Predicting Persistence of Functional Abdominal Pain From Childhood Into Young Adulthood
Open accessAbstract
Background & aims Pediatric functional abdominal pain has been linked to functional gastrointestinal disorders (FGIDs) in adulthood, but little is known about patient characteristics in childhood that increase the risk for FGID in young adulthood. We investigated the contribution of gastrointestinal symptoms, extraintestinal somatic symptoms, and depressive symptoms in pediatric patients with functional abdominal pain and whether these predicted FGIDs later in life.Methods In a longitudinal study, consecutive new pediatric patients, diagnosed with functional abdominal pain in a subspecialty clinic, completed a comprehensive baseline evaluation of the severity of their physical and emotional symptoms. They were contacted 5 to 15 years later and evaluated, based on Rome III symptom criteria, for abdominal pain-related FGIDs, including irritable bowel syndrome, functional dyspepsia, functional abdominal pain syndrome, and abdominal migraine. Controlling for age, sex, baseline severity of abdominal pain, and time to follow-up evaluation, multivariable logistic regression was used to evaluate the association of baseline gastrointestinal, extraintestinal somatic, and depressive symptoms in childhood with FGID in adolescence and young adulthood.Results Of 392 patients interviewed an average of 9.2 years after their initial evaluation, 41% (n = 162) met symptom criteria for FGID; most met the criteria for irritable bowel syndrome. Extraintestinal somatic and depressive symptoms at the initial pediatric evaluation were significant predictors of FGID later in life, after controlling for initial levels of GI symptoms. Age, sex, and abdominal pain severity at initial presentation were not significant predictors of FGID later in life.Conclusions In pediatric patients with functional abdominal pain, assessment of extraintestinal and depressive symptoms may be useful in identifying those at risk for FGID in adolescence and young adulthood.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FSS symptoms frequently sustain into adulthood, carrying a significant risk of long-term impairment, reduced probability of obtaining higher education and high use of health care costs.
“Frequently, symptoms sustain into adulthood, carrying a significant risk of long-term impairment, reduced probability of obtaining a higher education and a high use of health care costs [9–13].”
From Feasibility of group-based acceptance and commitment therapy for adolescents (AHEAD) with multiple functional somatic syndromes: A pilot study (2020) · cites this paper as [10]
The Discussion (page unavailable) reports that 41% of patients with pediatric functional abdominal pain met criteria for a functional gastrointestinal disorder at follow-up in adolescence or young adulthood, supporting symptom persistence in this specific group. The paper does not establish persistence across FSS generally, or report the claimed long-term impairment, reduced likelihood of higher education, or high health-care costs. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA substantial proportion of adolescents with FSS show continuity of functional symptoms into adulthood.
“A substantial proportion show continuity of functional symptoms into adulthood9–11”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [10]
The Discussion reports that a large proportion of patients with pediatric functional abdominal pain still had frequent abdominal pain at follow-up in adolescence and young adulthood; the Abstract Results specify that 41% met criteria for a functional gastrointestinal disorder. This supports continuity for pediatric functional abdominal pain, but does not establish the same pattern for adolescents with functional somatic symptoms generally. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works
Children’s Depression Inventory (CDI)
Kovacs, M. (2011) · Springer eBooks · doi:10.1007/978-0-387-79061-9_4285 · Cited by 3,885 · see citing works
Functional Gastroduodenal Disorders
Tack, J., Talley, N. J., Camilleri, M., Holtmann, G., Hu, P., Malagelada, J.-R., & Stanghellini, V. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.059 · Cited by 2,418 · see citing works
Rating scales to assess depression in school-aged children.
