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Cited by 60Wound Healing and TreatmentsFacial Rejuvenation and Surgery TechniquesSkin Protection and Aging

Polydeoxyribonucleotide: A promising skin anti-aging agent

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Khan, Aawrish, Wang, Guobao, Zhou, Feng, Gong, Lunli, Zhang, Jun, Qi, Lili, Cui, Haiyan·2022·Chinese Journal of Plastic and Reconstructive Surgery
DOI 10.1016/j.cjprs.2022.09.015
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Abstract

Polydeoxyribonucleotide (PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 ​kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many preclinical and clinical studies have demonstrated the properties of PDRN. These include anti-inflammatory, anti-apoptotic, anti-osteoporotic, anti-melanogenetic, anti-allodynic, anti-osteonecrotic, bone regenerative, tissue damage preventive, anti-ulcerative, and wound healing properties, which are mediated by the activation of the adenosine A2A receptor and salvage pathways. Moreover, PDRN promotes angiogenesis, cellular activity, collagen synthesis, soft tissue regeneration, and skin priming and revitalization and can be used to treat hyperpigmentation. Therefore, this review assessed the potential use of PDRN as an anti-aging agent for the skin.

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  • Both PN and PDRN are nucleic acid-derived polymers composed of nucleotide monomers connected via phosphodiester bonds.

    “Both PN and PDRN are nucleic acid-derived polymers composed of nucleotide monomers connected via phosphodiester bonds [11,17].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [17]

    The Introduction states that PDRN is a DNA-derived linear polymer of deoxyribonucleotide monomers joined by phosphodiester linkages. The paper also mentions polynucleotide-containing products, but the passages found do not separately describe PN’s composition or linkages, so the claim about both is only partly supported. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • PDRN has demonstrated a strong safety profile in both acute and chronic toxicity studies, with no significant immunogenic responses.

    “PDRN has demonstrated a strong safety profile in both acute and chronic toxicity studies, where no significant immunogenic responses were observed [11,17,19].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [17]

    The “Safety of use” passage reports no toxicity after repeated systemic administration in mice and rats and attributes an absence of immunological effects to PDRN’s purification process. It supports a favorable safety profile, but does not describe both acute and chronic toxicity studies or report measured immunogenic responses in those studies. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Khan, A., Wang, G., Zhou, F., Gong, L., Zhang, J., Qi, L., & Cui, H.
Affiliations
Tongji University (CN)
Corresponding author
Cui, Haiyan
ORCID
Venue
Chinese Journal of Plastic and Reconstructive Surgery
Publisher
Elsevier BV
Published
2022-12
Volume
4
Issue
4
Pages
187-193
ISSN
2096-6911 (ISSN-L)
DOI
10.1016/j.cjprs.2022.09.015
OpenAlex
W4307154922
Cited by
60
References
6
Citations by year
2026: 23 · 2025: 24 · 2024: 8 · 2023: 5
FWCI
4.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Chinese Journal of Plastic and Reconstructive Surgery (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
polydeoxyribonucleotide, skin anti-aging, salmon sperm DNA, adenosine A2A receptor, salvage pathway, wound healing, angiogenesis, collagen synthesis, hyperpigmentation, anti-inflammatory activity, anti-apoptotic effects, soft tissue regeneration

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