The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
Open accessAbstract
Insulin action in the central nervous system regulates energy homeostasis and glucose metabolism. To define the insulin-responsive neurons that mediate these effects, we generated mice with selective inactivation of the insulin receptor (IR) in either pro-opiomelanocortin (POMC)- or agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus. While neither POMC- nor AgRP-restricted IR knockout mice exhibited altered energy homeostasis, insulin failed to normally suppress hepatic glucose production during euglycemic-hyperinsulinemic clamps in AgRP-IR knockout (IR(DeltaAgRP)) mice. These mice also exhibited reduced insulin-stimulated hepatic interleukin-6 expression and increased hepatic expression of glucose-6-phosphatase. These results directly demonstrate that insulin action in POMC and AgRP cells is not required for steady-state regulation of food intake and body weight. However, insulin action specifically in AgRP-expressing neurons does play a critical role in controlling hepatic glucose production and may provide a target for the treatment of insulin resistance in type 2 diabetes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“insulin hyperpolarizes and silences both AgRP and POMC neurons (96) and activates PI3K signaling in both these neuronal populations (204).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [96]
In the citing paper
“implying a role for insulin action in AgRP expressing cells in the maintenance of normal liver insulin sensitivity (96).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [96]
Citations
Cites
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Self-citationRole of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Self-citationBrüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173
Self-citationMagistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
Agouti-related peptide–expressing neurons are mandatory for feeding
Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800
Self-citation
Cited by
Sorted by citations
Energy Metabolism in the Liver
Rui, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130024 · Cited by 2,401
The PI3K/AKT Pathway in Obesity and Type 2 Diabetes
Huang, X., Liu, G., Guo, J., & Su, Z. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27173 · Cited by 1,673
“Another way to regulate HGP is PI3K-stimulated generation of PIP3 in AgRP neurons, which activates K (ATP) channels, decreasing G6PC expression in the liver [91].”
BackgroundInfluentialInsulin signaling in osteoblasts integrates bone remodeling and energy metabolism
Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G. (2010) · Cell · doi:10.1016/j.cell.2010.06.003 · Cited by 1,123
IL-6 pathway in the liver: From physiopathology to therapy
Schmidt-Arras, D., & Rose-John, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.004 · Cited by 881
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Timper, K., & Brüning, J. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026609 · Cited by 851
Self-citationMauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727
Self-citationInsulin Action in Brain Regulates Systemic Metabolism and Brain Function
Kleinridders, A., Ferris, H. A., Cai, W., & Kahn, C. R. (2014) · Diabetes · doi:10.2337/db14-0568 · Cited by 625
Self-citationSanchez-Garrido, M. A., & Tena-Sempere, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.001 · Cited by 557
Jordan, S. D., Krüger, M., Willmes, D. M., Redemann, N., Wunderlich, F. T., Brönneke, H. S., Merkwirth, C., Kashkar, H., Olkkonen, V. M., Böttger, T., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2211 · Cited by 531
Self-citationVerdile, G., Keane, K. N., Cruzat, V. F., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R. N., Fraser, P. E., & Newsholme, P. (2015) · Mediators of Inflammation · doi:10.1155/2015/105828 · Cited by 509
Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483
Self-citationHypothalamic inflammation in obesity and metabolic disease
Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474
Self-citationThe cell biology of systemic insulin function
Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201802095 · Cited by 471
Unraveling the Regulation of Hepatic Metabolism by Insulin
Titchenell, P. M., Lazar, M. A., & Birnbaum, M. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.003 · Cited by 457
Hormonal regulation of hepatic glucose production in health and disease
Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429
Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 435
Versatile functions for IL-6 in metabolism and cancer
Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 415
Self-citationLeptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398
Self-citationHill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391
Self-citationBrain Regulation of Appetite and Satiety
Ahima, R. S., & Antwi, D. A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.08.005 · Cited by 412
Hypothalamic pathways linking energy balance and reproduction
Hill, J. W., Elmquist, J. K., & Elias, C. F. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00670.2007 · Cited by 367
Vogt, M. C., Paeger, L., Heß, S., Steculorum, S. M., Awazawa, M., Hampel, B., Neupert, S., Nicholls, H. T., Mauer, J., Hausen, A. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.008 · Cited by 374
Self-citationWilliams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., Elias, C. F., & Elmquist, J. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3118-09.2010 · Cited by 352
Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351
Regulation of Adipose Tissue Inflammation by Interleukin 6
Han, M. S., White, A., Perry, R. J., Camporez, J.-P., Hidalgo, J., Shulman, G. I., & Davis, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920004117 · Cited by 344
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338
“In contrast to leptin, however, insulin hyperpolarizes and silences both AgRP and POMC neurons (96) and activates PI3K signaling in both these neuronal populations (204).”