Kovács, M. (1981) · PubMed · Cited by 1,924 · see citing works
Pediatric Gastroesophageal Reflux Clinical Practice Guidelines
Rosen, R., Vandenplas, Y., Singendonk, M. M. J., Cabana, M. D., DiLorenzo, C., Gottrand, F., Gupta, S. K., Langendam, M. W., Staiano, A., Thapar, N., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001889 · Cited by 1,559 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
The British Child and Adolescent Mental Health Survey 1999: The Prevalence of DSM-IV Disorders
FORD, T., GOODMAN, R., & MELTZER, H. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200310000-00011 · Cited by 1,227 · see citing works
Recurrent Abdominal Pains: A Field Survey of 1,000 School Children
Apley, J., & Naish, N. (1958) · Archives of Disease in Childhood · doi:10.1136/adc.33.168.165 · Cited by 807 · see citing works
Vandenplas, Y., Rudolph, C. D., Lorenzo, C. D., Hassall, E. G., Liptak, G. S., Mazur, L. J., Sondheimer, J. M., Staiano, A., Thomson, M., Veereman‐Wauters, G., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181b7f563 · Cited by 733 · see citing works
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666 · see citing works
Prevalence of psychiatric disorders in preschoolers
Wichstrøm, L., Berg‐Nielsen, T. S., Angold, A. C., EGGER, H. L., Buøen, E. S., & Sveen, T. H. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02514.x · Cited by 534 · see citing works
Abdominal pain and irritable bowel syndrome in adolescents: a community-based study
Hyams, J. S., Burke, G., Davis, P. M., Rzepski, B., & Andrulonis, P. A. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)70246-9 · Cited by 532 · see citing works
Recurrent abdominal pain, anxiety, and depression in primary care
Campo, J. V., Bridge, J., Ehmann, M., Altman, S., Lucas, A., Birmaher, B., Lorenzo, C. D., Iyengar, S., & Brent, D. A. (2004) · Pediatrics · doi:10.1542/peds.113.4.817 · Cited by 467 · see citing works
A Biodegradable Esophageal Stent in the Treatment of a Corrosive Esophageal Stenosis in a Child
Vandenplas, Y., Hauser, B., Devreker, T., Urbain, D., & Reynaert, H. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31819de871 · Cited by 366 · see citing works
The Epidemiology of Childhood Recurrent Abdominal Pain in Western Countries: A Systematic Review
Chitkara, D. K., Rawat, D. J., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41893.x · Cited by 359 · see citing works
The frequency, trajectories and predictors of adolescent recurrent pain: A population-based approach
Stanford, E. A., Chambers, C. T., Biesanz, J. C., & Chen, E. (2008) · Pain · doi:10.1016/j.pain.2007.10.032 · Cited by 339 · see citing works
A Prospective School-based Study of Abdominal Pain and Other Common Somatic Complaints in Children
Saps, M., Seshadri, R., Sztainberg, M., Schaffer, G., Marshall, B. M., & Di Lorenzo, C. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.09.047 · Cited by 330 · see citing works
Walker, L. S., & Greene, J. W. (1989) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/14.2.231 · Cited by 329 · see citing works
Self-citationWalker, L. S., Garber, J., & Greene, J. W. (1991) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00919084 · Cited by 303 · see citing works
Self-citationDevelopment and validation of the pain response inventory for children
Walker, L. S., Smith, C. A., Garber, J., & Van Slyke, D. A. (1997) · Psychological Assessment · doi:10.1037/1040-3590.9.4.392 · Cited by 292 · see citing works
Self-citationFunctional Abdominal Pain in Childhood and Long-term Vulnerability to Anxiety Disorders
Shelby, G. D., Shirkey, K. C., Sherman, A. L., Beck, J. E., Haman, K., Shears, A. R., Horst, S. N., Smith, C. A., Garber, J., & Walker, L. S. (2013) · Pediatrics · doi:10.1542/peds.2012-2191 · Cited by 272 · see citing works
Self-citationWalker, L. S., Guite, J. W., Duke, M., Barnard, J. A., & Greene, J. W. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70400-7 · Cited by 246 · see citing works
Self-citationRecurrent Abdominal Pain in Children: Psychiatric Diagnoses and Parental Psychopathology
Garber, J., Zeman, J. L., & Walker, L. S. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199007000-00021 · Cited by 238 · see citing works
Self-citationParental Response to Child Illness Behavior
Walker, L. S., & Zeman, J. L. (1992) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/17.1.49 · Cited by 228 · see citing works
Self-citationWalker, L. S., Sherman, A. L., Bruehl, S. P., Garber, J., & Smith, C. A. (2012) · Pain · doi:10.1016/j.pain.2012.03.026 · Cited by 225 · see citing works
Self-citationLevy, R. L., Whitehead, W. E., Walker, L. S., Korff, M. V., Feld, A. D., Garner, M. D., & Christie, D. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40478.x · Cited by 223 · see citing works
Self-citationWalker, L. S., Garber, J., Smith, C. A., Slyke, D. A. V., & Claar, R. L. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.69.1.85 · Cited by 213 · see citing works
Self-citationComorbidity in Irritable Bowel Syndrome
Whitehead, W. E., Palsson, O. S., Levy, R. R., Feld, A. D., Turner, M., & Von Korff, M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01540.x · Cited by 210 · see citing works
Children with Recurrent Abdominal Pain: How Do They Grow Up?
