Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173

Energy on demand.

Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800

Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation

Patel, S., MacAulay, K., & Woodgett, J. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015845 · Cited by 43

Insulin action in the hypothalamus and dorsal vagal complex

Abraham, M. A., Filippi, B., Kang, G. M., Kim, M., & Lam, T. K. T. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079962 · Cited by 44

Glucagon action in the brain

Abraham, M. A., & Lam, T. K. T. (2016) · Diabetologia · doi:10.1007/s00125-016-3950-3 · Cited by 44

Melanocortin neurons: Multiple routes to regulation of metabolism

Shen, W.-J., Yao, T. S., Kong, X., Williams, K. W., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.007 · Cited by 45

Integration of Circadian and Metabolic Control of Reproductive Function

Evans, M. C., & Anderson, G. M. (2018) · Endocrinology · doi:10.1210/en.2018-00691 · Cited by 41

Where Does Insulin Resistance Start?

Pagotto, U. (2009) · Diabetes Care · doi:10.2337/dc09-s305 · Cited by 45

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Cai, W., Zhang, X., Batista, T. M., García-Martín, R., Softic, S., Wang, G., Ramirez, A. K., Konishi, M., O'Neill, B. T., Kim, J. H., et al. (2021) · Diabetes · doi:10.2337/db20-1119 · Cited by 40

CNS Control of Glucose Metabolism: Response to Environmental Challenges

Arble, D. M., & Sandoval, D. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00020 · Cited by 44

IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise

Fritsche, L., Hoene, M., Lehmann, R., Ellingsgaard, H., Hennige, A. M., Pohl, A. K., Häring, H., Schleicher, E. D., & Weigert, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1754-4 · Cited by 41

Melanocortin-3 Receptors and Metabolic Homeostasis

Begriche, K., Clemence, G., McDonald, P. H., & Butler, A. A. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00004-2 · Cited by 42

Astrocytes in neuroendocrine systems: An overview

MacDonald, A. J., Robb, J. L., Morrissey, N. A., Beall, C., & Ellacott, K. L. J. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12726 · Cited by 41

Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes

Sargsyan, A., & Herman, M. A. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1195-5 · Cited by 42

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact

Kowalchuk, C., Teo, C., Wilson, V. S., Chintoh, A. F., Lam, L., Agarwal, S. M., Giacca, A., Remington, G. J., & Hahn, M. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170092 · Cited by 40

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Timper, K., Paeger, L., Sánchez-Lasheras, C., Varela, L., Jaïs, A., Nolte, H., Vogt, M. C., Hausen, A. C., Heilinger, C., Evers, N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.034 · Cited by 41

Arcuate nucleus, median eminence, and hypophysial pars tuberalis

Korf, H., & Møller, M. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00015-x · Cited by 39

A novel neuropeptide Y neuronal pathway linking energy state and reproductive behavior

Muroi, Y., & Ishii, T. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.09.002 · Cited by 41

Mutations in Melanocortin-3 Receptor Gene and Human Obesity

Yang, Z., & Tao, Y. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.01.002 · Cited by 40

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Ramírez, S., Haddad-Tóvolli, R., Radosevic, M., Toledo, M., Pané, A., Alcolea, D. A., Ribas, V., Milà‐Guasch, M., Pozo, M., Obri, A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.023 · Cited by 42

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism

Rother, E., Könner, A. C., & Brüning, J. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00685.2007 · Cited by 38

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Landry, T., Li, P.-X., Shookster, D., Jiang, Z., Li, H., Laing, B. T., Bunner, W. P., Langton, T., Tong, Q., & Hu, H. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101136 · Cited by 37

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Dodd, G. T., Kim, S. J., Méquinion, M., Xirouchaki, C. E., Brüning, J. C., Andrews, Z. B., & Tiganis, T. (2021) · Science Advances · doi:10.1126/sciadv.abf4100 · Cited by 39

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity

Page‐Wilson, G., Meece, K., White, A. E., Rosenbaum, M. S., Leibel, R. L., Smiley, R. M., & Wardlaw, S. L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2015 · Cited by 36

Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice

Dinger, K., Kasper, P., Hucklenbruch‐Rother, E., Vohlen, C., Jobst, E., Janoschek, R., Bae‐Gartz, I., Koningsbruggen-Rietschel, S. V., Plank, C., Dötsch, J., et al. (2016) · Scientific Reports · doi:10.1038/srep24168 · Cited by 35

Novel roles for JNK1 in metabolism

Belgardt, B., Mauer, J., & Brüning, J. C. (2010) · Aging · doi:10.18632/aging.100192 · Cited by 36

Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver

Henschke, S., Nolte, H., Magoley, J., Kleele, T., Brandt, C., Hausen, A. C., Wunderlich, C. M., Bauder, C. A., Aschauer, P., Manley, S., et al. (2024) · Science · doi:10.1126/science.adk1005 · Cited by 37

An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics

Mathéus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., Lambert, V., Noël, A., Frédérich, M., Mottet, D., & Tullio, P. D. (2014) · Phytochemical Analysis · doi:10.1002/pca.2498 · Cited by 36

Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders

Quan, Y., Barszczyk, A., Feng, Z., & Sun, H. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.57 · Cited by 35

Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons

Huang, Y., He, Z., Gao, Y., Lieu, L., Yao, T. S., Sun, J. M., Liu, T., Javadi, C. S., Box, M., Afrin, S., et al. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00061 · Cited by 35

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism

He, Y., Shu, G., Yang, Y., Xu, P., Xia, Y., Wang, C., Saito, K., Hinton, A., Yan, X., Liu, C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.044 · Cited by 34

Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism

Lee, M., Matsunaga, H., Sugiura, Y., Hayasaka, T., Yamamoto, I., Ishimoto, T., Imoto, D., Suematsu, M., Iijima, N., Kimura, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22431-6 · Cited by 33

Hypothalamic sensing of circulating lactate regulates glucose production

Kokorovic, A., Cheung, G. W. C., Rossetti, L., & Lam, T. K. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00596.x · Cited by 36

Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons

Xu, Y. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00098 · Cited by 36

Hypothalamic serotonin–insulin signaling cross-talk and alterations in a type 2 diabetic model

Papazoglou, I., Berthou, F., Vicaire, N., Rouch, C., Markaki, E. M., Bailbé, D., Portha, B., Taouis, M., & Gerozissis, K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.007 · Cited by 33

AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting

Gupta, R., Ma, Y., Wang, M., & Whim, M. D. (2017) · Endocrinology · doi:10.1210/en.2016-1268 · Cited by 33

Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring

Bae‐Gartz, I., Janoschek, R., Breuer, S., Schmitz, L., Hoffmann, T., Ferrari, N., Branik, L., Oberthuer, A., Kloppe, C.-S., Appel, S., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00962 · Cited by 34

Effects of metabolic state on the regulation of melanocortin circuits

Lieu, L., Chau, D., Afrin, S., Dong, Y., Alhadeff, A. L., Betley, J. N., & Williams, K. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113039 · Cited by 35

Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit

Liu, T., Wang, Q., Berglund, E. D., & Tong, Q. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00200 · Cited by 34

KATP-Channel-Dependent Regulation of Catecholaminergic Neurons Controls BAT Sympathetic Nerve Activity and Energy Homeostasis

Tovar, S. A., Paeger, L., Heß, S., Morgan, D. A., Hausen, A. C., Brönneke, H. S., Hampel, B., Ackermann, P., Evers, N., Büning, H., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.006 · Cited by 32

Optogenetic and chemogenetic insights into the food addiction hypothesis

Krashes, M. J., & Kravitz, A. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00057 · Cited by 34

How mice are indispensable for understanding obesity and diabetes genetics

Attie, A., Churchill, G. A., & Nadeau, J. H. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000321 · Cited by 33

Acyl Ghrelin Acts in the Brain to Control Liver Function and Peripheral Glucose Homeostasis in Male Mice

Stark, R., Reichenbach, A., Lockie, S. H., Pracht, C., Wu, Q., Tups, A., & Andrews, Z. B. (2014) · Endocrinology · doi:10.1210/en.2014-1733 · Cited by 33

Peripheral and central regulation of insulin by the intestine and microbiome

Schertzer, J. D., & Lam, T. K. T. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00547.2020 · Cited by 31

