Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,629

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Intake of sugar-sweetened beverages and weight gain: a systematic review

Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Saul, N., Möller, S., Cirulli, F., Berry, A., Luyten, W. H. M. L., & Fuellen, G. (2021) · Biogerontology · doi:10.1007/s10522-021-09913-2 · Cited by 25

Microfluidic electric parallel egg-laying assay and application to in-vivo toxicity screening of microplastics using C. elegans

Youssef, K., Archonta, D.-E., Kubiseski, T. J., Tandon, A., & Rezai, P. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147055 · Cited by 22

Fragile lifespan expansion by dietary mitohormesis in C. elegans

Tauffenberger, A., Vaccaro, A., & Parker, J. A. (2016) · Aging · doi:10.18632/aging.100863 · Cited by 26

Alternate day fasting impacts the brain insulin‐signaling pathway of young adult male C57BL/6 mice

Lu, J., Lezi, E., Wang, W., Frontera, J. R., Zhu, H., Wang, W., Lee, P., Choi, I. Y., Brooks, W. M., Burns, J. M., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07184.x · Cited by 23

Reductive stress on life span extension in C. elegans

Ralser, M., & Benjamin, I. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-19 · Cited by 22

New roles for old actors, ROS and PRMT1

Palli, S. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715062114 · Cited by 21

Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole

Martinez, C. S., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A

Rozanov, L. F., Ravichandran, M., Grigolon, G., Zanellati, M. C., Mansfeld, J., Zarse, K., Barzilai, N., Atzmon, G., Fischer, F., & Ristow, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101448 · Cited by 21

2 -Deoxy – d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat

Kumar, R., Saraswat, K., & Rizvi, S. I. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104133 · Cited by 21

GSM2, a transaldolase, contributes to reactive oxygen species homeostasis in Arabidopsis

Zheng, M., Zhu, C., Yang, T., Qian, J., & Hsu, Y.-F. (2020) · Plant Molecular Biology · doi:10.1007/s11103-020-01022-x · Cited by 21

Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan

Grigolon, G., Araldi, E., Erni, R., Wu, J. Y., Thomas, C., Fortezza, M. L., Laube, B., Pöhlmann, D., Stoffel, M., Zarse, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27732-4 · Cited by 21

2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans

Schifano, E., Conta, G., Preziosi, A., Ferrante, C., Batignani, G., Mancini, P., Tomassini, A., Sciubba, F., Scopigno, T., Uccelletti, D., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.986022 · Cited by 21

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Varela‐López, A., Romero‐Márquez, J. M., Navarro‐Hortal, M. D., Ramírez-Tortosa, C. L., Battino, M. A., Forbes-Hernández, T. Y., & Quiles, J. L. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112221 · Cited by 22

Mitochondria: A Potential Rejuvenation Tool against Aging

Phua, Q. H., Ng, S., & Soh, B.-S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0712 · Cited by 21

Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity

Tsang, F. A., & Lin, S.-J. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1367-x · Cited by 21

Chemically induced oxidative stress affects ASH neuronal function and behavior in C. elegans

Gourgou, E., & Chronis, N. (2016) · Scientific Reports · doi:10.1038/srep38147 · Cited by 22

Oxidative Stress and Anti-Oxidant Enzyme Activities in the Trophocytes and Fat Cells of Queen Honeybees ( Apis mellifera )

Hsieh, Y.-S., & Hsu, C. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1420 · Cited by 21

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

McMahon, M. J., Ding, S., Acosta-Jimenez, L., Frangova, T. G., Henderson, C. J., & Wolf, C. R. (2017) · The Journal of Physiology · doi:10.1113/jp274915 · Cited by 21

DEAD-box RNA helicase DDX-23 mediates dietary restriction induced health span in Caenorhabditis elegans

Xiao, Y., Zhang, H., Li, X., Han, C., & Liu, F. (2024) · GeroScience · doi:10.1007/s11357-024-01434-3 · Cited by 20

The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment

Chang, Y., Hee, S., Hsieh, M.-L., Jeng, Y., & Chuang, L. (2015) · Analytical Cellular Pathology · doi:10.1155/2015/972891 · Cited by 21

Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans

Kadlecová, A., Jirsa, T., Novák, O., Kammenga, J. E., Strnad, M., & Voller, J. (2017) · Biogerontology · doi:10.1007/s10522-017-9742-4 · Cited by 20

Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males

Goncalves, J. F., Yu, W. C., Guo, X., Rha, K., LeBoeuf, B., Zhang, L., Estler, K., & Garcia, L. R. (2020) · iScience · doi:10.1016/j.isci.2020.100990 · Cited by 20

Characterization of an Agarophyton chilense Oleoresin Containing PPARγ Natural Ligands with Insulin-Sensitizing Effects in a C57Bl/6J Mouse Model of Diet-Induced Obesity and Antioxidant Activity in Caenorhabditis elegans

Pinto, C., Ibáñez, M. R., Loyola, G., León, L., Salvatore, Y., González, C., Barraza, V., Castañeda, F., Aldunate, R., Porcia, L. C., et al. (2021) · Nutrients · doi:10.3390/nu13061828 · Cited by 20

Insight of Silkworm Pupa Oil Regulating Oxidative Stress and Lipid Metabolism in Caenorhabditis elegans

Zhao, L., Wu, B., Shuyun, L., Min, D., & Jiang, H. (2022) · Foods · doi:10.3390/foods11244084 · Cited by 20

Future foods, dietary factors and healthspan

Li, K., Wang, C., Wang, Y., Fu, L., & Zhang, N. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.12.001 · Cited by 20

Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans

Cheng, Y., Hou, B.-H., Xie, G., Shao, Y.-T., Yang, J., & Xu, C. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.264 · Cited by 20

A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging

Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., Mitchell, S. J., Zarse, K., Carreira, E. M., & Ristow, M. (2023) · Nature Communications · doi:10.1038/s41467-023-43672-7 · Cited by 20

Sirtuins: A Family of Proteins With Implications for Human Performance and Exercise Physiology

Lappalainen, Z. (2010) · Research in Sports Medicine · doi:10.1080/15438627.2011.536068 · Cited by 20

Extension of Life Span by Impaired Glucose Metabolism in Caenorhabditis elegans Is Accompanied by Structural Rearrangements of the Transcriptomic Network

Priebe, S., Menzel, U., Zarse, K., Groth, M., Platzer, M., Ristow, M., & Guthke, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077776 · Cited by 20

Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction

Rattan, S. I. S., & Demirovic, D. (2010) · Springer eBooks · doi:10.1007/978-90-481-8556-6_13 · Cited by 21

Defining molecular basis for longevity traits in natural yeast isolates

Kaya, A., Ma, S., Wasko, B. M., Lee, M. B., Kaeberlein, M. R., & Gladyshev, V. N. (2015) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2015.1 · Cited by 20

4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans

You, X., Xi, J., Cao, Y., Zhang, J., & Luan, Y. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx064 · Cited by 20

Dietary Carbohydrates Impair Healthspan and Promote Mortality

Ravichandran, M., Grandl, G., & Ristow, M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.011 · Cited by 20

PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells

Xia, Q., Lu, S., Ostrovsky, J., McCormack, S. E., Falk, M. J., & Grant, S. F. A. (2018) · Aging and Disease · doi:10.14336/ad.2017.0230 · Cited by 20

Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans

Xu, J., Liu, K., Chen, T., Zhan, T., Ouyang, Z., Wang, Y., Liu, W., Zhang, X., Sun, Y., Xu, G., et al. (2019) · Aging · doi:10.18632/aging.102466 · Cited by 20

Para‐Hydroxybenzyl Alcohol Delays the Progression of Neurodegenerative Diseases in Models of Caenorhabditis elegans through Activating Multiple Cellular Protective Pathways

Liu, Y., Lu, Y.-Y., Huang, L., Shi, L., Zheng, Z.-Y., Chen, J., Qu, Y., Xiao, H., Luo, H., & Wu, G.-S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8986287 · Cited by 20

Artemisinin mimics calorie restriction to extend yeast lifespan via a dual-phase mode: a conclusion drawn from global transcriptome profiling

Wang, D., Wu, M., Li, S., Gao, Q., & Zeng, Q.-P. (2015) · Science China Life Sciences · doi:10.1007/s11427-014-4736-9 · Cited by 21

Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster

Rera, M., Monnier, V., & Tricoire, H. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.01.004 · Cited by 21

Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging

Min, S. H., Kang, G. M., Park, J.-W., & Kim, M. (2024) · Yonsei Medical Journal · doi:10.3349/ymj.2023.0131 · Cited by 20

Identification of a Hydroxygallic Acid Derivative, Zingibroside R1 and a Sterol Lipid as Potential Active Ingredients of Cuscuta chinensis Extract That Has Neuroprotective and Antioxidant Effects in Aged Caenorhabditis elegans

Sayed, S. M. A., Alseekh, S., Siems, K., Fernie, A. R., Luyten, W. H. M. L., Schmitz‐Linneweber, C., & Saul, N. (2022) · Nutrients · doi:10.3390/nu14194199 · Cited by 19

Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome

Zhang, J., Lv, W., Zhang, G., Zeng, M., Cao, W., Su, J., Cao, K. J., & Liu, J. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0339 · Cited by 22

Leaf litter leachates have the potential to increase lifespan, body size, and offspring numbers in a clone of Moina macrocopa

Hofmann, S., Timofeyev, M. A., Putschew, A., Saul, N., Menzel, R., & Steinberg, C. E. W. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.10.041 · Cited by 19

Restriction of glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster

Rovenko, B. M., Kubrak, O. I., Gospodaryov, D. V., Yurkevych, I. S., Sanz, A., Lushchak, O. V., & Lushchak, V. I. (2015) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2015.04.012 · Cited by 19

Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

Zhao, X., Li, Y., Zhang, S., Sudwarts, A., Zhang, H., Kozlova, A., Moulton, M. J., Goodman, L. D., Pang, Z. P., Sanders, A. R., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00840-1 · Cited by 18

Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans

Castelein, N., Muschol, M., Dhondt, I., Cai, H., Vos, W. H. D., Dencher, N. A., & Braeckman, B. P. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.009 · Cited by 18

Glucose effects on polyglutamine-induced proteotoxic stress in Caenorhabditis elegans

Gatrell, L. B., Wilkins, W., Rana, P., & Farris, M. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.159 · Cited by 19

Zein-based nanocarriers for the oral delivery of insulin. In vivo evaluation in Caenorhabditis elegans

Martínez‐López, A. L., González-Navarro, C. J., Vizmanos, J. L., & Irache, J. M. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00919-4 · Cited by 18

Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs

Thomas, C., Wurzer, L., Malle, E., Ristow, M., & Madreiter‐Sokolowski, C. T. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.905261 · Cited by 18

Is there a role of H2S in mediating health span benefits of caloric restriction?

Ng, L. T., Gruber, J., & Moore, P. K. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.030 · Cited by 19

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Staats, S., Rimbach, G. H., Künstner, A., Graspeuntner, S., Rupp, J., Busch, H. S., Sina, C., Ipharraguerre, I. R., & Wagner, A. E. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800424 · Cited by 19

The bridge between cell survival and cell death: reactive oxygen species-mediated cellular stress

Acar, N. V., & Özgül, R. K. (2023) · EXCLI journal · doi:10.17179/excli2023-6221 · Cited by 19

Testing the hormetic nature of homeopathic interventions through stress response pathways

Rattan, S. I. S., & Deva, T. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110369858 · Cited by 18

Insulin/IGF-1 Signaling, including Class II/III PI3Ks, β-Arrestin and SGK-1, Is Required in C. elegans to Maintain Pharyngeal Muscle Performance during Starvation

Dwyer, D. S., & Aamodt, E. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063851 · Cited by 20

Food Reduction in Avicenna’s View and Related Principles in Classical Medicine

Nozad, A., Naseri, M., Safari, M. B., Ahadi, A. A. A., & Ghaffari, F. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.25760 · Cited by 18

Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease

Fang, S., Jiang, M., Jiao, J., Zhao, H., Liu, D., Gao, D., Wang, T., Yang, Z. X., & Yuan, H. (2025) · Aging and Disease · doi:10.14336/ad.2024.1253 · Cited by 18

Caenorhabditis elegans as an emerging model in food and nutrition research: importance of standardizing base diet

