Relationships Between Periventricular Epicardial Adipose Tissue Accumulation, Coronary Microcirculation, and Left Ventricular Diastolic Dysfunction
Abstract
Background Obesity is related to left ventricular (LV) diastolic dysfunction, although its pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) is an ectopic fat with paracrine effects on coronary circulation and myocardium. We hypothesized that left ventricle-specific (periventricular) EAT may deteriorate diastolic function by impairing coronary microcirculation.Methods In protocol 1, 74 patients without obstructive narrowing of the left anterior descending artery on multidetector computed tomography (MDCT) underwent coronary flow reserve (CFR) examination to evaluate the relationship between EAT and coronary microcirculation. In protocol 2, 372 patients who underwent both MDCT and serial transthoracic Doppler echocardiographic (TTDE) examinations were enrolled to investigate the impact of periventricular EAT on changes in diastolic function. EAT volume was measured by MDCT. CFR and diastolic function were assessed by TTDE. Deterioration of LV diastolic function was defined as a ≥ 20% decrease in early diastolic mitral annular velocity.Results CFR was significantly correlated with periventricular EAT volume (r = -0.37; P = 0.001), but not with total EAT volume (r = -0.21; P = 0.071). Periventricular EAT volume (P = 0.010) was significantly associated with CFR independent of cardiovascular risk factors. Among the 372 patients who had serial TTDE examinations, the frequency of deteriorated LV diastolic function was lowest in the lower tertile of periventricular EAT, intermediate in the middle tertile, and highest in the upper tertile (12.9%, 21.0%, and 25.8%, respectively; P = 0.037). Age, diabetes mellitus, and periventricular EAT volume were significantly associated with deterioration of LV diastolic function (all P < 0.05).Conclusions This study demonstrated the close association of periventricular EAT with impaired CFR and deteriorated LV diastolic function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The impaired CFR in these patients likely reflected the presence of a microvasculopathy.
“Since CFR depends on the combined effects of microvascular dysfunction and epicardial coronary stenosis that was absent in the studied patients, the impaired CFR likely reflected the presence of a microvasculopathy [100].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [100]
Cites
Lang, R., Badano, L., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F., Foster, E., Goldstein, S., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 10,093 · see citing works
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499 · see citing works
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989 · see citing works
Spironolactone for heart failure with preserved ejection fraction
Pitt, B., Pfeffer, M. A., Assmann, S. F., Boineau, R., Anand, I. S., Claggett, B., Clausell, N., Desai, A. S., Diaz, R., Fleg, J. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313731 · Cited by 2,809 · see citing works
Budoff, M. J., Dowe, D. A., Jollis, J. G., Gitter, M. J., Sutherland, J., Halamert, E., Scherer, M. D., Bellinger, R. L., Martin, A., Benton, R., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.031 · Cited by 2,121 · see citing works
Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study
Bhatia, R. S., Tu, J. V., Lee, D. S., Austin, P. C., Fang, J., Haouzi, A., Gong, Y., & Liu, P. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051530 · Cited by 1,959 · see citing works
The perindopril in elderly people with chronic heart failure (PEP-CHF) study
Cleland, J. G. F. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl250 · Cited by 1,502 · see citing works
Rosito, G. A., Massaro, J. M., Hoffmann, U., Ruberg, F. L., Mahabadi, A. A., Vasan, R. S., O’Donnell, C. J., & Fox, C. S. (2008) · Circulation · doi:10.1161/circulationaha.107.743062 · Cited by 1,021 · see citing works
Human epicardial adipose tissue: A review
Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 971 · see citing works
Iacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842 · see citing works
Alterations of Left Ventricular Myocardial Characteristics Associated With Obesity
Wong, C. Y., O’Moore-Sullivan, T., Leano, R., Byrne, N., Beller, E., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147184.13872.0f · Cited by 713 · see citing works
Echocardiographic epicardial fat: a review of research and clinical applications
Iacobellis, G., & Willens, H. J. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.10.013 · Cited by 700 · see citing works
Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome
Wong, C. X. J., Abed, H. S., Molaee, P., Nelson, A. J., Brooks, A. G., Sharma, G., Leong, D. P., Lau, D. H., Middeldorp, M. E., Roberts‐Thomson, K. C., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.045 · Cited by 494 · see citing works
Ding, J., Hsu, F., Harris, T. B., Liu, Y., Kritchevsky, S. B., Szklo, M., Ouyang, P., Espeland, M. A., Lohman, K. K., Criqui, M. H., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27358 · Cited by 476 · see citing works
Acute Effects of Passive Smoking on the Coronary Circulation in Healthy Young Adults
Otsuka, R. (2001) · JAMA · doi:10.1001/jama.286.4.436 · Cited by 413 · see citing works
Effect of Obesity and Overweight on Left Ventricular Diastolic Function
Russo, C., Jin, Z., Homma, S., Rundek, T., Elkind, M. S. V., Sacco, R. L., & Di Tullio, M. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.042 · Cited by 361 · see citing works
Pericardial fat accumulation in men as a risk factor for coronary artery disease
Taguchi, R. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00709-7 · Cited by 274 · see citing works
Cheng, V., Dey, D., Tamarappoo, B. K., Nakazato, R., Gransar, H., Miranda-Peats, R., Ramesh, A., Wong, N. D., Shaw, L. J., Slomka, P. J., et al. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2009.12.013 · Cited by 251 · see citing works
Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
Iacobellis, G., Singh, N., Wharton, S., & Sharma, A. M. (2008) · Obesity · doi:10.1038/oby.2008.251 · Cited by 238 · see citing works
Clinical Significance of Epicardial Fat Measured Using Cardiac Multislice Computed Tomography
Sarin, S., Wenger, C., Marwaha, A., Qureshi, A., Go, B. D. M., Woomert, C. A., Clark, K., Nassef, L. A., & Shirani, J. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.04.058 · Cited by 222 · see citing works
Established and Novel Clinical Applications of Diastolic Function Assessment by Echocardiography
Oh, J. K., Park, S., & Nagueh, S. F. (2011) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.110.961623 · Cited by 171 · see citing works
Sympathetic dysfunction in type 1 diabetes
Pop-Busui, R., Kirkwood, I., Schmid, H., Marinescu, V., Schroeder, J., Larkin, D., Yamada, E., Raffel, D. M., & Stevens, M. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.09.033 · Cited by 170 · see citing works
Mahabadi, A. A., Reinsch, N., Lehmann, N., Altenbernd, J., Kälsch, H., Seibel, R. M. M., Erbel, R. M., & Möhlenkamp, S. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.02.013 · Cited by 169 · see citing works
Sade, L. E., Eroğlu, S., Bozbaş, H., Özbiçer, S., Hayran, M., Haberal, A., & Müderrisoğlu, H. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.038 · Cited by 149 · see citing works
Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography
Willens, H. J., Byers, P., Chirinos, J. A., Labrador, E., Hare, J. M., & de Marchena, E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.042 · Cited by 147 · see citing works
Coronary flow reserve and myocardial diastolic dysfunction in arterial hypertension
Galderisi, M., Cicala, S., Caso, P., De Simone, L., D’Errico, A., Petrocelli, A., & de Divitiis, O. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02708-x · Cited by 140 · see citing works
Fontes‐Carvalho, R., Oliveira, M. F., Sampaio, F., Mâncio, J., Bettencourt, N., Teixeira, M., Gonçalves, F. R., Gama, V., & Leite-Moreira, A. F. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.08.037 · Cited by 111 · see citing works
