Prognosis for Clear Cell Renal Cell Carcinoma Patients
Cui, W., Luo, W., Zhou, X., Lu, Y., Xu, W., Zhong, S., Feng, G., Liang, Y., Liang, L., Mo, Y., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01422 · Cited by 31 · see citing works
CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway
Deleye, Y., Cotte, A. K., Hannou, S. A., Hennuyer, N., Bernard, L., Derudas, B., Caron, S., Legry, V., Vallez, E., Dorchies, E., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012543 · Cited by 30 · see citing works
In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters
Selmi‐Ruby, S., Marín‐Sáez, J., Fildier, A., Buleté, A., Abdallah, M., Garcia, J., Deverchère, J., Spinner, L., Giroud, B., Ibanez, S., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6826 · Cited by 30 · see citing works
Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
Ow, J. R., Caldez, M. J., Zafer, G., Foo, J. C., Li, H. Y., Ghosh, S., Wollmann, H., Cazenave‐Gassiot, A., Ong, C. B., Wenk, M. R., et al. (2020) · eLife · doi:10.7554/elife.63835 · Cited by 31 · see citing works
Intermittent fasting—the future treatment in NASH patients?
Minciună, I., Gallage, S., Heikenwälder, M. F., Zelber‐Sagi, S., & Dufour, J. (2023) · Hepatology · doi:10.1097/hep.0000000000000330 · Cited by 31 · see citing works
HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids
Gonneaud, A., Turgeon, N., Jones, C. M., Couture, C., Lévesque, D., Boisvert, F., Boudreau, F., & Asselin, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-41842-6 · Cited by 27 · see citing works
Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
Zhang, L., Yao, W., Xia, J., Wang, T., & Huang, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081885 · Cited by 29 · see citing works
Involvement of nutrients and nutritional mediators in mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase gene expression
Rescigno, T., Capasso, A., & Tecce, M. F. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26177 · Cited by 28 · see citing works
Hepatocyte-specific Sirt6 deficiency impairs ketogenesis
Chen, L., Liu, Q., Tang, Q., Kuang, J., Li, H., Pu, S., Wu, T., Yang, X., Li, R., Zhang, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005309 · Cited by 28 · see citing works
Every-Other-Day Feeding Decreases Glycolytic and Mitochondrial Energy-Producing Potentials in the Brain and Liver of Young Mice
Sorochynska, O. M., Bayliak, M. M., Gospodaryov, D. V., Vasylyk, Y. V., Kuzniak, O. V., Pankiv, T. M., Garaschuk, O., Storey, K. B., & Lushchak, V. I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01432 · Cited by 28 · see citing works
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease
Shippy, D. C., Evered, A. H., & Ulland, T. K. (2024) · Immunological Reviews · doi:10.1111/imr.13365 · Cited by 29 · see citing works
βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet
Pérez-Liébana, I., Casarejos, M. J., Alcaide, A., Herrada-Soler, E., Llorente‐Folch, I., Contreras, L., Satrústegui, J., & Pardo, B. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0711-20.2020 · Cited by 27 · see citing works
Increasing Fat Deposition Via Upregulates the Transcription of Peroxisome Proliferator-Activated Receptor Gamma in Native Crossbred Chickens
Tunim, S., Phasuk, Y., Aggrey, S. E., & Duangjinda, M. (2021) · Animals · doi:10.3390/ani11010090 · Cited by 27 · see citing works
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle
Fukazawa, A., Koike, A., Karasawa, T., Tsutsui, M., Kondo, S., & Terada, S. (2020) · Nutrients · doi:10.3390/nu12051269 · Cited by 26 · see citing works
β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells
Benito, A., Hajji, N., O’Neill, K., Keun, H. C., & Syed, N. (2020) · Metabolites · doi:10.3390/metabo10090346 · Cited by 23 · see citing works
Qingfei oral liquid alleviates RSV-induced lung inflammation by promoting fatty-acid-dependent M1/M2 macrophage polarization via the Akt signaling pathway
Li, A., Lu, M., Xu, W., Chen, H., Lu, F., Xie, T., Shan, J., Wang, S., & Lin, L. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115637 · Cited by 26 · see citing works
Fatty acids uptake and oxidation are increased in the liver of rats with adjuvant-induced arthritis
Wendt, M. M. N., de Oliveira, M. C., Franco-Salla, G. B., Castro, L. D. S., Parizotto, Â. V., Silva, F. M. S., Natali, M. R. M., Bersani‐Amado, C. A., Bracht, A., & Comar, J. F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.019 · Cited by 26 · see citing works
Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety
Grundler, F., Mesnage, R., Ruppert, P. M. M., Kouretas, D., & de Toledo, F. W. (2024) · Nutrients · doi:10.3390/nu16121849 · Cited by 27 · see citing works
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions
Altaie, A. M., Venkatachalam, T., Samaranayake, L. P., Soliman, S. S. M., & Hamoudi, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707267 · Cited by 25 · see citing works
Green tea extract increases adiponectin and PPAR α levels to improve hepatic steatosis
Marinovic, M. P., Filho, C. P. B. S., Batista, F. A. H., Avelino, T. M., Cogliati, B., Figueira, A. C. M., Otton, R., & Rodrigues, A. C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108957 · Cited by 25 · see citing works
Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio)
Jia, J., Qin, J., Yuan, X., Liao, Z., Huang, J., Wang, B., Sun, C., & Li, W. (2019) · BMC Genomics · doi:10.1186/s12864-019-6309-6 · Cited by 25 · see citing works
Rethinking Fragility Fractures in Type 2 Diabetes: The Link between Hyperinsulinaemia and Osteofragilitas
Cooper, I. D., Brookler, K. H., & Crofts, C. A. P. (2021) · Biomedicines · doi:10.3390/biomedicines9091165 · Cited by 25 · see citing works
Bufei Jianpi Formula Improves Mitochondrial Function and Suppresses Mitophagy in Skeletal Muscle via the Adenosine Monophosphate-Activated Protein Kinase Pathway in Chronic Obstructive Pulmonary Disease
Mao, J., Li, Y., Feng, S., Liu, X., Tian, Y., Bian, Q., Li, J., Hu, Y., Zhang, L., Ji, H., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587176 · Cited by 24 · see citing works

