Cited by 695Regulation of Appetite and ObesityPancreatic function and diabetesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Open access

Könner, A. Christine, Janoschek, Ruth, Plum, Leona, Jordan, Sabine D., Rother, Eva, Ma, Xiaosong, Xu, Chun, Enriori, Pablo, Hampel, Brigitte, Barsh, Gregory S., Kahn, C. Ronald, Cowley, Michael A., Ashcroft, Frances M., Brüning, Jens C.·2007·Cell Metabolism

DOI 10.1016/j.cmet.2007.05.004

Open this paper in CoChat — free account Open PDF

Abstract

Insulin action in the central nervous system regulates energy homeostasis and glucose metabolism. To define the insulin-responsive neurons that mediate these effects, we generated mice with selective inactivation of the insulin receptor (IR) in either pro-opiomelanocortin (POMC)- or agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus. While neither POMC- nor AgRP-restricted IR knockout mice exhibited altered energy homeostasis, insulin failed to normally suppress hepatic glucose production during euglycemic-hyperinsulinemic clamps in AgRP-IR knockout (IR(DeltaAgRP)) mice. These mice also exhibited reduced insulin-stimulated hepatic interleukin-6 expression and increased hepatic expression of glucose-6-phosphatase. These results directly demonstrate that insulin action in POMC and AgRP cells is not required for steady-state regulation of food intake and body weight. However, insulin action specifically in AgRP-expressing neurons does play a critical role in controlling hepatic glucose production and may provide a target for the treatment of insulin resistance in type 2 diabetes.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2007.05.004

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Self-citation
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Self-citation
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173
Self-citation
Energy on demand.
Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
Agouti-related peptide–expressing neurons are mandatory for feeding
Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800
Self-citation