Hypothalamic microinflammation

Cai, D., & Khor, S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00023-3 · Cited by 33

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

Selle, J., Dinger, K., Jentgen, V., Zanetti, D., Will, J., Georgomanolis, T., Vohlen, C., Wilke, R., Kojonazarov, B. K., Klymenko, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31655-z · Cited by 33

Long-Term Intracerebroventricular Infusion of Insulin, but Not Glucose, Modulates Body Weight and Hepatic Insulin Sensitivity by Modifying the Hypothalamic Insulin Signaling Pathway in Type 2 Diabetic Rats

Park, S., Hong, S. M., & Ahn, I. S. (2009) · Neuroendocrinology · doi:10.1159/000197974 · Cited by 31

Reduced Melanocortin Production Causes Sexual Dysfunction in Male Mice With POMC Neuronal Insulin and Leptin Insensitivity

Faulkner, L. D., Dowling, A. R., Stuart, R. C., Nillni, E. A., & Hill, J. W. (2015) · Endocrinology · doi:10.1210/en.2014-1788 · Cited by 31

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet

Shibata, M., Banno, R., Sugiyama, M., Tominaga, T., Onoue, T., Tsunekawa, T., Azuma, Y., Hagiwara, D., Lu, W., Ito, Y., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1430 · Cited by 31

Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus

Lee, J., Kim, K., Yu, S.-W., & Kim, E. K. (2016) · Molecular Brain · doi:10.1186/s13041-016-0207-5 · Cited by 31

Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance

Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31

Hypothalamic Lipids and the Regulation of Energy Homeostasis

Carlos Diégueza, B., Gema Frühbeckb, C., & peza, B. M. L. O. (2009) · Obesity Facts · doi:10.1159/000209251 · Cited by 33

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Zhou, M., Xu, X., Wang, H., Yang, G., Yang, M., Zhao, X., Guo, H., Song, J., Zheng, H., Zhu, Z., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901836rr · Cited by 33

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons

Hashiguchi, H., Sheng, Z., Routh, V. H., Gerzanich, V., Simard, J. M., & Bryan, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184261 · Cited by 29

Targeting AgRP neurons to maintain energy balance: Lessons from animal models

Zagmutt, S., Mera, P., Soler‐Vázquez, M. C., Herrero, L., & Serra, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.008 · Cited by 30

Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion

Li, Y., Tian, M., Yang, M., Yang, G., Chen, J., Wang, H., Liu, D., Wang, H., Deng, W., Zhu, Z., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154029 · Cited by 29

Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism

Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30

Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration

Mehan, S., Bhalla, S., Siddiqui, E. M., Sharma, N., Shandilya, A., & Khan, A. (2022) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s247153 · Cited by 29

Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

de Moraes, D. A., Venâncio, D. P., & Suchecki, D. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.015 · Cited by 29

Dietary intervention in obese dams protects male offspring from WAT induction of TRPV4, adiposity, and hyperinsulinemia

Janoschek, R., Bae‐Gartz, I., Vohlen, C., Alcazar, M. A. A., Dinger, K., Appel, S., Dötsch, J., & Hucklenbruch‐Rother, E. (2016) · Obesity · doi:10.1002/oby.21486 · Cited by 29

Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti‐related peptide neurons of the adult ewe

Cernea, M., Phillips, R., Padmanabhan, V., Coolen, L. M., & Lehman, M. N. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13373 · Cited by 28

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation

Augustine, V., Gökçe, S. K., & Oka, Y. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.003 · Cited by 32

AgRP neuronal activity across feeding‐related behaviours

Gouveia, A., Beleza, R. O., & Steculorum, S. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15498 · Cited by 28

Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis

Stark, R., Reichenbach, A., & Andrews, Z. B. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.002 · Cited by 28

Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice.