Apley, J., & Hale, B. (1973) · BMJ · doi:10.1136/bmj.3.5870.7 · Cited by 196 · see citing works
Mulvaney, S. A., Lambert, E., Garber, J., & Walker, L. S. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/10.chi.0000214192.57993.06 · Cited by 183 · see citing works
Self-citationFunctional Abdominal Pain Syndrome
Clouse, R. E., Mayer, E. A., Aziz, Q., Drossman, D. A., Dumitrascu, D. L., Mönnikes, H., & Naliboff, B. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.062 · Cited by 158 · see citing works
Anxiety and somatic complaints in children with recurrent abdominal pain and anxiety disorders
Dufton, L. M., Dunn, M. J., & Compas, B. E. (2008) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn064 · Cited by 151 · see citing works
Testing a Model of Pain Appraisal and Coping in Children With Chronic Abdominal Pain.
Walker, L. S., Smith, C. A., Garber, J., & Claar, R. L. (2005) · Health Psychology · doi:10.1037/0278-6133.24.4.364 · Cited by 140 · see citing works
Self-citationLobovits, D. A., & Handal, P. J. (1985) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/10.1.45 · Cited by 138 · see citing works
Ramchandani, P. G., Hotopf, M. H., Sandhu, B. K., Stein, A. L., & and the ALSPAC Study Team (2005) · PEDIATRICS · doi:10.1542/peds.2004-1854 · Cited by 131 · see citing works
Sundblad, G. M. B., Saartok, T., Engström, L. T., & In collaboration with University College of Physical Education and Sports, S. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2006.02.006 · Cited by 119 · see citing works
Garber, J., Slyke, D. A. V., & Walker, L. S. (1998) · Research on Child and Adolescent Psychopathology · doi:10.1023/a:1021955907190 · Cited by 112 · see citing works
Self-citationGeisser, M. E., Donnell, C. S., Petzke, F. W., Gracely, R. H., Clauw, D. J., & Williams, D. A. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.3.235 · Cited by 111 · see citing works
Prognosis of Chronic or Recurrent Abdominal Pain in Children
Gieteling, M. J., Bierma‐Zeinstra, S. M., Passchier, J., & Berger, M. Y. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31815bc1c1 · Cited by 108 · see citing works
A typology of pain coping strategies in pediatric patients with chronic abdominal pain
Walker, L. S., Baber, K. F., Garber, J., & Smith, C. A. (2008) · Pain · doi:10.1016/j.pain.2007.08.038 · Cited by 107 · see citing works
Self-citationKazdin, A. E., Colbus, D., & Rodgers, A. Y. (1986) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01260519 · Cited by 88 · see citing works
Howell, S. C., Poulton, R., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41753.x · Cited by 72 · see citing works
Beck, J. E., Lipani, T. A., Baber, K. F., Dufton, L. M., Garber, J., Smith, C. A., & Walker, L. S. (2011) · Pain · doi:10.1016/j.pain.2011.01.029 · Cited by 49 · see citing works
Self-citationPrognostic Factors for Persistence of Chronic Abdominal Pain in Children
Gieteling, M. J., Bierma‐Zeinstra, S. M., van Leeuwen, Y., Passchier, J., & Berger, M. Y. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181e82a28 · Cited by 39 · see citing works
Increased wind-up to heat pain in women with a childhood history of functional abdominal pain
Crish, S. D., Bruehl, S. P., & Walker, L. S. (2011) · Pain · doi:10.1016/j.pain.2010.12.032 · Cited by 39 · see citing works
Self-citationLittle, C. A., Williams, S. E., Puzanovova, M., Rudzinski, E. R., & Walker, L. S. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000243423.93968.7c · Cited by 37 · see citing works
Self-citationRecollection of childhood abdominal pain in adults with functional gastrointestinal disorders
Chitkara, D. K., Talley, N. J., Schleck, C. D., Zinsmeister, A. R., Shah, N. D., & Locke, G. R. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802555975 · Cited by 26 · see citing works
Brown, W. H., Chey, W. D., & Elta, G. H. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200303000-00008 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [32]Walker LS Garber J Greene JW Somatization symptoms in pediatric abdominal pain patients: relation to chronicity of abdoinal pain and parent somatizaiton J Abnorm Child Psychol 2001 19 379 394 1757708
Cited by
Sorted by citations
Psychological therapies for the management of chronic and recurrent pain in children and adolescents
Eccleston, C., Palermo, T. M., Williams, A. C. D. C., Lewandowski Holley, A., Morley, S., Fisher, E., & Law, E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003968.pub4 · Cited by 745 · see citing works
Vigerland, S., Lenhard, F., Bonnert, M., Lalouni, M., Hedman, E., Ahlen, J., Olén, O., Serlachius, E., & Ljótsson, B. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.09.005 · Cited by 292 · see citing works
Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents
Lewis, M. L., Palsson, O. S., Whitehead, W. E., & van Tilburg, M. A. L. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.008 · Cited by 290 · see citing works
Psychological therapies for the management of chronic and recurrent pain in children and adolescents
Fisher, E., Law, E., Dudeney, J., Palermo, T. M., Stewart, G., & Eccleston, C. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003968.pub5 · Cited by 289 · see citing works
Paediatric functional abdominal pain disorders
Thapar, N., Benninga, M. A., Crowell, M. D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R. J., Szajewska, H., van Tilburg, M. A. L., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00222-5 · Cited by 221 · see citing works
Friedrichsdorf, S. J., Giordano, J. J., Dakoji, K. D., Warmuth, A., Daughtry, C., & Schulz, C. A. (2016) · Children · doi:10.3390/children3040042 · Cited by 192 · see citing works
Controversies and Recent Developments of the Low-FODMAP Diet.
