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Cited by 85Nutrition and Health in AgingClinical Nutrition and GastroenterologyDialysis and Renal Disease Management

Nutritional supplementation and dietary advice in geriatric patients at risk of malnutrition

Persson, Margareta, Hytter-Landahl, Åsa, Brismar, Kerstin, Cederholm, Tommy·2007·Clinical Nutrition
DOI 10.1016/j.clnu.2006.12.002
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Abstract

Background & aim Effects of combined nutritional treatment of patients at risk of protein-energy malnutrition (PEM) discharged from a geriatric service were evaluated. Methods Patients (n=108, age 85+/-6 years) at risk of malnutrition according to the short form of the mini nutritional assessment were randomly allocated to dietary counseling, including liquid and multivitamin supplementation, i.e. intervention (I, n=51) and to controls (C, n=57). Body weight, biochemical indices (e.g. insulin-like growth factor I (IGF-I)), Katz activities of daily living (ADL) index, mini mental status examination (MMSE) and quality of life (QoL) by SF-36 were assessed at the start of the study and after 4 months. Statistical analyses were performed on "intention-to-treat" and on "treated-as-protocol" bases. Results Fifty-four patients, 29 in the I-group (86+/-7 years, 66% females) and 25 in the C-group (85+/-7 years, 72% females) completed the study according to the protocol. Both modes of analysis revealed a significant positive effect of the combined nutritional intervention on weight maintenance. Treated-as-protocol analyses showed that Katz ADL index improved in the I-group (p Conclusions Combined nutritional intervention prevented weight loss and improved ADL functions in discharged geriatric patients at risk of malnutrition.

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Crossref · 10.1016/j.clnu.2006.12.002

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  • In the study by Persson et al., older patients at risk of malnutrition (85±6 years) treated with liquid supplements and dietary advice for four months had improvement of Katz's activities of daily living index (p<0.001; p=0.05 between groups), but not in QoL assessed by SF-36.

    “In the study by Persson et al., which included older patients at risk of malnutrition (85 ± 6 years), treatment with complete or incomplete liquid supplements (providing an average intake of 60 kcals and 11.25 g protein per day) and dietary advice for four months resulted in an improvement of Katz's activities of daily living index (p < 0.001; p ¼ 0.05 between groups), but not in QoL assessed by”

    From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [119]

  • In most RCTs on intervention with ONS, sip feeds were given for at least three months, whereas individualized nutritional support was usually carried out for longer periods (e.g. four months in Persson et al., or six months in Feldblum et al., Casals et al., Bonilla-Palomas et al., and Yang et al.).

    “However, in most RCTs on intervention with ONS, the sip feeds were given for at least three months [9,120e124], whereas individualized nutritional support (which might include ONS where necessary) was usually carried out for longer periods (e.g.four months in the study by Persson et al. [119], or six months in the studies of Feldblum et al. [116], Casals et al. [118], Bonilla-Palomas et al. [126],”

    From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [119]

  • In a RCT of malnourished patients aged 85±6 years, individualized nutritional support for four months after discharge maintained body weight in the intention-to-treat analysis (difference in mean weight from baseline to 4-month followup was 0.6 kg in IG vs -1.5 kg in CG, p<0.001), although a high dropout rate was reported.

    “in a RCT of malnourished patients (according to the MNA-SF) aged 85 ± 6 years, individualized nutritional support for four months after discharge maintained body weight in the intention-to-treat analysis (difference in mean weight from baseline to 4-month followup was 0.6 kg in the IG vs. À1.5 kg in the CG, p < 0.001), although a high dropout rate was reported”

    From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [119]

  • Two other RCTs reported that combined dietary counseling and ONS after hospital discharge prevented weight loss and improved activities of daily living and decreased functional limitations.

    “Two other RCTs (not included in this systematic review) studied the effects of a combined dietary counseling and ONS intervention after hospital discharge and reported prevention of weight loss and improved activities of daily living functions (124) and decreased functional limitations (52,125).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [124]

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Authors
Persson, M., Hytter-Landahl, Å., Brismar, K., & Cederholm, T.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
  • Uppsala University (SE)
Corresponding author
  • Persson, Margareta
  • Cederholm, Tommy
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2007-04
Volume
26
Issue
2
Pages
216-224
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2006.12.002
OpenAlex
W2018943334
Cited by
85
References
35
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 10
FWCI
3.80
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Karolinska Institutet
  • Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
protein-energy malnutrition, older adults, dietary supplementation, multivitamin supplementation, nutrition counseling, weight maintenance, activities of daily living, insulin-like growth factor I, quality of life, hospitalized older adults, Mini Nutritional Assessment
MeSH terms
Activities of Daily Living, Aged, 80 and over, Energy Intake, Diet, Female, Humans, Insulin-Like Growth Factor I, Male, Mental Health, Protein-Energy Malnutrition, Vitamins, Weight Gain, Weight Loss, Geriatric Assessment, Nutrition Assessment, Logistic Models, Dietary Supplements

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