The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
Open accessAbstract
Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes, whereas nutritive calorie restriction increases life expectancy. We show here that increased glucose availability decreases Caenorhabditis elegans life span, while impaired glucose metabolism extends life expectancy by inducing mitochondrial respiration. The histone deacetylase Sir2.1 is found here to be dispensable for this phenotype, whereas disruption of aak-2, a homolog of AMP-dependent kinase (AMPK), abolishes extension of life span due to impaired glycolysis. Reduced glucose availability promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival rates, altogether providing direct evidence for a hitherto hypothetical concept named mitochondrial hormesis or "mitohormesis." Accordingly, treatment of nematodes with different antioxidants and vitamins prevents extension of life span. In summary, these data indicate that glucose restriction promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of type 2 diabetes as well as the widespread use of antioxidant supplements.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although the mechanisms behind calorie restriction-driven longevity extension are still poorly understood, mitochondrial physiology is involved in the beneficial effects of calorie restriction in budding yeast11 and Caenorhabditis elegans12, as well as in mammals13.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [12]
In the citing paper
“Treatment of worms with antioxidants abolished this life extension 97.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
In the citing paper
“Furthermore, in C. elegans, lifespan extension mediated by glucose restriction is associated with increased mitochondrial metabolism and ROS production.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
In the citing paper
“This theory can be applied to mitochondrial ROS 97”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,629
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Intake of sugar-sweetened beverages and weight gain: a systematic review
Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Cited by
Sorted by citations
Items 901–1,000 of 1,000
Akhoon, B. A., Gupta, S. K., Tiwari, S., Rathor, L., Pant, A., Singh, N., Gupta, S. K., Dandekar, T., & Pandey, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-51649-0 · Cited by 7
Sofela, S., Sahloul, S., Bhattacharjee, S., Bose, A., Usman, U., & Song, Y. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa011 · Cited by 7
Pant, A., Krishnakumar, K. C., Dileep, N. C., Yamana, M., Alamelu, N. M., Paithankar, K., Vijayalakshmi, A., & Subbarao, S. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.08.002 · Cited by 7
To die or not to die – How mitochondrial processes affect lifespan of Podospora anserina
Hamann, A., & Osiewacz, H. D. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148568 · Cited by 7
The Genetic Network of Life-Span Extension by Dietary Restriction
Greer, E. L., & Brunet, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00001-4 · Cited by 7
Brain Aging and Performance Plasticity in Honeybees
Münch, D., & Amdam, G. V. (2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00037-x · Cited by 7
Fischer, A., Klapper, M., Onur, S., Menke, T., Niklowitz, P., & Döring, F. (2015) · BioFactors · doi:10.1002/biof.1210 · Cited by 7
5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans
Ahmadi, M., & Roy, R. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_15 · Cited by 8
Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life Span
Yadav, D., Tripathi, Y. B., Singh, P., Kesharwani, R. K., & Keservani, R. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805413-0.00002-8 · Cited by 7
Kropp, P. A., Wu, J., Reidy, M. J., Shrestha, S., Rhodehouse, K., Rogers, P. J., Sack, M. N., & Golden, A. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009771 · Cited by 8
Handley, A., Wu, Q., Sherry, T., Cornell, R., & Pocock, R. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001655 · Cited by 7