Wang, Y., Guo, K., Wang, Q., Zhong, G., Zhang, W., Jiang, Y., Mao, X., Li, X., & Huang, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2130875 · Cited by 20

Epigenetic mechanisms of dietary restriction induced aging in Drosophila

Lian, T., Gaur, U., Yang, D., Li, D., Li, Y., & Yang, M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.015 · Cited by 17

Lifespan effects of mitochondrial mutations

Hirose, M., Schilf, P., Gupta, Y., Wright, M. N., Wright, M. N., Jöhren, O., Wagner, A. E., Sina, C., Ziegler, A., Ristow, M., et al. (2016) · Nature · doi:10.1038/nature20778 · Cited by 17

Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)

Jia, J., Zhang, Y., Yuan, X., Qin, J., Yang, G., Yu, X., Wang, B., Sun, C., & Li, W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.149 · Cited by 17

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype

Al-Ajmi, N., Saretzki, G. C., Miles, C. G., & Spyridopoulos, I. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.07.010 · Cited by 17

Sexual Preferences in Nutrient Utilization Regulate Oxygen Consumption and Reactive Oxygen Species Generation in Schistosoma mansoni: Potential Implications for Parasite Redox Biology

Oliveira, M., Soares, J. B. R. C., & de Oliveira, M. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158429 · Cited by 17

Quantitative Assessment of Fat Levels inCaenorhabditis elegansUsing Dark Field Microscopy

Fouad, A. D., Pu, S., Teng, S., Mark, J. R., Fu, M., Zhang, K., Huang, J. Y., Raizen, D. M., & Fang-Yen, C. M. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.040840 · Cited by 17

Conserved roles of glucose in suppressing reactive oxygen species-induced cell death and animal survival

Wang, C., Zhang, Y., Li, F., & Wei, Y. (2019) · Aging · doi:10.18632/aging.102155 · Cited by 17

Endogenous metabolites promote stress resistance through induction of mitohormesis

Fischer, F., & Ristow, M. (2020) · EMBO Reports · doi:10.15252/embr.202050340 · Cited by 17

Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation

Finley, J. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.016 · Cited by 19

Calorie restriction causes healthy life span extension in the filamentous fungus Podospora anserina

van Diepeningen, A. D., Maas, M. F. P. M., Huberts, D. H. E. W., Goedbloed, D. J., Engelmoer, D. J. P., Slakhorst, S. M., Koopmanschap, A. B., Krause, F., Dencher, N. A., Sellem, C. H., et al. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.002 · Cited by 16

Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts

Adamczyk, J., Deręgowska, A., Skoneczny, M., Skoneczna, A., Kwiatkowska, A., Potocki, L., Rawska, E., Pabian, S., Kaplan, J., Lewińska, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8673 · Cited by 16

Is metformin a geroprotector? A peek into the current clinical and experimental data

Zajda, A., Huttunen, K. M., Sikora, J., Podsiedlik, M., & Markowicz-Piasecka, M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111350 · Cited by 16

Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

Hedges, C. P., Boix, J., Jaiswal, J. K., Shetty, B., Shepherd, P. R., & Merry, T. L. (2021) · Biomolecules · doi:10.3390/biom11020150 · Cited by 16

Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans

Hermeling, J. C., Herholz, M., Baumann, L. C., Cores, E. C., Zečić, A., Hoppe, T., Riemer, J., & Trifunović, A. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102533 · Cited by 16

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Branicky, R. S., Wang, Y., Khaki, A., Liu, J., Kramer‐Drauberg, M., & Hekimi, S. (2022) · Science Advances · doi:10.1126/sciadv.adc9851 · Cited by 16

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Hrizo, S., Fisher, I. J., Long, D. R., Hutton, J. A., Liu, Z., & Palladino, M. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.020 · Cited by 16

SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans

Guo, X., & Garcia, L. R. (2014) · eLife · doi:10.7554/elife.01730 · Cited by 18

In Vitro Maintenance of Clonorchis sinensis Adult Worms

Uddin, M. H., Li, S., Bae, Y. M., Choi, M., & Hong, S. (2012) · Korean Journal of Parasitology · doi:10.3347/kjp.2012.50.4.309 · Cited by 16

Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.