Hill, P., Muir, J. G., & Gibson, P. R. (2017) · PubMed Central · Cited by 147 · see citing works
Dietary interventions for recurrent abdominal pain in childhood
Newlove-Delgado, T. V., Martin, A. E., Abbott, R. A., Bethel, A. C., Coon, J. T., Whear, R., & Logan, S. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010972.pub2 · Cited by 134 · see citing works
Childhood functional abdominal pain: mechanisms and management
Korterink, J., Devanarayana, N. M., Rajindrajith, S., Vlieger, A. M., & Benninga, M. A. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.21 · Cited by 106 · see citing works
Holley, A. L., Wilson, A. C., Noel, M. E., & Palermo, T. M. (2016) · European Journal of Pain · doi:10.1002/ejp.879 · Cited by 104 · see citing works
The role of psychological factors in pediatric functional abdominal pain disorders
Newton, E. P., Schosheim, A., Patel, S. B., Chitkara, D. K., & van Tilburg, M. A. L. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13538 · Cited by 93 · see citing works
Lalouni, M., Ljótsson, B., Bonnert, M., Ssegonja, R., Benninga, M., Bjureberg, J., Högström, J., Sahlin, H., Simrén, M., Feldman, I., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.11.043 · Cited by 88 · see citing works
Epidemiology of Irritable Bowel Syndrome in Children and Adolescents in Asia
Devanarayana, N. M., Rajindrajith, S., Pathmeswaran, A., Abegunasekara, C., Gunawardena, N. K., & Benninga, M. A. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000714 · Cited by 85 · see citing works
Associations of Psychologic Factors with Multiple Chronic Overlapping Pain Conditions
Fillingim, R. B., Ohrbach, R. K., Greenspan, J. D., Sanders, A. E., Rathnayaka, N. S., Maixner, W. D., & Slade, G. D. (2020) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.2584 · Cited by 77 · see citing works
Pharmacologic Treatment in Functional Abdominal Pain Disorders in Children: A Systematic Review
Rexwinkel, R., de Bruijn, C. M. A., Gordon, M. A., Benninga, M. A., & Tabbers, M. M. (2021) · PEDIATRICS · doi:10.1542/peds.2020-042101 · Cited by 55 · see citing works
Sherman, A. L., Morris, M. C., Bruehl, S. P., Westbrook, T. D., & Walker, L. S. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9712-5 · Cited by 50 · see citing works
Self-citationHollier, J. M., van Tilburg, M. A. L., Liu, Y., Czyzewski, D. I., Self, M. M., Weidler, E. M., Heitkemper, M. M., & Shulman, R. J. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13509 · Cited by 49 · see citing works
Ayonrinde, O. T., Ayonrinde, O., Adams, L. A., Sanfilippo, F. M., O’Sullivan, T. A., Robinson, M., Oddy, W. H., & Olynyk, J. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-58543-0 · Cited by 46 · see citing works
Prevalence and Progression of Recurrent Abdominal Pain, From Early Childhood to Adolescence
Sjölund, J., Uusijärvi, A., Tornkvist, N. T., Kull, I., Bergström, A., Alm, J. S., Törnblom, H., Olén, O., & Simrén, M. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.04.047 · Cited by 45 · see citing works
Implementing psychological therapies for functional GI disorders in children and adults
Reed, B., Claar, R. L., Schurman, J. V., & van Tilburg, M. A. L. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2016.1207524 · Cited by 43 · see citing works
Lalouni, M., Hesser, H., Bonnert, M., Hedman‐Lagerlöf, E., Serlachius, E., Olén, O., & Ljótsson, B. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.110287 · Cited by 41 · see citing works
Nausea in Children With Functional Abdominal Pain Predicts Poor Health Outcomes in Young Adulthood
Russell, A. C., Stone, A. L., & Walker, L. S. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.07.006 · Cited by 39 · see citing works