Evans, M. C., Rizwan, M. Z., & Anderson, G. (2014) · Endocrinology · doi:10.1210/en.2014-1412 · Cited by 28

Running Exercise in Obese Pregnancies Prevents IL-6 Trans-signaling in Male Offspring

Bae‐Gartz, I., Janoschek, R., Kloppe, C.-S., Vohlen, C., Roels, F., Oberthür, A., Alcazar, M. A. A., Lippach, G., Muether, P. S., Dinger, K., et al. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000835 · Cited by 28

Chronic G q signaling in AgRP neurons does not cause obesity

Ewbank, S. N., Campos, C., Chen, J., Bowen, A. J., Padilla, S. L., Dempsey, J. L., Cui, J. Y., & Palmiter, R. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004941117 · Cited by 28

The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system

Pan, S., Worker, C. J., & Feng, Y. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00533.2022 · Cited by 31

The acromegaly lipodystrophy

Freda, P. U. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.933039 · Cited by 28

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

Horwath, J. A., Hurr, C., Butler, S. D., Guruju, M. R., Cassell, M. D., Mark, A. L., Davisson, R. L., & Young, C. N. (2017) · JCI Insight · doi:10.1172/jci.insight.90170 · Cited by 28

Short-Chain Fatty Acid Production and Functional Aspects on Host Metabolism

Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00002-8 · Cited by 29

Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice

Landry, T., Laing, B. T., Li, P.-X., Bunner, W., Rao, Z., Prete, A., Sylvestri, J., & Hu, H. (2020) · Diabetes · doi:10.2337/db19-0941 · Cited by 26

Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

Beddows, C. A., & Dodd, G. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12947 · Cited by 27

Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions

Zhang, N., Yan, Z., Liu, H., Yu, M., He, Y., Liu, H., Chen, L., Tu, L., Wang, L., Yin, N., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.714104 · Cited by 27

β-Arrestins as Important Regulators of Glucose and Energy Homeostasis

Pydi, S. P., Barella, L. F., Zhu, L., Meister, J., Rossi, M., & Wess, J. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092948 · Cited by 25

Distinct Firing Activities of the Hypothalamic Arcuate Nucleus Neurons to Appetite Hormones

Na, J., Park, B. S., Jang, D., Kim, D., Tu, T. H., Ryu, Y., Ha, C. M., Koch, M., Yang, S., Kim, J. K., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052609 · Cited by 26

Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes

Geffken, S. J., Moon, S., Smith, C. O., Tang, S. S., Lee, H. H., Lewis, K., Wong, C. W., Huang, Y., Huang, Q., Zhao, Y.-T., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101647 · Cited by 27

cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice

Blake, C. B., & Smith, B. N. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00138.2014 · Cited by 27

Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice

Becskei, C., Lutz, T. A., & Riediger, T. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00674.2009 · Cited by 26

Does Long-Term High Fat Diet Always Lead to Smaller Hippocampi Volumes, Metabolite Concentrations, and Worse Learning and Memory? A Magnetic Resonance and Behavioral Study in Wistar Rats

Setkowicz, Z., Gaździńska, A., Osoba, J. J., Karwowska, K., Majka, P., Orzel, J., Kossowski, B., Bogorodzki, P., Janeczko, K. J., Wyleżoł, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139987 · Cited by 26

Vagal pathways for systemic regulation of glucose metabolism

Borgmann, D., & Fenselau, H. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.07.010 · Cited by 27

Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents

Admin, A., Carey, M., Lontchi‐Yimagou, E., Mitchell, W., Reda, S., Zhang, K., Kehlenbrink, S., Koppaka, S., Maginley, S. R., Aleksić, S., et al. (2020) · Diabetes · doi:10.2337/db19-1256 · Cited by 26

Role of insulin in the neuroendocrine control of reproduction

Evans, M. C., Hill, J. W., & Anderson, G. M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12930 · Cited by 24

Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior

Wu, C.-T., CHAFFIN, A. T. B., & Ryan, K. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030580 · Cited by 24

Sustained inhibition of NPY/AgRP neuronal activity by FGF1

Hwang, E., Scarlett, J. M., Baquero, A. F., Bennett, C. M., Dong, Y., Chau, D., Brown, J. M., Mercer, A. J., Meek, T. H., Grove, K. L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.160891 · Cited by 24

Hormonal Control of Metabolism by the Hypothalamus-Autonomic Nervous System-Liver Axis

Kalsbeek, A., Bruinstroop, E., Yi, C., Klieverik, L. P., Liu, J., & Fliers, E. (2014) · Frontiers of hormone research · doi:10.1159/000358312 · Cited by 25

