Cited by 62Cardiovascular Disease and AdiposityCardiovascular Function and Risk FactorsCardiac Imaging and Diagnostics

Relationships Between Periventricular Epicardial Adipose Tissue Accumulation, Coronary Microcirculation, and Left Ventricular Diastolic Dysfunction

Nakanishi, Koki, Fukuda, Shota, Tanaka, Atsushi, Otsuka, Kenichiro, Taguchi, Haruyuki, Shimada, Kenei·2017·Canadian Journal of Cardiology

Abstract

Background Obesity is related to left ventricular (LV) diastolic dysfunction, although its pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) is an ectopic fat with paracrine effects on coronary circulation and myocardium. We hypothesized that left ventricle-specific (periventricular) EAT may deteriorate diastolic function by impairing coronary microcirculation.Methods In protocol 1, 74 patients without obstructive narrowing of the left anterior descending artery on multidetector computed tomography (MDCT) underwent coronary flow reserve (CFR) examination to evaluate the relationship between EAT and coronary microcirculation. In protocol 2, 372 patients who underwent both MDCT and serial transthoracic Doppler echocardiographic (TTDE) examinations were enrolled to investigate the impact of periventricular EAT on changes in diastolic function. EAT volume was measured by MDCT. CFR and diastolic function were assessed by TTDE. Deterioration of LV diastolic function was defined as a ≥ 20% decrease in early diastolic mitral annular velocity.Results CFR was significantly correlated with periventricular EAT volume (r = -0.37; P = 0.001), but not with total EAT volume (r = -0.21; P = 0.071). Periventricular EAT volume (P = 0.010) was significantly associated with CFR independent of cardiovascular risk factors. Among the 372 patients who had serial TTDE examinations, the frequency of deteriorated LV diastolic function was lowest in the lower tertile of periventricular EAT, intermediate in the middle tertile, and highest in the upper tertile (12.9%, 21.0%, and 25.8%, respectively; P = 0.037). Age, diabetes mellitus, and periventricular EAT volume were significantly associated with deterioration of LV diastolic function (all P < 0.05).Conclusions This study demonstrated the close association of periventricular EAT with impaired CFR and deteriorated LV diastolic function.

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Crossref · 10.1016/j.cjca.2017.08.001

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Authors
Nakanishi, K., Fukuda, S., Tanaka, A., Otsuka, K., Taguchi, H., & Shimada, K.
Affiliations
  • Baba Memorial Hospital (JP)
  • University of Occupational and Environmental Health Japan (JP)
  • Wakayama Medical University (JP)
  • Ishikiriseiki Hospital (JP)
  • Osaka Ekisaikai Hospital (JP)
  • Osaka City University (JP)
Corresponding author
Nakanishi, Koki
Venue
Canadian Journal of Cardiology
Publisher
Elsevier BV
Published
2017-11
Volume
33
Issue
11
Pages
1489-1497
ISSN
0828-282X (ISSN-L)
OpenAlex
W2742187097
Cited by
62
References
42
Citations by year
2026: 1 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 1
FWCI
5.88
Type
journal article
Language
en
Open access
closed
Locations
  • Canadian Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
epicardial adipose tissue, left ventricular diastolic dysfunction, coronary microcirculation, coronary flow reserve, obesity, ectopic fat, paracrine effects, mitral annular velocity, diabetes mellitus
MeSH terms
Adipose Tissue, Coronary Circulation, Diastole, Female, Follow-Up Studies, Humans, Male, Microcirculation, Middle Aged, Pericardium, Risk Factors, Echocardiography, Doppler, Ventricular Function, Left, Ventricular Dysfunction, Left, Fractional Flow Reserve, Myocardial, Multidetector Computed Tomography

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