Wang, Z.-H., Jiang, S., & Xu, W. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119414 · Cited by 6
The usefulness of Caenorhabditis elegans lifespan analysis in screening for functional foods
Yasuda, K. (2024) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbae178 · Cited by 6
Zhou, L., Bao, F., Zheng, J., Ding, Y., Xiao, J., Zhang, J., Qin, Y., Yang, L., Wu, Y., Meng, Q., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03069-y · Cited by 6
Hulme, S. E., & Whitesides, G. M. (2011) · Angewandte Chemie · doi:10.1002/ange.201005461 · Cited by 6
Pharmacologic Means of Extending Lifespan
Lamming, D. W. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-002 · Cited by 6
Ma, C., Huang, Z., Yu, X., Gao, D., Qi, B., Xiao, X., Zhai, X., & Wang, Q. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_313_18 · Cited by 6
AXIN-AMPK signaling: Implications for healthy aging
Mallick, A., & Gupta, B. P. (2021) · F1000Research · doi:10.12688/f1000research.74220.1 · Cited by 6
la Rosa, C. M. A.-D., Miard, S., Taubert, S., & Picard, F. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281887 · Cited by 6
Ageing and its relationship with psychoneuroimmunology
Singh, K., Choudhury, S. R., Ghosh, J., Koner, S., & Pal, R. (2023) · Journal of Comprehensive Health · doi:10.53553/jch.v11i02.004 · Cited by 6
Wetzker, R., & Rubio, I. (2011) · Dose-Response · doi:10.2203/dose-response.11-012.wetzker · Cited by 6
Boivin, A., Gaumer, S., & Sainsard‐Chanet, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.011 · Cited by 7
Maxwell, S., Harding, J., Brabin, C., Appleford, P. J., Brown, R., Delaney, C. A., Brown, G. K., & Woollard, A. C. S. (2013) · Longevity & Healthspan · doi:10.1186/2046-2395-2-9 · Cited by 6
Kadekar, P., Chaouni, R., Clark, E., Kazanets, A., & Roy, R. (2018) · BMC Genomics · doi:10.1186/s12864-018-4847-y · Cited by 6
Hormesis in Health and Disease: Molecular Mechanisms
Meiliana, A., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i4.1315 · Cited by 6
Targeting mitochondrial biogenesis: a potential approach for preventing and controlling diabetes
Singh, R., Mohapatra, L., & Tripathi, A. S. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00360-x · Cited by 7
Nutritional Regulation of Mitochondrial Function
Vasam, G., Reid, K., Burelle, Y., & Menzies, K. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00004-3 · Cited by 6
Hamon, M., Gergondey, R., L’honoré, A., & Friguet, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.039 · Cited by 6
Becker, F. R., & Rudolph, K. L. (2021) · Science · doi:10.1126/science.abf9566 · Cited by 6
In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brainPreprint
Ruetz, T. J., Kashiwagi, C. M., Morton, B., Yeo, R. W., Leeman, D. S., Morgens, D. W., Tsui, C. K., Li, A., Bassik, M. C., & Brunet, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.23.469762 · Cited by 9
An emerging role for cysteine-mediated redox signaling in aging
Jin, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103852 · Cited by 6
Physiological Effects of Oxidative Stress Caused by Saxitoxin in the Nematode Caenorhabditis elegans
Wu, H., Prithiviraj, B., & Tan, Z. (2023) · Marine Drugs · doi:10.3390/md21100544 · Cited by 5
Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
Delpino, M. V., & Quarleri, J. F. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1442323 · Cited by 5
Salminen, T. S., Vesala, L., Basikhina, Y., Kutzer, M. A. M., Tuomela, T., Lucas, R., Monteith, K. M., Prakash, A., Tietz, T., & Vale, P. F. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011476 · Cited by 8
Chromatin and epigenetics in aging biology
Greer, E. L., Lee, S. S., & Prahlad, V. (2025) · Genetics · doi:10.1093/genetics/iyaf055 · Cited by 5
A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans
Admasu, T. D., Barardo, D., Ng, L. F., Batchu, K. C., Cazenave‐Gassiot, A., Wenk, M. R., & Gruber, J. (2021) · GeroScience · doi:10.1007/s11357-021-00374-6 · Cited by 6
Amino Acid Availability Is Not Essential for Life-Span Extension by Dietary Restriction in the Fly
Gautrey, S. L., & Simons, M. J. P. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac100 · Cited by 5
Glucose stockpile in the intestinal apical brush border in C. elegans
Saito, T., Kikuchi, K., & Ishikawa, T. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149762 · Cited by 5
Zhou, Y., Zhang, M., Lu, S., Liu, L., Duan, Z., Wei, F., & Li, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.014 · Cited by 5
Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
Lim, Y. P., Go, M. K., Raida, M., Inoue, T., Wenk, M. R., Keasling, J. D., Chang, M. W., & Yew, W. S. (2018) · ACS Omega · doi:10.1021/acsomega.8b01620 · Cited by 5
Chrononutrition – ‘The Clock Makes Good Food’
Steinberg, C. E. W. (2018) · Springer eBooks · doi:10.1007/978-3-319-91767-2_5 · Cited by 5
Sugahara, M., Tanaka, T., Inagi, R., & Nangaku, M. (2017) · Springer eBooks · doi:10.1007/978-981-10-4376-5_1 · Cited by 5
Role of antioxidant compounds in promoting healthy ageing
Umaru, I. J., Amina, A. A., Umaru, K. I., David, B. C., & Haruna, D. E. (2019) · International Journal of Advanced Biochemistry Research · doi:10.33545/26174693.2019.v3.i2a.135 · Cited by 5
Go, J., Lee, K., Park, Y., & Yoon, S. S. (2014) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12196 · Cited by 5
Clinical & Experimental Pathology
Ren, R., Fedoriw, Y. D., & Willis, M. S. (2012) · Cited by 5
Nicotine affects protein complex rearrangement in Caenorhabditis elegans cells
Sobkowiak, R., Zieleziński, A., Karlowski, W. M., & Lesicki, A. (2017) · Drug and Chemical Toxicology · doi:10.1080/01480545.2016.1264411 · Cited by 5
Nutritional Ecology, Foraging Strategies and Food Selection
Costantini, D. (2014) · Springer eBooks · doi:10.1007/978-3-642-54663-1_4 · Cited by 5
Kim, S., Shin, E.-J., Hahm, J., Park, P.-J., Hwang, J., & Paik, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041755 · Cited by 5
Siswanto, F. M., Handayani, M. D. N., Firmasyah, R. D., Manalu, J. L., & Pramono, A. (2024) · Current Aging Science · doi:10.2174/0118746098292667240914024812 · Cited by 5
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
Viollet, B., & Guigas, B. (2024) · Cell Research · doi:10.1038/s41422-024-01040-0 · Cited by 4
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
Thériault, V., la Rosa, C. M. A. D., Miard, S., Taubert, S., & Picard, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-27444-5 · Cited by 4
Xiao-shuai, Z., Xiao-long, S., Shao-lei, G., & Zheng-hao, W. (2022) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(20)63578-x · Cited by 4
Thomas, R., Williams, M. M. A., Aldous, J. W. F., & Wyld, K. (2023) · Nutraceuticals · doi:10.3390/nutraceuticals3030027 · Cited by 4
Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity
Liontis, T., Senchuk, M. M., Zhu, S., Jacob‐Tomas, S., Anglas, U., Traa, A., Soo, S. K., & Raamsdonk, J. M. V. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.032 · Cited by 4
Bioinformatics in Aging Research: A Workshop Report
Fuellen, G., Adjaye, J., de Grey, A. D. N. J., Lepperdinger, G., de Magalhães, J. P., Sühnel, J., & Wipat, A. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1125 · Cited by 4
Mitochondrial Manipulation and the Quest for Alzheimer's Treatments
Swerdlow, R. H. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.03.017 · Cited by 4
Pinkas, A., & Aschner, M. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00264 · Cited by 4
Glycolytic Inhibitors as Caloric Restriction Mimetics (CRM)
Singh, A. L., Kumar, R., Arya, J. K., & Rizvi, S. I. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_4 · Cited by 4
Fu, W., Im, Y.-G., Kim, B., Kim, O., Yang, Y., Song, J., Liu, D., Zhu, S., Kang, J., & Kim, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119257 · Cited by 4
The role of nutrition and oxidative stress as aging factors in Caenorhabditis elegans
Yasuda, K., Miyazawa, M., Ishii, T., & Ishii, N. (2023) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.23-44 · Cited by 4
