Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,629

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Intake of sugar-sweetened beverages and weight gain: a systematic review

Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Mitochondrial longevity pathways

Vendelbo, M. H., & Nair, K. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.029 · Cited by 92

Mitochondrial stress management: a dynamic journey

Valera‐Alberni, M., & Cantó, C. (2018) · Cell Stress · doi:10.15698/cst2018.10.158 · Cited by 99

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

Parkhitko, A. A., Filine, E., Mohr, S. E., Moskalev, A., & Perrimon, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101188 · Cited by 91

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Mouchiroud, L., Molin, L., Kasturi, P., Triba, M. N., Dumas, M., Wilson, M. C., Halestrap, A. P., Roussel, D., Masse, I., Dallière, N., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00640.x · Cited by 92

Adaptive responses to glucose restriction enhance cell survival, antioxidant capability, and autophagy of the protozoan parasite Trichomonas vaginalis

Huang, K., Chen, Y. M., Fang, Y.-K., Cheng, W.-H., Cheng, C.-C., Chen, Y.-C., Wu, T. E., Ku, F.-M., Chen, S., Lin, R., et al. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.08.008 · Cited by 90

Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

Svensk, E., Devkota, R., Ståhlman, M., Ranji, P., Rauthan, M., Magnusson, F., Hammarsten, S., Johansson, M., Borén, J., & Pilon, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005982 · Cited by 92

The role of mitochondrial DNA damage in the development of atherosclerosis

Yu, E., & Bennett, M. R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.011 · Cited by 92

Antioxidant activities of the polysaccharides of Chuanminshen violaceum

Fan, J., Feng, H., Yu, Y., Sun, M., Liu, Y., Li, T., Sun, X. S., Liu, S., & Sun, M. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.10.040 · Cited by 90

ROS networks: designs, aging, Parkinson’s disease and precision therapies

Kolodkin, A. N., Sharma, R. P., Colangelo, A. M., Ignatenko, A., Martorana, F., Jennen, D. G. J., Briedé, J. J., Brady, N. R., Barberis, M., Mondeel, T. D. G. A., et al. (2020) · npj Systems Biology and Applications · doi:10.1038/s41540-020-00150-w · Cited by 89

Mitohormesis reprogrammes macrophage metabolism to enforce tolerance

Timblin, G. A., Tharp, K. M., Ford, B., Winchester, J., Wang, J., Zhu, S., Khan, R. I., Louie, S. K., Iavarone, A. T., ten Hoeve, J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00392-w · Cited by 91

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Ewald, C. Y. (2018) · Antioxidants · doi:10.3390/antiox7100130 · Cited by 88

Molecular Connections Between Circadian Clocks and Aging

Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 90

C. elegans longevity pathways converge to decrease mitochondrial membrane potential

Lemire, B. D., Behrendt, M., DeCorby, A., & Gášková, D. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.05.001 · Cited by 87

Neuronal Responses to Physiological Stress

Kagias, K., Nehammer, C., & Pocock, R. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00222 · Cited by 94

Is “Preparation for Oxidative Stress” a Case of Physiological Conditioning Hormesis?

de Oliveira, M. F., Geihs, M. A., França, T. F. A., Moreira, D. C., & Hermes‐Lima, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00945 · Cited by 86

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs

Sanese, P., Forte, G., Disciglio, V., Grossi, V., & Simone, C. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.06.011 · Cited by 90

Mitochondria and Organismal Longevity

Hwang, A. B., Jeong, D., & Lee, S. (2012) · Current Genomics · doi:10.2174/138920212803251427 · Cited by 87

Resistance to type 2 diabetes mellitus: a matter of hormesis?

