Cited by 785Mitochondrial Function and PathologyAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Brand, Martin D., Esteves, Telma C.·2005·Cell Metabolism

Abstract

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.

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Crossref · 10.1016/j.cmet.2005.06.002

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Metadata

Authors
Brand, M. D., & Esteves, T. C.
Affiliations
MRC Mitochondrial Biology Unit (GB)
Corresponding author
Brand, Martin D.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2005-08
Volume
2
Issue
2
Pages
85-93
ISSN
1550-4131 (ISSN-L)
OpenAlex
W1992678387
Cited by
785
References
101
Citations by year
2026: 16 · 2025: 18 · 2024: 16 · 2023: 26 · 2022: 34 · 2021: 41 · 2020: 33 · 2019: 40 · 2018: 48 · 2017: 44 · 2016: 39 · 2015: 40 · 2014: 32 · 2013: 41 · 2012: 35
FWCI
3.56
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
UCP2, UCP3, mitochondrial uncoupling proteins, thermogenesis, mitochondrial reactive oxygen species, insulin secretion, fatty acid export, aging, degenerative diseases, diabetes mellitus, obesity
MeSH terms
Uncoupling Protein 2, Uncoupling Protein 3, Insulin Secretion, Aging, Animals, Carrier Proteins, Fatty Acids, Insulin, Ion Channels, Mitochondria, Obesity, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress, Protein Isoforms, Thermogenesis, Mitochondrial Proteins, Membrane Transport Proteins

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