The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
Open accessAbstract
Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes, whereas nutritive calorie restriction increases life expectancy. We show here that increased glucose availability decreases Caenorhabditis elegans life span, while impaired glucose metabolism extends life expectancy by inducing mitochondrial respiration. The histone deacetylase Sir2.1 is found here to be dispensable for this phenotype, whereas disruption of aak-2, a homolog of AMP-dependent kinase (AMPK), abolishes extension of life span due to impaired glycolysis. Reduced glucose availability promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival rates, altogether providing direct evidence for a hitherto hypothetical concept named mitochondrial hormesis or "mitohormesis." Accordingly, treatment of nematodes with different antioxidants and vitamins prevents extension of life span. In summary, these data indicate that glucose restriction promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of type 2 diabetes as well as the widespread use of antioxidant supplements.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although the mechanisms behind calorie restriction-driven longevity extension are still poorly understood, mitochondrial physiology is involved in the beneficial effects of calorie restriction in budding yeast11 and Caenorhabditis elegans12, as well as in mammals13.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [12]
In the citing paper
“Treatment of worms with antioxidants abolished this life extension 97.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
In the citing paper
“Furthermore, in C. elegans, lifespan extension mediated by glucose restriction is associated with increased mitochondrial metabolism and ROS production.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
In the citing paper
“This theory can be applied to mitochondrial ROS 97”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [97]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,629
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Intake of sugar-sweetened beverages and weight gain: a systematic review
Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Cited by
Sorted by citations
Items 801–900 of 1,000
Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
Kim, G.-H., Lee, Y., Lee, G.-H., Cho, Y.-H., Lee, Y.-N., Jang, Y., Paik, D., & Park, J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.020 · Cited by 15
Phua, C. Z. J., Zhao, X., Turcios-Hernandez, L., McKernan, M., Abyadeh, M., Ma, S., Promislow, D., Kaeberlein, M. R., & Kaya, A. (2023) · GeroScience · doi:10.1007/s11357-023-00796-4 · Cited by 14
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
Li, M., Wang, Y., Wei, X., Cai, W.-F., Liu, Y., Wu, J., Chen, Y., Xiong, J., Cui, L.-F., Zhu, M., et al. (2024) · Cell Research · doi:10.1038/s41422-024-01021-3 · Cited by 14
Oxidative Stress in the Aging Process: Fundamental Aspects and New Insights
del Valle, L. G., Hernández, R. G., Roche, L. D., & Fernández, O. (2015) · ACS symposium series · doi:10.1021/bk-2015-1200.ch006 · Cited by 15
Messina, F., Cecconi, F., & Rodolfo, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00271 · Cited by 14
Damri, O., Asslih, S., Shemesh, N., Natour, S., Noori, O., Daraushe, A., Einat, H., Kara, N., Las, G., & Agam, G. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01215-y · Cited by 15
Methyl 3,4-dihydroxybenzoate extends the lifespan of Caenorhabditis elegans, partly via W06A7.4 gene
Zhang, W., Cai, L., Geng, H.-J., Su, C.-F., Li, Y., Wang, J., Gao, Q. F., & Luo, H. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.007 · Cited by 14
Levels and location are crucial in determining the effect of ROS on lifespan
Raamsdonk, J. M. V. (2015) · Worm · doi:10.1080/21624054.2015.1094607 · Cited by 15
Graf, B. L., Kamat, S., Cheong, K. Y., Komarnytsky, S., Driscoll, M., & Di, R. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.07.016 · Cited by 13
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
Easwaran, H., & Weeraratna, A. T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00868-x · Cited by 15
Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila
Salminen, T. S., Vesala, L., Basikhina, Y., Kutzer, M. A. M., Tuomela, T., Lucas, R., Monteith, K., Prakash, A., Tietz, T., & Vale, P. F. (2024) · BMC Biology · doi:10.1186/s12915-024-01858-5 · Cited by 15
Slade, L., Etheridge, T., & Szewczyk, N. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102456 · Cited by 15
The Biological Mechanisms of Aging: A Historical and Critical Overview
Goto, S. (2015) · Springer eBooks · doi:10.1007/978-4-431-55763-0_1 · Cited by 15
Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