Kolb, H., & Eizirik, D. L. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.158 · Cited by 87

Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases

Machado, I. F., Miranda, R. G., Dorta, D. J., Rolo, A. P., & Palmeira, C. M. (2023) · Antioxidants · doi:10.3390/antiox12061212 · Cited by 89

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

Mair, W. B., Panowski, S. H., Shaw, R. J., & Dillin, A. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004535 · Cited by 88

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

Wagner, A. E., Piegholdt, S., Rabe, D., Baenas, N., Schloesser, A., Eggersdorfer, M. L., Stocker, A., & Rimbach, G. H. (2015) · Oncotarget · doi:10.18632/oncotarget.5215 · Cited by 88

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

Ewald, C. Y., Hourihan, J. M., Bland, M. S., Obieglo, C., Katic, I., Mazzeo, L. E. M., Alcedo, J., Blackwell, T. K., & Hynes, N. E. (2017) · eLife · doi:10.7554/elife.19493 · Cited by 88

Reprogramming of energy metabolism as a driver of aging

Feng, Z., Hanson, R. W., Berger, N. A., & Trubitsyn, A. G. (2016) · Oncotarget · doi:10.18632/oncotarget.7645 · Cited by 84

Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!

Hekimi, S., Wang, Y., & Noë, A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00161 · Cited by 83

From rapalogs to anti-aging formula

Blagosklonny, M. V. (2017) · Oncotarget · doi:10.18632/oncotarget.18033 · Cited by 83

Pro‐ and Antioxidant Functions of the Peroxisome‐Mitochondria Connection and Its Impact on Aging and Disease

Pascual‐Ahuir, A., Manzanares‐Estreder, S., & Proft, M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9860841 · Cited by 87

Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathways

Shanmugam, G., Mohankumar, A., Duraisamy, K., Thiruppathi, G., Nivitha, S., & Sundararaj, P. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.128 · Cited by 84

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

Lublin, A. L., Isoda, F., Patel, H., Yen, K., Nguyen, L., Hajje, D., Schwartz, M., & Mobbs, C. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027762 · Cited by 88

The ω‐3 fatty acid α‐linolenic acid extends Caenorhabditis elegans lifespan via NHR ‐49/ PPAR α and oxidation to oxylipins

Qi, W., Gutierrez, G. E., Gao, X., Dixon, H., McDonough, J. A., Marini, A. M., & Fisher, A. L. (2017) · Aging Cell · doi:10.1111/acel.12651 · Cited by 83

Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

Duszka, K., Gregor, A., Guillou, H., König, J. S., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071708 · Cited by 86

Aging: All roads lead to mitochondria

Son, J. M., & Lee, C. D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.02.006 · Cited by 86

LET-767 Is Required for the Production of Branched Chain and Long Chain Fatty Acids in Caenorhabditis elegans

Entchev, E. V., Schwudke, D., Zagoriy, V., Matyash, V., Bogdanova, A. I., Habermann, B. H., Zhu, L., Shevchenko, A., & Kurzchalia, T. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800965200 · Cited by 82

The Paradox of Coenzyme Q10 in Aging

Díaz-Casado, M. E., Quiles, J. L., Barriocanal-Casado, E., González-García, P., Battino, M., López, L. C., & Varela-López, A. (2019) · Nutrients · doi:10.3390/nu11092221 · Cited by 81

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 82

Chlorothalonil induces oxidative stress and reduces enzymatic activities of Na+/K+-ATPase and acetylcholinesterase in gill tissues of marine bivalves

Haque, M. N., Eom, H.-J., Nam, S.-E., Shin, Y. K., & Rhee, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214236 · Cited by 80

Vitamin E supplementation and lifespan in model organisms

Ernst, I. M. A., Pallauf, K., Bendall, J. K., Paulsen, L., Nikolai, S., Huebbe, P., Roeder, T., & Rimbach, G. H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.10.002 · Cited by 80

Food safety risks and consumer health

Chassy, B. M. (2010) · New Biotechnology · doi:10.1016/j.nbt.2010.05.018 · Cited by 80

Detoxification reactions: Relevance to aging

Zimniak, P. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.04.001 · Cited by 80

Redox regulation of UPR signalling and mitochondrial ER contact sites

Casas-Martinez, J. C., Samali, A., & McDonagh, B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05286-0 · Cited by 85

