Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,629

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Intake of sugar-sweetened beverages and weight gain: a systematic review

Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

Protective effect of andrographolide against concanavalin A-induced liver injury

Shi, G., Zhang, Z., Zhang, R., Zhang, X., Lü, Y., Yang, J., Zhang, D., Zhang, Z., Li, X., & Ning, G. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0685-z · Cited by 44

Measuring Oxidative Stress Resistance of Caenorhabditis elegans in 96-well Microtiter Plates

Possik, E., & Pause, A. (2015) · Journal of Visualized Experiments · doi:10.3791/52746 · Cited by 49

Mitochondrial medicine and the neurodegenerative mitochondriopathies

Swerdlow, R. H. (2009) · Pharmaceuticals · doi:10.3390/ph2030150 · Cited by 43

An energetics perspective on geroscience: mitochondrial protonmotive force and aging

Berry, B. J., & Kaeberlein, M. R. (2021) · GeroScience · doi:10.1007/s11357-021-00365-7 · Cited by 44

Potential Therapeutic Implication of Herbal Medicine in Mitochondria-Mediated Oxidative Stress-Related Liver Diseases

Park, M. N., Rahman, M. A., Rahman, M. H., Kim, J. W., Choi, M. J., Kim, J. W., Choi, J., Moon, M., Ahmed, K. R., & Kim, B. (2022) · Antioxidants · doi:10.3390/antiox11102041 · Cited by 44

Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy

Narasimhan, M., & Rajasekaran, N. S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.11.010 · Cited by 44

Energy restriction and potential energy restriction mimetics

Nikolai, S., Pallauf, K., Huebbe, P., & Rimbach, G. H. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000062 · Cited by 43

A Novel Peptide from Soybean Protein Isolate Significantly Enhances Resistance of the Organism under Oxidative Stress

Ma, H., Liu, R., Zhao, Z., Zhang, Z., Cao, Y., Ma, Y., Guo, Y., & Xu, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159938 · Cited by 43

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

Zemva, J., Fink, C. A., Fleming, T. H., Schmidt, L., Loft, A., Herzig, S., Knieß, R. A., Mayer, M. P., Bukau, B., Nawroth, P. P., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.007 · Cited by 43

Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans

Dalton, H. M., & Curran, S. P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007520 · Cited by 43

Calorie restriction effects on silencing and recombination at the yeast rDNA

Smith, D. L., Li, C., Matecic, M., Maqani, N., Bryk, M., & Smith, J. S. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00516.x · Cited by 43

Fat Tissue and Long Life

her, M. B. U. (2008) · Obesity Facts · doi:10.1159/000145930 · Cited by 45

Glucose delays age‐dependent proteotoxicity

Tauffenberger, A., Vaccaro, A., Aulas, A., Velde, C. V., & Parker, J. A. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00855.x · Cited by 49

l-Theanine extends lifespan of adult Caenorhabditis elegans

Zarse, K., Jabin, S., & Ristow, M. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0341-5 · Cited by 42

Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3‐isoprostane measurement

Labuschagne, C. F., Stigter, E. C. A., Hendriks, M. M. W. B., Berger, R., Rokach, J., Korswagen, H. C., & Brenkman, A. B. (2012) · Aging Cell · doi:10.1111/acel.12043 · Cited by 43

Mitochondrial form, function and signalling in aging

Amigo, I., da Cunha, F. M., Forni, M. F., Garcia-Neto, W., Kakimoto, P. A., Luévano‐Martínez, L. A., Macedo, F. P., Menezes‐Filho, S. L., Peloggia, J., & Kowaltowski, A. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160451 · Cited by 42

Targeted mitochondrial uncoupling beyond UCP1 – The fine line between death and metabolic health

Ost, M., Keipert, S., & Klaus, S. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.013 · Cited by 42

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

Chaudhari, S. N., & Kipreos, E. T. (2018) · BioEssays · doi:10.1002/bies.201800005 · Cited by 42

The mechanoreceptor DEG‐1 regulates cold tolerance in Caenorhabditis elegans

Takagaki, N., Ohta, A., Ohnishi, K., Kawanabe, A., Minakuchi, Y., Toyoda, A., Fujiwara, Y., & Kuhara, A. (2020) · EMBO Reports · doi:10.15252/embr.201948671 · Cited by 42

Predicting whether dietary restriction would increase longevity in species not tested so far

Bourg, É. L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.01.001 · Cited by 44

Antidepressants of the Serotonin-Antagonist Type Increase Body Fat and Decrease Lifespan of Adult Caenorhabditis elegans

Zarse, K., & Ristow, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004062 · Cited by 45

Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy

de Moraes, G., & Layton, C. J. (2016) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12795 · Cited by 41

AMPK as a Pro-longevity Target

Burkewitz, K., Weir, H. J. M., & Mair, W. B. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_10 · Cited by 42

Defective glycolysis and the use of 2-deoxy-d-glucose in polycystic kidney disease: from animal models to humans

Magistroni, R., & Boletta, A. (2017) · Journal of Nephrology · doi:10.1007/s40620-017-0395-9 · Cited by 42

Glyphosate-based herbicides modulate oxidative stress response in the nematode Caenorhabditis elegans

Kronberg, F., Clavijo, A., Moya, A., Rossen, A., Calvo, D., Pagano, E. A., & Munarriz, E. R. (2018) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2018.08.002 · Cited by 41

Energy metabolism and survival of the juvenile recruits of the American lobster (Homarus americanus) exposed to a gradient of elevated seawater pCO2

Menu-Courey, K., Noisette, F., Piedalue, S., Daoud, D., Blair, T. J., Blier, P. U., Azetsu‐Scott, K., & Calosi, P. (2018) · Marine Environmental Research · doi:10.1016/j.marenvres.2018.10.002 · Cited by 44

Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways

Bao, Z., Dai, X., Wang, Z. P., Tao, Y., & Chai, D. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1618119 · Cited by 41

Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

Ng, L. T., Ng, L. F., Tang, R. M. Y., Barardo, D., Halliwell, B. B., Moore, P. K., & Gruber, J. (2020) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-020-0044-8 · Cited by 42

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection

Fischer, F., Grigolon, G., Benner, C., & Ristow, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00017.2021 · Cited by 42

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

Kirchweger, B., Zwirchmayr, J., Grienke, U., & Rollinger, J. M. (2023) · Natural Product Reports · doi:10.1039/d3np00021d · Cited by 40

OXIDATIVE STRESS AND THE EVOLUTION OF SEX DIFFERENCES IN LIFE SPAN AND AGEING IN THE DECORATED CRICKET,GRYLLODES SIGILLATUS

Archer, C. R., Sakaluk, S. K., Selman, C., Royle, N. J., & Hunt, J. (2012) · Evolution · doi:10.1111/j.1558-5646.2012.01805.x · Cited by 40

Early life nutrient restriction impairs blood–brain metabolic profile and neurobehavior predisposing to Alzheimer’s disease with aging

Tomi, M., Zhao, Y., Thamotharan, S., Shin, B., & Devaskar, S. U. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.050 · Cited by 40

Targeting the mitochondria to augment myocardial protection

SCHWARTZ, D., & Sack, M. N. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.008 · Cited by 41

Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria

Kim, H., Yang, J., Kim, M. J., Choi, S., Chung, J.-R., Kim, J., Yoo, Y. H., Chung, J., & Koh, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656934 · Cited by 40

Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?

Basisty, N., Dai, D., Gagnidze, A., Gitari, L., Fredrickson, J., Maina, Y., Beyer, R. P., Emond, M. J., Hsieh, E. J., MacCoss, M. J., et al. (2016) · Aging Cell · doi:10.1111/acel.12472 · Cited by 41

Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity

Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S., & van der Spek, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187424 · Cited by 40

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Beaudoin‐Chabot, C., Wang, L., Celik, C., Khalid, A. T.-F. A., Thalappilly, S., Xu, S., Koh, J. H., Lim, V. W. X., Low, A. D., & Thibault, G. (2022) · Nature Communications · doi:10.1038/s41467-022-33630-0 · Cited by 41

The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans

Wu, N., Ma, Y., Gong, X.-Q., Zhao, P., Jia, Y.-J., Zhao, Q., Duan, J.-H., & Zou, C. (2023) · Nature Communications · doi:10.1038/s41467-023-35899-1 · Cited by 41

The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress

Wang, Y., Yang, J., Yang, K., Cang, H., Huang, X., Li, H., & Yi, J. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.40 · Cited by 40

The Phytochemical Glaucarubinone Promotes Mitochondrial Metabolism, Reduces Body Fat, and Extends Lifespan ofCaenorhabditis elegans

Zarse, K., Boßecker, A., Müller‐Kuhrt, L., Siems, K., Hernandez, M. A., Berendsohn, W. G., Birringer, M., & Ristow, M. (2011) · Hormone and Metabolic Research · doi:10.1055/s-0030-1270524 · Cited by 40

d -Allulose, a stereoisomer of d -fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic

Shintani, T., Sakoguchi, H., Yoshihara, A., Izumori, K., & Sato, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.147 · Cited by 40

Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito

Goncalves, R. L. S., Machado, A. C. L., Paiva‐Silva, G. O., Sorgine, M. H. F., Momoli, M. M., Oliveira, J. H. M., Vannier-Santos, M. A., Galina, A., Oliveira, J. H. M., & de Oliveira, M. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007854 · Cited by 43

A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4

Rauthan, M., Ranji, P., Abukar, R., & Pilon, M. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.018598 · Cited by 39

Gene-diet interactions and aging in C. elegans

Yen, C. A., & Curran, S. P. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.012 · Cited by 38

The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective

Bresgen, N., Kovacs, M., Lahnsteiner, A., Felder, T. K., & Rinnerthaler, M. (2023) · Biomolecules · doi:10.3390/biom13060912 · Cited by 41

The modifying effect of vitamin C on the association between perfluorinated compounds and insulin resistance in the Korean elderly: a double-blind, randomized, placebo-controlled crossover trial

Kim, J. H., Park, H. Y., Jeon, J. D., Kho, Y., Kim, S., Park, M.-S., & Hong, Y. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0915-0 · Cited by 40

Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming

Ying, Z., Chen, K., Zheng, L., Wu, Y., Li, L., Wang, R., Long, Q., Yang, L., Guo, J., Yao, D., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.002 · Cited by 38

Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans

Yuan, Y., Hakimi, P., Kao, C., Kao, A. H., Liu, R., Janocha, A. J., Tressler, A. B., Hang, X., Alhoraibi, H., Slater, E., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691766 · Cited by 39

Glucose-induced abnormal egg-laying rate inCaenorhabditis elegans

eri, T., Miyahara, K., & Takeya, H. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2016.1158634 · Cited by 38

Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids

Jung, Y., Kwon, S., Ham, S., Lee, D.-Y., Park, H. H., Yamaoka, Y., Jeong, D., Artan, M., Altıntaş, Ö., Park, S., et al. (2020) · Aging Cell · doi:10.1111/acel.13150 · Cited by 38

Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

Franco-Juárez, B., Gómez‐Manzo, S., Hernández‐Ochoa, B., Cárdenas‐Rodríguez, N., Arreguín‐Espinosa, R., de la Cruz, V. P., & Ortega-Cuéllar, D. (2021) · Cells · doi:10.3390/cells10092359 · Cited by 41

Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages

Kraus, B., Wolff, H., Elstner, E. F., & Heilmann, J. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0512-y · Cited by 38

RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae

Torelli, N. Q., Ferreira-Júnior, J. R., Kowaltowski, A. J., & da Cunha, F. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.12.025 · Cited by 37

Bacterial processing of glucose modulates C. elegans lifespan and healthspan

Kingsley, S. F., Seo, Y., Allen, C., Ghanta, K. S., Finkel, S. E., & Tissenbaum, H. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-85046-3 · Cited by 39

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

Jeong, J.-H., Han, J.-S., Jung, Y., Lee, S.-M., Park, S., Park, M., Shin, M.-G., Kim, N., Kang, M. S., Kim, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35952-z · Cited by 38

Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment

Jin, R., Hao, J., Yu, J., Wang, P., Sauter, E. R., & Li, B. (2023) · Cancers · doi:10.3390/cancers15030657 · Cited by 38

Genetics and Pharmacology of Longevity

Castillo-Quan, J. I., Kinghorn, K. J., & Bjedov, I. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.002 · Cited by 37

Role of the hypothalamus in mediating protective effects of dietary restriction during aging

Dacks, P. A., Moreno, C. L., Kim, E. S., Marcellino, B. K., & Mobbs, C. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.12.001 · Cited by 38

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner

Brandstädt, S. M., Schmeißer, K., Zarse, K., & Ristow, M. (2013) · Aging · doi:10.18632/aging.100548 · Cited by 37

In Vivo Determination of Mitochondrial Function Using Luciferase‐ExpressingCaenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant‐Induced Dysfunction

Luz, A. L., Lagido, C., Hirschey, M. D., & Meyer, J. N. (2016) · Current Protocols in Toxicology · doi:10.1002/cptx.10 · Cited by 39

NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson’s disease

Zhang, S., Glukhova, S. A., Caldwell, K. A., & Caldwell, G. A. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx269 · Cited by 37

Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival

Chen, A. J., Li, J., Jannasch, A., Mutlu, A. S., Wang, M. C., & Cheng, J. (2018) · ChemPhysChem · doi:10.1002/cphc.201800545 · Cited by 37

ER reductive stress caused by Ero1α S-nitrosation accelerates senescence

Qiao, X., Zhang, Y., Ye, A., Zhang, Y., Xie, T., Lv, Z., Chang, S., Wu, D., Chu, B., Wu, X., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.006 · Cited by 39

