Automated Three‐Chambered Social Approach Task for Mice
Open accessAbstract
Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions, impaired communication, and repetitive behaviors with restricted interests. Direct social approach in mice has strong face validity to simple social approach behaviors in humans, which are frequently impaired in autism. This unit presents a basic protocol for a standardized, high‐throughput social approach test for assaying mouse sociability. Our automated three‐chambered social approach task quantifies direct social approach behaviors when a subject mouse is presented with the choice of spending time with either a novel mouse or a novel object. Sociability is defined as the subject mouse spending more time in the chamber containing the novel target mouse than in the chamber containing the inanimate novel object. The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection. Curr. Protoc. Neurosci . 56:8.26.1‐8.26.16. © 2011 by John Wiley & Sons, Inc.
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The three-chambered social approach test is commonly used as a first line screening assay for autism-like phenotypes in mouse models.
“Although the three-chambered social approach test is commonly used as a first line screening assay for autism like phenotypes in mouse models [47]”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [47]
Automated behavioral assays, such as the three-chamber social approach, provide a relatively simple assay of social interest as determined by the time the experimental animal spends near another animal confined to a small cage.
“Automated behavioral assays, such as the commonly used three-chamber social approach, provide a relatively simple assay of social interest as determined by the time the experimental animal spends near another animal that is confined to a small cage [47].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [47]
Many variables may influence social approach behavior, such as prior stress, illness, or previous aggressive behavior within a home cage.
“In addition, there are many variables that may influence social approach behavior, such as prior stress, illness, or previous aggressive behavior within a home cage [38].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [38]
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Low sociability in BTBR T+tf/J mice is independent of partner strain
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- Authors
- Yang, M., Silverman, J. L., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- Venue
- Current Protocols in Neuroscience
- Publisher
- Wiley
- Published
- 2011-07
- Volume
- 56
- Issue
- 1
- Pages
- Unit 8.26-Unit 8.26
- ISSN
- 1934-8576 (ISSN-L)
- 1934-8584
- PMC
- PMC4904775
- OpenAlex
- W1481250329
- Cited by
- 598
- References
- 64
- Citations by year
- 2026: 36 · 2025: 42 · 2024: 46 · 2023: 52 · 2022: 62 · 2021: 52 · 2020: 49 · 2019: 51 · 2018: 47 · 2017: 26 · 2016: 36 · 2015: 31 · 2014: 21 · 2013: 22 · 2012: 21
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Protocols in Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (Z01MH002179)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD079125)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- social approach behavior, autism spectrum disorder, automated behavioral testing, novel object preference, reciprocal social interaction, mouse models of autism
- MeSH terms
- Animals, Autistic Disorder, Behavior, Animal, Disease Models, Animal, Social Behavior, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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