Flagged first, then by citations

Show all 34 references

Sorted by citations

Items 601–692 of 692

Central and peripheral mechanisms regulating energy and glucose homeostasis
Tom, R. Z. (2013) · Figshare
Mechanisms of lifespan extension and preventive effects of calorie restriction on tumor development: Possible link between central neuroendocrine system and peripheral metabolic adaptation
Chiba, T., Dong, K., Nishizono, S., & Shimokawa, I. (2013) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.2.259
Molecular basis of brain-mediated regulation of hepatic glucose metabolism
Inoue, H. (2014) · Diabetology International · doi:10.1007/s13340-014-0185-8
Hypothalamic Melanocortin Regulation of Energy Balance and Metabolism
Dutia, R. (2012) · doi:10.7916/d85b00j6 · Cited by 1
The Metabolic Role of Saturated and Monounsaturated Dietary Fatty Acids
Sartorius, T., & Häring, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420168-2.00022-3
Kiss1 neurons and Metabolic Sensing
Qiu, X. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
REVIEW (REVISIÓN) NEUROENDOCRINE EFFECTS OF INSULIN, IGF-I AND LEPTIN ON THE SECRETION OF THE GONADOTROPIN-RELEASING HORMONE (GnRH) (EFECTOS NEUROENDOCRINOS DE INSULINA, IGF-I Y LEPTINA SOBRE LA SECRECIÓN DE HORMONA LIBERADORA DE GONADOTROPINAS (GnRH))
Sánchez, A. G., Rosales‐Torres, A. M., & Gutiérrez, C. G. (2012)
T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate
Fukushima, G., Loh, K., Galić, S., Fam, B. C., Shields, B., Wiede, F., Tremblay, M. L., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2010)
Insulin Action in Brain Regulates Systemic Metabolism and Brain
Kleinridders, A., Ferris, H. A., Cai, W., & Kahn, C. R. (2014)
Self-citation
Fatores moleculares envolvidos nas alterações metabólicas durante a gestação: papel do SOCS3.
Zampieri, T. T. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-07122015-181252
Physiological Regulation of Short-term Food Intake in Children During Puberty
Patel, B. P. (2014) · TSpace (University of Toronto)
Nutritional regulation of central fat mass and obesity-associated (FTO) expression, and its association with the central melanocortin signaling in the regulation of energy homeostasis
Poritsanos, N. J. (2010) · Mspace (University of Manitoba)
ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
Penque, B. A. (2013)
Control of Appetite/Satiety and Energy Balance
Elmquist, J. K., & Horton, J. D. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch28
Acute Glucose Response Properties Beyond Feeding
Burnett, C. J., & Krashes, M. J. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.001
Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression
Jois, T., & Sleeman, M. W. (2016) · Wiley eBooks · doi:10.1002/9781118839317.ch7
Obesity and Appetite: Central Control Mechanisms
Horváth, T. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00085-7
Central Nervous System (CNS) Nutrient Sensing in Diabetes
Chari, M. (2010) · TSpace (University of Toronto)
Central Nervous System Nutrient-sensing and the Regulation of Energy and Glucose Homeostasis
Lam, K. L. C. (2010) · TSpace (University of Toronto)
The Role of AMP-activated Protein Kinase in Alleviating Insulin Resistance in Hypothalamic Neurons
Menchella, J. A. (2014) · TSpace (University of Toronto)
Neuroendocrine Control of Hepatic Gluconeogenesis
Mao, Z., & Zhang, W. (2017) · InTech eBooks · doi:10.5772/67535
Proteína CLK2 (Cdc-2-like kinase 2) no hipotálamo é importante para a manutenção da homeostase energética
Quaresma, P. G. F. (2017) · doi:10.47749/t/unicamp.2017.989403
CNS hormonal and nutritional regulation of glucose and energy homeostasis
Abraham, M. A. (2017) · TSpace (University of Toronto)
Role of ceacam1 and shp1 in the regulation of insulin sensitivity and hepatic glucose and lipid metabolism
Xu, E. (2012) · Corpus Université Laval (Université Laval)
The Link Between Diabetes, Glucose Control, and Alzheimer's Disease and Neurodegenerative Diseases
Verdile, G., Fraser, P. E., & Martins, R. N. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch4
Structure-function relationship of human melanocortin-4 receptor and characterization of fish neural melanocortin receptors
Yang, L. (2019)
Insulin action in the brain and how this may cause/exacerbate obesity or diabetes
Dalvi, P. S. (2012) · Health Science Inquiry · doi:10.29173/hsi73
Glucose Production and Glucose Disposal Integrated by an Intrinsic Inverse Coupling in Vivo: hypothesis of inter-organ reflex on glucose regulationPreprint
Liu, N., Zou, W., Xing, Y., Zhang, X., Song, B., & Wang, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.009035
La synthèse des céramides C18:0 par les muscles squelettiques, à l’origine de l’insulino-résistance induite par l’obésité ?
Pineau, A.-M., Vessely, R., & Stunff, H. L. (2021) · médecine/sciences · doi:10.1051/medsci/2020264
Effects of Nutrition on Pubertal Timing at the Neuroendocrine and Cellular Levels
Rodríguez-Vázquez, E., Castellano, J. M., & Tena‐Sempere, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00008-9
Fatty Acid Sensing in the Dorsal Vagal Complex and Regulation of Triglyceride-rich very Low-density Lipoprotein Secretion
Wang, B. (2016) · TSpace (University of Toronto)
Associação de variantes em MC3R, MC4R, IRS1 e IRS2 com obesidade e marcadores metabólicos, inflamatórios e adipocinas
Fajardo, C. M. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2020.tde-25062021-154412
Neuroinflammation and insulin resistance underly cognitive impairment. Sex differences and potential treatments
Sánchez‐Sarasúa, S. (2021) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) · doi:10.6035/14112.2021.368012
Precedencia Difusa y Generación de Itinerarios Docentes en Sistemas LCMS
Serrano, J. D. A., Díez, J. R. F. D. C., Sotos, L. A. G., & Martínez-Herráiz, J.-J. (2007)