Aging, Oxidative Stress and Antioxidants

Poljšak, B., & Milisav, I. (2013) · InTech eBooks · doi:10.5772/51609 · Cited by 40

Energy metabolism and ageing regulation: Metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction

Hipkiss, A. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.05.003 · Cited by 37

The role of dietary carbohydrates in organismal aging

Lee, D.-Y., Son, H. G., Jung, Y., & Lee, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2432-6 · Cited by 38

Neuronal Inputs and Outputs of Aging and Longevity

Alcedo, J., Flatt, T., & PASYUKOVA, E. G. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00071 · Cited by 39

Metabotyping ofCaenorhabditis elegansand their Culture Media Revealed Unique Metabolic Phenotypes Associated to Amino Acid Deficiency and Insulin-Like Signaling

Martin, F., Spanier, B., Collino, S., Montoliu, I., Kolmeder, C. A., Giesbertz, P., Affolter, M., Kussmann, M., Daniel, H., Kochhar, S., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr100703a · Cited by 38

Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease

Ahmad, W. (2018) · Experimental Brain Research · doi:10.1007/s00221-018-5341-0 · Cited by 36

Intimate Relations—Mitochondria and Ageing

Webb, M., & Sideris, D. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207580 · Cited by 36

Analyses of C. elegans Fat Metabolic Pathways

Barros, A. G. D. A., Liu, J., Lemieux, G. A., Mullaney, B., & Ashrafi, K. (2012) · Methods in cell biology · doi:10.1016/b978-0-12-394620-1.00013-8 · Cited by 36

Stress Resistance and Longevity Are Not Directly Linked to Levels of Enzymatic Antioxidants in the Ponerine Ant Harpegnathos saltator

Schneider, S. A., Schrader, C., Wagner, A. E., Boesch, C., Liebig, J., Rimbach, G. H., & Roeder, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014601 · Cited by 36

Intragenic repeat expansion in the cell wall protein gene HPF1 controls yeast chronological agingPreprint

Barré, B. P., Hallin, J., Yue, J., Persson, K. O., Mikhalev, E., Irizar, A., Holt, S., Thompson, D. A., Molin, M., Warringer, J., et al. (2020) · Genome Research · doi:10.1101/gr.253351.119 · Cited by 37

Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases

H. Swerdlow, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072535 · Cited by 35

Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans

Xiao, Y., Zhang, H., Sheng, Y., Liu, F., Gao, J., Liu, G., Li, S., Jiang, N., Yu, C., & Liu, Y. (2022) · iScience · doi:10.1016/j.isci.2022.105539 · Cited by 36

FoxO1 at the nexus between fat catabolism and longevity pathways

Lettieri‐Barbato, D., Aquilano, K., & Ciriolo, M. R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.004 · Cited by 35

Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels

Li, B., Skinner, C., Castello, P. R., Kato, M., Easlon, E. J., Xie, L., Li, T., Lu, S.-P., Wang, C., Tsang, F. A., et al. (2011) · Journal of Aging Research · doi:10.4061/2011/673185 · Cited by 36

Reactive oxygen species—Control and management using amphiphilic biosynthetic hydrogels for cardiac applications

Finosh, G. T., & Jayabalan, M. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.412150 · Cited by 35

Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice

Lin, A., Pulliam, D. A., Deepa, S. S., Halloran, J. J., Hussong, S. A., Burbank, R. R., Bresnen, A., Liu, Y., Podlutskaya, N., Soundararajan, A., et al. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.116 · Cited by 38

daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans

Mendler, M., Schlotterer, A., Ibrahim, Y., Kukudov, G., Fleming, T. H., Bierhaus, A., Riedinger, C., Schwenger, V., Herzig, S., Hecker, M., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3415-5 · Cited by 35

Feast and famine: Adipose tissue adaptations for healthy aging

Lettieri‐Barbato, D., & Aquilano, K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.007 · Cited by 35

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose

Shen, D. L., Liu, T.-W., Zandberg, W. F., Clark, T., Eskandari, R., Alteen, M. G., Tan, H. Y., Zhu, Y., Cecioni, S., & Vocadlo, D. J. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00876 · Cited by 35

Extracellular matrix/mitochondria pathway: A novel potential target for sarcopenia

Melouane, A., Yoshioka, M., & St‐Amand, J. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.10.007 · Cited by 35

Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

Roger, F., Picazo, C., Reiter, W., Libiad, M., Asami, C., Hanzén, S., Gao, C., Lagniel, G., Welkenhuysen, N., Labarre, J., et al. (2020) · eLife · doi:10.7554/elife.60346 · Cited by 37

Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction

Kim, S.-E., Mori, R., Komatsu, T., Chiba, T., Hayashi, H., Park, S., Sugawa, M. D., Dencher, N. A., & Shimokawa, I. (2015) · AGE · doi:10.1007/s11357-015-9787-8 · Cited by 34

Aging of Brown and Beige/Brite Adipose Tissue

Graja, A., Gohlke, S., & Schulz, T. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_151 · Cited by 38

Ilex paraguariensis extract provides increased resistance against oxidative stress and protection against Amyloid beta-induced toxicity compared to caffeine in Caenorhabditis elegans

Machado, M. L., Arantes, L. P., da Silveira, T. L., Zamberlan, D. C., Cordeiro, L. M., Baptista, F. B. O., da Silva, A. F., da Cruz, I. B. M., Soares, F. A. A., & Oliveira, R. D. P. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1671694 · Cited by 34

Validating the predictions of murburn model for oxygenic photosynthesis: Analyses of ligand-binding to protein complexes and cross-system comparisons

Manoj, K. M., Gideon, D. A., Parashar, A., Nirusimhan, V., Annadurai, P., Jacob, V. D., & Manekkathodi, A. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1953607 · Cited by 34

Caloric restriction and redox state: Does this diet increase or decrease oxidant production?

Kowaltowski, A. J. (2011) · Redox Report · doi:10.1179/1351000211y.0000000014 · Cited by 34

Aging and drug discovery

Bakula, D., Aliper, A. M., Mamoshina, P., Petr, M. A., Teklu, A., Baur, J. A., Campisi, J., Ewald, C. Y., Georgievskaya, A., Gladyshev, V. N., et al. (2018) · Aging · doi:10.18632/aging.101646 · Cited by 34

A genome-scale database and reconstruction of Caenorhabditis elegans metabolism

Gebauer, J., Gentsch, C., Mansfeld, J., Schmeißer, K., Waschina, S., Brandes, S., Klimmasch, L., Zamboni, N., Zarse, K., Schuster, S., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.04.017 · Cited by 33

Caloric Restriction-Induced Extension of Chronological Lifespan Requires Intact Respiration in Budding Yeast

Kwon, Y.-Y., Lee, S.-K., & Lee, C. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2279 · Cited by 33

SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2

Richter, M., Nickel, C., Apel, L., Kaas, A., Dodel, R. C., Culmsee, C., & Dolga, A. M. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2014.12.007 · Cited by 33

Age-Related Increase in Lactate Dehydrogenase Activity in Skeletal Muscle Reduces Life Span in Drosophila

Hunt, L. C., & Demontis, F. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab260 · Cited by 33

Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus

Mobbs, C. V., Moreno, C. L., & Poplawski, M. M. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.007 · Cited by 34

TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine

Kraig, R. P., Mitchell, H. M., Christie-Pope, B. C., Kunkler, P. E., White, D. M., Tang, Y., & Langan, G. P. (2010) · Dose-Response · doi:10.2203/dose-response.09-056.kraig · Cited by 34

Genetic cartography of longevity in humans and mice: Current landscape and horizons

Hook, M., Roy, S., Williams, E. G., Sleiman, M. S. B., Mozhui, K., Nelson, J. F., Lu, L., Auwerx, J. H., & Williams, R. W. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.026 · Cited by 33

Early Molecular Events during Onset of Diapause in Silkworm Eggs Revealed by Transcriptome Analysis

Gong, J., Zheng, X., Zhao, S., Yang, L., Zhao, X., Fan, Z., & Tang, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176180 · Cited by 32

Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway

Zhu, X., Liu, F., Wu, Q., Li, S., Guoyong, R. U. A. N., Yang, J., Yu, C., Jiang, N., Xiao, Y., & Liu, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109385 · Cited by 32

Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans

Possik, E., Klein, L.-L., Sanjab, P., Zhu, R., Côté, L., Bai, Y., Zhang, D., Sun, H. H., Al‐Mass, A., Oppong, A. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40857-y · Cited by 33

A Long, Deprived Life or a Short, Sweet One?

Adler, E. M. (2007) · Science s STKE · doi:10.1126/stke.4072007tw358

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Weimer, S., Priebs, J., Kuhlow, D., Groth, M., Priebe, S., Mansfeld, J., Merry, T. L., Dubuis, S., Laube, B., Pfeiffer, A. F. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4563 · Cited by 245

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789

Reductive stress on life span extension in C. elegans

Ralser, M., & Benjamin, I. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-19 · Cited by 22

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Reynoldson, L. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33915604