Self-citationde Bruijn, C. M. A., Rexwinkel, R., Gordon, M. A., Sinopoulou, V., Benninga, M. A., & Tabbers, M. M. (2022) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2022.2055547 · Cited by 37 · see citing works
Hulgaard, D., Dehlholm‐Lambertsen, G., & Rask, C. U. (2019) · Journal of Family Therapy · doi:10.1111/1467-6427.12199 · Cited by 34 · see citing works
The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children
Somarajan, S., Muszynski, N. D., Olson, J. D., Comstock, A. H., Russell, A. C., Walker, L. S., Acra, S. A., & Bradshaw, L. A. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14035 · Cited by 33 · see citing works
Self-citationKallesøe, K. H., Schröder, A., Wicksell, R. K., Preuss, T., Jensen, J. S., & Rask, C. U. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02862-z · Cited by 24 · see citing works
Lee, E. H., Yang, H. R., & Lee, H. S. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18050 · Cited by 28 · see citing works
Tolley, J. A., Michel, M. A., Williams, A. E., & Renschler, J. S. (2020) · Children · doi:10.3390/children7090129 · Cited by 27 · see citing works
Rexwinkel, R., Vlieger, A. M., Saps, M., Tabbers, M. M., & Benninga, M. A. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04459-y · Cited by 29 · see citing works
Kallesøe, K. H., Schröder, A., Wicksell, R. K., Fink, P., Ørnbøl, E., & Rask, C. U. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012743 · Cited by 23 · see citing works
Exposure-Based Cognitive Behavior Therapy for Children with Abdominal Pain: A Pilot Trial
Lalouni, M., Olén, O., Bonnert, M., Hedman‐Lagerlöf, E., Serlachius, E., & Ljótsson, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164647 · Cited by 24 · see citing works
Palsson, O. S., & van Tilburg, M. A. L. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1012705 · Cited by 24 · see citing works
Gulewitsch, M. D., & Schlarb, A. A. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000984 · Cited by 23 · see citing works
Murray, C. B., Li, R., Kashikar‐Zuck, S., Zhou, C., & Palermo, T. M. (2024) · Pain · doi:10.1097/j.pain.0000000000003308 · Cited by 22 · see citing works
Khayat, A. A., Algethami, G., Baik, S., Alhajori, M., & Banjar, D. (2021) · Global Pediatric Health · doi:10.1177/2333794x211022265 · Cited by 20 · see citing works
Sjölund, J., Kull, I., Bergström, A., Ljótsson, B., Törnblom, H., Olén, O., & Simrén, M. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.09.022 · Cited by 20 · see citing works
Chogle, A. S., El‐Chammas, K. I., Santucci, N. R., Grimm, M., Dorfman, L., Graham, K. D., Kelly, D. R., Dranove, J. E., Rosen, R., Nurko, S., et al. (2024) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12174 · Cited by 19 · see citing works
Do Children Just Grow Out of Irritable Bowel Syndrome?
Giannetti, E., Maglione, M., Sciorio, E., Coppola, V., Miele, E., & Staiano, A. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.12.036 · Cited by 18 · see citing works
Jiang, C., Yan, X., Sharma, S., Zhang, L., Wang, H., Song, J., Qian, W., Bai, T., & Hou, X. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18028 · Cited by 17 · see citing works
Law, E., Kim, A., Ickmans, K., & Palermo, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061491 · Cited by 18 · see citing works
Prolonged constipation and diarrhea in childhood and disordered eating in adolescence
Wiklund, C. A., Kuja‐Halkola, R., Thornton, L. M., Hübel, C., Leppä, V., & Bulik, C. M. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109797 · Cited by 17 · see citing works
Functional gastrointestinal disorders in children: What is new?