BackgroundResultInfluentialResolving the paradox of hepatic insulin resistance
Santoleri, D., & Titchenell, P. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.016 · Cited by 336
“rons results in a failure of insulin to inhibit HGP but had no impact on insulin’s effects on body weight.(79) In response to insulin, activation of potassium adenosine triphosphate channels in the hypothalamus signals through the vagus nerve to the liver, which inhibit hepatic gluconeogenesis.”
BackgroundToll-like receptors: linking inflammation to metabolism
Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 338
Self-citationHypothalamic nutrient sensing in the control of energy homeostasis
Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 343
Hypothalamic Survival Circuits: Blueprints for Purposive Behaviors
Sternson, S. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.018 · Cited by 313
Selective Insulin and Leptin Resistance in Metabolic Disorders
Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 320
Self-citationHypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.
Schneeberger, M., Gomis, R., & Claret, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0398 · Cited by 301
Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan, H.-B., Dietrich, M. O., Liu, Z.-W., Zimmer, M. R., Li, M.-D., Singh, J. P., Zhang, K., Yin, R., Wu, J., Horvath, T. L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.010 · Cited by 281
Genetic identification of leptin neural circuits in energy and glucose homeostases
Xu, J., Bartolome, C. L., Low, C., Yi, X., Chien, C.-H., Wang, P., & Kong, D. (2018) · Nature · doi:10.1038/s41586-018-0049-7 · Cited by 289
Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B. R., Chen, J., Rabinowitz, J. D., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.022 · Cited by 298
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298
Self-citationAgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue
Steculorum, S. M., Ruud, J., Karakasilioti, I., Backes, H., Engström, L., Timper, K., Hess, M. E., Tsaousidou, E., Mauer, J., Vogt, M. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.044 · Cited by 293
Self-citationCNS leptin and insulin action in the control of energy homeostasis
Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 287
Self-citationThe role of type 2 diabetes in neurodegeneration
Verdile, G., Fuller, S. J., & Martins, R. N. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.008 · Cited by 290
Neuronal circuits that regulate feeding behavior and metabolism
Sohn, J., Elmquist, J. K., & Williams, K. W. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.003 · Cited by 282
The melanocortin pathway and control of appetite-progress and therapeutic implications
Baldini, G., & Phelan, K. D. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0596 · Cited by 300
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 278
Self-citationWang, L., Li, J., & Di, L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21867 · Cited by 283
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
Yung, J. H. M., & Giacca, A. (2020) · Cells · doi:10.3390/cells9030706 · Cited by 284
The brain as an insulin-sensitive metabolic organ
Milstein, J. L., & Ferris, H. A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101234 · Cited by 274
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Ramkhelawon, B., Hennessy, E. J., Ménager, M. M., Ray, T. D., Sheedy, F. J., Hutchison, S. B., Wanschel, A. C. B. A., Oldebeken, S. R., Geoffrion, M., Spiro, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3467 · Cited by 280
Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity
Jaïs, A., Solas, M., Backes, H., Chaurasia, B., Kleinridders, A., Theurich, S., Mauer, J., Steculorum, S. M., Hampel, B., Goldau, J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.033 · Cited by 262
Self-citationOxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0232 · Cited by 254
Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
Wang, Q., Liu, C., Uchida, A., Chuang, J.-C., Walker, A. K., Liu, T., Osborne-Lawrence, S. L., Mason, B. L., Mosher, C. A., Berglund, E. D., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.001 · Cited by 253
Neuronal control of peripheral insulin sensitivity and glucose metabolism
Ruud, J., Steculorum, S. M., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms15259 · Cited by 245
Self-citationImpaired insulin action in the human brain: causes and metabolic consequences
Heni, M., Kullmann, S., Preissl, H., Fritsche, A., & Häring, H.-U. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.173 · Cited by 245
Hormone and glucose signalling in POMC and AgRP neurons
Belgardt, B., Okamura, T., & Brüning, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179192 · Cited by 257