Wang, T., Lee, W., Shih, F., Huang, C., Chen, W., Lee, Y., Shih, T. T., & Chen, M.-F. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.055 · Cited by 98 · see citing works
Central obesity: Association with left ventricular dysfunction and mortality in the community
Ammar, K. A., Redfield, M. M., Mahoney, D. W., Johnson, M. P., Jacobsen, S. J., & Rodeheffer, R. J. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.06.018 · Cited by 85 · see citing works
Nakanishi, K., Fukuda, S., Tanaka, A., Otsuka, K., Jissho, S., Taguchi, H., Yoshikawa, J., & Shimada, K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.015 · Cited by 76 · see citing works
Yilmaz, Y. N., Kurt, R., Gürdal, A., Alahdab, Y. Ö., Yönal, O., Şenateş, E., Polat, N., Eren, F., İmeryüz, N., & Oflaz, H. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.026 · Cited by 64 · see citing works
Peri-Atrial Epicardial Adipose Tissue Is Associated With New-Onset Nonvalvular Atrial Fibrillation
Nakanishi, K., Fukuda, S., Tanaka, A., Otsuka, K., Sakamoto, M., Taguchi, H., Yoshikawa, J., Shimada, K., & Yoshiyama, M. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0637 · Cited by 63 · see citing works
Fenk, S., Fischer, M., Strack, C., Schmitz, G., Loew, T. H., Lahmann, C., & Baessler, A. (2015) · International Heart Journal · doi:10.1536/ihj.14-261 · Cited by 53 · see citing works
Konishi, M., Sugiyama, S., Sugamura, K., Nozaki, T., Matsubara, J., Akiyama, E., Utsunomiya, D., Matsuzawa, Y., Yamashita, Y., Kimura, K., et al. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.01.006 · Cited by 52 · see citing works
Martin, J., Bergeron, S., Pîbarot, P., Bastien, M., Biertho, L. D., Lescelleur, O., Bertrand, F., Simard, S., & Poirier, P. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.11.010 · Cited by 50 · see citing works
Hirata, K., Kadirvelu, A., Elina, R. A., Hozumi, T., Yoshikawa, J., Homma, S., & Lang, C. C. (2004) · Clinical Science · doi:10.1042/cs20040226 · Cited by 49 · see citing works
Hozumi, T., Eisenberg, M. S., Sugioka, K., Kokkirala, A. R., Watanabe, H., Teragaki, M., Yoshikawa, J., & Homma, S. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-7-200204020-00009 · Cited by 48 · see citing works
Kitagawa, T., Yamamoto, H., Sentani, K., Takahashi, S., Tsushima, H., Senoo, A., Yasui, W., Sueda, T., & Kihara, Y. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.013 · Cited by 47 · see citing works
Wu, C., Yang, C., Lin, J., Hsieh, H., Chiu, F., Chen, J.-J., Lee, J., Huang, S., Li, H., Chiang, F., et al. (2011) · Obesity · doi:10.1038/oby.2011.30 · Cited by 39 · see citing works
Ng, A. C. T., Goo, S. Y., Roche, N., van der Geest, R. J., & Wang, W. Y. S. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.06.009 · Cited by 39 · see citing works
Sato, T., Kameyama, T., Ohori, T., Matsuki, A., & Inoue, H. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.23390 · Cited by 24 · see citing works
Young Women With Abdominal Obesity Have Subclinical Myocardial Dysfunction
Share, B. L., Gerche, A. L., Naughton, G. A., Obert, P., & Kemp, J. G. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.02.004 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Packer, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.509 · Cited by 656 · see citing works
Epicardial adipose tissue and cardiovascular diseases
Ansaldo, A. M., Montecucco, F., Sahebkar, A., Dallegri, F., & Carbone, F. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.09.089 · Cited by 247 · see citing works
Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities
Cuijpers, I., Simmonds, S. J., van Bilsen, M., Czarnowska, E., González, A., Heymans, S. R. B., Kuhn, A.-R., Mulder, P. G. H., Ratajska, A., Jones, E. A. V., et al. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0798-y · Cited by 139 · see citing works
Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review
Konwerski, M., Gąsecka, A., Opolski, G., Grabowski, M., & Mazurek, T. (2022) · Biology · doi:10.3390/biology11030355 · Cited by 127 · see citing works
Packer, M. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.05.019 · Cited by 116 · see citing works
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?