Nightingale, S. L., & Sharma, A. (2020) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.14857 · Cited by 18 · see citing works
Does bile reflux reduce Helicobacter pylori gastritis?
Taşçı, E. K., Karakoyun, M., Sezak, M., Doğanavşargıl, B., Çetin, F., & Aydoğdu, S. (2022) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2020.2839 · Cited by 16 · see citing works
A comprehensive review of functional dyspepsia in pediatrics
Waseem, S., & Rubin, L. N. (2021) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-021-01561-w · Cited by 17 · see citing works
Li, R., Gibler, R. C., Rheel, E., Slack, K. E., & Palermo, T. M. (2023) · Pain · doi:10.1097/j.pain.0000000000002998 · Cited by 15 · see citing works
He, S., Chen, L., Wang, P., & Xi, X. (2023) · Value in Health · doi:10.1016/j.jval.2023.08.007 · Cited by 15 · see citing works
Vega, E., Rivera, G. M., Echevarría, G. C., Prylutskyy, Z., Pérez, J., & Ingelmo, P. M. (2018) · Pediatric Anesthesia · doi:10.1111/pan.13494 · Cited by 15 · see citing works
Helgeland, H., Gjone, I. H., & Diseth, T. H. (2022) · Human Systems Therapy Culture and Attachments · doi:10.1177/26344041221099644 · Cited by 14 · see citing works
Lalouni, M., Bujacz, A., Bonnert, M., Jensen, K. B., Rosengren, A., Hedman-Lagerlöf, E., Serlachius, E., Olén, O., & Ljótsson, B. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.962037 · Cited by 13 · see citing works
Gordon, M. A., Benninga, M. A., Borlack, R. E., Borrelli, O., Chogle, A. S., Darbari, A., Dolinšek, J., Groen, J., Khlevner, J., Lorenzo, C. D., et al. (2023) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2023-002166 · Cited by 13 · see citing works
Butt, M. F., Groen, J., Jonker, C. A. L., Murray, H. B., Carrington, E. V., Chang, L., Lorenzo, C. D., Ellis, J., Escher, J. C., Gorter, R. R., et al. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14869 · Cited by 13 · see citing works
Subgroups of Pediatric Patients With Functional Abdominal Pain
Stone, A. L., Han, G. T., Bruehl, S. P., Garber, J., Smith, C. A., Anderson, J., Palermo, T. M., & Walker, L. S. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000882 · Cited by 13 · see citing works
Self-citationPapachrisanthou, M. M., & Davis, R. L. (2015) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2015.07.009 · Cited by 13 · see citing works
Cardiovagal modulation in pediatric functional gastrointestinal disorders
Chelimsky, G. G., Rausch, S., Bierer, D. W., Feng, M., Simpson, P. M., Awe, E., & Chelimsky, T. C. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13564 · Cited by 12 · see citing works
Bae, E. J., Kim, D. E., Sagong, H., & Yoon, J. Y. (2022) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2022.04.003 · Cited by 12 · see citing works
Kallesøe, K. H., Rimvall, M. K., Schröder, A., Jensen, J. S., Wicksell, R. K., & Rask, C. U. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110430 · Cited by 12 · see citing works
Stone, A. L., Epstein, I., Bruehl, S. P., Garber, J., Smith, C. A., & Walker, L. S. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.09.007 · Cited by 12 · see citing works
Self-citationZeiter, D. K. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.01.012 · Cited by 12 · see citing works
Voepel‐Lewis, T., Seng, J. S., Chen, B., & Scott, E. L. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000896 · Cited by 11 · see citing works
Zanchi, C., Pintaldi, S., Leo, G. D., Ronfani, L., Zamagni, G., Viel, M., Barbi, E., & Cozzi, G. (2021) · Children · doi:10.3390/children8100838 · Cited by 11 · see citing works
Chogle, A. S., Visnagra, K. M., Janchoi, J., Tran, T., Davis, R., Callas, N., & Ornelas, E. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1223932 · Cited by 10 · see citing works
Education and Hypnosis for Treatment of Functional Gastrointestinal Disorders (FGIDs) in Pediatrics
Mahler, T. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1033676 · Cited by 10 · see citing works
Zhou, Q., Wesselmann, U., Walker, L. S., Lee, L. S., Zeltzer, L. K., & Verne, G. N. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.10.002 · Cited by 10 · see citing works
Self-citationDyk, T. R. V., Krietsch, K. N., King, C. D., & Byars, K. C. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9522 · Cited by 10 · see citing works
Zeevenhooven, J., van der Heijden, H. S., Devanarayana, N. M., Rajindrajith, S., & Benninga, M. A. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002623 · Cited by 9 · see citing works
Dutta, R. A., Ely, S. L., & Cunningham, N. R. (2021) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000952 · Cited by 9 · see citing works
Papachrisanthou, M. M., & Davis, R. L. (2015) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2015.08.004 · Cited by 9 · see citing works
Arce, A. B. G., Richardson, P. A., Tran, S. T., & Bhandari, R. P. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001020 · Cited by 9 · see citing works
Redux: Do Little Bellyachers Grow up to Become Big Bellyachers?