de la Vega, M. R., Castillo, D., de Cubas, L., Wang, Y., Huang, Y. K., Hidalgo, E., & Cabrera, M. (2022) · BMC Biology · doi:10.1186/s12915-022-01352-w · Cited by 14
ROS elevate HIF-1α phosphorylation for insect lifespan through the CK2-MKP3-p38 pathway
Su, X., Su, Z., & Xu, W. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119389 · Cited by 13
Ageing-associated phenotypes in mice
Xie, K., & Ehninger, D. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111852 · Cited by 14
Gröger, A., Martínez-Albo, I., Albà, M. M., Ayté, J., de la Vega, M. R., & Hidalgo, E. (2023) · Antioxidants · doi:10.3390/antiox12101810 · Cited by 16
Dassanayaka, S., Zheng, Y., Gibb, A., Cummins, T. D., McNally, L. A., Brittian, K. R., Jagatheesan, G., Audam, T. N., Long, B. W., Brainard, R. E., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.016 · Cited by 13
Kumar, R., Saraswat, K., & Rizvi, S. I. (2021) · Rejuvenation Research · doi:10.1089/rej.2020.2399 · Cited by 13
Viollet, B., & Foretz, M. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_18 · Cited by 14
Leveraging mitochondrial stress to improve healthy aging
Gorgori-González, A., Soto-Rodriguez, S., Tamayo-Torres, E., García-Domínguez, E., Sebastiá, V., Gambini, J., González, G. O., & Gómez‐Cabrera, M. C. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.10.003 · Cited by 13
A Radical Role for TOR in Longevity
Lamming, D. W., & Sabatini, D. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.006 · Cited by 12
Calorie restriction up-regulates iron and coppertransportgenes in Saccharomyces cerevisiae
Sharma, P. K., Mittal, N., Deswal, S., & Roy, N. (2010) · Molecular BioSystems · doi:10.1039/c0mb00084a · Cited by 13
Shcherbakov, D., Juskeviciene, R., Sanchón, A. C., Brilkova, M., Rehrauer, H., Laczkó, E., & Böttger, E. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052746 · Cited by 12
Nakitto, A. M. S., Rudloff, S., Borsch, C., & Wagner, A. E. (2021) · Food & Function · doi:10.1039/d1fo01363g · Cited by 12
Metabolites in aging and aging‐relevant diseases: Frailty, sarcopenia and cognitive decline
Kondoh, H., & Kameda, M. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14684 · Cited by 12
Longevity. The allostatic load of dietary restriction
Pijl, H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.030 · Cited by 12
Alternative Mitochondrial Fuel Extends Life Span
Schroeder, E. A., & Shadel, G. S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.011 · Cited by 12
Jung, U., Kim, M. J., Wang, T., Lee, J., Jeon, S. W., Jo, N., Kim, W. S., Baik, M., & Lee, H. (2017) · Livestock Science · doi:10.1016/j.livsci.2017.05.009 · Cited by 12
Functional genomics of dietary restriction and longevity in yeast
Campos, S. E., & DeLuna, A. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.003 · Cited by 13
The effects of polysaccharides from Rehmannia glutinosa on Caenorhabditis elegans
Liu, Y., Tan, P., Yuan, Y., Kang, N., Lü, Y., Miao, X., & Zhang, X. (2019) · Pharmacognosy Magazine · doi:10.4103/pm.pm_618_18 · Cited by 12
A glucose-supplemented diet enhances gut barrier integrity in Drosophila
Galenza, A., & Foley, E. (2021) · Biology Open · doi:10.1242/bio.056515 · Cited by 15
Cai, H., Rasulova, M., Vandemeulebroucke, L., Meagher, L., Vlaeminck, C., Dhondt, I., & Braeckman, B. P. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx013 · Cited by 13
Wang, J., Jiang, B., Lin, X., Zhang, J., Xiong, L., Feng, Y., Cheang, W. S., & Xu, B. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.10.263 · Cited by 11
Yu, Y.-T., Lin, H., Chen, X., Sun, M., Wei, C., Xue, M.-F., Gao, Y., Tang, W., Zheng, C.-Y., Li, S., et al. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.105924 · Cited by 11
Nguyen, U. T. T., Youn, E., Le, T. A. N., Ha, N. M., Tran, S. H., Lee, S., Cha, J. W., Park, J., Kwon, H. C., & Kang, K. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.023 · Cited by 11
The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process
Majumder, A., Bano, S., & Nayak, K. B. (2024) · Biomolecules · doi:10.3390/biom14111387 · Cited by 11
Sestrin2 is a central regulator of mitochondrial stress responses in disease and aging
Machado, I. F., Palmeira, C. M., & Rolo, A. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102762 · Cited by 12
Gomez-Perez, A., Kyryakov, P., Burstein, M. T., Asbah, N., Noohi, F., Iouk, T., & Titorenko, V. I. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00216 · Cited by 11
dos Santos, F. B., Quines, C. B., Pilissão, L. E. B., Forno, A. H. D., Rodrigues, C. D. F., Denardin, C. C., Farias, F. M., & Ávila, D. S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1321354 · Cited by 11
Changes in the Mitochondria in the Aging Process—Can α-Tocopherol Affect Them?