Identification of a discrete neuronal circuit that relays insulin signaling into the brain to regulate glucose homeostasisPreprint
Mehdi, M. E., Takhlidjt, S., Devère, M., Arabo, A., Solliec, M.-A. L., Maucotel, J., Bénani, A., Nédélec, E., Duparc, C., Lefranc, B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.13.460055
Faculty Opinions recommendation of MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.
Elmquist, J. K., & Williams, K. W. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1836978.1378083
Faculty Opinions recommendation of Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.
Rosenzweig, S. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735100370.793572329
The Role of Brain in Glucose Metabolism
Obici, S., & Martins, P. J. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_6-1
The Role of Brain in Glucose Metabolism
Obici, S., & Martins, P. J. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-18741-9_6
Faculty Opinions recommendation of Genetic identification of leptin neural circuits in energy and glucose homeostases.
Horváth, T. L. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733068728.793549316
Where Do We Go From Here?
Watve, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4409-1_15
Faculty Opinions recommendation of Regulation of substrate utilization and adiposity by Agrp neurons.
Münzberg, H. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734885420.793574563
Faculty Opinions recommendation of Genetic identification of leptin neural circuits in energy and glucose homeostases.
Münzberg, H. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733068728.793574560
Obesity Pathogenesis
Vettor, R., & Conci, S. (2017) · Endocrinology · doi:10.1007/978-3-319-47685-8_14-1
Faculty Opinions recommendation of PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.
Elmquist, J. K., & Williams, K. W. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2319957.5580054
The Potential of Intranasal Insulin in the Management of Metabolic Disorders
Hallschmid, M., & Schultes, B. (2008) · US Endocrinology · doi:10.17925/use.2008.04.2.40
Faculty Opinions recommendation of NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.
Münzberg, H. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737248885.793574566
Obesity Pathogenesis
Vettor, R., & Conci, S. (2019) · Endocrinology · doi:10.1007/978-3-319-46933-1_14
Faculty Opinions recommendation of Hypothalamic dopamine signaling regulates brown fat thermogenesis.
Horváth, T. L., & Miletta, M. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736481047.793567170
Ingestão aguda de lipídeos e alteração da perfusão cerebral de pacientes obesos
de Lima, C. M. M. (2015) · doi:10.11606/t.17.2015.tde-11052022-153438
La alteración hipotalámica en la obesidad
Guerrero, H. T., Carreto, R. J. R., Rodríguez-Cortés, Y. M., & Chavarría, A. (2023) · Medicina e Investigación Universidad Autónoma del Estado de México · doi:10.36677/medicinainvestigacion.v11i1.19791
TUBEROMAMMILLARY NUCLEUS HISTAMINERGIC NEURONS UNDERLIE SUSCEPTIBILITY AND RESILIENCE TO PSYCHOSOCIAL STRESS
Costa, A., Provensi, G., & Passani, M. B. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.08.1259
Intranasal Insulin and Gangliosides Correct Cognitive Impairments and Signaling Pathways in the Hippocampus of Rats with Type 2 Diabetes Mellitus
Zakharova, I. O., Bayunova, L. V., Derkach, K. V., Shpakov, A. O., & Avrova, N. F. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093023060042
CORRECTION OF COGNITIVE IMPAIRMENTS AND SIGNALING PATHWAYS IN THE HIPPOCAMPUS OF RATS WITH TYPE 2 DIABETES MELLITUS USING INTRANASALLY ADMINISTERED INSULIN AND GANGLIOSIDES
Zakharova, I. O., Bayunova, L. V., Derkach, K. V., Shpakov, A. O., & Avrova, N. F. (2023) · Журнал эволюционной биохимии и физиологии · doi:10.31857/s0044452923060104
The Effects of Insulin on Spike Activity of the Suprachiasmatic Nucleus Neurones and Functional State of Afferent Inputs from the Arcuate Nucleus in Rats
Inyushkin, A. N., Mistryugov, K. A., Ledyaeva, O. V., Romanova, I. D., Isakova, T. S., & Inyushkin, A. A. (2023) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s086981392302005x
Insulin Signaling in Neurons of the Tuberal Area of the Hypothalamus of Rats During Aging
Anfimova, P. A., Порсева, В. В., Pankrasheva, L. G., Shirina, E. S., & Masliukov, P. M. (2024) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813924040041
Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticityPreprint
Thomas, W. R., Richter, T. A., O’Neil, E. T., Baldoni, C., Corthals, A., von Elverfeldt, D., Nieland, J. D., Dechmann, D. K. N., Hunter, R. G., & Dávalos, L. M. (2025) · eLife · doi:10.7554/elife.100788.2
Hypothalamic astrocytes and metabolism homeostasis
Zhang, Y., & Hu, C. (2025) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0706
The Hypothalamus-Pituitary in Males in Health and Disease
Winters, S. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_7
Reduced melanocortin tone mediates increased feeding during pregnancy in micePreprint
Possa‐Paranhos, I. C., Catalbas, K., Congdon, S., Pattnaik, T., Nelson, C., Cho, D., & Sweeney, P. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.22.671837
Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female micePreprint
Brothers, T., Wei, W., Korgan, A. C., Bridges, Z., & O’Connell, K. M. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.20.689576
Additional file 6 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577734
Additional file 1 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577719
Additional file 5 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577731
Additional file 7 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577737
Additional file 3 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577725