Healthy Aging in Times of Extreme Temperatures: Biomedical Approaches
Kowald, A., Palmer, D. H., Secci, R., & Fuellen, G. (2023) · Aging and Disease · doi:10.14336/ad.2023.0619 · Cited by 4
Shephard, A. M., Hund, A. K., & Snell‐Rood, E. C. (2023) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2023.1616 · Cited by 4
Chi, W., Fu, J., Martyniuk, C. J., Wang, J., & Zhou, L. (2022) · Journal of Molecular Evolution · doi:10.1007/s00239-023-10138-9 · Cited by 5
Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson’s disease
Ma, Q., Han, R., Wu, Z.-J., Zhou, J., Chen, M.-T., Zhang, X., Ma, W., & Feng, N. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1363212 · Cited by 4
Meeting Report: International Symposium on the Genetics of Aging and Life History II
Artan, M., Hwang, A. B., Lee, S., & Nam, H. G. (2015) · Aging · doi:10.18632/aging.100762 · Cited by 4
Pitt, J. N., Leiser, S. F., & Kaeberlein, M. R. (2014) · Annual Review of Gerontology and Geriatrics · doi:10.1891/0198-8794.34.59 · Cited by 4
Stress response capacity analysis during aging and possible new insights into aging studies
Chen, K., Shen, W., Gao, Z., & Luo, C. (2021) · Current Genetics · doi:10.1007/s00294-021-01159-2 · Cited by 4
Technology, Science and Culture - A Global Vision, Volume II
Picazo-Vela, S., & Hernández, L. R. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90099 · Cited by 4
Calorie Restriction Mimetics: Progress and Potential
Roth, G. S., & Ingram, D. K. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-14830-4_10 · Cited by 5
Free Radicals and Oxidative Stress: Basic Concepts and Misconceptions
Xu, J., & Leeuwenburgh, C. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-13473-4_2 · Cited by 4
Statin and Fibrate‐Induced Dichotomy of Mitochondrial Function
Neergheen, V., Dyson, A., Wainwright, L., & Hargreaves, I. P. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch30 · Cited by 4
Intragenic repeat expansions control yeast chronological agingPreprint
Barré, B. P., Hallin, J., Yue, J., Persson, K. O., Mikhalev, E., Irizar, A., Thompson, D. A., Molin, M., Warringer, J., & Liti, G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/653006 · Cited by 4
ROS-dependent localization of glycolytic enzymes to mitochondria
Esparza‐Moltó, P. B., Goswami, A. V., Bozkurt, S., Münch, C., Newman, L. E., Moyzis, A. G., Rojas, G. R., Guan, D., Jones, J. R., Gage, F. H., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103812 · Cited by 3
Energy deprivation in youth and old age
Stern, M. (2025) · Journal of Cell Science · doi:10.1242/jcs.264018 · Cited by 3
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Bresilla, D., Tawfik, I., Hirtl, M., Gabrijelčič, S., Ostaku, J., Mossegger, F., Wurzer, L., Lederer, S., Kalinová, K., Malle, E., et al. (2025) · Aging Cell · doi:10.1111/acel.70247 · Cited by 4
Self-citationZhang, G., Zhao, L., Li, Z., Dong, Y., Ju, Z., & Sun, Y. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119333 · Cited by 3
Mitochondrial responses to thermal stress: ROS dynamics and metabolic shifts in Drosophila
Léger, A., Herpe, L., & Pichaud, N. (2026) · Mitochondrion · doi:10.1016/j.mito.2026.102114 · Cited by 3
Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens
Chevret, C. J. L., Echegaray, J. F., Walton, A., Lo, M., Rueppell, O., & Lemieux, H. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341233 · Cited by 3
Li, P., Zheng, Y., Casas-Martinez, J. C., Xia, Q., Miranda‐Vizuete, A., Goljanek‐Whysall, K., & McDonagh, B. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104231 · Cited by 3
Mitochondrial Regulation by Protein Acetylation
Lombard, D. B., Tishkoff, D. X., & Zwaans, B. M. M. (2012) · Oxidative stress and disease · doi:10.1201/b12308-17 · Cited by 3
Dietary Restriction in C. elegans
Zhang, Y., & Mair, W. B. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_16 · Cited by 4
Campbell, J. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62141-4 · Cited by 3
N1-Methylnicotinamide: The Mysterious Anti-aging Actor in Renal Transplantation