TOR Signaling Couples Oxygen Sensing to Lifespan in C. elegans

Schieber, M., & Chandel, N. S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.075 · Cited by 80

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

Ravichandran, M., Priebe, S., Grigolon, G., Rozanov, L. F., Groth, M., Laube, B., Guthke, R., Platzer, M., Zarse, K., & Ristow, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.004 · Cited by 79

Hormesis does not make sense except in the light of TOR-driven aging

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100411 · Cited by 83

O-Linked-N-Acetylglucosamine Cycling and Insulin Signaling Are Required for the Glucose Stress Response inCaenorhabditis elegans

Mondoux, M. A., Love, D. C., Ghosh, S. K., Fukushige, T., Bond, M. R., Weerasinghe, G. R., Hanover, J. A., & Krause, M. (2011) · Genetics · doi:10.1534/genetics.111.126490 · Cited by 80

Reactive oxygen species, ageing and the hormesis police

Ludovico, P., & Burhans, W. C. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12070 · Cited by 80

Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

Akhoon, B. A., Pandey, S., Tiwari, S., & Pandey, R. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.03.004 · Cited by 78

Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults

Tyrrell, D. J., Bharadwaj, M. S., Horn, C. G. V., Marsh, A. P., Nicklas, B. J., & Molina, A. J. A. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.07.015 · Cited by 78

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

Tian, J., Geiss, C., Zarse, K., Madreiter‐Sokolowski, C. T., & Ristow, M. (2021) · Aging · doi:10.18632/aging.203597 · Cited by 81

Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction

Lu, S.-P., & Lin, S.-J. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.030 · Cited by 77

Antioxidant and anti-aging activities and structural elucidation of polysaccharides from Panax notoginseng root

Feng, S., Cheng, H., Zhou, X., Feng, S., Yuan, M., Huang, Y., Liao, J., & Ding, C. (2019) · Process Biochemistry · doi:10.1016/j.procbio.2019.01.007 · Cited by 76

Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae

Xie, M., & Roy, R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.016 · Cited by 78

Hexokinase is a key regulator of energy metabolism and ROS activity in insect lifespan extension

Lin, X.-W., & Xu, W. (2016) · Aging · doi:10.18632/aging.100885 · Cited by 75

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

Aspernig, H., Heimbucher, T., Qi, W., Gangurde, D., Curic, S., Yan, Y., von Gromoff, E. D., Baumeister, R., & Thien, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.072 · Cited by 75

Selectively Starving Cancer Cells Through Dietary Manipulation: Methods and Clinical Implications

Simone, B. A., Champ, C. E., Rosenberg, A., Berger, A. C., Monti, D., Dicker, A. P., & Simone, N. L. (2013) · Future Oncology · doi:10.2217/fon.13.31 · Cited by 78

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

Nunn, A. V. W., Bell, J. D., & Guy, G. W. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-16 · Cited by 77

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

Brys, K., Castelein, N., Matthijssens, F., Vanfleteren, J. R., & Braeckman, B. P. (2010) · BMC Biology · doi:10.1186/1741-7007-8-91 · Cited by 74

Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Moreno-Arriola, E., Cárdenas‐Rodríguez, N., Coballase-Urrutía, E., Pedraza‐Chaverrí, J., Carmona‐Aparicio, L., & Ortega-Cuéllar, D. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/705253 · Cited by 79

Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension

Musci, R., Hamilton, K., & Linden, M. (2019) · Sports · doi:10.3390/sports7070170 · Cited by 73

Antioxidant Vitamins and Ageing

Milisav, I., Ribarič, S., & Poljšak, B. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_1 · Cited by 74

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice

Keipert, S., Voigt, A., & Klaus, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00648.x · Cited by 74

Effects of nutritional components on aging

Lee, D.-Y., Hwang, W., Artan, M., Jeong, D., & Lee, S. (2014) · Aging Cell · doi:10.1111/acel.12277 · Cited by 77

Targeting Mitochondrial Oxidative Stress as a Strategy to Treat Aging and Age-Related Diseases