Additional file 2 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577722
Additional file 4 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt, S., Mera, P., González‐García, I., Ibeas, K., Romero, M. D. M., Obri, A., Martin, B., Esteve‐Codina, A., Soler‐Vázquez, M. C., Bastías-Pérez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26577728
Targeting brain insulin signaling to combat metabolic disorders
Metz, M., & Fenselau, H. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.002
ATP-sensitive potassium channels in neurons: Roles in and beyond metabolic control
Leão, R. M., Migliaccio, M. M., de Siqueira, D. F., & Barbosa, P. S. Z. (2026) · Current topics in membranes · doi:10.1016/bs.ctm.2026.01.001
Cross-talk between insulin and serotonin signaling in the brain : Involvement of the PI3K/Akt pathway and behavioral consequences in models of insulin resistance
Papazoglou, I. (2013) · theses.fr (ABES) · doi:10.70675/06d278b5zf0a0z456dz9c4cz9dc680b45fd3 · Cited by 1
Caractérisation des effets centraux de la metformine sur des modèles murins sains ou obèses et diabétiques
Rouquet, T. (2015) · theses.fr (ABES) · doi:10.70675/680971a6z149ez4296z9c76z5ee9dfd53ce5
Mécanismes moléculaires régulant l'action du glucagon-like peptide one dans la physiopathologie du diabète de type 2
Grasset, E. (2016) · theses.fr (ABES) · doi:10.70675/e5821324ze30ez4b18z84d4zb8a6264141d3
Exploration de la plasticité neuronale et gliale dans le système à mélanocortine à l'échelle des repas dans un modèle murin.
Nuzzaci, D. (2017) · theses.fr (ABES) · doi:10.70675/6118a764z9b87z4152z8a92zf068439a60e0
Analyse du rôle du système PTH/PTHrp dans la régulation de la balance énergétique et des fonctions cognitives contrôlées par le système nerveux central
Rousseaud, A. (2018) · theses.fr (ABES) · doi:10.70675/646b4e48z73b6z4801z94d3z20d15d31ffe7
Rôle de la voie de signalisation Sonic Hedgehog dans les cellules Glast positives du cerveau de souris adulte
Tirou, L. (2020) · theses.fr (ABES) · doi:10.70675/5a9de569zf953z4f2cz9ccaz89ba17ab8490
Le rôle respectif des différents populations de neurones épineux moyens du noyau accumbens dans la motivation et la prise alimentaire
Walle, R. (2021) · theses.fr (ABES) · doi:10.70675/4121b221z3107z40a2za0dfz06b8fde8c4b0
Résistance à l’Insuline du Système Sérotoninergique : Implication dans les Troubles de l’Humeur Comorbides au Diabete De Type 2
Martin, H. (2021) · theses.fr (ABES) · doi:10.70675/63526938z3197z4632za668z0b62aa1e8cb8
Signalisation de l'insuline au sein du système sérotoninergique central : nexus de la comorbidité diabète-dépression
Bullich, S. (2021) · theses.fr (ABES) · doi:10.70675/d63a5130zf11dz4a56z9c65za3e7d3844c7d
Role of PTH and PTHrP in the central regulation of energy metabolism
Galerne, M. (2024) · theses.fr (ABES) · doi:10.70675/31092b82za087z48dczb698z1409347feb21
Découverte et caractérisation de nouveaux réseaux neuronaux peptidergiques gouvernant l'homéostasie énergétique et glucidique.
Devère, M. (2024) · theses.fr (ABES) · doi:10.70675/62dbac23ze16fz4a68z87a6zc72ab10e8d27
From brain bioenergetics to hypothalamic glucoregulation: A shared-systems hypothesis for intrinsic dysglycemia in schizophrenia
Hamel, L., Pereira, S. X. E. R. L., Yang, Z., Garrido, A. N., Agarwal, S. M., Lam, T. K. T., & Hahn, M. K. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10034-9 · Cited by 1
Mitochondrial Signaling and Stress Responses, Key Regulators of Aging and Longevity
SHENG, Y., Markovich, Z., Han, S. M., & Xiao, R. (2026) · BioEssays · doi:10.1002/bies.70146
17α-Estradiol: A mildly feminizing estrogen with sex-specific metabolic and lifespan benefits
Santín-Márquez, R., Fornalik, M., Janovic, S. R., Isola, J. V. V., Biswas, S., Sathiaseelan, R., Cox, J. E. J., Ocañas, S. R., & Stout, M. B. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103182
Hypothalamic Regulation of the Gonadal Axis and Roles of Leptin and Insulin in It
Zorina, I. I., Derkach, K. V., & Shpakov, A. O. (2026) · Biochemistry (Moscow) · doi:10.1134/s0006297926600353
Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus
Kaga, H., Ogawa, A., Osada, T., Kiya, M., Oka, S., Adachi, Y., Yu, M., Sakamoto, S., Kakehi, S., Kogai, T., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.198707
Neural Melanocortin Receptors in Fish: Insights into Growth Regulation and Aquaculture Advancement
Ji, R., & Tao, Y. (2026) · Biomolecules · doi:10.3390/biom16060839
A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to moodPreprint
Cherix, A., Godlewska, B. R., Lazari, A., Zhao, S., Dugan, G., Tachrount, M., Greco, M., Smart, S., Clarke, W. T., Bannerman, D. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.17.732833
Astrocytes in systemic regulation of blood glucose and the development of type 2 diabetes
Wen, Z., Bai, P., Du, L., Zhao, Q., Yang, M., Shan, J., Hu, X., Min, J., Qiu, K., Liao, Y., et al. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1850636
Brain-body crosstalk in T2DM: An integrative framework from central sensing to peripheral feedback
Zhang, Y., Zhang, X., Fang, X., Zhao, X., Xiao, C., Fan, M., Zhang, Y., & Liu, Z. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106975
Molecular signaling networks that connect tissue dysfunction to systemic insulin resistance
Mir, R., Algehainy, N. A., Jalal, M. M., Altayar, M. A., Almotairi, R., Tayeb, F. J., Bedaiwi, R. I., Altemani, F. H., Almasoudi, K. S., Albalawi, I. A., et al. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1952238
Central Responses to SGLT2 Inhibition: Distinguishing Direct CNS Pharmacology from the Brain–Kidney–Metabolism Axis
Kim, D. H., Lee, M. J., Lee, S. H., Kim, J. Y., Bae, J. H., Khang, A. R., Kang, Y. H., & Yi, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219514

