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Cited by 28Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Targeting Anabolic Impairment in Response to Resistance Exercise in Older Adults with Mobility Impairments: Potential Mechanisms and Rehabilitation Approaches

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Drummond, Micah J., Marcus, Robin L., LaStayo, Paul C.·2012·Journal of Aging Research
DOI 10.1155/2012/486930PMC PMC3446726
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Abstract

Muscle atrophy is associated with healthy aging (i.e., sarcopenia) and may be compounded by comorbidities, injury, surgery, illness, and physical inactivity. While a bout of resistance exercise increases protein synthesis rates in healthy young skeletal muscle, the effectiveness of resistance exercise to mount a protein synthetic response is less pronounced in older adults. Improving anabolic sensitivity to resistance exercise, thereby enhancing physical function, is most critical in needy older adults with clinical conditions that render them "low responders". In this paper, we discuss potential mechanisms contributing to anabolic impairment to resistance exercise and highlight the need to improve anabolic responsiveness in low responders. This is followed with evidence suggesting that the recovery period of resistance exercise provides an opportunity to amplify the exercise-induced anabolic response using protein/essential amino acid ingestion. This anabolic strategy, if repeated chronically, may improve lean muscle gains, decrease time to recovery of function during periods of rehabilitation, and overall, maintain/improve physical independence and reduce mortality rates in older adults.

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Crossref · 10.1155/2012/486930

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96 of 96 references verified0 citation errors · 0 not checkable

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  • Exercise consistently reduced the difference between muscle protein breakdown and synthesis.

    “Exercise consistently reduced the difference between muscle protein breakdown and synthesis; net positive protein balance (ie, synthesis greater than breakdown) was achieved only when protein or amino acid intake was supplemented.140,141”

    From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [141]

    Section 5, “Amplifying the Anabolic Response to Exercise” (page unavailable), says protein balance remains negative after resistance exercise without nutrients and becomes positive when protein or essential amino acids are provided near the exercise bout. Section 3 says exercise stimulates protein synthesis, but the paper does not establish that exercise consistently reduces the difference between breakdown and synthesis. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Net positive protein balance was achieved only when protein or amino acid intake was supplemented.

    “Exercise consistently reduced the difference between muscle protein breakdown and synthesis; net positive protein balance (ie, synthesis greater than breakdown) was achieved only when protein or amino acid intake was supplemented.140,141”

    From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [141]

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Research works printed but not linked: 3

  1. [13]Fiatarone MA Marks EC Ryan ND Meredith CN Lipsitz LA Evans WJ High-intensity strength training in nonagenarians Journal of the American Medical Association 1990 263 22 3029 3034 2-s2.0-0025316666 2342214
  2. [41]Baar K Esser K Phosphorylation of p70S6k correlates with increased skeletal muscle mass following resistance exercise American Journal of Physiology 1999 276 1 C120 C127 2-s2.0-0032948278 9886927
  3. [66]Symons TB Sheffield-Moore M Wolfe RR Paddon-Jones D A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects Journal of the American Dietetic Association 2009 109 9 1582 1586 2-s2.0-68849100887 19699838 PMC3197704

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Authors
Drummond, M. J., Marcus, R. L., & LaStayo, P. C.
Affiliations
University of Utah (US)
Corresponding author
Drummond, Micah J.
ORCID
Venue
Journal of Aging Research
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-8
ISSN
  • 2090-2204 (ISSN-L)
  • 2090-2212
DOI
10.1155/2012/486930
PMC
PMC3446726
OpenAlex
W2141485228
Cited by
28
References
96
Citations by year
2026: 3 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 4 · 2013: 2 · 2012: 1
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Aging Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute on Aging (K01AG038556)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sarcopenia, muscle atrophy, resistance training, older adults, mobility impairment, anabolic response, protein synthesis, low responders, essential amino acids, protein supplementation, post-exercise recovery, rehabilitation, physical function, aging

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