Elrakaybi, A., Laubner, K., Zhou, Q., Hug, M. J., & Seufert, J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101549 · Cited by 114 · see citing works
Inflammation in Metabolic Cardiomyopathy
Wenzl, F. A., Ambrosini, S., Mohammed, S. A., Kraler, S. C., Lüscher, T. F., Costantino, S., & Paneni, F. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.742178 · Cited by 109 · see citing works
Warbrick, I., & Rabkin, S. W. (2019) · Obesity Reviews · doi:10.1111/obr.12828 · Cited by 97 · see citing works
Epicardial Adipose Tissue and Cardiovascular Disease
Jemtel, T. H. L., Samson, R., Ayinapudi, K., Singh, T., & Oparil, S. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0939-6 · Cited by 91 · see citing works
Inflammation and Cardiovascular Diseases in the Elderly: The Role of Epicardial Adipose Tissue
Conte, M., Petraglia, L., Poggio, P., Valerio, V., Cabaro, S., Campana, P., Comentale, G., Attena, E., Russo, V., Pilato, E., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.844266 · Cited by 82 · see citing works
Kintscher, U., Foryst‐Ludwig, A., Haemmerle, G., & Zechner, R. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100001 · Cited by 68 · see citing works
Proteomics of epicardial adipose tissue in patients with heart failure
Zhao, L., Guo, Z., Wang, P., Zheng, M., Yang, X., Liu, Y., Ma, Z., Chen, M., & Yang, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14758 · Cited by 65 · see citing works
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Di Martino, A., Albanese, G., Colantuoni, S., Medicamento, G., et al. (2022) · Biomolecules · doi:10.3390/biom12020176 · Cited by 62 · see citing works
Rafeh, R. W., Viveiros, A., Oudit, G. Y., & EL‐Yazbi, A. F. (2020) · Clinical Science · doi:10.1042/cs20190227 · Cited by 63 · see citing works
Zhao, L., Harrop, D., Ng, A. C. T., & Wang, W. Y. S. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.05.002 · Cited by 30 · see citing works
Daudé, P., Ancel, P., Sylviane Confort-gouny, A., Jacquier, A., Kober, F., Dutour, A., Bernard, M., Gaborit, B., & Rapacchi, S. (2022) · Diagnostics · doi:10.3390/diagnostics12010126 · Cited by 28 · see citing works
Tu, Y., Li, Q., Zhou, Y.-C., Ye, Z., Wu, C., Xie, E., Li, Y., Li, P., Wu, Y., Guo, Z., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.995216 · Cited by 30 · see citing works
Sawada, N., Nakanishi, K., Daimon, M., Yoshida, Y., Ishiwata, J., Hirokawa, M., Nakao, T., Morita, H., Tullio, M. R. D., Homma, S., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319891286 · Cited by 27 · see citing works
Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction
Abusnina, W. A., Merdler, I., Cellamare, M., Chitturi, K. R., Chaturvedi, A., Feuerstein, I. M., Zhang, C., Ozturk, S. T., Deksissa, T., Sawant, V., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038484 · Cited by 17 · see citing works
Maimaituxun, G., Yamada, H., Fukuda, D., Yagi, S., Kusunose, K., Hirata, Y., Nishio, S., Soeki, T., Masuzaki, H., Sata, M., et al. (2020) · Circulation Journal · doi:10.1253/circj.cj-19-0793 · Cited by 17 · see citing works
Coronary microvascular disease in heart failure with preserved ejection fraction
Sen, P., Wang, L., d'Ambrosio, L., Bierschenk, S., Hamers, J., Ornek, I., Sittig, T., Zhang, H., Zhang, J., & Merkus, D. (2025) · Physiological Reports · doi:10.14814/phy2.70521 · Cited by 16 · see citing works
Packer, M. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1183 · Cited by 15 · see citing works
Aboumsallem, J. P., Muthuramu, I., Mishra, M., & Geest, B. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092222 · Cited by 15 · see citing works
Toya, T., Corban, M., Imamura, K., Bois, J. P., Gulati, R., Oh, J. K., Lerman, L. O., & Lerman, A. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.04.012 · Cited by 15 · see citing works
Expression profile of circular RNAs in epicardial adipose tissue in heart failure
Zheng, M., Du, X.-P., Zhao, L., & Yang, X. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001056 · Cited by 14 · see citing works
The immunology of heart failure with preserved ejection fraction