Authors: Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., Kahn, C. R., Cowley, M. A., Ashcroft, F. M., & Brüning, J. C.
Affiliations: University of Cologne (DE)
University of Oxford (GB)
Oregon National Primate Research Center (US)
Stanford Medicine (US)
Joslin Diabetes Center (US)
Corresponding author: Brüning, Jens C.
ORCID: Janoschek, Ruth
Jordan, Sabine D.
Ma, Xiaosong
Xu, Chun
Enriori, Pablo
Barsh, Gregory S.
Kahn, C. Ronald
Cowley, Michael A.
Ashcroft, Frances M.
Brüning, Jens C.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2007-06
Volume: 5
Issue: 6
Pages: 438-449
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2007.05.004
OpenAlex: W2072556905
Cited by: 695
References: 34
Citations by year: 2026: 17 · 2025: 22 · 2024: 38 · 2023: 31 · 2022: 21 · 2021: 58 · 2020: 42 · 2019: 37 · 2018: 44 · 2017: 52 · 2016: 45 · 2015: 38 · 2014: 46 · 2013: 36 · 2012: 33
FWCI: 13.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2274 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-6-2202)
National Center for Research Resources (RR-0163)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: insulin action, insulin receptor, agouti-related protein, proopiomelanocortin, arcuate nucleus, hypothalamic neurons, hepatic glucose production, energy homeostasis, dietary intake, body weight, interleukin-6, glucose-6-phosphatase, insulin resistance, type 2 diabetes, hyperinsulinemic-euglycemic clamp
MeSH terms: Animals, Body Weight, Electrophysiology, Female, Glucose, Glucose Tolerance Test, Glucose-6-Phosphatase, Homeostasis, Hyperinsulinism, Hypothalamus, Immunoenzyme Techniques, Insulin, Liver, Male, Mice, Inbred C57BL, Neurons, Pro-Opiomelanocortin, Receptor, Insulin, Blotting, Western, Interleukin-6, Phosphatidylinositol Phosphates, Mice, Knockout, Integrases, Phosphatidylinositol 3-Kinases, Mice, Agouti-Related Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks