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Cited by 124COVID-19 and Mental HealthCancer survivorship and careCOVID-19 and healthcare impacts

Patient-reported outcomes of patients with breast cancer during the COVID-19 outbreak in the epicenter of China: A cross-sectional survey study

Open access
Juanjuan, Li, Santa-Maria, Cesar Augusto, Hongfang, Feng, Lingcheng, Wang, Pengcheng, Zhang, Yuanbing, Xu, Yuyan, Tan, Zhongchun, Liu +8 more·2020·Clinical Breast Cancer
DOI 10.1016/j.clbc.2020.06.003PMC PMC7275993
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Abstract

INTRODUCTION: We aimed to analyze the psychological status in patients with breast cancer (BC) in the epicenter of the coronavirus disease 2019 (COVID-19) pandemic. PATIENTS AND METHODS: A total of 658 individuals were recruited from multiple BC centers in Hubei Province. Online questionnaires were conducted, and these included demographic information, clinical features, and 4 patient-reported outcome scales (Generalized Anxiety Disorder Questionnaire [GAD-7], Patient Health Questionnaire [PHQ-9], Insomnia Severity Index [ISI], and Impact of Events Scale-Revised [IES-R]). Multivariable logistic regression analysis was designed to identify potential factors on mental health outcomes. RESULTS: Questionnaires were collected from February 16, 2020 to February 19, 2020, the peak time point of the COVID-19 outbreak in China. Of patients with BC, 46.2% had to modify planned necessary anti-cancer treatment during the outbreak. Severe anxiety and severe depression were reported by 8.9% and 9.3% of patients, respectively. Severe distress and insomnia were reported by 20.8% and 4.0% of patients, respectively. Multivariable logistic regression analysis demonstrated poor general condition, shorter duration after BC diagnosis, aggressive BC molecular subtypes, and close contact with patients with COVID-19 as independent factors associated with anxiety. Poor general condition and central venous catheter flushing delay were factors that were independently associated with depression. In terms of insomnia, poor generation condition was the only associated independent factor. Poor physical condition and treatment discontinuation were underlying risk factors for distress based on multivariable analysis. CONCLUSION: High rates of anxiety, depression, distress, and insomnia were observed in patients with BC during the COVID-19 outbreak. Special attention should be paid to the psychological status of patients with BC, especially those with poor general condition, treatment discontinuation, aggressive molecular subtypes, and metastatic BC.

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  • Women who were in active treatment for breast cancer had higher levels of depression, anxiety and stress than those who survived breast cancer.

    “in another study comparing the depression, anxiety and stress levels of 658 women who were treated for active breast cancer and those who survived breast cancer, it was found that women who were in active treatment had higher levels of depression, anxiety and stress.[44]”

    From Psychological Distress of Breast Cancer Survivors During the COVID-19 Pandemic and Related Factors: A Controlled Study. (2023) · cites this paper as [44]

    The Patients and Methods section and Table 1 report 658 participants, including patients with breast cancer and survivors. The Results section reports anxiety, depression and distress, but does not compare women in active treatment with survivors or show that the former had higher levels of all three. Its finding about treatment discontinuation concerns a different comparison. (LLM, conf=0.85)

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  • Similar reports of anxiety, depressive symptoms, and psychological distress during the lockdown were gathered from patients with breast cancer, ovarian cancer, thyroid cancer, and lymphoma.

    “Similar reports of anxiety, depressive symptoms, and psychological distress during the lockdown were gathered from patients with breast cancer, ovarian cancer, thyroid cancer, and lymphoma [36,37,38,39].”

    From The Psychosocial Impact of COVID-19 on Older Adults with Cancer: A Rapid Review (2022) · cites this paper as [36]

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Authors
Juanjuan, L., Santa-Maria, C. A., Hongfang, F., Lingcheng, W., Pengcheng, Z., Yuanbing, X., Yuyan, T., Zhongchun, L., Bo, D., Meng, L., Qingfeng, Y., Feng, Y., Yi, T., Shengrong, S., Xingrui, L., & Chuang, C.
Affiliations
  • Johns Hopkins University (US)
  • Hubei University of Medicine (CN)
  • Renmin Hospital of Wuhan University (CN)
  • Wuhan University (CN)
ORCID
Santa-Maria, Cesar Augusto
Venue
Clinical Breast Cancer
Publisher
Elsevier BV
Published
2020-10
Volume
20
Issue
5
Pages
e651-e662
ISSN
1526-8209 (ISSN-L)
DOI
10.1016/j.clbc.2020.06.003
PMC
PMC7275993
OpenAlex
W3034171540
Cited by
124
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 11 · 2023: 22 · 2022: 40 · 2021: 40 · 2020: 7
FWCI
10.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Breast Cancer (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundamental Research Funds for the Central Universities
Topics
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
Keywords
breast cancer, COVID-19 pandemic, patient-reported outcomes, anxiety, depression, psychological distress, insomnia, treatment discontinuation, molecular subtypes, metastatic breast cancer, Hubei Province, mental health risk factors
MeSH terms
Patient Reported Outcome Measures, Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, Anxiety, Breast Neoplasms, China, Cross-Sectional Studies, Depression, Female, Health Services Accessibility, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Pneumonia, Viral, Surveys and Questionnaires, Risk Factors, Stress, Psychological, Infection Control, Coronavirus Infections, Pandemics

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