Drossman, D. A. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.06.009 · Cited by 9 · see citing works
Pediatric Functional Gastrointestinal Disorders: Pathophysiology, Diagnosis and Management
Mahesan, A., Kamila, G., & Gulati, S. (2024) · Journal of Translational Gastroenterology · doi:10.14218/jtg.2023.00075 · Cited by 8 · see citing works
Difficulties in the Diagnosis and Management of Functional or Recurrent Abdominal Pain in Children
Gomez‐Suarez, R. A. (2016) · Pediatric Annals · doi:10.3928/19382359-20161019-01 · Cited by 8 · see citing works
Shulman, R. J., Öhman, L., Stridsberg, M., Cain, K. C., Simrén, M., & Heitkemper, M. M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13486 · Cited by 8 · see citing works
Madani, S., Parikh, S., Madani, R. S., & Krasaelap, A. (2017) · Gastroenterology Research · doi:10.14740/gr798w · Cited by 8 · see citing works
Editorial: Pediatric Functional Gastrointestinal Disorders: Challenges in Diagnosis and Treatment
Vernon‐Roberts, A., Safe, M., & Day, A. S. (2024) · Gastrointestinal Disorders · doi:10.3390/gidisord6010021 · Cited by 10 · see citing works
Navigating through 65 years of insights: lessons learned on functional abdominal pain in children
Rajindrajith, S., Boey, C. C. M., Devanarayana, N. M., Niriella, M. A., Thapar, N., & Benninga, M. A. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05667-4 · Cited by 7 · see citing works
Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders
Dipasquale, V., Palermo, L., Barbalace, A., Tumminello, G., & Romano, C. (2023) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.16323 · Cited by 7 · see citing works
Maintenance of Pain in Children With Functional Abdominal Pain
Czyzewski, D. I., Self, M. M., Williams, A. E., Weidler, E. M., Blatz, A. M., & Shulman, R. J. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000947 · Cited by 7 · see citing works
Psychoneuroimmunological approach to gastrointestinal related pain
Toljan, K., & Vrooman, B. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.10.010 · Cited by 7 · see citing works
Where do we start? Health care transition in adolescents and young adults with chronic primary pain
Feinstein, A. B., Brown, K., Dunn, A. L., Neville, A., Sokol, O. E., Poupore‐King, H., Sturgeon, J. A., Kwon, A. H., & Griffin, A. T. (2024) · Pain · doi:10.1097/j.pain.0000000000003324 · Cited by 8 · see citing works
Jones, M., Koloski, N. A., Walker, M. M., Holtmann, G., Shah, A., Eslick, G. D., & Talley, N. J. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002751 · Cited by 6 · see citing works
The Approach to the Management of a Child with Chronic Abdominal Pain
Farrell, P. R., Farrell, L., & Farrell, M. K. (2024) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-023-00288-9 · Cited by 5 · see citing works
Garr, K., Stough, C. C. O., Flannery, M. K., Yacob, D., Puri, N. B., & Diest, A. M. K. V. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70014 · Cited by 4 · see citing works
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain
Osborne, N. R., Hellman, K. M., Burda, E. M., Darnell, S. E., Singh, L., Schrepf, A., Walker, L. S., & Tu, F. F. (2025) · Pain · doi:10.1097/j.pain.0000000000003597 · Cited by 4 · see citing works
Self-citationUnderstanding and Treatment of Chronic Abdominal Pain Among School Nurses: A National Survey
Deacy, A. D., & Morrison, C. (2015) · Clinical Practice in Pediatric Psychology · doi:10.1037/cpp0000107 · Cited by 4 · see citing works
Tarsitano, F., Castelluzzo, M. A., Concolino, D., & Pensabene, L. (2018) · Current Pediatrics Reports · doi:10.1007/s40124-018-0158-7 · Cited by 4 · see citing works
Secular trends in childhood pain and comorbid psychiatric symptoms: a population-based study
Luntamo, T., Lempinen, L., & Sourander, A. (2022) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-022-02234-w · Cited by 4 · see citing works
Tobacco Smoke Exposure and Gastrointestinal Problems Among US Children