Napolitano, G., Fasciolo, G., Tomajoli, M. T. M., & Venditti, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512453 · Cited by 12
Fluoxetine Promotes Longevity via Reactive Oxygen Species in Caenorhabditis elegans
Zhou, C., Zhou, Y., Liang, Y., Chen, L., Liu, L., Wei, F., & Li, G. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad220 · Cited by 12
Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53
Godthi, A., Min, S., Das, S., Cruz-Corchado, J., Deonarine, A., Misel‐Wuchter, K., Issuree, P. D. A., & Prahlad, V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315248121 · Cited by 11
Abate, J. P., & Blackwell, T. K. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.006 · Cited by 11
MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans
Hoffmann, M., Honnen, S., Mayatepek, E., Wätjen, W., Koopman, W. J. H., Bossinger, O., & Distelmaier, F. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.011 · Cited by 11
Mendler, M., Riedinger, C., Schlotterer, A., Volk, N., Fleming, T. H., Herzig, S., Nawroth, P. P., & Morcos, M. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.09.014 · Cited by 11
Ferreira, C. M., Oliveira, M., Paes, M. C., & de Oliveira, M. F. (2018) · Cell Biology International · doi:10.1002/cbin.10945 · Cited by 11
Schlotterer, A., Masri, B., Humpert, M., Krämer, B. K., Hammes, H., & Morcos, M. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1158-9248 · Cited by 11
Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes
Flanagan, B. A., Li, N., & Edmands, S. (2021) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2021.1813 · Cited by 11
Adaptive responses to alloxan‐induced mild oxidative stress ameliorate certain tauopathy phenotypes
Yoshiike, Y., Yamashita, S., Mizoroki, T., Maeda, S., Murayama, M., Kimura, T., Sahara, N., Soeda, Y., & Takashima, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00756.x · Cited by 11
Combined loss of three DNA damage response pathways renders C. elegans intolerant to light
van Bostelen, I., & Tijsterman, M. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.04.002 · Cited by 11
Trade-Offs Between Anti-Aging Dietary Supplementation and Exercise
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1484 · Cited by 11
Su, X.-L., Su, Z., & Xu, W. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119648 · Cited by 10
Zhang, Y., Wu, Y., Li, B., & Tian, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.005 · Cited by 10
McLean, S., Lee, M. B., Liu, W., Hameed, R., Gujjala, V. A., Zhou, X., Kaeberlein, M. R., & Kaya, A. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1408160 · Cited by 10
Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects
Torres‐Isidro, O., González-Montoya, M., Vargas-Vargas, M. A., Florian-Rodriguez, U., Garcia‐Berumen, C. I., Montoya-Pérez, R. D. C., Saavedra‐Molina, A., Cortés, E. C., Rodríguez-Orozco, A. R., & Cortés‐Rojo, C. (2025) · Pharmaceuticals · doi:10.3390/ph18020246 · Cited by 11
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways
Das, P., Ravi, R., & Singh, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00634-7 · Cited by 10
Fluorescent Imaging of Redox Species in Multicellular Organisms
Fujikawa, Y., Morgan, B., & Dick, T. P. (2013) · Springer eBooks · doi:10.1007/978-94-007-5787-5_5 · Cited by 10
Mitochondria Inspire a Lifestyle