Marcellino, B. K., Ekasumara, N., & Mobbs, C. V. (2018) · PubMed · Cited by 16

Red blood cell glutathione peroxidase activity in female nulligravid and pregnant rats

Gallo, G., & Martino, G. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-7 · Cited by 16

Do UCP2 and mild uncoupling improve longevity?

Dikov, D., Aulbach, A., Muster, B., Dröse, S., Jendrach, M., & Bereiter‐Hahn, J. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.011 · Cited by 16

Hydrogen Peroxide in Adaptation

Spasojević, I., Jones, D. R., & Andrades, M. É. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/596019 · Cited by 16

Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans

Chang, H.-W., Shtessel, L., & Lee, S. S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.576 · Cited by 15

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

Parkhitko, A. A., & Cracan, V. (2025) · Science Advances · doi:10.1126/sciadv.adu1710 · Cited by 15

Luteolin Decreases Fat Accumulation and Extends Lifespan in Caenorhabditis elegans via DAF-16/FOXO and NHR-49/PPAR-α

Liu, F., Hong, C.-A., Gong, S., Fan, Z., Xiao, X., & Xiao, Y. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c08997 · Cited by 16

Hormesis-Mediated Mechanisms Underlying Bioactivities of Phytochemicals

Murakami, A. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-020-00235-4 · Cited by 15

Protective effects of interleukin-22 on oxalate-induced crystalline renal injury via alleviating mitochondrial damage and inflammatory response

Gu, Y., Shen, Y., Chen, W., He, H., Ma, Y., Mei, X., Ju, D., & Liu, H. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11876-4 · Cited by 15

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Fischer, F., Benner, C., Goyala, A., Grigolon, G., Vitiello, D., Wu, J. Y., Zarse, K., Ewald, C. Y., & Ristow, M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102085 · Cited by 16

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Li, Y., Wang, C., Fu, X., Wu, D., He, C., Dai, W., Yue, X., Luo, Z., Yang, J., & Wan, Q.-L. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103598 · Cited by 16

Pharmaceutical Intervention of Aging

Qian, M., & Liu, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_15 · Cited by 17

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Ademowo, O. S., Dias, I. H. K., Pararasa, C., & Griffiths, H. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00006-1 · Cited by 15

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Xiong, L., Pan, L., Gong, Y., Huang, J., & Liu, Z. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.05.040 · Cited by 15

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Lourenço, A. B., & Artal‐Sanz, M. (2021) · Metabolites · doi:10.3390/metabo11090636 · Cited by 15

Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells

Kostyuk, S. V., Proskurnina, E. V., Konkova, M. S., Abramova, M. S., Кальянов, А. А., Ershova, E. S., Izhevskaya, V. L., Kutsev, S. I., & Veiko, N. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010261 · Cited by 16

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Hipkiss, A. R. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1025 · Cited by 15

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Karpac, J., & Jasper, H. (2013) · Cell · doi:10.1016/j.cell.2013.06.046 · Cited by 15

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Padilla, P. A., Garcia, A. M., Ladage, M. L., & Toni, L. S. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu039 · Cited by 16

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Lushchak, V. I. (2016) · Redox Report · doi:10.1080/13510002.2015.1126940 · Cited by 15

Basics of aging theories and disease related aging-an overview

De, A., & Ghosh, C. (2017) · Pharmatutor · Cited by 15

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Stern, M. (2017) · Aging Cell · doi:10.1111/acel.12579 · Cited by 16

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Leow, S.-S., LUU, A., Shrestha, S., Hayes, K. C., & Sambanthamurthi, R. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.03.013 · Cited by 15

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Weber, M., Basu, S., González, B., Greslehner, G. P., Singer, S., Haskova, D., Hašek, J., Breitenbach, M., Gourlay, C. W., Cullen, P. J., et al. (2021) · Antioxidants · doi:10.3390/antiox10020322 · Cited by 17

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Adler, E. M. (2007) · Science s STKE · doi:10.1126/stke.4072007tw358

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Weimer, S., Priebs, J., Kuhlow, D., Groth, M., Priebe, S., Mansfeld, J., Merry, T. L., Dubuis, S., Laube, B., Pfeiffer, A. F. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4563 · Cited by 245

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Ralser, M., & Benjamin, I. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-19 · Cited by 22

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Reynoldson, L. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33915604