PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

The Neuroendocrinology of Stress: A Never Ending Story

Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works

Psychobiology and molecular genetics of resilience

Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works

BDNF - a key transducer of antidepressant effects

Björkholm, C., & Monteggia, L. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.034 · Cited by 958 · see citing works

Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle

Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885 · see citing works

The science of resilience: implications for the prevention and treatment of depression

Southwick, S. M., & Charney, D. S. (2012) · Science · doi:10.1126/science.1222942 · Cited by 875 · see citing works

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739 · see citing works

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722 · see citing works

Energy balance and its components: implications for body weight regulation

Hall, K. D., Heymsfield, S. B., Kemnitz, J. W., Klein, S., Schoeller, D. A., & Speakman, J. R. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.036350 · Cited by 721 · see citing works

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.136 · Cited by 605 · see citing works

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 596 · see citing works

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works

Critical Role of Brain-Derived Neurotrophic Factor in Mood Disorders

Hashimoto, K., Shimizu, E., & Iyo, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.003 · Cited by 522 · see citing works

Neural Mechanisms of Stress Resilience and Vulnerability

Franklin, T. B., Saab, B. J., & Mansuy, I. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.016 · Cited by 500 · see citing works

Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions

Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works

Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability

Westerblad, H., Bruton, J. D., & Katz, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.019 · Cited by 334 · see citing works

Muscle as a “Mediator” of Systemic Metabolism

Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333 · see citing works

Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits

Shimizu, E., Hashimoto, K., & Iyo, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20118 · Cited by 328 · see citing works

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Zhang, J.-C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.-X., Shirayama, Y., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu077 · Cited by 289 · see citing works

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

Yang, C., Ren, Q., Qu, Y., Zhang, J., Ma, M., Dong, C., & Hashimoto, K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.016 · Cited by 252 · see citing works

Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model

Yang, C., Qu, Y., Fujita, Y., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0031-4 · Cited by 225 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Molecular networks in skeletal muscle plasticity

Hoppeler, H. H. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.128207 · Cited by 194 · see citing works

Clinical role of brain-derived neurotropic factor in mood disorders

Hashimoto, K. (2004) · Medical Entomology and Zoology · Cited by 183 · see citing works

Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis

Yang, B., Ren, Q., Zhang, J.-C., Chen, Q.-X., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.95 · Cited by 182 · see citing works

Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist

Shirayama, Y., Yang, C., Zhang, J.-C., Ren, Q., Yao, W., & Hashimoto, K. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.002 · Cited by 137 · see citing works

Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Lindholm, J. S. O., & Castrén, E. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00143 · Cited by 114 · see citing works

Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway

Azimi, M., Gharakhanlou, R., Naghdi, N., Khodadadi, D., & Heysieattalab, S. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.027 · Cited by 109 · see citing works

Glutamate Signaling in Synaptogenesis and NMDA Receptors as Potential Therapeutic Targets for Psychiatric Disorders

Ohgi, Y., Futamura, T., & Hashimoto, K. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150330143008 · Cited by 107 · see citing works

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice

Ieraci, A., Madaio, A. I., Mallei, A., Lee, F. S., & Popoli, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.120 · Cited by 103 · see citing works

BDNF–TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms

Ren, Q., Ma, M., Yang, C., Zhang, J.-C., Yao, W., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.157 · Cited by 99 · see citing works

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience

Yang, B., Yang, C., Ren, Q., Zhang, J.-C., Chen, Q., Shirayama, Y., & Hashimoto, K. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0693-6 · Cited by 69 · see citing works

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

Qu, Y., Yang, C., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.16 · Cited by 68 · see citing works

Dynamic Expression and the Role of BDNF in Exercise-induced Skeletal Muscle Regeneration

Yu, T., Chang, Y., Gao, X., Li, H., & Zhao, P. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0043-118343 · Cited by 50 · see citing works

Effects of exercise training on brain‐derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction

Lee, H. W., Ahmad, M., Wang, H., & Leenen, F. H. H. (2017) · Experimental Physiology · doi:10.1113/ep086049 · Cited by 37 · see citing works

Stress resilience and cancer risk: a nationwide cohort study

Kennedy, B., Fang, F., Valdimarsdóttir, U. A., Udumyan, R., Montgomery, S., & Fall, K. (2017) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2016-208706 · Cited by 35 · see citing works

Does skeletal muscle carnitine availability influence fuel selection during exercise?

Stephens, F. B. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117003937 · Cited by 24 · see citing works

The molecular and cellular mechanisms of depression: a focus on reward circuitry

Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites

Yang, C., Yang, J., Luo, A., & Hashimoto, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0624-1 · Cited by 190 · see citing works

A Comprehensive Review on Bioavailability, Safety and Antidepressant Potential of Natural Bioactive Components from Tea

Shao, J., Wei, Y., & Wei, X. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111540 · Cited by 58 · see citing works

Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms

Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12 · see citing works

Effects of brain-derived neurotrophic factor and tvrosinekinase B in the disease of behavioral development in children

Chen, J. (2012) · International journal of pediatrics · doi:10.3760/cma.j.issn.1673-4408.2012.02.016

从噬菌体展示的构象限制性随机肽库中筛选有 trkB 结合活性的小肽

马仲才, 吴晓兰, 曹明媚, et al. (2002) · Science in China Series C-Life Sciences (in Chinese) · doi:10.1360/zc2002-32-5-463

Effect of Glatiramer Acetate on Peripheral Blood Brain-Derived Neurotrophic Factor and Phosphorylated TrkB Levels in Relapsing- Remitting Multiple Sclerosis

Văcăraș, V., Major, Z., Muresanu, D. F., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140618110049 · Cited by 11 · see citing works

Locomotor exercise alters expression of pro‐brain‐derived neurotrophic factor, brain‐derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats

Macias, M., Dwornik, A., Ziemlińska, E., Fehr, S., Schachner, M., Czarkowska‐Bauch, J., & Skup, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05498.x · Cited by 64 · see citing works

Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain

Kim, M.-W., Bang, M.-S., Han, T.-R., Ko, Y.-J., Yoon, B.-W., Kim, J.-H., Kang, L.-M., Lee, K.-M., & Kim, M.-H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.070 · Cited by 113 · see citing works