Cited by 381Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentMuscle metabolism and nutrition

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Provision of protein and energy in relation to measured requirements in intensive care patients

Allingstrup, Matilde Jo, Esmailzadeh, Negar, Wilkens Knudsen, Anne, Espersen, Kurt, Hartvig Jensen, Tom, Wiis, Jørgen, Perner, Anders, Kondrup, Jens·2012·Clinical Nutrition

DOI 10.1016/j.clnu.2011.12.006

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Abstract

Background & aims Adequacy of nutritional support in intensive care patients is still a matter of investigation. This study aimed to relate mortality to provision, measured requirements and balances for energy and protein in ICU patients. Design Prospective observational cohort study of 113 ICU patients in a tertiary referral hospital. Results Death occurred earlier in the tertile of patients with the lowest provision of protein and amino acids. The results were confirmed in Cox regression analyses which showed a significantly decreased hazard ratio of death with increased protein provision, also when adjusted for baseline prognostic variables (APACHE II, SOFA scores and age). Provision of energy, measured resting energy expenditure or energy and nitrogen balance was not related to mortality. The possible cause-effect relationship is discussed after a more detailed analysis of the initial part of the admission. Conclusion In these severely ill ICU patients, a higher provision of protein and amino acids was associated with a lower mortality. This was not the case for provision of energy or measured resting energy expenditure or energy or nitrogen balances. The hypothesis that higher provision of protein improves outcome should be tested in a randomised trial.

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Authors: Allingstrup, M. J., Esmailzadeh, N., Wilkens Knudsen, A., Espersen, K., Hartvig Jensen, T., Wiis, J., Perner, A., & Kondrup, J.
Affiliations: Copenhagen University Hospital (DK)
University of Copenhagen (DK)
Corresponding author: Allingstrup, Matilde Jo
ORCID: Perner, Anders
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2012-08
Volume: 31
Issue: 4
Pages: 462-468
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2011.12.006
OpenAlex: W2054596359
Cited by: 381
References: 27
Citations by year: 2026: 9 · 2025: 13 · 2024: 24 · 2023: 19 · 2022: 23 · 2021: 33 · 2020: 37 · 2019: 41 · 2018: 31 · 2017: 42 · 2016: 23 · 2015: 28 · 2014: 30 · 2013: 23 · 2012: 3
FWCI: 16.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: amino acids, energy supply, intensive care unit patients, nutritional support, mortality, resting energy expenditure, nitrogen balance, energy balance, critically ill patients
MeSH terms: Adult, Aged, Energy Intake, Critical Care, Dietary Proteins, Humans, Intensive Care Units, Length of Stay, Middle Aged, Nutritional Requirements, Prospective Studies, Proportional Hazards Models, Treatment Outcome, Hospital Mortality, Nutritional Support, APACHE, Tertiary Care Centers

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Provision of protein and energy in relation to measured requirements in intensive care patients

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