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Cited by 47Adipokines, Inflammation, and Metabolic DiseasesNutritional Studies and DietDietary Effects on Health

Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial

Markova, Mariya, Koelman, Liselot, Hornemann, Silke, Pivovarova, Olga, Sucher, Stephanie, Machann, Juergen, Rudovich, Natalia, Thomann, Ralph +4 more·2020·Clinical Nutrition
DOI 10.1016/j.clnu.2019.03.019
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Abstract

Background & aims Pro-inflammatory biomarkers are well-established contributors to insulin resistance and represent valid targets for diabetes management and prevention. Yet, little is known whether nutrition could play a role in modulating various aspects of immune-inflammatory responses. Our aim is to assess the effect of isocaloric animal and plant protein dietary interventions on selected biomarkers representing various immune-inflammatory pathways.Methods We enrolled 37 participants with type 2 diabetes (age 64 ± 6 years, body mass index 30.2 ± 3.6 kg/m 2, glycated hemoglobin 7.0 ± 0.6%) who underwent an either high-animal protein (AP) or high-plant protein (PP) diet (30 E% protein, 40 E% carbohydrates, 30 E% fat) for 6-weeks. Clinical examinations were performed at beginning and end of the study. Levels of pro-inflammatory adipokines [chemerin, progranulin], cytokines [tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), soluble urokinase-type plasminogen activator receptor (suPAR), transforming growth factor beta 1 (TGF-β1)], and proteins [calprotectin, lactoferrin and growth differentiation factor 15 (GDF-15)] were determined in blood serum using enzyme-linked immunosorbent assay.Results Chemerin and progranulin concentrations decreased following AP and PP diets. TGF-β1 increased in AP and decreased in PP, whereas calprotectin increased in PP and decreased in AP. No statistically significant differences in the concentrations of IL-6, TNF-α, suPAR, lactoferrin and GDF-15 could be seen in either of the protein diet arms.Conclusions These results suggest that both AP and PP diets may effectively reduce the levels of the pro-inflammatory adipokines chemerin and progranulin. The effects on the additional immune-inflammatory biomarkers seem to be more complex.Clinical trial registry number NCT02402985 (ww.clinicaltrials.gov).

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  • A randomized clinical study of 37 diabetic individuals placed on either a high animal protein diet (80.2% of total protein) or a high plant protein diet (72.3% of total protein) for six weeks found that both diets similarly reduced body weight, BMI, HbA1c, and blood lipid markers after the intervention, with no difference between the protein groups.

    “This randomized clinical study of 37 diabetic individuals placed on either a high animal protein diet (80.2% of total protein in intervention) or a high plant protein diet (72.3% of total protein in intervention) for six weeks found that both diets similarly reduced body weight, BMI, HbA1c, and blood lipid markers after the intervention [83].”

    From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [83]

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Authors
Markova, M., Koelman, L., Hornemann, S., Pivovarova, O., Sucher, S., Machann, J., Rudovich, N., Thomann, R., Schneeweiss, R., Rohn, S., Pfeiffer, A. F. H., & Aleksandrova, K.
Affiliations
  • German Center for Diabetes Research (DE)
  • German Institute of Human Nutrition (DE)
  • University of Tübingen (DE)
  • Institut für Getreideverarbeitung (Germany) (DE)
  • Institute for Food and Environmental Research (DE)
  • Universität Hamburg (DE)
  • University of Potsdam (DE)
Corresponding author
  • Markova, Mariya
  • Aleksandrova, Krasimira
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2020-03
Volume
39
Issue
3
Pages
862-869
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2019.03.019
OpenAlex
W2924858906
Cited by
47
References
65
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 12 · 2022: 7 · 2021: 5 · 2020: 6
FWCI
3.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • publish.UP (University of Potsdam) (submittedVersion)
Funders
  • Federal Ministry of Food and Agriculture
  • Federal Republic of Germany via the Federal Office for Agriculture and Food (2815407110)
  • German Center for Diabetes Research
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
high-protein diet, plant proteins, animal protein, immune-inflammatory biomarkers, chemerin, progranulin, TGF-β1, calprotectin, interleukin-6, TNF-α, suPAR, lactoferrin, GDF15, insulin resistance, diabetes prevention, isocaloric diet
MeSH terms
Diet, High-Protein, Animal Proteins, Dietary, Aged, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Male, Middle Aged, Plant Proteins, Dietary, Biomarkers, Transforming Growth Factor beta, Leukocyte L1 Antigen Complex, Adipokines

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