Self-citationInsulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior
Soto, M., Cai, W., Konishi, M., & Kahn, C. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817391116 · Cited by 253
Self-citationHigh-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 247
Self-citationIL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling
Timper, K., Denson, J. L., Steculorum, S. M., Heilinger, C., Engström-Ruud, L., Wunderlich, C. M., Rose-John, S., Wunderlich, F. T., & Brüning, J. C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.043 · Cited by 233
Self-citationWunderlich, F. T., Ströhle, P., Könner, A. C., Gruber, S., Tovar, S., Brönneke, H. S., Juntti-Berggren, L., Li, L.-S., van Rooijen, N., Libert, C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.011 · Cited by 229
Self-citationQiu, J., Zhang, C., Borgquist, A., Nestor, C. C., Smith, A. W., Bosch, M. A., Ku, S., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.004 · Cited by 244
Insulin regulates astrocyte gliotransmission and modulates behavior
Cai, W., Xue, C., Sakaguchi, M., Konishi, M., Shirazian, A., Ferris, H. A., Li, M. E., Yu, R., Kleinridders, A., Pothos, E. N., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99366 · Cited by 229
Self-citationDe Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance
Pierce, A. A., & Xu, A. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2479-09.2010 · Cited by 224
Dietrich, M. O., Antunes, C., Geliang, G., Liu, Z.-W., Borók, E., Nie, Y., Xu, A. W., Souza, D. O., Gao, Q., Diano, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2234-10.2010 · Cited by 229
FGF19 action in the brain induces insulin-independent glucose lowering
Morton, G. J., Matsen, M. E., Bracy, D. P., Meek, T. H., Hồng, N. T., Stefanovski, D., Bergman, R. N., Wasserman, D. H., & Schwartz, M. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70710 · Cited by 218
Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
Diano, S., & Horváth, T. L. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.08.003 · Cited by 220
Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
Könner, A. C., Klöckener, T., & Brüning, J. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.027 · Cited by 230
Self-citationPTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214
Homeostasis Meets Motivation in the Battle to Control Food Intake
Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 227
Brain insulin signalling in metabolic homeostasis and disease
Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205
Insulin Regulates Brain Function, but How Does It Get There?
Gray, S. M., Meijer, R. I., & Barrett, E. J. (2014) · Diabetes · doi:10.2337/db14-0340 · Cited by 206
FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Ren, H., Orozco, I. J., Su, Y., Suyama, S., Juárez, R. G., Horváth, T. L., Wardlaw, S. L., Plum, L., Arancio, O., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.04.032 · Cited by 201
Self-citationBrain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis
Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.021 · Cited by 194
Self-citationPOMC neuronal heterogeneity in energy balance and beyond: an integrated view
Quarta, C., Claret, M., Zeltser, L. M., Williams, K. W., Yeo, G. S. H., Tschöp, M. H., Diano, S., Brüning, J. C., & Cota, D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00345-3 · Cited by 194
Self-citationThe Sense of Smell Impacts Metabolic Health and Obesity
Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., Ruud, L. E., Alber, J., Tharp, K., Anderson, C. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.015 · Cited by 191
Self-citationVogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 194
Self-citationCerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance
Turpin-Nolan, S. M., Hammerschmidt, P., Chen, W., Jaïs, A., Timper, K., Awazawa, M., Brodesser, S., & Brüning, J. C. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.031 · Cited by 194
Self-citationInflammatory cause of metabolic syndrome via brain stress and NF-κB
Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 192
Critical Role for Hypothalamic mTOR Activity in Energy Balance
Mori, H., Inoki, K., Münzberg, H., Opland, D. M., Faouzi, M., Villanueva, E. C., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.005 · Cited by 189
Hypothalamic-autonomic control of energy homeostasis
Seoane‐Collazo, P., Fernø, J., González, F., Diéguez, C., Leis, R., Nogueiras, R., & López, M. (2015) · Endocrine · doi:10.1007/s12020-015-0658-y · Cited by 189
Ernst, M. B., Wunderlich, C. M., Hess, S., Paehler, M., Mesaros, A., Koralov, S. B., Kleinridders, A., Husch, A., Münzberg, H., Hampel, B., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-08.2009 · Cited by 185
Self-citationAgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
