HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, Ioanna, Cairns, Rob A., Fontana, Lucrezia, Lim, Ai Lin, Denko, Nicholas C.·2006·Cell Metabolism

Cited by (137)

Items 101–137 of 137

  1. Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
    Chen, Lian, Cui, Hengmin · 2015 · International Journal of Molecular Sciences
  2. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
    Zhao, F, Mancuso, A, Bui, T V, Tong, X, Gruber, J J, Swider, C R, Sanchez, P V, Lum, J J, Sayed, N, Melo, J V et al. · 2010 · Oncogene
  3. Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
    Frezza, Christian, Zheng, Liang, Tennant, Daniel A., Papkovsky, Dmitri B., Hedley, Barbara A., Kalna, Gabriela, Watson, David G., Gottlieb, Eyal · 2011 · PLoS ONE
  4. HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
    Lee, Shen-Han, Golinska, Monika, Griffiths, John R. · 2021 · Cells
  5. Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
    Kaelin, W. G. · 2011 · Cold Spring Harbor Symposia on Quantitative Biology
  6. Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapies
    Olson, Kristofor A., Schell, John C., Rutter, Jared · 2016 · Trends in Biochemical Sciences
  7. Hypoxia Tolerance in Animals: Biology and Application
    Gorr, T. A., Wichmann, D., Hu, J., Hermes‐Lima, M., Welker, A. F., Terwilliger, N., Wren, J. F., Viney, M., Morris, S., Nilsson, G. E. et al. · 2010 · Physiological and Biochemical Zoology
  8. Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
    March-Diaz, Rosana, Lara-Ureña, Nieves, Romero-Molina, Carmen, Heras-Garvin, Antonio, Ortega-de San Luis, Clara, Alvarez-Vergara, Maria I., Sanchez-Garcia, Manuel A., Sanchez-Mejias, Elisabeth, Davila, Jose C., Rosales-Nieves, Alicia E. et al. · 2021 · Nature Aging
  9. Oxygen delivery and fetal-placental growth: Beyond a question of supply and demand?
    Murray, A.J. · 2012 · Placenta
  10. Suppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for miRNA-210 and Protein Synthesis Inhibition
    Colleoni, Francesca, Padmanabhan, Nisha, Yung, Hong-wa, Watson, Erica D., Cetin, Irene, Tissot van Patot, Martha C., Burton, Graham J., Murray, Andrew J. · 2013 · PLoS ONE
  11. D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
    Böttcher, Martin, Renner, Kathrin, Berger, Raffaela, Mentz, Kristin, Thomas, Simone, Cardenas-Conejo, Zugey Elizabeth, Dettmer, Katja, Oefner, Peter J., Mackensen, Andreas, Kreutz, Marina et al. · 2018 · OncoImmunology
  12. Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes
    Chun, Sang Y, Johnson, Craig, Washburn, Joseph G, Cruz-Correa, Marcia R, Dang, Duyen T, Dang, Long H · 2010 · Molecular Cancer
  13. Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?
    Illsley, Nicholas P., Caniggia, Isabella, Zamudio, Stacy · 2010 · The International Journal of Developmental Biology
  14. Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth
    Fan, Jun, Lin, Ruiting, Xia, Siyuan, Chen, Dong, Elf, Shannon E., Liu, Shuangping, Pan, Yaozhu, Xu, Haidong, Qian, Zhiyu, Wang, Mei et al. · 2016 · Molecular Cell
  15. Oxygen Sensing in Retinal Health and Disease
    Lange, Clemens A.K., Bainbridge, James W.B. · 2012 · Ophthalmologica
  16. The impact of hypoxia on cell death pathways
    Lenihan, Colin R., Taylor, Cormac T. · 2013 · Biochemical Society Transactions
  17. Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
    Biswas, Swethajit, Troy, Helen, Leek, Russell, Chung, Yuen-Li, Li, Ji-liang, Raval, Raju R., Turley, Helen, Gatter, Kevin, Pezzella, Francesco, Griffiths, John R. et al. · 2010 · Journal of Oncology
  18. Respiratory chain complex II as general sensor for apoptosis