Merianos, A. L., & Mahabee‐Gittens, E. M. (2023) · Clinical Pediatrics · doi:10.1177/00099228231154135 · Cited by 4 · see citing works
Love, S. C., Mara, C. A., Kalomiris, A. E., & Cunningham, N. R. (2019) · Children · doi:10.3390/children6120134 · Cited by 4 · see citing works
Saps, M., Arrizabalo, S., & Garza, J. M. (2025) · Children · doi:10.3390/children12091209 · Cited by 3 · see citing works
Frequency of Irritable Bowel Syndrome Among Children Aged 4 to 9 Years: A Cross-Sectional Study
Doğan, L., Gökdemir, Ö., & Özçakar, N. (2023) · Clinical Pediatrics · doi:10.1177/00099228231204455 · Cited by 3 · see citing works
Philipson, A., Duberg, A., Hagberg, L., Högström, S., Lindholm, L. H., Möller, M., & Ryen, L. (2023) · PharmacoEconomics - Open · doi:10.1007/s41669-022-00384-w · Cited by 3 · see citing works
Khayat, A. A., Aldharman, S. S., Alharbi, N., Alayyaf, A. S., abdulmuttalib, J. A., & Altalhi, E. R. (2023) · SAGE Open Medicine · doi:10.1177/20503121231163519 · Cited by 3 · see citing works
Hildenbrand, A., Amaro, C. M., Bear, B., Soprano, C. M., & Salamon, K. S. (2024) · Journal of Pain Research · doi:10.2147/jpr.s430411 · Cited by 2 · see citing works
Pediatric functional gastrointestinal disorders
van Tilburg, M. A. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813037-7.00039-x · Cited by 3 · see citing works
Risk Factors for Recurrent Abdominal Pain in Children with Nonorganic Acute Abdominal Pain
Piriyakitphaiboon, V., Sirinam, S., Noipayak, P., Sirivichayakul, C., Pornrattanarungsri, S., & Limkittikul, K. (2022) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2022.25.2.129 · Cited by 3 · see citing works
Functional Abdominal Pain In Children
McClellan, N., & Ahlawat, R. (2019) · StatPearls · Cited by 3 · see citing works
Dorfman, L., El‐Chammas, K. I., Graham, K. D., Sahay, R. D., Hardy, J., Kaul, A., & Santucci, N. R. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70109 · Cited by 2 · see citing works
Kallesøe, K. H., Ørnbøl, E., Wellnitz, K. B., & Rask, C. U. (2025) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2025.2521719 · Cited by 3 · see citing works
Yang, R., Che, Y., Zeng, R., Xie, Y., Cao, Y., Li, T., He, Y., Huang, W., Liu, S., Yin, X., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120000 · Cited by 2 · see citing works
Differential diagnosis of abdominal pain in children
Dudnyk, V. M., Mantak, H., Andrikevych, I., Zvenigorodska, G. Y., & Odnorohova, H. (2019) · SOVREMENNAYA PEDIATRIYA · doi:10.15574/sp.2019.97.75 · Cited by 2 · see citing works
- Authors
- Horst, S., Shelby, G., Anderson, J., Acra, S., Polk, D. B., Saville, B. R., Garber, J., & Walker, L. S.
- Affiliations
- Vanderbilt University Medical Center (US)
- Vanderbilt University (US)
- Monroe Carell Jr. Children's Hospital (US)
- University of Southern California (US)
- Corresponding author
- Walker, Lynn S.
- ORCID
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 12
- Issue
- 12
- Pages
- 2026-2032
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC4195814
- OpenAlex
- W2135236679
- Cited by
- 133
- References
- 47
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 12 · 2020: 18 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 2
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000445)
- National Institute of Mental Health (T32MH018921)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK058404, P30DK058404)
- National Center for Research Resources (UL1RR024975)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, P30 HD-15052, R01 HD 23264, R01HD023264)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- functional abdominal pain, functional gastrointestinal disorders, pediatric patients, irritable bowel syndrome, functional dyspepsia, abdominal migraine, depressive symptoms, risk prediction, early adulthood, adolescence
- MeSH terms
- Adolescent, Child, Depression, Female, Gastrointestinal Diseases, Humans, Longitudinal Studies, Male, Prognosis, Abdominal Pain, Comorbidity, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