Pyruvate induces torpor in obese mice

Soto, M., Orliaguet, L., Reyzer, M. L., Manier, M. L., Caprioli, R. M., & Kahn, C. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717507115 · Cited by 25

The (dys)regulation of energy storage in obesity

Levin, B. E., Geary, N., & Lutz, T. A. (2025) · Physiological Reviews · doi:10.1152/physrev.00002.2024 · Cited by 27

Serotonergic Regulation of Hepatic Energy Metabolism

Park, J., Jeong, W., Yun, C., Kim, H., & Oh, C. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1331 · Cited by 24

Diabetes, Insulin and Alzheimer's Disease

Craft, S., & Christen, Y. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0 · Cited by 24

Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K., & Kelly, M. J. (2019) · Neuroendocrinology · doi:10.1159/000501560 · Cited by 24

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation

Manaserh, I. H., Maly, E. F., Jahromi, M. S., Chikkamenahalli, L. L., Park, J. C., & Hill, J. W. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0052 · Cited by 23

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice

Coomans, C. P., Geerling, J. J., Guigas, B., van den Hoek, A. M., Parlevliet, E. T., Ouwens, D. M., Pijl, H., Voshol, P. J., Rensen, P. C. N., Havekes, L. M., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015396 · Cited by 26

The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism

Arrieta‐Cruz, I., & Juárez, R. G. (2016) · Advances in Nutrition · doi:10.3945/an.115.011171 · Cited by 25

Peripheral glucose homeostasis: does brain insulin matter?

Levin, B. E., & Sherwin, R. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59653 · Cited by 24

Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans

Page‐Wilson, G., Nguyen, K. T., Atalayer, D., Meece, K., Bainbridge, H. A., Körner, J., Gordon, R. J., Panigrahi, S. K., White, A. E., Smiley, R. M., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2016 · Cited by 22

Metabolic control of teleost reproduction by leptin and its complements: Understanding current insights from mammals

Parker, C. G., & Cheung, E. Y. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113467 · Cited by 21

Ablation of Growth Hormone Receptor in GABAergic Neurons Leads to Increased Pulsatile Growth Hormone Secretion

dos Santos, W. O., Wasinski, F., Tavares, M. R., Campos, A. M. P., Elias, C. F., List, E. O., Kopchick, J. J., Szawka, R. E., & Donato, J. (2022) · Endocrinology · doi:10.1210/endocr/bqac103 · Cited by 22

Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals

Yang, F., Zhao, S., Wang, P., & Xiang, W. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0079 · Cited by 22

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

Reilly, A. M., Zhou, S., Panigrahi, S. K., Yan, S., Conley, J. M., Sheets, P. L., Wardlaw, S. L., & Ren, H. (2019) · Nutrition and Diabetes · doi:10.1038/s41387-019-0096-7 · Cited by 22

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Ma, J., Hu, W., Zhang, D., Xie, J., Duan, C., Liu, Y., Wang, Y., Xu, X., Cheng, K., Jin, B., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03150-4 · Cited by 22

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Lorch, C. M., Hayes, N. W., Xia, J. L., Fleps, S. W., McMorrow, H. E., Province, H. S., Frydman, J. A., Parker, J. G., & Beutler, L. R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113675 · Cited by 20

ORIGINAL ARTICLE Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

Lin, H. V., Plum, L., Ono, H., Gutiérrez-juárez, R., Shanabrough, M., Borók, E., Horvath, T. L., Rossetti, L., & Accili, D. (2013)

Genetic Microdissection of Insulin Action on Neurocircuits in Control of Glucose and Energy Homeostasis

Könner, A. C. (2009) · Kölner Universitäts PublikationsServer (Universität zu Köln)

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 162

Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action

Shin, A. C., Filatova, N., Lindtner, C., Chi, T., Degann, S., Oberlin, D. J., & Buettner, C. (2017) · Diabetes · doi:10.2337/db16-1238 · Cited by 105

Regulation of glucose metabolism by central insulin action

Inoue, H. (2011) · Biomedical Reviews · doi:10.14748/bmr.v22.33 · Cited by 1