    Grimm, Stefan · 2013 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  19. Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress
    Packer, Milton · 2021 · Cardiovascular Research
  20. Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance
    Matsuura, Hirohide, Ichiki, Toshihiro, Inoue, Eriko, Nomura, Masatoshi, Miyazaki, Ryohei, Hashimoto, Toru, Ikeda, Jiro, Takayanagi, Ryoichi, Fong, Guo-Hua, Sunagawa, Kenji · 2013 · Circulation
  21. Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis
    Li, Xu-Hui, Chen, Xiang-Jun, Ou, Wen-Bin, Zhang, Qian, Lv, Zhi-Rong, Zhan, Yi, Ma, Long, Huang, Tao, Yan, Yong-Bin, Zhou, Hai-Meng · 2013 · The International Journal of Biochemistry & Cell Biology
  22. Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy
    2019 · Advances in Cancer Research
  23. The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy
    Hoerner, Christian R., Chen, Viola J., Fan, Alice C. · 2019 · Kidney Cancer
  24. Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy
    Weijer, Ruud, Broekgaarden, Mans, Krekorian, Massis, Alles, Lindy K., van Wijk, Albert C., Mackaaij, Claire, Verheij, Joanne, van der Wal, Allard C., van Gulik, Thomas M., Storm, Gert et al. · 2016 · Oncotarget
  25. Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
    Ortmann, Brian M · 2024 · BMJ Oncology
  26. Oxygen-induced cell migration and on-line monitoring biomarkers modulation of cervical cancers on a microfluidic system
    Lin, Xuexia, Chen, Qiushui, Liu, Wu, Zhang, Jie, Wang, Shiqi, Lin, Zhixiong, Lin, Jin-Ming · 2015 · Scientific Reports
  27. PPARs and the orchestration of metabolic fuel selection
    Sugden, Mary C., Zariwala, M. Gulrez, Holness, Mark J. · 2009 · Pharmacological Research
  28. Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
    González-Domínguez, Raúl, García-Barrera, Tamara, Vitorica, Javier, Gómez-Ariza, José Luis · 2015 · Biochimie
  29. Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
    Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A. · 2021 · Oncogene
  30. Growing concerns about using hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of renal anemia
    Nakanishi, Takeshi, Kuragano, Takahiro · 2024 · Clinical Kidney Journal
  31. The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer
    Nam, Hyeyoung, Kundu, Anirban, Karki, Suman, Brinkley, Garrett J., Chandrashekar, Darshan S., Kirkman, Richard L., Liu, Juan, Liberti, Maria V., Locasale, Jason W., Mitchell, Tanecia et al. · 2021 · JCI Insight
  32. Regulation of mitochondrial function by forkhead transcription factors
    Jerome, Maria Sona, Kuthethur, Raviprasad, Kabekkodu, Shama Prasada, Chakrabarty, Sanjiban · 2022 · Biochimie
  33. Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas
    Golinska, Monika, Troy, Helen, Chung, Yuen-Li, McSheehy, Paul M, Mayr, Manuel, Yin, Xiaoke, Ly, Lucy, Williams, Kaye J, Airley, Rachel E, Harris, Adrian L et al. · 2011 · BMC Cancer
  34. Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer
    Mendes, Cindy, Serpa, Jacinta · 2019 · Antioxidants
  35. Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver
    Tsukada, Kosuke, Tajima, Toshihide, Hori, Shutaro, Matsuura, Tomomi, Johnson, Randall S., Goda, Nobuhito, Suematsu, Makoto · 2013 · Microcirculation
  36. Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
    Lin, Zhaoheng, Zheng, Yuxiao, Zhong, Yu, Wang, Hongyan · 2026 · Advanced Science
  37. Hypoxic microenvironment in cancer: role in metabolic reprogramming
    Sureka, Niti, Maheshwari, Rashi, Agravat, Amit, Singhal, Shweta, Zaman, Shamsuz, Rishi, Bhavika, Siraj, Fouzia, Zaheer, Sufian, Misra, Aroonima · 2026 · Frontiers in Oncology