Smart, C. D., & Madhur, M. S. (2023) · Clinical Science · doi:10.1042/cs20230226 · Cited by 15 · see citing works
Kim, M., Park, S., Cho, D., Kim, H., Shin, M., Kim, M., Hong, K.-S., & Shim, W. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0212-8 · Cited by 13 · see citing works
Ishikawa, H., Otsuka, K., Kono, Y., Hojo, K., Yamaura, H., Hirata, K., Kasayuki, N., Izumiya, Y., & Fukuda, D. (2023) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2023.101176 · Cited by 13 · see citing works
Bansal, B., Lajeunesse‐Trempe, F., Keshvani, N., Lavie, C. J., & Pandey, A. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.04.012 · Cited by 15 · see citing works
Drapkina, O. M., Angarsky, R. K., Александровна, Р. Е., Максимова, О. А., Ivanova, A. A., Zyatenkova, E. V., & Dzhioeva, O. N. (2023) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2023-3552 · Cited by 11 · see citing works
Sonaglioni, A., Ferrulli, A., Nicolosi, G. L., Lombardo, M., & Luzi, L. (2024) · Cureus · doi:10.7759/cureus.51698 · Cited by 11 · see citing works
Sidhu, G., & Rabkin, S. W. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185533 · Cited by 11 · see citing works
Fu, Z., Wang, Y., Wang, Y., Shi, S., Li, Y., Zhang, B., Wu, H., & Song, Q. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02266-y · Cited by 10 · see citing works
Rabkin, S. W. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.013 · Cited by 10 · see citing works
Aspects of transthoracic echocardiography protocol in obese patients
Dzhioeva, O. N., Максимова, О. А., Александровна, Р. Е., & Drapkina, O. M. (2023) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2022-5243 · Cited by 14 · see citing works
Metabolic syndrome – Evidence-based strategies for patient optimization
Reyes, S., Pak, T. J., & Moon, T. S. (2020) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2020.04.002 · Cited by 9 · see citing works
Yamaura, H., Otsuka, K., Ishikawa, H., Hojo, K., Matsumoto, K., Fujisawa, N., Okamoto, A., Yamaguchi, T., Kagawa, S., Shimada, T., et al. (2025) · European Heart Journal - Imaging Methods and Practice · doi:10.1093/ehjimp/qyaf079 · Cited by 8 · see citing works
Zhou, Y., Yan, H., Zhu, Y., Jiang, W., & Zhang, S. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1701459 · Cited by 8 · see citing works
Blinova, N. V., Azimova, M. O., Zhernakova, Y. V., Zheleznova, E. A., Yarovaya, E. B., Orlovskiy, A. A., Ризвановна, А. М., Валерьевна, Д. С., Ternovoy, S. K., & Чазова, И. Е. (2019) · Terapevticheskii arkhiv · doi:10.26442/00403660.2019.09.000334 · Cited by 8 · see citing works
Kahl, K. G., Fraccarollo, D., Winter, L., Bauersachs, J. K., & Westhoff‐Bleck, M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.070 · Cited by 9 · see citing works
Wacker, J., Farpour‐Lambert, N. J., Viallon, M., Didier, D., Beghetti, M., & Maggio, A. B. R. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11120383 · Cited by 5 · see citing works
Zamani, S. K., Wei, J., Hathorn, B., Robuck, E., Kwan, A. C., Pepine, C. J., Handberg, E. M., Cipher, D. J., Dey, D., Merz, C. N. B., et al. (2024) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeae203 · Cited by 5 · see citing works
Li, Q., Muhib, U. R., Ma, X., Liu, Z., Gao, F., & Wang, Z. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2509311 · Cited by 5 · see citing works
Hardt, F., Becker, M., Brandenburg, V. M., Grebe, J., Dirrichs, T., Gohmann, R. F., Fehrenbacher, K., Schmoee, J., & Reinartz, S. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229636 · Cited by 5 · see citing works
Ran, C.-Q., Su, Y., Li, J., Wu, K. C., Liu, Z., Yang, Y., Zhang, M., Yuan, G., Yu, X., & He, W. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2387302 · Cited by 4 · see citing works
Epicardial fat accumulation and left heart remodelling in patients with chronic coronary syndrome
Seki, H., Nakanishi, K., Daimon, M., Hirose, K., Mukai, Y., Yoshida, Y., Nakao, T., Morita, H., Tullio, M. R. D., Homma, S., et al. (2022) · European Heart Journal Open · doi:10.1093/ehjopen/oeac082 · Cited by 4 · see citing works
Correlation between epicardial adipose tissue and myocardial injury in patients with COVID-19