Lee, Y. H., Kuk, M. U., So, M. K., Song, E. S., Lee, H., Ahn, S. K., Kwon, H. W., Park, J. T., & Park, S. C. (2023) · Antioxidants · doi:10.3390/antiox12040934 · Cited by 72

Hormesis: Decoding Two Sides of the Same Coin

Bhakta-Guha, D., & Efferth, T. (2015) · Pharmaceuticals · doi:10.3390/ph8040865 · Cited by 74

Beyond ROS clearance: Peroxiredoxins in stress signaling and aging

Detienne, G., Haes, W. D., Mergan, L., Edwards, S. L., Temmerman, L., & Bael, S. V. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.03.005 · Cited by 77

CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells

Ruetz, T. J., Pogson, A. N., Kashiwagi, C. M., Gagnon, S. D., Morton, B., Sun, E., Na, J., Yeo, R. W., Leeman, D. S., Morgens, D. W., et al. (2024) · Nature · doi:10.1038/s41586-024-07972-2 · Cited by 75

A novel kinase regulates dietary restriction‐mediated longevity in C aenorhabditis elegans

Chamoli, M., Singh, A., Malik, Y., & Mukhopadhyay, A. (2014) · Aging Cell · doi:10.1111/acel.12218 · Cited by 74

PGC‐1α, a potential therapeutic target against kidney aging

Lee, G.-Y., Uddin, M. J., Kim, Y., Ko, M., Yu, I., & Ha, H. (2019) · Aging Cell · doi:10.1111/acel.12994 · Cited by 71

Pharmacological lifespan extension of invertebrates

Lucanic, M., Lithgow, G. J., & Alavez, S. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.006 · Cited by 70

Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms

Scialò, F., Mallikarjun, V., Stefanatos, R. K. A., & Sanz, A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4900 · Cited by 70

The chromatin remodeler DDM1 promotes hybrid vigor by regulating salicylic acid metabolism

Zhang, Q., Li, Y., Xu, T., Srivastava, A. K., Wang, D., Zeng, L., Yang, L., He, L. S., Zhang, H., Zheng, Z., et al. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.27 · Cited by 70

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

Zhang, Y., & Hood, W. R. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.132183 · Cited by 72

Antioxidant supplements for preventing gastrointestinal cancers

Bjelaković, G., Nikolova, D., Simonetti, R., & Gluud, C. N. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004183.pub2 · Cited by 70

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki, E., Markaki, M., & Tavernarakis, N. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.001 · Cited by 61

Vitamin C and lifespan in model organisms

Pallauf, K., Bendall, J. K., Scheiermann, C., Watschinger, K., Hoffmann, J., Roeder, T., & Rimbach, G. H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.04.046 · Cited by 69

Getting the better of ER stress

Mollereau, B., Manié, S. N., & Napoletano, F. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0251-9 · Cited by 72

Lifespan and oxidative stress show a non-linear response to atmospheric oxygen inDrosophila

Rascón, B., & Harrison, J. F. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.044867 · Cited by 69

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

Urban, N., Tsitsipatis, D., Hausig, F., Kreuzer, K., Erler, K., Stein, V., Ristow, M., Steinbrenner, H., & Klotz, L. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.003 · Cited by 69

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Shintani, H., Shintani, T., Ashida, H., & Sato, M. (2018) · Nutrients · doi:10.3390/nu10121821 · Cited by 68

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner

Bithi, N., Link, C., Henderson, Y. O., Kim, S., Yang, J., Li, L., Wang, R., Willard, B. B., & Hine, C. (2021) · Nature Communications · doi:10.1038/s41467-021-22001-w · Cited by 68

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks

Lisanti, S., Tavecchio, M., Chae, Y. C., Liu, Q., Brice, A. K., Thakur, M. L., Languino, L. R., & Altieri, D. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.061 · Cited by 69

NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction

Hine, C. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-004 · Cited by 69

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease

Jayatunga, D. P. W., Hone, E., Khaira, H., Lunelli, T., Singh, H., Guillemin, G. J., Fernando, B., Garg, M. L., Verdile, G., & Martins, R. N. (2021) · Nutrients · doi:10.3390/nu13113744 · Cited by 67

Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

Shinmura, K. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/528935 · Cited by 67

Promotion of behavior and neuronal function by reactive oxygen species in C. elegans

Li, G., Gong, J., Lei, H., Liu, J., & Xu, X. Z. S. (2016) · Nature Communications · doi:10.1038/ncomms13234 · Cited by 67

Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster

Scialò, F., Sriram, A., Stefanatos, R. K. A., Spriggs, R. V., Loh, S. H. Y., Martins, L. M., & Sanz, A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101450 · Cited by 67

Novel strategies for anti-aging drug discovery

Saraswat, K., & Rizvi, S. I. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1349750 · Cited by 66

Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

Lee, Y. H., Park, J. Y., Lee, H., Song, E. S., Kuk, M. U., Joo, J., Oh, S., Kwon, H. W., Park, J. T., & Park, S. C. (2021) · Cells · doi:10.3390/cells10113003 · Cited by 66

Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

Chen, K., Xu, X., Kobayashi, S., Timm, D. J., Jepperson, T. N., & Liang, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225805 · Cited by 66

Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss

Calixto, A., Jara, J. S., & Court, F. A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003141 · Cited by 70

Age‐associated mitochondrial dysfunction in skeletal muscle: Contributing factors and suggestions for long‐term interventions

Huang, J. H., & Hood, D. A. (2009) · IUBMB Life · doi:10.1002/iub.164 · Cited by 71

Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids

Watts, J. L. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5020019 · Cited by 70

Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging

Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 68

Physiological Control of Germline Development

Hubbard, E. J. A., Korta, D. Z., & Dalfó, D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4015-4_5 · Cited by 68

Targeting glucose metabolism for healthy aging

Brewer, R. A., Gibbs, V. K., & Smith, D. L. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160007 · Cited by 69

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Bennett, C. F., Kwon, J. J., Chen, C., Russell, J., Acosta, K., Burnaevskiy, N., Crane, M. M., Bitto, A., Wende, H. V., Simko, M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006695 · Cited by 66

Mitochondrially-targeted treatment strategies

Bozi, L. H. M., Campos, J. C., Zambelli, V. O., Ferreira, N. D., & Ferreira, J. C. B. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.100836 · Cited by 67

Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway

Wierman, M. B., Maqani, N., Strickler, E., Li, M., & Smith, J. S. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00562-16 · Cited by 68

Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans

Wang, H., Zhang, S., Zhai, L., Sun, L., Zhao, D., Wang, Z., & Li, X. (2021) · Food & Function · doi:10.1039/d1fo00576f · Cited by 66

Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis elegans

Zhu, A., Zheng, F., Zhang, W., Li, L., Li, Y., Hu, H., Wu, Y., Bao, W., Li, G., Wang, Q., et al. (2022) · Antioxidants · doi:10.3390/antiox11040705 · Cited by 68

LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

Depuydt, G., Xie, F., Petyuk, V., Smolders, A., Brewer, H. M., Camp, D., Smith, R. D., & Braeckman, B. P. (2014) · Journal of Proteome Research · doi:10.1021/pr401081b · Cited by 64

A Long, Deprived Life or a Short, Sweet One?

Adler, E. M. (2007) · Science s STKE · doi:10.1126/stke.4072007tw358

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Weimer, S., Priebs, J., Kuhlow, D., Groth, M., Priebe, S., Mansfeld, J., Merry, T. L., Dubuis, S., Laube, B., Pfeiffer, A. F. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4563 · Cited by 245

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789

Reductive stress on life span extension in C. elegans

Ralser, M., & Benjamin, I. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-19 · Cited by 22

Investigating how germline removal and dietary restriction enable glucose-mediated lifespan extension in Caenorhabditis elegans

Reynoldson, L. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33915604