Krämer, P., & Bressan, P. (2019) · Advances in anatomy, embryology and cell biology · doi:10.1007/102_2018_5 · Cited by 10
Lin, X.-W., Fan, Z., Liu, Y. H., Li, J., Ma, Q., & Yan, R. H. (2021) · Insect Molecular Biology · doi:10.1111/imb.12721 · Cited by 10
A robust LC-MS/MS method to measure 8-oxoGuo, 8-oxodG, and NMN in human serum and urine
Zou, Y., Ma, X., Tang, Y., Lin, L., Yu, J., Zhong, J., Wang, D., Cheng, X., Gao, J., Yu, S., et al. (2022) · Analytical Biochemistry · doi:10.1016/j.ab.2022.114970 · Cited by 10
Konieczny, L., Roterman-Konieczna, I., & Spólnik, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-31557-2 · Cited by 11
Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
Shadel, G. S., & New Haven, C. 0.-8. (2014) · Microbial Cell · doi:10.15698/mic2014.05.143 · Cited by 10
Aging: The Mitochondrial Connection
Brown, K. V. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-003 · Cited by 11
Mechanistic perspectives of calorie restriction on vascular homeostasis
Liu, Y., Chen, H., & Liu, D. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4709-z · Cited by 10
The dynamic replicon: adapting to a changing cellular environment
Herrick, J. (2010) · BioEssays · doi:10.1002/bies.200900129 · Cited by 10
Metabolic Biomarkers in Nematode C. elegans During Aging
Yanase, S., Ishii, T., Yasuda, K., & Ishii, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_9 · Cited by 10
NAD+ and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?
Hipkiss, A. R. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.006 · Cited by 10
Antioxidants and respiratory disease: the uric acid paradox
Shaheen, S. O. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205751 · Cited by 10
Gao, A. W., Alam, G. E., Zhu, Y., Li, W., Sulc, J., Li, X., Katsyuba, E., Li, T. Y., Overmyer, K. A., Lalou, A., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114836 · Cited by 10
Quan, H., Lu, Y., Lin, Y., Xue, P., Zhang, Y., Wang, Y., Yu, W., Lin, X., Yang, W., Lv, C., et al. (2025) · Aging Cell · doi:10.1111/acel.70052 · Cited by 9
Arya, J. K., Kumar, R., Singh, A. L., Srivastava, P., Yadawa, A. K., & Rizvi, S. I. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0032 · Cited by 9
Hu, Y., Xu, Z., Pan, Q., & Ma, L. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010740 · Cited by 9
Finley, J. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.06.003 · Cited by 9
Molecular cloning and characterization of glucose-6-phosphate dehydrogenase from Brugia malayi
VERMA, A., Suthar, M. K., Doharey, P. K., Gupta, S., Yadav, S. K., Chauhan, P. M. S., & Saxena, J. K. (2013) · Parasitology · doi:10.1017/s0031182013000115 · Cited by 9
Li, F., Nie, J., Lu, Y., Tong, T. K., Yi, L., Yan, H., Fu, F. H. K., & Ma, S. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3460-5 · Cited by 9
Supply Analysis of Supplementary Products in Poland
Hys, K., & Koziarska, A. (2020) · EUROPEAN RESEARCH STUDIES JOURNAL · doi:10.35808/ersj/1777 · Cited by 9
Zhang, X., Li, W., & Xu, W. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102950 · Cited by 9
Building a new bridge between metabolism, free radicals and longevity
Ralser, M., & Lehrach, H. R. (2009) · Aging · doi:10.18632/aging.100089 · Cited by 9
Schriner, S. E., Coskun, V., Hogan, S. P., Nguyen, C. D., Lopez, T. E., & Jafari, M. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.0105 · Cited by 9
Ageing and oxidants in the nematode Caenorhabditis elegans.