Su, T., Zhong, B., Tang, C., Qiao, S., Feng, Y. Y., Peng, H. Y., & Gu, X. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1368542 · Cited by 4 · see citing works
Blinova, N. V., Azimova, M. O., Zhernakova, Y. V., Saidova, M. A., Ternovoy, S. K., Zheleznova, E. A., Ризвановна, А. М., & Chazova, I. E. (2021) · Systemic Hypertension · doi:10.26442/2075082x.2020.4.200557 · Cited by 4 · see citing works
Landes, S., Aldiwani, H., Thomson, L., Wei, J., AlBadri, A., Mehta, P. K., Pedram, M., Motwani, M., Cook-Weins, G., Sopko, G. S., et al. (2024) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2024.100379 · Cited by 3 · see citing works
Hu, Y., Yu, W., Zhang, F., Wang, Y., Wang, J., Wan, P., Shao, X., Wang, J., Sun, Y., & Wang, Y. (2024) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-1413 · Cited by 3 · see citing works
Gustafsson, B., Rovio, S., Ruohonen, S., Mykkänen, J., Lehtimäki, T. J., Jokinen, E., Tossavainen, P. H., Laitinen, T. P., Kähönen, M. A. P., Viikari, J. S. A., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf394 · Cited by 3 · see citing works
Clinical correlates of perivascular adipose tissue in coronary artery disease and obesity
Upadhaya, S., Pandey, A. C., Wiley, J., & Jemtel, T. H. L. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1651249 · Cited by 2 · see citing works
Characterization of Cardiac Fat in Atrial Fibrillation Patients Prior to Ablation Treatment
Peer-Zada, F., Hamze, D., & García, J. (2023) · Applied Sciences · doi:10.3390/app132112005 · Cited by 1 · see citing works
EET Intervention on HO-1 Prevent Obesity Derived Cardiovascular Diseases
Liu, L., Huang, X., Gao, J.-L., Guo, Y., Di, Y., Sun, S., & Cao, J. (2018) · Journal of Biomolecular Research & Therapeutics · doi:10.4172/2167-7956.1000163 · Cited by 1 · see citing works
Patients With Obesity Exhibit a Plateau Pattern of the Right Ventricular Waveform
Arita, Y., Okada, M., Ogasawara, N., & Hasegawa, S. (2019) · Cardiology Research · doi:10.14740/cr865 · Cited by 1 · see citing works
Kostyakova, I. V., Сотникова, Л. С., OOO ProfMed, T., Beloborodova, E. V., Burkovskaya, V. A., Леонидовна, О. В., & Aspembitova, A. T. (2019) · Doctor Ru · doi:10.31550/1727-2378-2019-157-2-41-46
Pagel, P. S., Millen, H. T., Peterson, T. S., Gandhi, S. D., Lohr, N. L., & Almassi, G. H. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.08.053
Epicardial Fat and Hepatic Steatosis as Cardiovascular Risk Markers
Rodríguez-Granillo, G. A., Arufe, D., & Berg, G. A. (2020) · Revista Argentina de Cardiología · doi:10.7775/rac.v88.i4.18387
Grasa epicárdica y esteatosis hepática como marcadores de riesgo cardiovascular
Rodríguez-Granillo, G. A., Arufe, D., & Berg, G. A. (2020) · Revista Argentina de Cardiología · doi:10.7775/rac.es.v88.i4.18387
Inflammation, oxidative stress, and endothelial dysfunction
Heymans, S. R. B. (2023) · Oxford University Press eBooks · doi:10.1093/med/9780198891628.003.0025
- Authors
- Nakanishi, K., Fukuda, S., Tanaka, A., Otsuka, K., Taguchi, H., & Shimada, K.
- Affiliations
- Baba Memorial Hospital (JP)
- University of Occupational and Environmental Health Japan (JP)
- Wakayama Medical University (JP)
- Ishikiriseiki Hospital (JP)
- Osaka Ekisaikai Hospital (JP)
- Osaka City University (JP)
- Corresponding author
- Nakanishi, Koki
- Venue
- Canadian Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 33
- Issue
- 11
- Pages
- 1489-1497
- ISSN
- 0828-282X (ISSN-L)
- OpenAlex
- W2742187097
- Cited by
- 62
- References
- 42
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 1
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- epicardial adipose tissue, left ventricular diastolic dysfunction, coronary microcirculation, coronary flow reserve, obesity, ectopic fat, paracrine effects, mitral annular velocity, diabetes mellitus
- MeSH terms
- Adipose Tissue, Coronary Circulation, Diastole, Female, Follow-Up Studies, Humans, Male, Microcirculation, Middle Aged, Pericardium, Risk Factors, Echocardiography, Doppler, Ventricular Function, Left, Ventricular Dysfunction, Left, Fractional Flow Reserve, Myocardial, Multidetector Computed Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review