Vohra, M. S., Benchoula, K., Serpell, C. J., & Wong, E. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174611 · Cited by 199
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling
Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 186
Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
de Morentin, P. B. M., Whittle, A. J., Fernø, J., Nogueiras, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2012) · Diabetes · doi:10.2337/db11-1079 · Cited by 185
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176
Divergent roles of growth factors in the GnRH regulation of puberty in mice
DiVall, S. A., Williams, T. R., Carver, S. E., Koch, L., Brüning, J. C., Kahn, C. R., Wondisford, F. E., Radovick, S., & Wolfe, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41069 · Cited by 176
Self-citationSweet talk in the brain: Glucosensing, neural networks, and hypoglycemic counterregulation
Watts, A. G., & Donovan, C. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.006 · Cited by 177
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 183
Insulin controls food intake and energy balance via NPY neurons
Loh, K., Zhang, L., Brandon, A. E., Wang, Q., Begg, D. P., Qi, Y., Fu, M., Kulkarni, R. N., Teo, J. D., Baldock, P. A. J., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.013 · Cited by 173
Self-citationTimper, K., del Río-Martín, A., Cremer, A. L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.001 · Cited by 170
Self-citationHepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
Titchenell, P. M., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Nature Communications · doi:10.1038/ncomms8078 · Cited by 169
McTaggart, J. S., Clark, R. H., & Ashcroft, F. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.191767 · Cited by 172
Self-citationKubota, T., Kubota, N., & Kadowaki, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.004 · Cited by 174
Belgardt, B., Mauer, J., Wunderlich, F. T., Ernst, M. B., Pál, M., Spohn, G., Brönneke, H. S., Brodesser, S., Hampel, B., Schauss, A. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001796107 · Cited by 171
Self-citationPOMC Neurons: From Birth to Death
Toda, C., Santoro, A. N., Kim, J. D., & Diano, S. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034110 · Cited by 175
Biglari, N., Gaziano, I., Schumacher, J., Radermacher, J., Paeger, L., Klemm, P., Chen, W., Corneliussen, S., Wunderlich, C. M., Sue, M. W., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00854-0 · Cited by 164
Self-citationGerman, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
Jordan, S. D., Könner, A. C., & Brüning, J. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0414-7 · Cited by 172
Self-citationMehrpouya‐Bahrami, P., Chitrala, K. N., Ganewatta, M. S., Tang, C., Murphy, E. A., Enos, R. T., Velázquez, K. T., McCellan, J., Nagarkatti, M., & Nagarkatti, P. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-15154-6 · Cited by 168
Manfredi-Lozano, M., Roa, J., & Tena-Sempere, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.008 · Cited by 162
Hypothalamic inflammation: a double‐edged sword to nutritional diseases
Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 162
Metadata
- Authors
- Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., Kahn, C. R., Cowley, M. A., Ashcroft, F. M., & Brüning, J. C.
- Affiliations
- University of Cologne (DE)
- University of Oxford (GB)
- Oregon National Primate Research Center (US)
- Stanford Medicine (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Brüning, Jens C.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 5
- Issue
- 6
- Pages
- 438-449
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2072556905
- Cited by
- 695
- References
- 34
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 38 · 2023: 31 · 2022: 21 · 2021: 58 · 2020: 42 · 2019: 37 · 2018: 44 · 2017: 52 · 2016: 45 · 2015: 38 · 2014: 46 · 2013: 36 · 2012: 33
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-6-2202)
- National Center for Research Resources (RR-0163)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin action, insulin receptor, agouti-related protein, proopiomelanocortin, arcuate nucleus, hypothalamic neurons, hepatic glucose production, energy homeostasis, dietary intake, body weight, interleukin-6, glucose-6-phosphatase, insulin resistance, type 2 diabetes, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Animals, Body Weight, Electrophysiology, Female, Glucose, Glucose Tolerance Test, Glucose-6-Phosphatase, Homeostasis, Hyperinsulinism, Hypothalamus, Immunoenzyme Techniques, Insulin, Liver, Male, Mice, Inbred C57BL, Neurons, Pro-Opiomelanocortin, Receptor, Insulin, Blotting, Western, Interleukin-6, Phosphatidylinositol Phosphates, Mice, Knockout, Integrases, Phosphatidylinositol 3-Kinases, Mice, Agouti-Related Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
