HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, Ioanna, Cairns, Rob A., Fontana, Lucrezia, Lim, Ai Lin, Denko, Nicholas C.·2006·Cell Metabolism
Cited by (137)
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- Oxygen Sensing in Retinal Health and DiseaseLange, Clemens A.K., Bainbridge, James W.B. · 2012 · Ophthalmologica
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- Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 XenograftsBiswas, Swethajit, Troy, Helen, Leek, Russell, Chung, Yuen-Li, Li, Ji-liang, Raval, Raju R., Turley, Helen, Gatter, Kevin, Pezzella, Francesco, Griffiths, John R. et al. · 2010 · Journal of Oncology
- Respiratory chain complex II as general sensor for apoptosisGrimm, Stefan · 2013 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stressPacker, Milton · 2021 · Cardiovascular Research
- Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose IntoleranceMatsuura, Hirohide, Ichiki, Toshihiro, Inoue, Eriko, Nomura, Masatoshi, Miyazaki, Ryohei, Hashimoto, Toru, Ikeda, Jiro, Takayanagi, Ryoichi, Fong, Guo-Hua, Sunagawa, Kenji · 2013 · Circulation
- Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysisLi, Xu-Hui, Chen, Xiang-Jun, Ou, Wen-Bin, Zhang, Qian, Lv, Zhi-Rong, Zhan, Yi, Ma, Long, Huang, Tao, Yan, Yong-Bin, Zhou, Hai-Meng · 2013 · The International Journal of Biochemistry & Cell Biology
- Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy2019 · Advances in Cancer Research
- The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment StrategyHoerner, Christian R., Chen, Viola J., Fan, Alice C. · 2019 · Kidney Cancer
- Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapyWeijer, Ruud, Broekgaarden, Mans, Krekorian, Massis, Alles, Lindy K., van Wijk, Albert C., Mackaaij, Claire, Verheij, Joanne, van der Wal, Allard C., van Gulik, Thomas M., Storm, Gert et al. · 2016 · Oncotarget
- Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunityOrtmann, Brian M · 2024 · BMJ Oncology
- Oxygen-induced cell migration and on-line monitoring biomarkers modulation of cervical cancers on a microfluidic systemLin, Xuexia, Chen, Qiushui, Liu, Wu, Zhang, Jie, Wang, Shiqi, Lin, Zhixiong, Lin, Jin-Ming · 2015 · Scientific Reports
- PPARs and the orchestration of metabolic fuel selectionSugden, Mary C., Zariwala, M. Gulrez, Holness, Mark J. · 2009 · Pharmacological Research
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- Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumorsCasillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A. · 2021 · Oncogene
- Growing concerns about using hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of renal anemiaNakanishi, Takeshi, Kuragano, Takahiro · 2024 · Clinical Kidney Journal
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- Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomasGolinska, Monika, Troy, Helen, Chung, Yuen-Li, McSheehy, Paul M, Mayr, Manuel, Yin, Xiaoke, Ly, Lucy, Williams, Kaye J, Airley, Rachel E, Harris, Adrian L et al. · 2011 · BMC Cancer
- Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung CancerMendes, Cindy, Serpa, Jacinta · 2019 · Antioxidants
- Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liverTsukada, Kosuke, Tajima, Toshihide, Hori, Shutaro, Matsuura, Tomomi, Johnson, Randall S., Goda, Nobuhito, Suematsu, Makoto · 2013 · Microcirculation
- Single‐Cell Insights Into Macrophage Subtypes in Pulmonary InfectionsLin, Zhaoheng, Zheng, Yuxiao, Zhong, Yu, Wang, Hongyan · 2026 · Advanced Science
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