Gems, D. (2009) · PubMed · Cited by 9
Riedinger, C., Mendler, M., Schlotterer, A., Fleming, T. H., Okun, J. G., Hammes, H., Herzig, S., & Nawroth, P. P. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.805879 · Cited by 9
Geng, S., Li, H., Zhang, X., Wang, T., Zhou, S., & Xu, W. (2022) · FEBS Journal · doi:10.1111/febs.16691 · Cited by 8
Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
Liang, Q., Yang, H., Zhang, Z., Zheng, J., & Qin, Z. (2023) · iScience · doi:10.1016/j.isci.2023.106206 · Cited by 8
Zhang, M., Li, B., & Tian, J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109400 · Cited by 8
Kim, J. H., & Hong, Y. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21884 · Cited by 8
Valencak, T. G., Raith, J., Staniek, K., Gille, L., & Strasser, A. (2016) · Antioxidants · doi:10.3390/antiox5010002 · Cited by 8
Calorie Restriction An Approach towards Obesity Management
Jain, S., & Singh, S. N. (2015) · Journal of Nutritional Disorders & Therapy · doi:10.4172/2161-0509.1000s1006 · Cited by 8
Hedges, C. P., Pham, T., Shetty, B., Masson, S. W. C., Hickey, A. J., Shepherd, P. R., & Merry, T. L. (2020) · Bioscience Reports · doi:10.1042/bsr20201128 · Cited by 8
Arya, J. K., Kumar, R., Tripathi, S. S., & Rizvi, S. I. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1828485 · Cited by 8
Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8
Møller, K. V., Nguyen, H. T. T., Mørch, M. G. M., Hesselager, M. O., Mulder, F. A. A., Fuursted, K., & Olsen, A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.886206 · Cited by 8
Zhu, L., Lu, Y., Zhang, J., & Hu, Q. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_25 · Cited by 9
Protective Effects of Transient Glucose Exposure in Adult C. elegans
Murillo, K., Samigullin, A., Humpert, P. M., Fleming, T., Özer, K., Schlotterer, A., Hammes, H., & Morcos, M. (2022) · Antioxidants · doi:10.3390/antiox11010160 · Cited by 8
Braeckman, B. P., Back, P., & Matthijssens, F. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_10 · Cited by 8
Escherichia coli carbon source metabolism affects longevity of its predator Caenorhabditis elegans
Brokate-Llanos, A. M., Garzón, A., & Muñoz, M. J. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.09.001 · Cited by 8
Measurement of Oxygen Consumption Rates in Intact Caenorhabditis elegans
Sarasija, S., & Norman, K. R. (2019) · Journal of Visualized Experiments · doi:10.3791/59277 · Cited by 8
Antioxidants prevent health-promoting effects of physical exercise in humans
Shephard, R. J. (2010) · Yearbook of Sports Medicine · doi:10.1016/s0162-0908(09)79535-2 · Cited by 8
Glucose increases the lifespan of post-reproductive C. elegans independently of FOXOPreprint
Lei, W., Beaudoin‐Chabot, C., & Thibault, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/347435 · Cited by 8
Charidemou, E., Andreou, E. P., & Papaneophytou, C. P. (2026) · Biomolecules · doi:10.3390/biom16060867 · Cited by 7
Metadata
- Authors
- Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Ristow, Michael
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 6
- Issue
- 4
- Pages
- 280-293
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2056673369
- Cited by
- 1,209
- References
- 65
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 44 · 2023: 63 · 2022: 61 · 2021: 66 · 2020: 68 · 2019: 67 · 2018: 75 · 2017: 68 · 2016: 90 · 2015: 82 · 2014: 92 · 2013: 77 · 2012: 70
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- glucose restriction, lifespan extension, Caenorhabditis elegans, mitochondrial respiration, oxidative stress, reactive oxygen species, aak-2, AMPK, glycolysis, catalase, antioxidants, type 2 diabetes, caloric restriction
- MeSH terms
- Animals, Glucose, Glycolysis, Longevity, Mitochondria, Multienzyme Complexes, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Reactive Oxygen Species, Oxidative Stress, Cell Respiration, Caenorhabditis elegans Proteins, Sirtuins, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review