Nejabati, H. R., & Roshangar, L. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230330083649 · Cited by 3
Energy in Biology: Demand and Use
Konieczny, L., Roterman‐Konieczna, I., & Spólnik, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-31557-2_2 · Cited by 4
Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function
Gao, X., Yu, J., Zhang, L., Shi, H., Yan, Y., Han, Y., Fang, M., Liu, Y., Wu, C., Fan, S., et al. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4578 · Cited by 3
Thiruppathi, G., Mohankumar, A., Shanmugam, G., Duraisamy, K., Cho, J. H., Tawata, S., Bhavan, P. S., & Sundararaj, P. (2024) · 3 Biotech · doi:10.1007/s13205-024-04017-3 · Cited by 3
Intermittent Fasting-Dietary Restriction as a Geroprotector
Kaur, G., Kaur, T., Sharma, A., Manchanda, S., Singh, H., Kalotra, S., & Bajaj, P. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_13 · Cited by 3
Arulalan, K. S., Huayta, J., Stallrich, J. W., & San‐Miguel, A. (2021) · Exposome · doi:10.1093/exposome/osab005 · Cited by 4
Role of Oxidative Stress in Aging
Knoefler, D., Tienson, H. L., & Jakob, U. (2013) · Springer eBooks · doi:10.1007/978-94-007-5787-5_14 · Cited by 3
F3‐Isoprostanes as a Measure of in vivo Oxidative Damage in Caenorhabditis elegans
Nguyen, T., & Aschner, M. (2014) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1117s62 · Cited by 3
Mercury as a Source of Reactive Oxygen Species
Nabi, S. (2014) · Springer eBooks · doi:10.1007/978-81-322-1922-4_12 · Cited by 3
Aging: The Blurry Line between Life and Death
Liu, J. C., & Finkel, T. (2014) · Current Biology · doi:10.1016/j.cub.2014.05.057 · Cited by 4
Regulation of Mitochondrial Functions by Transcription Factor NRF2
Reddy, N. M., Qureshi, W., Potteti, H. R., Kalvakolanu, D. V., & Reddy, S. P. (2014) · Respiratory medicine · doi:10.1007/978-1-4939-0829-5_2 · Cited by 4
Nanoparticles: An Activator of Oxidative Stress
Singh, A., Raj, A., Shah, P., & Agrawal, N. (2020) · Springer eBooks · doi:10.1007/978-981-15-5522-0_6 · Cited by 3
Wang, D.-T., Wu, M., Li, S., Gao, Q., & Zeng, Q.-P. (2014) · doi:10.7287/peerj.preprints.565v1 · Cited by 3
A metabolic and mitochondrial angle on aging
Duarte, A. I., Sadowska‐Bartosz, I., Karkucińska‐Więckowska, A., Lebiedzińska, M., Palmeira, C. M., Rolo, A. P., Kabiri, Y., Zavan, B., Pinton, P., Borges, F., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00024-0 · Cited by 3
Wang, C.-W., Chiu, P., Monsalve, S., Roure, R., Bai, X., Law, J.-J., Wu, Y., Chen, Y., Cheng, Y.-L., Chen, R., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1622695 · Cited by 3
Button, E. L., Dwyer, E., Lewis, J. B., Mortensen, M. S., McDonald, E., Butler, E., Pearson, F., Tang, A. E., Watts, J. L., & Veal, E. A. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103992 · Cited by 2
Campbell, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00013-8 · Cited by 2
Li, R., Tao, M., Xu, T., Wang, J., Duan, R., Wu, T., Pan, S., & Xu, X. (2023) · Journal of Food Biochemistry · doi:10.1155/2023/5762922 · Cited by 2
Metadata
- Authors
- Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Ristow, Michael
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 6
- Issue
- 4
- Pages
- 280-293
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2056673369
- Cited by
- 1,209
- References
- 65
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 44 · 2023: 63 · 2022: 61 · 2021: 66 · 2020: 68 · 2019: 67 · 2018: 75 · 2017: 68 · 2016: 90 · 2015: 82 · 2014: 92 · 2013: 77 · 2012: 70
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- glucose restriction, lifespan extension, Caenorhabditis elegans, mitochondrial respiration, oxidative stress, reactive oxygen species, aak-2, AMPK, glycolysis, catalase, antioxidants, type 2 diabetes, caloric restriction
- MeSH terms
- Animals, Glucose, Glycolysis, Longevity, Mitochondria, Multienzyme Complexes, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Reactive Oxygen Species, Oxidative Stress, Cell Respiration, Caenorhabditis elegans Proteins, Sirtuins, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review