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting
Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 54 · see citing works
Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man
Christodoulides, C., Dyson, P., Sprecher, D., Tsintzas, K., & Karpe, F. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0111 · Cited by 153 · see citing works
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
Shi, M. Y., Yu, H. C., Han, C. Y., Bang, I. H., Park, H. S., Jang, K. Y., Lee, S., Son, J. B., Kim, N. D., Park, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40597-z · Cited by 28 · see citing works
mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis
Alpergin, E. S. S., & Wolfgang, M. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100884 · Cited by 15 · see citing works
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

Authors: Grabacka, M., Pierzchalska, M., Dean, M., & Reiss, K.
Affiliations: University of Agriculture in Krakow (PL)
Department of Food Biotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Kraków, Poland
Louisiana State University (US)
Neurological Cancer Research, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA 70112, USA
Corresponding author: Grabacka, Maja
ORCID: Grabacka, Maja
Dean, Matthew
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2016-12-13
Volume: 17
Issue: 12
Pages: 2093
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms17122093
PMC: PMC5187893
OpenAlex: W2562858475
Cited by: 305
References: 209
Citations by year: 2026: 19 · 2025: 34 · 2024: 26 · 2023: 22 · 2022: 54 · 2021: 42 · 2020: 44 · 2019: 34 · 2018: 25 · 2017: 4
FWCI: 1.90
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health, USA (P20-GM103501)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: ketone body metabolism, ketogenesis, ketolysis, PPARα, fasting, AMPK, PGC-1α, mTOR, FGF21, cancer metabolism, neuropathology, nuclear receptors
MeSH terms: Animals, Brain, Humans, Ketone Bodies, Neoplasms, Signal Transduction, Neuroprotective Agents, PPAR alpha

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Ketone Body Metabolism and the Role of PPARα

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks